Target type: biologicalprocess
The developmental process in which the stucture of the notochord is destroyed in an embryo. [GOC:dph]
Notochord regression is a critical developmental process that occurs in vertebrates during embryogenesis. It involves the gradual disappearance of the notochord, a rod-like structure that serves as the primary axial support for the developing embryo. This regression is essential for the proper formation of the vertebral column and the development of other structures, such as the intervertebral discs.
The process begins with the degeneration of notochord cells, which undergo programmed cell death (apoptosis). This is triggered by various signaling pathways, including the Wnt and BMP pathways. As notochord cells die, their extracellular matrix also degrades.
Concurrently, the surrounding tissues, specifically the somites, proliferate and differentiate to form the vertebral column. The somitic cells migrate towards the notochord, enveloping it and eventually replacing it. The notochord remnants become incorporated into the intervertebral discs, forming the nucleus pulposus, which provides cushioning and flexibility to the spine.
Notochord regression is a highly regulated process involving complex interactions between various signaling pathways, cell types, and extracellular matrix components. It is crucial for the proper development of the vertebral column and for the overall health and well-being of the organism. Failure of notochord regression can lead to various developmental abnormalities, including spina bifida, a condition in which the spinal cord does not close properly.'
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Protein | Definition | Taxonomy |
---|---|---|
Zinc finger protein GLI1 | A zinc finger protein GLI1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P08151] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
---|---|---|---|
staurosporine aglycone | staurosporine aglycone: metabolite from culture broth of Nocardiopsis sp.; a neurotrophin antag; inhibits BDNF TrkB receptor | ||
betulinic acid | hydroxy monocarboxylic acid; pentacyclic triterpenoid | anti-HIV agent; anti-inflammatory agent; antimalarial; antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; plant metabolite | |
ceanothic acid | ceanothic acid: isolated from Ceanothus americanus; structure in first source | ||
gant 61 | GANT 61: a sonic hedgehog pathway inhibitor and Gli inhibitor; structure in first source GANT61 : An aminal that is hexahydropyrimidine which is substituted on each nitrogen by a 2-(dimethylamino)benzyl group, and at the aminal carbon by a pyridin-4-yl group. A Hedgehog signaling pathway and Gli protein inhibitor. | aminal; dialkylarylamine; pyridines; substituted aniline; tertiary amino compound | antineoplastic agent; apoptosis inducer; glioma-associated oncogene inhibitor; Hedgehog signaling pathway inhibitor |
zerumbone | zerumbone : A sesquiterpenoid and cyclic ketone that is (1E,4E,8E)-alpha-humulene which is substituted by an oxo group at the carbon atom attached to two double bonds. It is obtained by steam distillation from a type of edible ginger, Zingiber zerumbet Smith, grown particularly in southeast Asia. zerumbone: RN given for (E,E,E)-isomer; structure in first source | cyclic ketone; sesquiterpenoid | anti-inflammatory agent; glioma-associated oncogene inhibitor; plant metabolite |
nsc-287088 | |||
2alpha,3beta-dihydroxy-20(29)-lupen-28-oic acid | 2alpha,3beta-dihydroxy-20(29)-lupen-28-oic acid : A pentacyclic triterpenoid that is betulinic acid carrying an additional alpha-hydroxy group at position 2. It has been isolated from Breynia fruticosa. alphitolic acid: from the aerial parts of Gouania longipetala; structure in first source | dihydroxy monocarboxylic acid; pentacyclic triterpenoid | plant metabolite |
physalin f | physalin F : A physalin with antimalarial and antitumour activities isolated from Physalis angulata. physalin F: has immunosuppressive activity; from Physalis angulata L; structure given in first source | enone; epoxy steroid; lactone; physalin | antileishmanial agent; antimalarial; antineoplastic agent; apoptosis inducer; immunosuppressive agent |