| Assay ID | Title | Year | Journal | Article |
|---|
| AID692735 | Inhibition of human Shh-induced mouse C3H10T1/2 cell differentiation after 48 hrs by alkaline phosphatase reporter assay relative to cyclopamine | 2012 | ACS medicinal chemistry letters, Oct-11, Volume: 3, Issue:10
| Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies. |
| AID692753 | Effect on purmorphamine-induced Gli1 transcription in mouse C3H10T1/2 cells at 103 to 25000 nM by qPCR analysis | 2012 | ACS medicinal chemistry letters, Oct-11, Volume: 3, Issue:10
| Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies. |
| AID467016 | Inhibition of SHH in mouse Ptch deffective MEF cells after 30 hrs by Gli-responsive beta-galactosidse reporter gene assay | 2009 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22
| Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog. |
| AID351773 | Binding affinity to SHH | 2009 | Journal of medicinal chemistry, Jul-09, Volume: 52, Issue:13
| Hedgehog-Gli signaling pathway inhibitors as anticancer agents. |
| AID467021 | Cytotoxicity against mouse Shh Light2 cells by cell titer glo assay | 2009 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22
| Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog. |
| AID498489 | Binding affinity to N-terminal Shh by surface plasmon resonance assay | 2009 | Nature chemical biology, Mar, Volume: 5, Issue:3
| A small molecule that binds Hedgehog and blocks its signaling in human cells. |
| AID498505 | Inhibition of of N-terminal N-palmitoylated Shh-mediated Gli2 transcription in human keratinocytes after 30 hrs by real-time quantitative PCR analysis in presence of 100 nM Smo agonist SAG | 2009 | Nature chemical biology, Mar, Volume: 5, Issue:3
| A small molecule that binds Hedgehog and blocks its signaling in human cells. |
| AID498492 | Inhibition of N-palmitoylated Shh in mouse Shh Light2 cells at > 30 uM after 30 hrs by firefly luciferase reporter gene assay | 2009 | Nature chemical biology, Mar, Volume: 5, Issue:3
| A small molecule that binds Hedgehog and blocks its signaling in human cells. |
| AID692734 | Inhibition of human Shh-induced mouse C3H10T1/2 cell differentiation after 48 hrs by alkaline phosphatase reporter assay | 2012 | ACS medicinal chemistry letters, Oct-11, Volume: 3, Issue:10
| Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies. |
| AID692746 | Effect on SAG-induced Gli1 transcription in mouse C3H10T1/2 cells at 103 to 25000 nM by qPCR analysis | 2012 | ACS medicinal chemistry letters, Oct-11, Volume: 3, Issue:10
| Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies. |
| AID498508 | Inhibition of Shh in MEF deficient in ptch1 gene assessed as beta-galactosidase activity at 1.56 to 25 uM after 30 mins by luminometry | 2009 | Nature chemical biology, Mar, Volume: 5, Issue:3
| A small molecule that binds Hedgehog and blocks its signaling in human cells. |
| AID498495 | Inhibition of N-palmitoylated Shh in mouse Shh Light2 cells at 6.3 to 50 uM after 30 hrs by firefly luciferase reporter assay in presence of 3.6 uM Smo agonist purmorphamine | 2009 | Nature chemical biology, Mar, Volume: 5, Issue:3
| A small molecule that binds Hedgehog and blocks its signaling in human cells. |
| AID498506 | Inhibition of Shh-mediated Gli1 mRNA transcription in human synthetic skin by real-time quantitative PCR analysis | 2009 | Nature chemical biology, Mar, Volume: 5, Issue:3
| A small molecule that binds Hedgehog and blocks its signaling in human cells. |
| AID498504 | Inhibition of of N-terminal N-palmitoylated Shh-mediated Gli2 transcription in human keratinocytes after 30 hrs by real-time quantitative PCR analysis in presence of 3.6 uM Smo agonist purmorphamine | 2009 | Nature chemical biology, Mar, Volume: 5, Issue:3
| A small molecule that binds Hedgehog and blocks its signaling in human cells. |
| AID498507 | Inhibition of Shh-mediated Gli2 mRNA transcription in human synthetic skin by real-time quantitative PCR analysis | 2009 | Nature chemical biology, Mar, Volume: 5, Issue:3
| A small molecule that binds Hedgehog and blocks its signaling in human cells. |
| AID498496 | Inhibition of N-palmitoylated Shh in mouse Shh Light2 cells at 6.3 to 50 uM after 30 hrs by firefly luciferase reporter assay in presence of 100 nM Smo agonist SAG | 2009 | Nature chemical biology, Mar, Volume: 5, Issue:3
| A small molecule that binds Hedgehog and blocks its signaling in human cells. |
| AID498497 | Inhibition of N-terminal Shh-induced differentiation in mouse C3H10T1/2 cells assessed as inhibition of alkaline phosphatase induction | 2009 | Nature chemical biology, Mar, Volume: 5, Issue:3
| A small molecule that binds Hedgehog and blocks its signaling in human cells. |
| AID467017 | Inhibition of SHH in mouse Shh Light2 cells after 30 hrs by GLI-responsive bright glo luciferase reporter gene assay | 2009 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22
| Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog. |
| AID467019 | Inhibition of SHH in mouse Shh Light2 cells after 30 hrs by GLI-responsive bright glo luciferase reporter gene assay relative to 6 uM cyclopamine | 2009 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22
| Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog. |
| AID498503 | Inhibition of of N-terminal N-palmitoylated Shh-mediated Gli1 transcription in human keratinocytes after 30 hrs by real-time quantitative PCR analysis in presence of 100 nM Smo agonist SAG | 2009 | Nature chemical biology, Mar, Volume: 5, Issue:3
| A small molecule that binds Hedgehog and blocks its signaling in human cells. |
| AID467022 | Binding affinity to recombinant Shh N-terminal peptide by surface plasma resonance | 2009 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22
| Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog. |
| AID498490 | Inhibition of N-palmitoylated Shh in mouse Shh Light2 cells after 30 hrs by firefly luciferase reporter gene assay | 2009 | Nature chemical biology, Mar, Volume: 5, Issue:3
| A small molecule that binds Hedgehog and blocks its signaling in human cells. |
| AID498499 | Displacement of BODIPY-cyclopamine from Smo expressed in HEK293T cells after 30 mins | 2009 | Nature chemical biology, Mar, Volume: 5, Issue:3
| A small molecule that binds Hedgehog and blocks its signaling in human cells. |
| AID509548 | Antagonist activity at hedgehog receptor | 2010 | Bioorganic & medicinal chemistry, Sep-15, Volume: 18, Issue:18
| Modulators of the hedgehog signaling pathway. |
| AID498502 | Inhibition of of N-terminal N-palmitoylated Shh-mediated Gli1 transcription in human keratinocytes after 30 hrs by real-time quantitative PCR analysis in presence of 3.6 uM Smo agonist purmorphamine | 2009 | Nature chemical biology, Mar, Volume: 5, Issue:3
| A small molecule that binds Hedgehog and blocks its signaling in human cells. |
| AID1525379 | Inhibition of sonic hedgehog signaling in mouse Shh Light2 cells after 30 mins by Bright-Glo luciferase assay | 2019 | Journal of medicinal chemistry, 09-26, Volume: 62, Issue:18
| Inhibiting Hedgehog: An Update on Pharmacological Compounds and Targeting Strategies. |
| AID711515 | Inhibition of sonic hedgehog pathway in mouse NIH-3T3 cells | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
| Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery. |
| AID498501 | Inhibition of of N-terminal N-palmitoylated Shh-mediated Gli1 transcription in human keratinocytes after 30 hrs by real-time quantitative PCR analysis | 2009 | Nature chemical biology, Mar, Volume: 5, Issue:3
| A small molecule that binds Hedgehog and blocks its signaling in human cells. |
| AID498500 | Inhibition of of N-terminal N-palmitoylated Shh-mediated Gli2 transcription in human keratinocytes at 100 uM after 30 hrs by real-time quantitative PCR analysis | 2009 | Nature chemical biology, Mar, Volume: 5, Issue:3
| A small molecule that binds Hedgehog and blocks its signaling in human cells. |
| AID711518 | Inhibition of sonic hedgehog pathway in mouse NIH-3T3 cells relative to control | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
| Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery. |
| AID498498 | Inhibition of N-terminal Shh-induced differentiation in mouse C3H10T1/2 cells assessed as inhibition of alkaline phosphatase induction in presence of 3.6 uM purmorphamine | 2009 | Nature chemical biology, Mar, Volume: 5, Issue:3
| A small molecule that binds Hedgehog and blocks its signaling in human cells. |
| AID498491 | Cytotoxicity against mouse Shh Light2 cells assessed as cell viability | 2009 | Nature chemical biology, Mar, Volume: 5, Issue:3
| A small molecule that binds Hedgehog and blocks its signaling in human cells. |
| AID1525378 | Binding affinity to N-terminal sonic hedgehog (unknown origin) by surface plasmon resonance analysis | 2019 | Journal of medicinal chemistry, 09-26, Volume: 62, Issue:18
| Inhibiting Hedgehog: An Update on Pharmacological Compounds and Targeting Strategies. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |