Page last updated: 2024-08-23

disoxaril and isoxazoles

disoxaril has been researched along with isoxazoles in 46 studies

Research

Studies (46)

Timeframe	Studies, this research(%)	All Research%
pre-1990	16 (34.78)	18.7374
1990's	21 (45.65)	18.2507
2000's	7 (15.22)	29.6817
2010's	2 (4.35)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Chapman, MS; Diana, GD; Dutko, FJ; Kim, KH; Mallamo, JP; Minor, I; Oliveira, M; Pevear, DC; Rossmann, MG	1
Diana, GD; Dutko, FJ; Fox, MP; McKinlay, MA	1
Andries, K; Dewindt, B; Lewi, PJ; Snoeks, J; Stokbroekx, R; Willebrords, R	1
Boeyé, A; Rombaut, B	1
Andries, K; Boeyé, A; Rombaut, B	1
Blaas, D; Diana, GD; Gruenberger, M; Kuechler, E; Pevear, D	1
Almela, MJ; Carrasco, L; González, ME	1
Boeyé, A; Brioen, P; Rombaut, B	1
de Jong, JC	1
Guidinger, PL; Jubelt, B; McKinlay, MA; Ropka, SL; Wilson, AK	1
Badger, J; Dutko, FJ; Fancher, M; Heinz, BA; McKinlay, MA; Rossmann, MG; Rueckert, RR; Shepard, DA; Smith, TJ	1
al-Nakib, W; Andries, K; Dearden, C; Tyrrell, DA; Woestenborghs, R	1
Habermehl, KO; McKinlay, MA; Otto, MJ; Willingmann, P; Zeichhardt, H	1
Diana, GD; Maliski, EG; McKinlay, MA; Oglesby, RC; Otto, MJ; Rossmann, MG; Smith, TJ; Treasurywala, AM	1
Akullian, V; Cutcliffe, D; Diana, GD; Mallamo, JP; McKinlay, MA; Oglesby, RC; Otto, MJ	1
Diana, GD; Fancher, MJ; Fox, MP; Kuhrt, MF; McKinlay, MA; Otto, MJ	1
Akullian, V; Diana, GD; McKinlay, MA; Oglesby, C; Otto, MJ	1
Diana, GD; McKinlay, MA; Otto, MJ	1
Arnold, E; Diana, GD; Kamer, G; Kremer, MJ; Luo, M; McKinlay, MA; Otto, MJ; Rossmann, MG; Smith, TJ; Vriend, G	1
Fox, MP; McKinlay, MA; Otto, MJ	1
Rossmann, MG	1
McKinlay, MA; Steinberg, BA	1
Benziger, DP; Frank, JA; McKinlay, MA; Steinberg, BA	1
McKinlay, MA	1
Andries, K; Dewindt, B; van Eemeren, K	1
Mosser, AG; Rueckert, RR; Sgro, JY	1
Aldous, S; Bailey, TR; Diana, GD; Dutko, FJ; Long, MA; Nitz, TJ; Pevear, DC; Vescio, N; Volkots, DL	1
Didarholm, H; Frisk, G; Halloran, M	1
Boeyé, A; Delaet, I	1
Bailey, TR; Cutcliffe, D; Diana, GD; Giranda, V; Mallamo, JP; Nitz, TJ; Oglesby, RC; Vescio, N; Volkots, DL; Wetzel, J	1
Guha-Biswas, M; Holder, M; Pettitt, BM	1
Mosser, AG; Rueckert, RR	1
Arnold, E; Buontempo, P; Cox, S; De Martino, J; Miller, G; O'Connell, J; Rozhon, E; Schwartz, J; Slater, W; Zhang, A	1
Galabov, AS; Nikolaeva, L	4
Balbi, A; Corrias, S; De Montis, A; Garzoglio, R; Grandi, T; La Colla, P; Mazzei, M	1
Dove, AW; Racaniello, VR	1
Demontis, F; Dondero, R; Ledda, B; Mazzei, M; Vargiu, L	1
Galabov, AS; Nikolova, I	1
Galabov, AS; Nikolaeva-Glomb, L	1
Crowder, S; Kirkegaard, K	1
Giannone, I; Landolfi, C; Milanese, C; Musumeci, T; Paolino, D; Pignatello, R; Puglisi, G; Ragni, L; Ventura, CA	1
Cardosa, J; Kuhn, RJ; Perera, R; Plevka, P; Rossmann, MG; Yap, ML	1
Galabov, AS; Vassileva-Pencheva, R	1

Reviews

1 review(s) available for disoxaril and isoxazoles

Article	Year
Inhibitors of picornavirus uncoating as antiviral agents. Pharmacology & therapeutics, 1985, Volume: 29, Issue:3 Topics: Animals; Anti-Infective Agents; Antiviral Agents; Chalcone; Chalcones; Ciprofloxacin; Flavonoids; Fluoroquinolones; Furans; Humans; Isoxazoles; Ketones; Picornaviridae; Picornaviridae Infections; Quinolines; Rhinovirus; Structure-Activity Relationship	1985

Other Studies

45 other study(ies) available for disoxaril and isoxazoles

Article	Year
Conformationally restricted analogues of disoxaril: a comparison of the activity against human rhinovirus types 14 and 1A. Journal of medicinal chemistry, 1992, Dec-11, Volume: 35, Issue:25 Topics: Antiviral Agents; Binding Sites; Humans; Isoxazoles; Models, Molecular; Rhinovirus; Structure-Activity Relationship	1992
Binding affinities of structurally related human rhinovirus capsid-binding compounds are related to their activities against human rhinovirus type 14. Antimicrobial agents and chemotherapy, 1991, Volume: 35, Issue:6 Topics: Antiviral Agents; Capsid; Cells, Cultured; Dose-Response Relationship, Drug; Half-Life; Humans; Isoxazoles; Kinetics; Microbial Sensitivity Tests; Rhinovirus	1991
A comparative test of fifteen compounds against all known human rhinovirus serotypes as a basis for a more rational screening program. Antiviral research, 1991, Volume: 16, Issue:3 Topics: Antiviral Agents; Capsid; Drug Design; Drug Evaluation, Preclinical; Isoxazoles; Models, Biological; Rhinovirus; Structure-Activity Relationship	1991
In vitro assembly of poliovirus 14 S subunits: disoxaril stabilization as a model for the antigenicity conferring activity of infected cell extracts. Virology, 1991, Volume: 180, Issue:2 Topics: Antibodies, Monoclonal; Antigens, Viral; Antiviral Agents; Capsid; Epitopes; HeLa Cells; Humans; Isoxazoles; Kinetics; Poliovirus; Temperature	1991
A comparison of WIN 51711 and R 78206 as stabilizers of poliovirus virions and procapsids. The Journal of general virology, 1991, Volume: 72 ( Pt 9) Topics: Antiviral Agents; Capsid; Epitopes; Half-Life; Isoxazoles; Molecular Structure; Piperidines; Poliovirus; Protein Precursors; Pyridazines; Viral Core Proteins; Virion	1991
Stabilization of human rhinovirus serotype 2 against pH-induced conformational change by antiviral compounds. The Journal of general virology, 1991, Volume: 72 ( Pt 2) Topics: Antiviral Agents; Hydrogen-Ion Concentration; Isoxazoles; Precipitin Tests; Protein Conformation; Rhinovirus; Serotyping; Viral Proteins	1991
Inhibitors of poliovirus uncoating efficiently block the early membrane permeabilization induced by virus particles. Journal of virology, 1991, Volume: 65, Issue:5 Topics: Antiviral Agents; Cell Membrane; Cell Membrane Permeability; Cells, Cultured; Chalcone; Chalcones; Endoribonucleases; Fungal Proteins; HeLa Cells; Heparin; Humans; Isoxazoles; Phosphatidylcholines; Poliovirus; Protein Synthesis Inhibitors; Virion	1991
Disoxaril stabilization and immunogenicity of poliovirus procapsids. The Journal of general virology, 1990, Volume: 71 ( Pt 5) Topics: Animals; Antibodies, Viral; Antigens, Viral; Capsid; HeLa Cells; Humans; Hydrogen-Ion Concentration; Immunization; Isoxazoles; Mice; Mice, Inbred BALB C; Neutralization Tests; Oxazoles; Poliovirus; Protein Denaturation; Temperature; Virion	1990
[Can anything curative be done against the common cold?]. Nederlands tijdschrift voor geneeskunde, 1986, Sep-20, Volume: 130, Issue:38 Topics: Antiviral Agents; Common Cold; Humans; Interferons; Isoxazoles; Rhinovirus; Viral Vaccines	1986
Clearance of a persistent human enterovirus infection of the mouse central nervous system by the antiviral agent disoxaril. The Journal of infectious diseases, 1989, Volume: 159, Issue:5 Topics: Animals; Antiviral Agents; Brain; Cyclophosphamide; Disease Models, Animal; Drug Resistance, Microbial; Enterovirus Infections; Immunosuppression Therapy; Isoxazoles; Male; Mice; Mice, Inbred BALB C; Oxazoles; Poliomyelitis; Poliovirus	1989
Genetic and molecular analyses of spontaneous mutants of human rhinovirus 14 that are resistant to an antiviral compound. Journal of virology, 1989, Volume: 63, Issue:6 Topics: Antiviral Agents; Dose-Response Relationship, Drug; Drug Resistance, Microbial; HeLa Cells; Humans; Isoxazoles; Models, Molecular; Molecular Conformation; Molecular Structure; Mutation; Oxazoles; Rhinovirus; Viral Plaque Assay	1989
Drug resistant rhinoviruses from the nose of experimentally treated volunteers. Archives of virology, 1989, Volume: 109, Issue:1-2 Topics: Antiviral Agents; Chalcone; Drug Resistance, Microbial; Flavonoids; Humans; Isoxazoles; Microbial Sensitivity Tests; Nose; Pyridazines; Rhinovirus	1989
Inhibition of poliovirus uncoating by disoxaril (WIN 51711). Virology, 1987, Volume: 160, Issue:1 Topics: Antiviral Agents; Capsid; Depression, Chemical; Endocytosis; HeLa Cells; Humans; Isoxazoles; Lysosomes; Oxazoles; Poliovirus; RNA, Viral; Virus Replication	1987
Enantiomeric effects of homologues of disoxaril on the inhibitory activity against human rhinovirus-14. Journal of medicinal chemistry, 1988, Volume: 31, Issue:3 Topics: Antiviral Agents; Computer Simulation; Humans; Isoxazoles; Models, Molecular; Oxazoles; Rhinovirus; Stereoisomerism; Structure-Activity Relationship; X-Ray Diffraction	1988
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus. Journal of medicinal chemistry, 1989, Volume: 32, Issue:2 Topics: Antiviral Agents; Coronaviridae; Humans; Isoxazoles; Oxazoles; Structure-Activity Relationship	1989
In vitro activity of WIN 51711, a new broad-spectrum antipicornavirus drug. Antimicrobial agents and chemotherapy, 1985, Volume: 27, Issue:6 Topics: Antiviral Agents; Culture Media; Enterovirus; HeLa Cells; Humans; Isoxazoles; Oxazoles; Picornaviridae; Rhinovirus; Time Factors; Viral Plaque Assay; Virus Replication	1985
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating. Journal of medicinal chemistry, 1985, Volume: 28, Issue:12 Topics: Animals; Chemical Phenomena; Chemistry; Dose-Response Relationship, Drug; Isoxazoles; Mice; Oxazoles; Picornaviridae Infections; Poliovirus; Rhinovirus; Structure-Activity Relationship; Time Factors; Virus Replication	1985
The site of attachment in human rhinovirus 14 for antiviral agents that inhibit uncoating. Science (New York, N.Y.), 1986, Sep-19, Volume: 233, Issue:4770 Topics: Antiviral Agents; Binding Sites; Chemical Phenomena; Chemistry; Humans; Isoxazoles; Poliovirus; Rhinovirus; X-Ray Diffraction	1986
Prevention of rhinovirus and poliovirus uncoating by WIN 51711, a new antiviral drug. Antimicrobial agents and chemotherapy, 1986, Volume: 30, Issue:1 Topics: Antiviral Agents; Cells, Cultured; Centrifugation, Density Gradient; Hot Temperature; Humans; Isoxazoles; Oxazoles; Poliovirus; Rhinovirus; Sucrose; Time Factors; Uridine; Virus Replication	1986
Antiviral agents targeted to interact with viral capsid proteins and a possible application to human immunodeficiency virus. Proceedings of the National Academy of Sciences of the United States of America, 1988, Volume: 85, Issue:13 Topics: Antiviral Agents; Capsid; HIV; HIV Core Protein p24; Isoxazoles; Models, Molecular; Picornaviridae; Protein Conformation; Retroviridae Proteins; Structure-Activity Relationship	1988
Oral efficacy of WIN 51711 in mice infected with human poliovirus. Antimicrobial agents and chemotherapy, 1986, Volume: 29, Issue:1 Topics: Animals; Antiviral Agents; Brain; Female; Humans; Isoxazoles; Mice; Mice, Inbred ICR; Oxazoles; Poliomyelitis; Spinal Cord; Time Factors	1986
Use of WIN 51711 to prevent echovirus type 9-induced paralysis in suckling mice. The Journal of infectious diseases, 1986, Volume: 154, Issue:4 Topics: Administration, Oral; Animals; Animals, Suckling; Antiviral Agents; Echovirus 9; Echovirus Infections; Injections, Intraperitoneal; Isoxazoles; Mice; Oxazoles; Paralysis; Tissue Distribution	1986
WIN 51711, a new systematically active broad-spectrum antipicornavirus agent. The Journal of antimicrobial chemotherapy, 1985, Volume: 16, Issue:3 Topics: Antiviral Agents; Capsid; Isoxazoles; Oxazoles; Picornaviridae; Viral Proteins	1985
Antiviral capsid-binding compounds can inhibit the adsorption of minor receptor rhinoviruses. Antiviral research, 1994, Volume: 25, Issue:1 Topics: Adsorption; Antiviral Agents; Capsid; Chalcone; Chalcones; Flavonoids; HeLa Cells; Humans; Isoxazoles; Mutation; Protein Conformation; Pyridazines; Receptors, Virus; Rhinovirus	1994
Distribution of drug resistance mutations in type 3 poliovirus identifies three regions involved in uncoating functions. Journal of virology, 1994, Volume: 68, Issue:12 Topics: Amino Acid Sequence; Antiviral Agents; Binding Sites; Capsid; Drug Resistance, Microbial; HeLa Cells; Humans; Isoxazoles; Kinetics; Membrane Proteins; Models, Biological; Models, Molecular; Point Mutation; Poliovirus; Protein Conformation; Protein Structure, Secondary; Receptors, Virus; RNA, Viral; Temperature; Viral Plaque Assay	1994
Oxadiazoles as ester bioisosteric replacements in compounds related to disoxaril. Antirhinovirus activity. Journal of medicinal chemistry, 1994, Jul-22, Volume: 37, Issue:15 Topics: Antiviral Agents; Esters; HeLa Cells; Humans; Isoxazoles; Oxadiazoles; Rhinovirus	1994
Stabilization of the antigenicity of coxsackie B procapsids by disoxaril. Journal of virological methods, 1993, Dec-15, Volume: 45, Issue:2 Topics: Antibodies, Viral; Antigens, Viral; Capsid; Drug Stability; Enterovirus; Enterovirus B, Human; Enterovirus Infections; Humans; Immunoglobulin M; Isoxazoles; Proviruses; Radioimmunoassay; Virology	1993
Capsid destabilization is required for antibody-mediated disruption of poliovirus. The Journal of general virology, 1994, Volume: 75 ( Pt 3) Topics: Antibodies, Monoclonal; Antibodies, Viral; Capsid; Isoxazoles; Neutralization Tests; Osmolar Concentration; Poliovirus; Temperature	1994
Antipicornavirus activity of tetrazole analogues related to disoxaril. Journal of medicinal chemistry, 1993, Oct-29, Volume: 36, Issue:22 Topics: Amino Acid Sequence; Antiviral Agents; Binding Sites; Humans; Isoxazoles; Microbial Sensitivity Tests; Molecular Sequence Data; Picornaviridae; Rhinovirus; Structure-Activity Relationship; Tetrazoles	1993
On the mechanism of HRV-14 antiviral compounds: "slow growth" as a conformational search procedure. Journal of medicinal chemistry, 1993, Nov-12, Volume: 36, Issue:23 Topics: Amino Acid Sequence; Antiviral Agents; Binding Sites; Chemical Phenomena; Chemistry, Physical; Crystallography, X-Ray; Electrochemistry; Hydrogen Bonding; Isoxazoles; Molecular Conformation; Molecular Sequence Data; Molecular Structure	1993
WIN 51711-dependent mutants of poliovirus type 3: evidence that virions decay after release from cells unless drug is present. Journal of virology, 1993, Volume: 67, Issue:3 Topics: Antiviral Agents; Drug Resistance, Microbial; HeLa Cells; Hot Temperature; Humans; Isoxazoles; Mutagenesis; Poliovirus; Virion; Virus Replication	1993
SCH 38057: a picornavirus capsid-binding molecule with antiviral activity after the initial stage of viral uncoating. Antiviral research, 1993, Volume: 21, Issue:1 Topics: Animals; Antiviral Agents; Capsid; Enterovirus B, Human; HeLa Cells; Humans; Imidazoles; Isoxazoles; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Picornaviridae; Poliovirus; Rhinovirus; Therapeutic Equivalency	1993
Synergistic inhibitory effect of enviroxime and disoxaril on poliovirus type 1 replication. Acta virologica, 1995, Volume: 39, Issue:5-6 Topics: Antiviral Agents; Benzimidazoles; Cell Line; Drug Resistance; Drug Synergism; Humans; Isoxazoles; Oximes; Poliovirus; Ribavirin; Sulfonamides; Virus Replication	1995
Synthesis and antirhinovirus activity of 3-(diethylamino)-5-phenylisoxazole derivatives. Farmaco (Societa chimica italiana : 1989), 1996, Volume: 51, Issue:5 Topics: Antiviral Agents; Cytopathogenic Effect, Viral; HeLa Cells; HIV-1; Humans; Isoxazoles; Rhinovirus; Virus Replication	1996
An antiviral compound that blocks structural transitions of poliovirus prevents receptor binding at low temperatures. Journal of virology, 2000, Volume: 74, Issue:8 Topics: Antiviral Agents; Capsid; HeLa Cells; Humans; Isoxazoles; Poliovirus; Receptors, Virus; Temperature	2000
Cytotoxicity of the synergistic antienteroviral combination of enviroxime and disoxaril. Acta virologica, 1999, Volume: 43, Issue:4 Topics: Antiviral Agents; Benzimidazoles; Cells, Cultured; Drug Synergism; Humans; Isoxazoles; Oximes; Poliovirus; Sulfonamides; Virus Replication	1999
In vitro inhibitory effects of dual combinations of picornavirus replication inhibitors. Acta virologica, 1999, Volume: 43, Issue:5 Topics: Antiviral Agents; Benzimidazoles; Cell Line; Drug Combinations; Drug Interactions; Drug Synergism; Guanidine; Humans; Isoxazoles; Ketones; Oximes; Phenylthiourea; Poliovirus; Pyrimidines; Sulfonamides; Virus Replication	1999
Disoxaril-related 3-(diethylamino)-5-phenylisoxazoles. Farmaco (Societa chimica italiana : 1989), 2000, Volume: 55, Issue:2 Topics: Antiviral Agents; HIV-1; Isoxazoles; Rhinovirus; Structure-Activity Relationship	2000
Antiviral effect of the combination of enviroxime and disoxaril on coxsackievirus B1 infection. Acta virologica, 2000, Volume: 44, Issue:2 Topics: Animals; Antiviral Agents; Benzimidazoles; Cell Line; Coxsackievirus Infections; Drug Synergism; Enterovirus B, Human; Humans; Isoxazoles; Mice; Mice, Inbred ICR; Oximes; Sulfonamides; Virus Replication	2000
Development of resistance to disoxaril in Coxsackie B1 virus-infected newborn mice. Antiviral research, 2003, Volume: 60, Issue:1 Topics: Animals; Animals, Newborn; Antiviral Agents; Brain; Cell Line; Coxsackievirus Infections; Drug Resistance, Viral; Enterovirus B, Human; Isoxazoles; Mice; Mutation; Phenotype; Temperature; Viral Plaque Assay; Virulence	2003
Synergistic drug combinations against the in vitro replication of Coxsackie B1 virus. Antiviral research, 2004, Volume: 62, Issue:1 Topics: Antiviral Agents; Benzimidazoles; Cell Line; Drug Combinations; Drug Synergism; Enterovirus B, Human; Humans; Isoxazoles; Ketones; Oximes; Phenylthiourea; Pyrimidines; Sulfonamides; Virus Replication	2004
Trans-dominant inhibition of RNA viral replication can slow growth of drug-resistant viruses. Nature genetics, 2005, Volume: 37, Issue:7 Topics: Alleles; Antiviral Agents; Capsid Proteins; Cysteine Endopeptidases; Drug Resistance, Viral; Genome, Viral; HeLa Cells; Humans; Isoxazoles; Models, Molecular; Mutation; Phenotype; Poliovirus; Protein Biosynthesis; Viral Proteins; Virus Replication	2005
Physico-chemical characterization of disoxaril-dimethyl-beta-cyclodextrin inclusion complex and in vitro permeation studies. European journal of medicinal chemistry, 2006, Volume: 41, Issue:2 Topics: Animals; beta-Cyclodextrins; Cattle; Cell Membrane Permeability; Chemistry, Pharmaceutical; Drug Carriers; Drug Stability; Hydrophobic and Hydrophilic Interactions; Isoxazoles; Kinetics; Nasal Mucosa; Rabbits; Solubility; Spectrum Analysis; Thermodynamics; Water	2006
Structure of human enterovirus 71 in complex with a capsid-binding inhibitor. Proceedings of the National Academy of Sciences of the United States of America, 2013, Apr-02, Volume: 110, Issue:14 Topics: Capsid Proteins; Crystallization; Enterovirus A, Human; Flow Cytometry; Humans; Isoxazoles; Models, Molecular; Protein Conformation; Virion; X-Ray Diffraction	2013
Effectiveness of the Consecutive Alternating Administration Course of a Triple Antiviral Combination in Coxsackievirus B3 Infections in Mice. Drug research, 2016, Volume: 66, Issue:12 Topics: Animals; Animals, Newborn; Antiviral Agents; Apomorphine; Coxsackievirus Infections; Drug Therapy, Combination; Enterovirus B, Human; Guanidine; Isoxazoles; Mice; Mice, Inbred ICR	2016