meperidine hydrochloride profile

pethidine hydrochloride : The hydrochloride salt of pethidine. An analgesic used for the treatment of postoperative and labour pain. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID Source	ID
PubMed CID	5750
CHEMBL ID	1701
CHEBI ID	31984
SCHEMBL ID	41046
MeSH ID	M0330121

Synonyms (133)

Synonym
piperidine, n-methyl-4-phenyl-4-carbethoxy-, hydrochloride
chlorbicyclene [french]
nsc 400479
isonipecotic acid, 1-methyl-4-phenyl-, ethyl ester, hydrochloride
einecs 200-013-3
mephedine
spasmodolin
sauteralgyl
pantalgine
nih 10522
4-piperidinecarboxylic acid, 1-methyl-4-phenyl-, ethyl ester, hydrochloride
(+-)-pethidine hydrochloride
dolsin
spasmedal
dolopethin
endolat
meperidine hcl
ethyl 1-methyl-4-phenylpiperidine-4-carboxylate hydrochloride
ethyl 1-methyl-4-phenylisonipecotate hydrochloride
mefedina
petantin
ethyl 1-methyl-4-phenylpiperidine-4-carboxylate,hydrochloride
centralgin
dolin
operidine
n-methyl-4-phenyl-4-carbethoxypiperidine hydrochloride
synelaudine
lydol
demerol hydrochloride
isonipecotic acid, ethyl ester, hydrochloride
1-methyl-4-phenyl-4-carboethoxypiperidine hydrochloride
nsc-400479
dolantin hydrochloride
dolenol
dolargan
nsc400479
algil
dolaren
s 140
doloneurine
pethidine chloride
pethidine hydrochloride
wln: t6ntj a1 dvo2 dr &gh
alodan (gerot)
lidol
1-methyl-4-phenylisonipecotic acid ethyl ester hydrochloride
petidin
50-13-5
dolcontral
wy 554
dolantol
dolestine
dolantin
dispadol
piridosal
dolvanolendolatethyl 1-methyl-4-phenylpiperidine-4-carboxylate hydrochloride
1-methyl-4-carbethoxy-4-phenylpiperidine hydrochloride
ethyl 1-methyl-4-phenylpiperidyl-4-carboxylate hydrochloride
petantin hydrochloride
meperidine hydrochloride
dolenal
chlorbicyclene
chlorbycyclen
antiduol
isonipecaine hydrochloride
dolosal
mepadin
4-piperidinecarboxylic acid, ethyl ester, hydrochloride
antidurol
dolantal
ethyl-1-methyl-4-phenylisonipecotate hydrochloride
meperidine hydrochloride (usp)
demerol (tn)
pethidine hydrochloride (jp17)
D01383
meperidine hydrochloride cii
pethidini hydrochloridum
CHEMBL1701
meperidine hydrochloride [usan:usp]
meperidine hydrochloride preservative free
meperitab
unii-n8e7f7q170
meperidin
pethidine hydrochloride [jan]
n8e7f7q170 ,
FT-0603214
pethidine hydrochloride [who-dd]
meperidine hydrochloride [vandf]
meperidine hydrochloride [usp monograph]
pethidini hydrochloridum [who-ip latin]
pethidine hydrochloride [mart.]
meperidine hydrochloride [orange book]
meperidine hydrochloride [usan]
pethidine hydrochloride [ep monograph]
mepergan component meperidine hydrochloride
meperidine hydrochloride component of mepergan
meperidine hydrochloride cii [usp-rs]
pethidine hydrochloride [ep impurity]
meperidine hydrochloride [mi]
pethidine hydrochloride [who-ip]
SCHEMBL41046
WCNLCIJMFAJCPX-UHFFFAOYSA-N
1-methyl-4-phenyl-piperidine-4-carboxylic acid ethyl ester hydrochloride
pethidine hcl
meperidine hydrochloride, united states pharmacopeia (usp) reference standard
pethidine hydrochloride (meperidine hydrochloride)
cluyer
meperdol
petisel
doloblok
4-(ethoxycarbonyl)-1-methyl-4-phenylpiperidinium chloride
petholan
opystan
dolantina
petidin dak
g-pethidine
CHEBI:31984 ,
clopedin
ethyl 1-methyl-4-phenylpiperidine-4-carboxylate;hydrochloride
50-13-5 (hcl)
Q27284706
DTXSID30950620 ,
1-methyl-4-phenyl-4-piperidinecarboxylic acid ethyl ester hydrochloride (1:1)
meperidine hydrochloride (usp monograph)
ethyl 1-methyl-4-phenylpiperidine-4-carboxylate monohydrochloride
pethidine hydrochloride (mart.)
pethidine hydrochloride (ep impurity)
pethidine hydrochloride (ep monograph)
meperidine hydrochloride (usan:usp)
meperidine hydrochloride cii (usp-rs)
dtxcid701378770
meperidine.hcl (pethidine.hcl), 1mg/ml in methanol
meperidine.hcl (pethidine.hcl)

Role	Description
kappa-opioid receptor agonist	A compound that exhibits agonist activity at the kappa-opioid receptor.
mu-opioid receptor agonist	A compound that exhibits agonist activity at the mu-opioid receptor.
antispasmodic drug	A drug that suppresses spasms. These are usually caused by smooth muscle contraction, especially in tubular organs. The effect is to prevent spasms of the stomach, intestine or urinary bladder.
opioid analgesic	A narcotic or opioid substance, synthetic or semisynthetic agent producing profound analgesia, drowsiness, and changes in mood.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
hydrochloride	A salt formally resulting from the reaction of hydrochloric acid with an organic base.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Sodium-dependent dopamine transporter	Rattus norvegicus (Norway rat)	Ki	17.8000	0.0003	0.3708	8.1600	AID238628
Sodium-dependent serotonin transporter	Rattus norvegicus (Norway rat)	Ki	0.4130	0.0000	0.7056	10.0000	AID238637; AID539398
Mu-type opioid receptor	Homo sapiens (human)	Ki	0.9200	0.0000	0.4197	10.0000	AID238453; AID539404
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	Mu-type opioid receptor	Homo sapiens (human)
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	Mu-type opioid receptor	Homo sapiens (human)
phospholipase C-activating G protein-coupled receptor signaling pathway	Mu-type opioid receptor	Homo sapiens (human)
sensory perception	Mu-type opioid receptor	Homo sapiens (human)
negative regulation of cell population proliferation	Mu-type opioid receptor	Homo sapiens (human)
sensory perception of pain	Mu-type opioid receptor	Homo sapiens (human)
G protein-coupled opioid receptor signaling pathway	Mu-type opioid receptor	Homo sapiens (human)
behavioral response to ethanol	Mu-type opioid receptor	Homo sapiens (human)
positive regulation of neurogenesis	Mu-type opioid receptor	Homo sapiens (human)
negative regulation of Wnt protein secretion	Mu-type opioid receptor	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Mu-type opioid receptor	Homo sapiens (human)
calcium ion transmembrane transport	Mu-type opioid receptor	Homo sapiens (human)
cellular response to morphine	Mu-type opioid receptor	Homo sapiens (human)
regulation of cellular response to stress	Mu-type opioid receptor	Homo sapiens (human)
regulation of NMDA receptor activity	Mu-type opioid receptor	Homo sapiens (human)
neuropeptide signaling pathway	Mu-type opioid receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
G-protein alpha-subunit binding	Mu-type opioid receptor	Homo sapiens (human)
G protein-coupled receptor activity	Mu-type opioid receptor	Homo sapiens (human)
beta-endorphin receptor activity	Mu-type opioid receptor	Homo sapiens (human)
voltage-gated calcium channel activity	Mu-type opioid receptor	Homo sapiens (human)
protein binding	Mu-type opioid receptor	Homo sapiens (human)
morphine receptor activity	Mu-type opioid receptor	Homo sapiens (human)
G-protein beta-subunit binding	Mu-type opioid receptor	Homo sapiens (human)
neuropeptide binding	Mu-type opioid receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
endosome	Mu-type opioid receptor	Homo sapiens (human)
endoplasmic reticulum	Mu-type opioid receptor	Homo sapiens (human)
Golgi apparatus	Mu-type opioid receptor	Homo sapiens (human)
plasma membrane	Mu-type opioid receptor	Homo sapiens (human)
axon	Mu-type opioid receptor	Homo sapiens (human)
dendrite	Mu-type opioid receptor	Homo sapiens (human)
perikaryon	Mu-type opioid receptor	Homo sapiens (human)
synapse	Mu-type opioid receptor	Homo sapiens (human)
plasma membrane	Mu-type opioid receptor	Homo sapiens (human)
neuron projection	Mu-type opioid receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (33)

Assay ID	Title	Year	Journal	Article
AID1135665	Displacement of [3H]naloxone from Sprague-Dawley rat cerebellum opioid receptor assessed as relative receptor affinity by scintillation counting	1978	Journal of medicinal chemistry, Jul, Volume: 21, Issue:7	Conformation of 2,9-dimethyl-3'-hydroxy-5-phenyl-6,7-genzomorphan and its relation to other analgetics and enkephalin.
AID242948	Ratio of binding affinity of mu-opioid receptor and dopamine transporter	2005	Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5	Synthesis and biological evaluation of meperidine analogues at monoamine transporters.
AID1144259	Drug metabolism in iv dosed Swiss-Webster mouse liver assessed as norme-peridine concentration measured per gram of tissue over 5 to 45 mins	1976	Journal of medicinal chemistry, Jan, Volume: 19, Issue:1	Relationship between analgetic ED50 dose and time-course brain levels N-alkylnormeperidine homologues.
AID114545	Tested for narcotic antagonistic property using tail-flick procedure in mice after giving subcutaneous dose of 6.3 mg/kg of morphine sulphate	1980	Journal of medicinal chemistry, Apr, Volume: 23, Issue:4	4-Amino-4-arylcyclohexanones and their derivatives, a novel class of analgesics. 1. Modification of the aryl ring.
AID1136970	Analgesic activity in sc dosed mouse assessed as inhibition of AcOH-induced writhing	1977	Journal of medicinal chemistry, Feb, Volume: 20, Issue:2	Azabicycloalkanes as analgetics. 3. Structure-activity relationships of 1-phenyl-6-azabicyclo[3.2.1]octanes and absolute stereochemistry of (+)-1-(3-hydroxyphenyl)-6-methyl-6-azabicyclo[3.2.1]octane and its 7-endo-methyl derivative.
AID248017	Inhibitory concentration against [3H]-DA uptake in rat brain tissue	2005	Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5	Synthesis and biological evaluation of meperidine analogues at monoamine transporters.
AID1135666	Analgesic activity in sc dosed mouse assessed as inhibition of phenylquinone-induced writhing	1978	Journal of medicinal chemistry, Jul, Volume: 21, Issue:7	Conformation of 2,9-dimethyl-3'-hydroxy-5-phenyl-6,7-genzomorphan and its relation to other analgetics and enkephalin.
AID238453	Inhibition of [3H]DAMGO binding to mu-opioid receptor	2005	Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5	Synthesis and biological evaluation of meperidine analogues at monoamine transporters.
AID242940	Ratio of binding affinity of dopamine and serotonin transporters	2005	Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5	Synthesis and biological evaluation of meperidine analogues at monoamine transporters.
AID114388	Tested for analgesic activity using tail flick assay in mice	1980	Journal of medicinal chemistry, Apr, Volume: 23, Issue:4	4-Amino-4-arylcyclohexanones and their derivatives, a novel class of analgesics. 1. Modification of the aryl ring.
AID539400	Displacement of [3H]nisoxetine from norepinephrine transporter in Sprague-Dawley rat frontal cortex after 1 hr by liquid scintillation counting	2010	Bioorganic & medicinal chemistry, Dec-01, Volume: 18, Issue:23	Synthesis and structure-activity studies of benzyl ester meperidine and normeperidine derivatives as selective serotonin transporter ligands.
AID539401	Selectivity ratio of Ki for dopamine transporter in Sprague-Dawley rat brain to Ki for serotonin transporter in Sprague-Dawley rat brain	2010	Bioorganic & medicinal chemistry, Dec-01, Volume: 18, Issue:23	Synthesis and structure-activity studies of benzyl ester meperidine and normeperidine derivatives as selective serotonin transporter ligands.
AID238628	Inhibition of [3H]WIN-35428 binding to rat dopamine transporter	2005	Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5	Synthesis and biological evaluation of meperidine analogues at monoamine transporters.
AID1136973	Analgesic activity in sc dosed mouse by hot-plate method	1977	Journal of medicinal chemistry, Feb, Volume: 20, Issue:2	Azabicycloalkanes as analgetics. 3. Structure-activity relationships of 1-phenyl-6-azabicyclo[3.2.1]octanes and absolute stereochemistry of (+)-1-(3-hydroxyphenyl)-6-methyl-6-azabicyclo[3.2.1]octane and its 7-endo-methyl derivative.
AID1144254	1-Octanol-phosphate buffer partition coefficient, log P of the compound at pH 7.4 using [3H]normeperidine hydrochloride	1976	Journal of medicinal chemistry, Jan, Volume: 19, Issue:1	Relationship between analgetic ED50 dose and time-course brain levels N-alkylnormeperidine homologues.
AID114564	Tested for sedation using inclined screen test in mice	1980	Journal of medicinal chemistry, Apr, Volume: 23, Issue:4	4-Amino-4-arylcyclohexanones and their derivatives, a novel class of analgesics. 1. Modification of the aryl ring.
AID539398	Displacement of [3H]citalopram from serotonin transporter in Sprague-Dawley rat brain after 1 hr by liquid scintillation counting	2010	Bioorganic & medicinal chemistry, Dec-01, Volume: 18, Issue:23	Synthesis and structure-activity studies of benzyl ester meperidine and normeperidine derivatives as selective serotonin transporter ligands.
AID242949	Ratio of binding affinity of mu-opioid receptor to serotonin transporter	2005	Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5	Synthesis and biological evaluation of meperidine analogues at monoamine transporters.
AID1136976	Acute toxicity in sc dosed mouse	1977	Journal of medicinal chemistry, Feb, Volume: 20, Issue:2	Azabicycloalkanes as analgetics. 3. Structure-activity relationships of 1-phenyl-6-azabicyclo[3.2.1]octanes and absolute stereochemistry of (+)-1-(3-hydroxyphenyl)-6-methyl-6-azabicyclo[3.2.1]octane and its 7-endo-methyl derivative.
AID539399	Displacement of [3H]WIN 35428 from dopamine transporter in Sprague-Dawley rat brain after 1 hr by liquid scintillation counting	2010	Bioorganic & medicinal chemistry, Dec-01, Volume: 18, Issue:23	Synthesis and structure-activity studies of benzyl ester meperidine and normeperidine derivatives as selective serotonin transporter ligands.
AID1134336	Analgesic activity in sc dosed rat assessed as dose required for 2 times increase in reaction time after 15 mins by tail jerk test relative to control	1977	Journal of medicinal chemistry, Jul, Volume: 20, Issue:7	Various 5-substituted and 2,5-disubstituted 1,3-dioxanes, a new class of analgesic agents.
AID1144255	Analgetic potency in iv dosed Swiss-Webster mouse	1976	Journal of medicinal chemistry, Jan, Volume: 19, Issue:1	Relationship between analgetic ED50 dose and time-course brain levels N-alkylnormeperidine homologues.
AID114387	Tested for analgesic activity using HCl writhe assay in mice in mice	1980	Journal of medicinal chemistry, Apr, Volume: 23, Issue:4	4-Amino-4-arylcyclohexanones and their derivatives, a novel class of analgesics. 1. Modification of the aryl ring.
AID1144258	Drug metabolism in iv dosed Swiss-Webster mouse liver measured per gram of tissue over 5 to 45 mins	1976	Journal of medicinal chemistry, Jan, Volume: 19, Issue:1	Relationship between analgetic ED50 dose and time-course brain levels N-alkylnormeperidine homologues.
AID251779	Percent inhibition of [3H]DA uptake in rat brain tissue at 100 uM	2005	Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5	Synthesis and biological evaluation of meperidine analogues at monoamine transporters.
AID125746	Analgesic antagonistic activity in mice using morphine(56.07 umol/kg) induced Straub-tail test after sc administration; No antagonist activity up to 846 umol/ kg	1986	Journal of medicinal chemistry, Apr, Volume: 29, Issue:4	N-substituent modulation of opiate agonist/antagonist activity in resolved 3-methyl-3-(m-hydroxyphenyl)piperidines.
AID114389	Tested for analgesic activity using tail pinch assay in mice	1980	Journal of medicinal chemistry, Apr, Volume: 23, Issue:4	4-Amino-4-arylcyclohexanones and their derivatives, a novel class of analgesics. 1. Modification of the aryl ring.
AID1134335	Analgesic activity in sc dosed mouse assessed as inhibition of acetic acid-induced writhing after 15 to 30 mins	1977	Journal of medicinal chemistry, Jul, Volume: 20, Issue:7	Various 5-substituted and 2,5-disubstituted 1,3-dioxanes, a new class of analgesic agents.
AID128032	Compound was tested for analgesic activity in mouse using mouse writhing test after sc administration of compound	1986	Journal of medicinal chemistry, Apr, Volume: 29, Issue:4	N-substituent modulation of opiate agonist/antagonist activity in resolved 3-methyl-3-(m-hydroxyphenyl)piperidines.
AID539404	Binding affinity at mu-opioid receptor	2010	Bioorganic & medicinal chemistry, Dec-01, Volume: 18, Issue:23	Synthesis and structure-activity studies of benzyl ester meperidine and normeperidine derivatives as selective serotonin transporter ligands.
AID1144260	Drug metabolism in iv dosed Swiss-Webster mouse liver assessed as norme-peridine N-alkyl parent integral ratio over 5 to 45 mins	1976	Journal of medicinal chemistry, Jan, Volume: 19, Issue:1	Relationship between analgetic ED50 dose and time-course brain levels N-alkylnormeperidine homologues.
AID238637	Inhibition of [3H]paroxetine binding to rat serotonin transporter	2005	Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5	Synthesis and biological evaluation of meperidine analogues at monoamine transporters.
AID1144256	Drug uptake in iv dosed Swiss-Webster mouse brain measured per gram of tissue	1976	Journal of medicinal chemistry, Jan, Volume: 19, Issue:1	Relationship between analgetic ED50 dose and time-course brain levels N-alkylnormeperidine homologues.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	6 (75.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (12.50)	29.6817
2010's	1 (12.50)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
meperidine Meperidine: A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.. pethidine : A piperidinecarboxylate ester that is piperidine which is substituted by a methyl group at position 1 and by phenyl and ethoxycarbonyl groups at position 4. It is an analgesic which is used for the treatment of moderate to severe pain, including postoperative pain and labour pain.	1.96	1	ethyl ester; piperidinecarboxylate ester; tertiary amino compound	antispasmodic drug; kappa-opioid receptor agonist; mu-opioid receptor agonist; opioid analgesic
fluoxetine hydrochloride fluoxetine hydrochloride : A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine hydrochloride. A selective serotonin reuptake inhibitor (SSRI), it is used for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.	2.05	1	hydrochloride; N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine
paroxetine hydrochloride paroxetine hydrochloride : The hydrochloride salt of paroxetine. It is an antidepressant drug.	2.05	1	hydrochloride	antidepressant; anxiolytic drug; hepatotoxic agent; P450 inhibitor; serotonin uptake inhibitor
enkephalin, methionine [no description available]	1.95	1	pentapeptide; peptide zwitterion	analgesic; antineoplastic agent; delta-opioid receptor agonist; human metabolite; mu-opioid receptor agonist
cocaine Cocaine: An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.. cocaine : A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.	2.02	1	benzoate ester; methyl ester; tertiary amino compound; tropane alkaloid	adrenergic uptake inhibitor; central nervous system stimulant; dopamine uptake inhibitor; environmental contaminant; local anaesthetic; mouse metabolite; plant metabolite; serotonin uptake inhibitor; sodium channel blocker; sympathomimetic agent; vasoconstrictor agent; xenobiotic
etorphine [no description available]	1.96	1	alcohol; morphinane alkaloid	opioid analgesic; opioid receptor agonist; sedative
nalorphine Nalorphine: A narcotic antagonist with some agonist properties. It is an antagonist at mu opioid receptors and an agonist at kappa opioid receptors. Given alone it produces a broad spectrum of unpleasant effects and it is considered to be clinically obsolete.	1.96	1	morphinane alkaloid
naloxone Naloxone: A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.. naloxone : A synthetic morphinane alkaloid that is morphinone in which the enone double bond has been reduced to a single bond, the hydrogen at position 14 has been replaced by a hydroxy group, and the methyl group attached to the nitrogen has been replaced by an allyl group. A specific opioid antagonist, it is used (commonly as its hydrochloride salt) to reverse the effects of opioids, both following their use of opioids during surgery and in cases of known or suspected opioid overdose.	1.96	1	morphinane alkaloid; organic heteropentacyclic compound; tertiary alcohol	antidote to opioid poisoning; central nervous system depressant; mu-opioid receptor antagonist
codeine phosphate [no description available]	1.95	1
dihydromorphine Dihydromorphine: A semisynthetic analgesic used in the study of narcotic receptors.	1.96	1	morphinane alkaloid
naloxone hydrochloride naloxone hydrochloride : A hydrochloride resulting from the formal reaction of equimolar amounts of naloxone and hydrogen chloride. A specific opioid antagonist, it is used to reverse the effects of opioids, both following their use of opioids during surgery and in cases of known or suspected opioid overdose.	1.95	1	hydrochloride	antidote to opioid poisoning; central nervous system depressant; mu-opioid receptor antagonist
morphine chloride morphine hydrochloride : The hydrochloride salt of morphine.	1.95	1	hydrochloride
nalorphine hydrochloride [no description available]	2.36	2
morphine sulfate [no description available]	1.95	1	alkaloid sulfate salt; hydrate
enkephalin, leucine-2-alanine Enkephalin, Leucine-2-Alanine: A delta-selective opioid (ANALGESICS, OPIOID). It can cause transient depression of mean arterial blood pressure and heart rate.	1.96	1
morphine sulfate [no description available]	2.65	3	alkaloid sulfate salt

Condition	Indicated	Relationship Strength	Studies
Chemical Dependence [description not available]	0	1.95	1
Drug Withdrawal Symptoms [description not available]	0	1.95	1
Substance Withdrawal Syndrome Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.	0	1.95	1
Substance-Related Disorders Disorders related to substance use or abuse.	1	3.95	1

meperidine hydrochloride

Description

Cross-References

Synonyms (133)

Roles (4)

Drug Classes (1)

Protein Targets (3)

Inhibition Measurements

Biological Processes (16)

Molecular Functions (8)

Ceullar Components (9)

Bioassays (33)

Research

Studies (8)

Market Indicators

Research Demand Index: 54.78

Study Types

meperidine hydrochloride

Description

Cross-References

Synonyms (133)

Roles (4)

Drug Classes (1)

Protein Targets (3)

Inhibition Measurements

Biological Processes (16)

Molecular Functions (8)

Ceullar Components (9)

Bioassays (33)

Research

Studies (8)

Market Indicators

Research Demand Index: 54.78

Study Types

Related Drugs (16)

Related Conditions (4)