Page last updated: 2024-10-24

protein sequestering activity

Definition

Target type: molecularfunction

Binding to a protein to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active. [PMID:1493333]

Protein sequestering activity is a molecular function that involves the binding and retention of other proteins within a specific compartment or structure, effectively removing them from their normal cellular location and function. This process often plays a crucial role in regulating cellular processes by:

1. **Controlling protein activity:** By sequestering proteins, cells can modulate their activity, preventing them from interacting with their targets or performing their normal functions. This can be particularly important for controlling signaling pathways or preventing the inappropriate activation of enzymes.

2. **Preventing aggregation:** Sequestering proteins can help prevent the formation of harmful protein aggregates, which can occur when misfolded or damaged proteins accumulate in cells. This is particularly important for maintaining protein homeostasis and preventing neurodegenerative diseases.

3. **Directing protein trafficking:** Sequestering proteins can also be used to direct their trafficking to specific locations within the cell, ensuring their proper localization and function.

4. **Modulating cellular responses:** Protein sequestration can be used to modulate cellular responses to different stimuli, such as stress or infection. For example, sequestering key transcription factors can prevent the activation of specific genes in response to stress.

5. **Protecting proteins from degradation:** Sequestering proteins can protect them from degradation by cellular proteases. This can be important for maintaining the levels of essential proteins or for regulating the lifespan of proteins.

The mechanism of protein sequestration can vary depending on the specific protein and cellular context. Some common mechanisms include:

* **Binding to specific proteins:** Proteins can be sequestered by binding to specific chaperones or other regulatory proteins that prevent them from interacting with their targets.
* **Localization to specific compartments:** Proteins can be sequestered within specific cellular compartments, such as the nucleus, cytoplasm, or organelles.
* **Formation of protein complexes:** Proteins can be sequestered within multiprotein complexes, which can regulate their activity and prevent them from interacting with other proteins.

Overall, protein sequestering activity is a versatile mechanism that plays a critical role in regulating cellular processes and maintaining cellular homeostasis.'
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Proteins (5)

ProteinDefinitionTaxonomy
Smoothened homologA protein smoothened that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99835]Homo sapiens (human)
RISC-loading complex subunit TARBP2A RISC-loading complex subunit TARBP2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q15633]Homo sapiens (human)
14-3-3 protein zeta/deltaA 14-3-3 protein zeta/delta that is encoded in the genome of human. [PRO:DNx]Homo sapiens (human)
14-3-3 protein gammaA 14-3-3 protein gamma that is encoded in the genome of human. [PRO:DNx, UniProtKB:P61981]Homo sapiens (human)
NF-kappa-B inhibitor alphaAn NF-kappa-B inhibitor alpha that is encoded in the genome of human. [TLR:AMM, UniProtKB:P25963]Homo sapiens (human)

Compounds (24)

CompoundDefinitionClassesRoles
enoxacinenoxacin : A 1,8-naphthyridine derivative that is 1,4-dihydro-1,8-naphthyridine with an ethyl group at the 1 position, a carboxy group at the 3-position, an oxo sustituent at the 4-position, a fluoro substituent at the 5-position and a piperazin-1-yl group at the 7 position. An antibacterial, it is used in the treatment of urinary-tract infections and gonorrhoea.

Enoxacin: A broad-spectrum 6-fluoronaphthyridinone antibacterial agent that is structurally related to NALIDIXIC ACID.
1,8-naphthyridine derivative;
amino acid;
fluoroquinolone antibiotic;
monocarboxylic acid;
N-arylpiperazine;
quinolone antibiotic
antibacterial drug;
DNA synthesis inhibitor
schisanhenol bschisanhenol B: isolated from kernels of Schisandra rubriflora; structure given in first source
8-(4-benzenesulfonylamino)quinoline8-(4-benzenesulfonylamino)quinoline: has diabetogenic properties; structure given in first source
cyclopaminepiperidinesglioma-associated oncogene inhibitor
pd 173955PD 173955: inhibits src family-selective tyrosine kinase; structure in first sourcearyl sulfide;
dichlorobenzene;
methyl sulfide;
pyridopyrimidine
tyrosine kinase inhibitor
benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde: proteasome inhibitor

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal : A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.
amino aldehyde;
carbamate ester;
tripeptide
proteasome inhibitor
5H-quinolino[8,7-c][1,2]benzothiazine 6,6-dioxidebenzothiazine
mrs2159MRS2159: an antagonist of both P2X1 and P2X7 receptors
purmorphaminepurmorphamine : A member of the class of purines that is purine substituted at C-2 by a 1-naphthyloxy group, at C-4 by a 4-morpholinophenylamino group, and at N-9 by a cyclohexyl group.

purmorphamine: structure in first source
aromatic ether;
morpholines;
purines;
secondary amino compound
osteogenesis regulator;
SMO receptor agonist
cur 61414CUR 61414: inhibits the hedehog signaling pathway; structure in first source
abt 869aromatic amine;
indazoles;
phenylureas
angiogenesis inhibitor;
antineoplastic agent;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
nsc-287088
lde225sonidegib : A member of the classo of biphenyls that is the amide obtained by formal condensation of the carboxy group of 2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxylic acid with the amino group of 6-(2,6-dimethylmorpholin-4-yl)pyridin-3-amine. Used (as its phosphate salt) for treatment of locally advanced basal cell carcinoma.

sonidegib: specific Smoothened/Smo antagonist
aminopyridine;
aromatic ether;
benzamides;
biphenyls;
morpholines;
organofluorine compound;
tertiary amino compound
antineoplastic agent;
Hedgehog signaling pathway inhibitor;
SMO receptor antagonist
gdc 0449HhAntag691: inhibits the hedgehog pathway and ABC transporters; has antineoplastic activitybenzamides;
monochlorobenzenes;
pyridines;
sulfone
antineoplastic agent;
Hedgehog signaling pathway inhibitor;
SMO receptor antagonist;
teratogenic agent
N-[[3-fluoro-4-[[2-(1-methyl-4-imidazolyl)-7-thieno[3,2-b]pyridinyl]oxy]anilino]-sulfanylidenemethyl]-2-phenylacetamidethioureas
ipi-926IPI-926: a semisynthetic derivative of cyclopamine that is a smoothened inhibitor with antineoplastic activity; structure in first sourcepiperidines
gsk 1363089GSK 1363089: a multikinase inhibitor that acts on Met, RON, Axl, and VEGFR; structure in first sourcearomatic ether
tak-441TAK-441: structure in first source
physalin aphysalin A: an anti-inflammatory agent isolated from Physalis alkekengi var; structure in first sourcephysalin
ly2940680
physalin fphysalin F : A physalin with antimalarial and antitumour activities isolated from Physalis angulata.

physalin F: has immunosuppressive activity; from Physalis angulata L; structure given in first source
enone;
epoxy steroid;
lactone;
physalin
antileishmanial agent;
antimalarial;
antineoplastic agent;
apoptosis inducer;
immunosuppressive agent
3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylureaBGJ-398 : A member of the class of phenylureas that is urea in which a hydrogen attached to one of the nitrogens is replaced by a 2,6-dichloro-3,5-dimethoxyphenyl group, while the hydrogens attached to the other nitrogen are replaced by a methyl group and a 6-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl group. It is a potent and selective fibroblast growth factor receptor inhibitor.

infigratinib: structure in first source
aminopyrimidine;
dichlorobenzene;
N-alkylpiperazine;
N-arylpiperazine;
phenylureas
antineoplastic agent;
fibroblast growth factor receptor antagonist
cep-32496agerafenib: inhibitor of RAF family kinases; structure in first source
pf-52748571-(4-(5'-chloro-3,5-dimethyl-2,4'-bipyridin-2'-yl)piperazin-1-yl)-3-(methylsulfonyl)propan-1-one: a potent and selective Smoothened antagonist that penetrates the blood-brain barrier; structure in first source