Page last updated: 2024-10-24

molecular sequestering activity

Definition

Target type: molecularfunction

Binding to a specific molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active. [PMID:13130076]

Molecular sequestering activity refers to the ability of a molecule to bind to and remove another molecule from its active site, effectively preventing it from participating in biological processes. This binding can be achieved through various mechanisms, including electrostatic interactions, hydrophobic interactions, hydrogen bonding, and van der Waals forces. The molecule that is sequestered, often a target protein or signaling molecule, is rendered inactive or less active by its removal from the environment where it would typically function. This process is crucial for regulating cellular processes by controlling the availability and activity of specific molecules. Sequestration can be achieved through a variety of mechanisms including:
- **Protein-protein interactions:** Binding to a target protein to prevent its interaction with other proteins or substrates.
- **Protein-small molecule interactions:** Binding to small molecules, such as inhibitors or drugs, to prevent their interaction with target proteins.
- **Sequestration within organelles:** Encapsulating the target molecule within organelles, such as vesicles or lysosomes, to isolate it from the rest of the cell.
- **Binding to specific regions within cells:** Localizing the target molecule to specific regions of the cell where it cannot perform its function.
- **Binding to extracellular matrix components:** Binding the target molecule to components of the extracellular matrix to prevent it from diffusing and interacting with other molecules.
This activity plays a vital role in a variety of biological processes, including signal transduction, gene expression, and cell differentiation. Examples of molecules exhibiting molecular sequestering activity include chaperone proteins, which prevent misfolded proteins from aggregating, and protein kinases, which can sequester substrates and modulate their activity. '
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Proteins (3)

ProteinDefinitionTaxonomy
Probable ubiquitin carboxyl-terminal hydrolase FAF-XA probable ubiquitin carboxyl-terminal hydrolase FAF-X that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q93008]Homo sapiens (human)
NF-kappa-B inhibitor alphaAn NF-kappa-B inhibitor alpha that is encoded in the genome of human. [TLR:AMM, UniProtKB:P25963]Homo sapiens (human)
Complement C1r subcomponentA complement C1r subcomponent that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00736]Homo sapiens (human)

Compounds (9)

CompoundDefinitionClassesRoles
nafamostatnafamostat: inhibitor of trypsin, plasmin, pancreatic kallikrein, plasma kallikrein & thrombin; strongly inhibits esterolytic activities of C1r & C1 esterase complement-mediated hemolysis; antineoplasticbenzoic acids;
guanidines
sepimostate mesilatesepimostate mesilate: used in therapy of pancreatitis; structure given in first source
8-(4-benzenesulfonylamino)quinoline8-(4-benzenesulfonylamino)quinoline: has diabetogenic properties; structure given in first source
benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde: proteasome inhibitor

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal : A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.
amino aldehyde;
carbamate ester;
tripeptide
proteasome inhibitor
5H-quinolino[8,7-c][1,2]benzothiazine 6,6-dioxidebenzothiazine
degrasyndegrasyn: a JAK2 kinase inhibitor that induces rapid degradation of c-Myc protein in MM-1 multiple myeloma and other tumor cell lines; structure in first source
nsc-287088
physalin aphysalin A: an anti-inflammatory agent isolated from Physalis alkekengi var; structure in first sourcephysalin
physalin fphysalin F : A physalin with antimalarial and antitumour activities isolated from Physalis angulata.

physalin F: has immunosuppressive activity; from Physalis angulata L; structure given in first source
enone;
epoxy steroid;
lactone;
physalin
antileishmanial agent;
antimalarial;
antineoplastic agent;
apoptosis inducer;
immunosuppressive agent