Page last updated: 2024-10-24

kinesin complex

Definition

Target type: cellularcomponent

Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work. [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]

The kinesin complex is a molecular motor that uses the energy from ATP hydrolysis to move along microtubules. The cellular component of the kinesin complex is a complex assembly of proteins that includes the following:

- **Kinesin heavy chains:** These are the motor proteins that bind to microtubules and move along them. They consist of a globular head domain that binds to microtubules, a neck linker that connects the head domain to the tail domain, and a tail domain that binds to cargo.

- **Kinesin light chains:** These proteins are associated with the tail domain of the kinesin heavy chain and help to link the kinesin complex to cargo. They are thought to regulate the activity of the kinesin motor.

- **Other accessory proteins:** These proteins can be associated with the kinesin complex, and they may have a role in regulating the activity of the complex, stabilizing its structure, or targeting it to specific locations in the cell.

The specific composition of the kinesin complex can vary depending on the type of kinesin and the cargo it is transporting. However, the basic structure of the complex is always the same: two kinesin heavy chains, two kinesin light chains, and a variety of other accessory proteins.

The kinesin complex is essential for a wide variety of cellular processes, including organelle transport, cell division, and cell migration. It is also involved in many diseases, such as cancer and neurodegenerative disorders.'
"

Proteins (5)

ProteinDefinitionTaxonomy
Kinesin-like protein KIF15A kinesin-like protein KIF15 that is encoded in the genome of human. [PRO:CNx, Reactome:R-HSA-984825]Homo sapiens (human)
Kinesin-1 heavy chainA kinesin-1 heavy chain that is encoded in the genome of human. [PRO:DNx, UniProtKB:P33176]Homo sapiens (human)
Kinesin-like protein KIF20BA kinesin-like protein KIF20B that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96Q89]Homo sapiens (human)
Kinesin-like protein KIFC1A kinesin-like protein KIFC1 that is encoded in the genome of human. [PRO:DNx]Homo sapiens (human)
Kinesin-like protein KIF11A kinesin-like protein KIF11 that is encoded in the genome of human. [PRO:DNx]Homo sapiens (human)

Compounds (29)

CompoundDefinitionClassesRoles
gossypolGossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
whi p180
cysteinecysteine;
cysteine zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
serine family amino acid
EC 4.3.1.3 (histidine ammonia-lyase) inhibitor;
flour treatment agent;
human metabolite
s-methylcysteineS-methylcysteine : A cysteine derivative that is L-cysteine in which the hydrogen attached to the sulfur is replaced by a methyl group.

S-methylcysteine: RN given refers to parent cpd without isomeric designation
S-alkyl-L-cysteine;
S-alkyl-L-cysteine zwitterion
human urinary metabolite;
plant metabolite
staurosporineindolocarbazole alkaloid;
organic heterooctacyclic compound
apoptosis inducer;
bacterial metabolite;
EC 2.7.11.13 (protein kinase C) inhibitor;
geroprotector
physodic acidphysodic acid: lichen constituentcarbonyl compound
3-tritylthio-l-alaninebenzenoid aromatic compound
s-2-aminoethyl cysteineL-thialysine : A cysteine derivative that is the S-(2-aminoethyl) analogue of L-cysteine; reported to have cytotoxic effects.

S-2-aminoethyl cysteine: inhibits protein synthesis in mammalian cells; RN given refers to parent cpd; structure
L-cysteine thioether;
non-proteinogenic L-alpha-amino acid
EC 5.4.3.2 (lysine 2,3-aminomutase) inhibitor;
metabolite;
protein synthesis inhibitor
docetaxel anhydrousdocetaxel anhydrous : A tetracyclic diterpenoid that is paclitaxel with the N-benzyloxycarbonyl group replaced by N-tert-butoxycarbonyl, and the acetoxy group at position 10 replaced by a hydroxy group.

Docetaxel: A semisynthetic analog of PACLITAXEL used in the treatment of locally advanced or metastatic BREAST NEOPLASMS and NON-SMALL CELL LUNG CANCER.
secondary alpha-hydroxy ketone;
tetracyclic diterpenoid
antimalarial;
antineoplastic agent;
photosensitizing agent
s-benzylcysteineS-aryl-L-cysteine zwitterion
carbocysteineCarbocysteine: A compound formed when iodoacetic acid reacts with sulfhydryl groups in proteins. It has been used as an anti-infective nasal spray with mucolytic and expectorant action.

S-carboxymethyl-L-cysteine : An L-cysteine thioether that is L-cysteine in which the hydrogen of the thiol group has been replaced by a carboxymethyl group.
L-cysteine thioether;
non-proteinogenic L-alpha-amino acid
mucolytic
1-acetyl-3,5-diphenyl-4,5-dihydro-(1h)-pyrazole
(S)-monastrolethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
k 858K 858: an Eg5 inhibitor and antineoplastic agent; structure in first sourcebenzenes
monastrol(S)-monastrol : An ethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate that has S configuration.

ethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate : A member of the class of thioureas that is 3,4-dihydropyrimidine-2(1)-thione substituted by a 3-hydroxyphenyl group at position 4, an ethoxycarbonyl group at position 5, and a methyl group at position 6.

monastrol : A racemate comprising equimolar amounts of R- and S-monastrol.

monastrol: stops mitosis by fostering formation of monopolar spindles; structure in first source
enoate ester;
ethyl ester;
phenols;
racemate;
thioureas
antileishmanial agent;
antimitotic;
antineoplastic agent;
EC 3.5.1.5 (urease) inhibitor
zd 6474CH 331: structure in first sourcearomatic ether;
organobromine compound;
organofluorine compound;
piperidines;
quinazolines;
secondary amine
antineoplastic agent;
tyrosine kinase inhibitor
gw-5074
ispinesibbenzamides
3-tritylthio-l-alanine, (d)-isomer
lenvatiniblenvatinib : A member of the class of quinolines that is the carboxamide of 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxylic acid. A multi-kinase inhibitor and orphan drug used (as its mesylate salt) for the treatment of various types of thyroid cancer that do not respond to radioiodine.aromatic amide;
aromatic ether;
cyclopropanes;
monocarboxylic acid amide;
monochlorobenzenes;
phenylureas;
quinolines
antineoplastic agent;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
fibroblast growth factor receptor antagonist;
orphan drug;
vascular endothelial growth factor receptor antagonist
sb 743921
adociasulfate-2adociasulfate-2: inhibits kinesin ATPase; from marine sponge Haliclona (also known as Adocia) sp.; structure in first source
terpendole eterpendole E: structure in first sourceorganic heterotricyclic compound;
organooxygen compound
ck0106023CK0106023: is an allosteric inhibitor of KSP motor domain ATPase with a Ki of 12 nM. Among five kinesins tested, CK0106023 was specific for KSP. In tumor-bearing mice.; structure in first source
dimethylenastrondimethylenastron: a kinesin Eg5 inhibitor and antiproliferative agent; structure in first source
emd 534085EMD 534085: a kinesin-5 inhibitor; structure in first source
cabozantinibcabozantinib : A dicarboxylic acid diamide that is N-phenyl-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide in which the hydrogen at position 4 on the phenyl ring is substituted by a (6,7-dimethoxyquinolin-4-yl)oxy group. A multi-tyrosine kinase inhibitor, used (as its malate salt) for the treatment of progressive, metastatic, medullary thyroid cancer.

cabozantinib: a multikinase inhibitor
aromatic ether;
dicarboxylic acid diamide;
organofluorine compound;
quinolines
antineoplastic agent;
tyrosine kinase inhibitor
litronesiblitronesib: an Eg5 inhibitor
arry 520filanesib: a kinesin spindle protein inhibitor