Page last updated: 2024-10-24

notochord regression

Definition

Target type: biologicalprocess

The developmental process in which the stucture of the notochord is destroyed in an embryo. [GOC:dph]

Notochord regression is a critical developmental process that occurs in vertebrates during embryogenesis. It involves the gradual disappearance of the notochord, a rod-like structure that serves as the primary axial support for the developing embryo. This regression is essential for the proper formation of the vertebral column and the development of other structures, such as the intervertebral discs.

The process begins with the degeneration of notochord cells, which undergo programmed cell death (apoptosis). This is triggered by various signaling pathways, including the Wnt and BMP pathways. As notochord cells die, their extracellular matrix also degrades.

Concurrently, the surrounding tissues, specifically the somites, proliferate and differentiate to form the vertebral column. The somitic cells migrate towards the notochord, enveloping it and eventually replacing it. The notochord remnants become incorporated into the intervertebral discs, forming the nucleus pulposus, which provides cushioning and flexibility to the spine.

Notochord regression is a highly regulated process involving complex interactions between various signaling pathways, cell types, and extracellular matrix components. It is crucial for the proper development of the vertebral column and for the overall health and well-being of the organism. Failure of notochord regression can lead to various developmental abnormalities, including spina bifida, a condition in which the spinal cord does not close properly.'
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Proteins (1)

ProteinDefinitionTaxonomy
Zinc finger protein GLI1A zinc finger protein GLI1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P08151]Homo sapiens (human)

Compounds (8)

CompoundDefinitionClassesRoles
staurosporine aglyconestaurosporine aglycone: metabolite from culture broth of Nocardiopsis sp.; a neurotrophin antag; inhibits BDNF TrkB receptor
betulinic acidhydroxy monocarboxylic acid;
pentacyclic triterpenoid
anti-HIV agent;
anti-inflammatory agent;
antimalarial;
antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
plant metabolite
ceanothic acidceanothic acid: isolated from Ceanothus americanus; structure in first source
gant 61GANT 61: a sonic hedgehog pathway inhibitor and Gli inhibitor; structure in first source

GANT61 : An aminal that is hexahydropyrimidine which is substituted on each nitrogen by a 2-(dimethylamino)benzyl group, and at the aminal carbon by a pyridin-4-yl group. A Hedgehog signaling pathway and Gli protein inhibitor.
aminal;
dialkylarylamine;
pyridines;
substituted aniline;
tertiary amino compound
antineoplastic agent;
apoptosis inducer;
glioma-associated oncogene inhibitor;
Hedgehog signaling pathway inhibitor
zerumbonezerumbone : A sesquiterpenoid and cyclic ketone that is (1E,4E,8E)-alpha-humulene which is substituted by an oxo group at the carbon atom attached to two double bonds. It is obtained by steam distillation from a type of edible ginger, Zingiber zerumbet Smith, grown particularly in southeast Asia.

zerumbone: RN given for (E,E,E)-isomer; structure in first source
cyclic ketone;
sesquiterpenoid
anti-inflammatory agent;
glioma-associated oncogene inhibitor;
plant metabolite
nsc-287088
2alpha,3beta-dihydroxy-20(29)-lupen-28-oic acid2alpha,3beta-dihydroxy-20(29)-lupen-28-oic acid : A pentacyclic triterpenoid that is betulinic acid carrying an additional alpha-hydroxy group at position 2. It has been isolated from Breynia fruticosa.

alphitolic acid: from the aerial parts of Gouania longipetala; structure in first source
dihydroxy monocarboxylic acid;
pentacyclic triterpenoid
plant metabolite
physalin fphysalin F : A physalin with antimalarial and antitumour activities isolated from Physalis angulata.

physalin F: has immunosuppressive activity; from Physalis angulata L; structure given in first source
enone;
epoxy steroid;
lactone;
physalin
antileishmanial agent;
antimalarial;
antineoplastic agent;
apoptosis inducer;
immunosuppressive agent