notochord regression

Definition

Target type: biologicalprocess

The developmental process in which the stucture of the notochord is destroyed in an embryo. [GOC:dph]

Notochord regression is a critical developmental process that occurs in vertebrates during embryogenesis. It involves the gradual disappearance of the notochord, a rod-like structure that serves as the primary axial support for the developing embryo. This regression is essential for the proper formation of the vertebral column and the development of other structures, such as the intervertebral discs.

The process begins with the degeneration of notochord cells, which undergo programmed cell death (apoptosis). This is triggered by various signaling pathways, including the Wnt and BMP pathways. As notochord cells die, their extracellular matrix also degrades.

Concurrently, the surrounding tissues, specifically the somites, proliferate and differentiate to form the vertebral column. The somitic cells migrate towards the notochord, enveloping it and eventually replacing it. The notochord remnants become incorporated into the intervertebral discs, forming the nucleus pulposus, which provides cushioning and flexibility to the spine.

Notochord regression is a highly regulated process involving complex interactions between various signaling pathways, cell types, and extracellular matrix components. It is crucial for the proper development of the vertebral column and for the overall health and well-being of the organism. Failure of notochord regression can lead to various developmental abnormalities, including spina bifida, a condition in which the spinal cord does not close properly.'
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Proteins (1)

Compounds (8)