Target type: molecularfunction
A motor activity that generates movement along a microtubule toward the plus end, driven by ATP hydrolysis. [GOC:vw, PMID:32842864]
Plus-end-directed microtubule motor activity describes the ability of proteins, specifically motor proteins, to move along microtubules towards their plus ends. This movement is fueled by ATP hydrolysis and is essential for various cellular processes, including:
1. **Vesicle transport:** Motor proteins like kinesins transport cargo, such as vesicles, organelles, and proteins, along microtubule tracks towards the cell periphery or towards specific cellular destinations. This directed movement ensures the proper distribution of cellular components and facilitates communication within the cell.
2. **Chromosomal movement during cell division:** During mitosis and meiosis, motor proteins play a crucial role in separating chromosomes. Motor proteins like kinesins attach to chromosomes and move them towards opposite poles of the cell, ensuring that each daughter cell receives a complete set of chromosomes.
3. **Organelle positioning and dynamics:** Microtubule motors help in organizing and positioning organelles within the cell. This includes positioning the Golgi apparatus, endoplasmic reticulum, and mitochondria. The movement of these organelles is vital for their function and proper cellular organization.
4. **Cellular migration and motility:** In some cell types, microtubule motors contribute to cellular movement by interacting with the cytoskeleton. These motors can generate forces that propel cells along surfaces or facilitate changes in cell shape during migration.
5. **Cell signaling and communication:** Motor proteins can transport signaling molecules along microtubules, allowing for rapid and efficient communication within the cell. This ensures that signals are delivered to the appropriate targets and contribute to cellular responses to stimuli.
The movement of plus-end-directed motors is regulated by various factors, including the type of motor protein, the presence of accessory proteins, and the concentration of ATP. These motors are highly specific in their interaction with microtubules, ensuring that cargo is delivered to the correct location within the cell.
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| Protein | Definition | Taxonomy |
|---|---|---|
| Kinesin-1 heavy chain | A kinesin-1 heavy chain that is encoded in the genome of human. [PRO:DNx, UniProtKB:P33176] | Homo sapiens (human) |
| Kinesin-like protein KIF11 | A kinesin-like protein KIF11 that is encoded in the genome of human. [PRO:DNx] | Homo sapiens (human) |
| Kinesin-like protein KIF15 | A kinesin-like protein KIF15 that is encoded in the genome of human. [PRO:CNx, Reactome:R-HSA-984825] | Homo sapiens (human) |
| Kinesin-like protein KIF20B | A kinesin-like protein KIF20B that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96Q89] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| gossypol | Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer. | ||
| whi p180 | |||
| cysteine | cysteine; cysteine zwitterion; L-alpha-amino acid; proteinogenic amino acid; serine family amino acid | EC 4.3.1.3 (histidine ammonia-lyase) inhibitor; flour treatment agent; human metabolite | |
| s-methylcysteine | S-methylcysteine : A cysteine derivative that is L-cysteine in which the hydrogen attached to the sulfur is replaced by a methyl group. S-methylcysteine: RN given refers to parent cpd without isomeric designation | S-alkyl-L-cysteine; S-alkyl-L-cysteine zwitterion | human urinary metabolite; plant metabolite |
| staurosporine | indolocarbazole alkaloid; organic heterooctacyclic compound | apoptosis inducer; bacterial metabolite; EC 2.7.11.13 (protein kinase C) inhibitor; geroprotector | |
| physodic acid | physodic acid: lichen constituent | carbonyl compound | |
| 3-tritylthio-l-alanine | benzenoid aromatic compound | ||
| s-2-aminoethyl cysteine | L-thialysine : A cysteine derivative that is the S-(2-aminoethyl) analogue of L-cysteine; reported to have cytotoxic effects. S-2-aminoethyl cysteine: inhibits protein synthesis in mammalian cells; RN given refers to parent cpd; structure | L-cysteine thioether; non-proteinogenic L-alpha-amino acid | EC 5.4.3.2 (lysine 2,3-aminomutase) inhibitor; metabolite; protein synthesis inhibitor |
| docetaxel anhydrous | docetaxel anhydrous : A tetracyclic diterpenoid that is paclitaxel with the N-benzyloxycarbonyl group replaced by N-tert-butoxycarbonyl, and the acetoxy group at position 10 replaced by a hydroxy group. Docetaxel: A semisynthetic analog of PACLITAXEL used in the treatment of locally advanced or metastatic BREAST NEOPLASMS and NON-SMALL CELL LUNG CANCER. | secondary alpha-hydroxy ketone; tetracyclic diterpenoid | antimalarial; antineoplastic agent; photosensitizing agent |
| s-benzylcysteine | S-aryl-L-cysteine zwitterion | ||
| carbocysteine | Carbocysteine: A compound formed when iodoacetic acid reacts with sulfhydryl groups in proteins. It has been used as an anti-infective nasal spray with mucolytic and expectorant action. S-carboxymethyl-L-cysteine : An L-cysteine thioether that is L-cysteine in which the hydrogen of the thiol group has been replaced by a carboxymethyl group. | L-cysteine thioether; non-proteinogenic L-alpha-amino acid | mucolytic |
| 1-acetyl-3,5-diphenyl-4,5-dihydro-(1h)-pyrazole | |||
| (S)-monastrol | ethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate | ||
| k 858 | K 858: an Eg5 inhibitor and antineoplastic agent; structure in first source | benzenes | |
| monastrol | (S)-monastrol : An ethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate that has S configuration. ethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate : A member of the class of thioureas that is 3,4-dihydropyrimidine-2(1)-thione substituted by a 3-hydroxyphenyl group at position 4, an ethoxycarbonyl group at position 5, and a methyl group at position 6. monastrol : A racemate comprising equimolar amounts of R- and S-monastrol. monastrol: stops mitosis by fostering formation of monopolar spindles; structure in first source | enoate ester; ethyl ester; phenols; racemate; thioureas | antileishmanial agent; antimitotic; antineoplastic agent; EC 3.5.1.5 (urease) inhibitor |
| zd 6474 | CH 331: structure in first source | aromatic ether; organobromine compound; organofluorine compound; piperidines; quinazolines; secondary amine | antineoplastic agent; tyrosine kinase inhibitor |
| gw-5074 | |||
| ispinesib | benzamides | ||
| 3-tritylthio-l-alanine, (d)-isomer | |||
| lenvatinib | lenvatinib : A member of the class of quinolines that is the carboxamide of 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxylic acid. A multi-kinase inhibitor and orphan drug used (as its mesylate salt) for the treatment of various types of thyroid cancer that do not respond to radioiodine. | aromatic amide; aromatic ether; cyclopropanes; monocarboxylic acid amide; monochlorobenzenes; phenylureas; quinolines | antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; fibroblast growth factor receptor antagonist; orphan drug; vascular endothelial growth factor receptor antagonist |
| sb 743921 | |||
| adociasulfate-2 | adociasulfate-2: inhibits kinesin ATPase; from marine sponge Haliclona (also known as Adocia) sp.; structure in first source | ||
| terpendole e | terpendole E: structure in first source | organic heterotricyclic compound; organooxygen compound | |
| ck0106023 | CK0106023: is an allosteric inhibitor of KSP motor domain ATPase with a Ki of 12 nM. Among five kinesins tested, CK0106023 was specific for KSP. In tumor-bearing mice.; structure in first source | ||
| dimethylenastron | dimethylenastron: a kinesin Eg5 inhibitor and antiproliferative agent; structure in first source | ||
| emd 534085 | EMD 534085: a kinesin-5 inhibitor; structure in first source | ||
| cabozantinib | cabozantinib : A dicarboxylic acid diamide that is N-phenyl-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide in which the hydrogen at position 4 on the phenyl ring is substituted by a (6,7-dimethoxyquinolin-4-yl)oxy group. A multi-tyrosine kinase inhibitor, used (as its malate salt) for the treatment of progressive, metastatic, medullary thyroid cancer. cabozantinib: a multikinase inhibitor | aromatic ether; dicarboxylic acid diamide; organofluorine compound; quinolines | antineoplastic agent; tyrosine kinase inhibitor |
| litronesib | litronesib: an Eg5 inhibitor | ||
| arry 520 | filanesib: a kinesin spindle protein inhibitor |