Compounds > win 52084
Page last updated: 2024-11-04

win 52084

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Win 52084: structure given in first source; RN given refers to (+-)-isomer; RN for cpd without isomeric designation not available 7/89 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID1790
CHEMBL ID6641
CHEBI ID10027
SCHEMBL ID9668076
MeSH IDM0142690

Synonyms (16)

Synonym
win 52084
3-methyl-5-[7-[4-(4-methyl-4,5-dihydrooxazol-2-yl)phenoxy]heptyl]isoxazole
98034-32-3
isoxazole, 5-[7-[4-(4,5-dihydro-4-methyl-2-oxazolyl)phenoxy]heptyl]-3-methyl-
C06497
win i(s)
5-(7-(4-(4-methyl-4,5-dihydrooxazol-2-yl)phenoxy)heptyl)-3-methylisoxazole
win 52084 (s)
chebi:10027 ,
CHEMBL6641
isoxazole, 5-(7-(4-(4,5-dihydro-4-methyl-2-oxazolyl)phenoxy)heptyl)-3-methyl-
SCHEMBL9668076
Q27108558
120666-36-6
3-methyl-5-(7-(4-(4-methyl-4,5-dihydrooxazol-2-yl)phenoxy)heptyl)isoxazole
PD035982
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
aromatic etherAny ether in which the oxygen is attached to at least one aryl substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (10)

Assay IDTitleYearJournalArticle
AID23690Partition coefficient (logP)1992Journal of medicinal chemistry, Mar-20, Volume: 35, Issue:6
CoMFA analysis of the interactions of antipicornavirus compounds in the binding pocket of human rhinovirus-14.
AID93742In vitro minimum inhibitory concentration against human rhinovirus-14 (HRV-14)1988Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
Enantiomeric effects of homologues of disoxaril on the inhibitory activity against human rhinovirus-14.
AID26042log (1/MIC) value of the compound1992Journal of medicinal chemistry, Mar-20, Volume: 35, Issue:6
CoMFA analysis of the interactions of antipicornavirus compounds in the binding pocket of human rhinovirus-14.
AID89493Compound was evaluated for inhibitory effect against human Rhinovirus-141992Journal of medicinal chemistry, Mar-20, Volume: 35, Issue:6
CoMFA analysis of the interactions of antipicornavirus compounds in the binding pocket of human rhinovirus-14.
AID115931In vitro antiviral activity against mice infected intracerebrally with Poliovirus type-21985Journal of medicinal chemistry, Dec, Volume: 28, Issue:12
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
AID199858In vitro antiviral activity against Rhinovirus type-21985Journal of medicinal chemistry, Dec, Volume: 28, Issue:12
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
AID222916In vitro minimum inhibitory concentration for the inhibition of human rhinovirus-14 replication.1990Journal of medicinal chemistry, May, Volume: 33, Issue:5
A model for compounds active against human rhinovirus-14 based on X-ray crystallography data.
AID115948MIC at the Maximal testable level in mice was evaluated1985Journal of medicinal chemistry, Dec, Volume: 28, Issue:12
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
AID1562980Antiviral activity against Human rhinovirus A22019European journal of medicinal chemistry, Sep-15, Volume: 178Back to the future: Advances in development of broad-spectrum capsid-binding inhibitors of enteroviruses.
AID1562974Antiviral activity against Human poliovirus 22019European journal of medicinal chemistry, Sep-15, Volume: 178Back to the future: Advances in development of broad-spectrum capsid-binding inhibitors of enteroviruses.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (21)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (19.05)18.7374
1990's8 (38.10)18.2507
2000's8 (38.10)29.6817
2010's1 (4.76)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.36

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.36 (24.57)
Research Supply Index3.09 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.36)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (4.76%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other20 (95.24%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
urea
pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.		2.0310isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
sch-48973
[no description available]		3.3110
pleconaril
WIN 63843: structure given in first source		3.5720
win 52035
Win 52035: structure given in first source		4.4770aromatic ether
win 53338
WIN 53338: structure given in first source. 5-{5-[2-chloro-4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]pentyl}-3-methylisoxazole : An isoxazole compound having a methyl substituent at the 3-position and a 5-[2-chloro-4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]pentyl substituent at the 5-position.		2.3820isoxazoles;
monochlorobenzenes		antiviral agent
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.		2.0110pyrrole;
secondary amine
isoxazoles
Isoxazoles: Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.. isoxazole : A monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of isoxazoles.. isoxazoles : Oxazoles in which the N and O atoms are adjacent.		4.14160isoxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
oxazoles
Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.		2.39201,3-oxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
disoxaril
disoxaril: antipicornavirus agent		4.4670aromatic ether
4',6-dichloroflavan
4',6-dichloroflavan: antirhinovirus cpd; structure given in first source		1.9610
r 61837
R 61837: antirhinovirus cpd; structure given in first source		3.3110
win 54954
Win 54954: broad-spectrum antipicornavirus drug; structure given in first source		2.3820aromatic ether
oxadiazoles
Oxadiazoles: Compounds containing five-membered heteroaromatic rings containing two carbons, two nitrogens, and one oxygen atom which exist in various regioisomeric forms.		2.0110
ConditionIndicatedRelationship StrengthStudiesTrials
Infections, Picornaviridae
[description not available]		01.9610