Compounds > cephalostatin i
Page last updated: 2024-11-08

cephalostatin i

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Description

cephalostatin I: two steroid units are annulated to a 1,4-pyrazine ring; RN given for (3'R-(3'alpha(R*),4'alpha,4'abeta,6'balpha,8'abeta,11'aalpha,11'bbeta,13'alpha,13'aalpha,13'bbeta,14'beta,15'alpha(3*R*,5''S*),16'abeta,17'balpha,19'abeta,22'aalpha,22'bbeta,24'aR'*))-isomer; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10328411
CHEMBL ID269081
CHEBI ID69376
MeSH IDM0424696
PubMed CID137325902
MeSH IDM0424696

Synonyms (6)

Synonym
cephalostatin 1
CHEMBL269081
chebi:69376 ,
C20060
Q27137715
cephalostatin i
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
oxo steroid
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (170)

Assay IDTitleYearJournalArticle
AID332988Growth inhibition of human TK10 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID327929Antitumor activity against mouse P388 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
Review of cytotoxic cephalostatins and ritterazines: isolation and synthesis.
AID329281Cytotoxicity against human SN12C cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID329279Cytotoxicity against human RXF393 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID332957Growth inhibition of human KM20L2 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID332975Growth inhibition of human UACC62 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID332949Growth inhibition of human DMS114 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID329252Cytotoxicity against human SF268 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID45942In vitro cytotoxicity against CNS SF-295 human tumors following a 2 day exposure.1999Bioorganic & medicinal chemistry letters, Sep-06, Volume: 9, Issue:17
On topography and functionality in the B-D rings of cephalostatin cytotoxins.
AID332942Growth inhibition of human HOP92 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID329253Cytotoxicity against human SF295 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID329271Cytotoxicity against human OVCAR4 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID332951Growth inhibition of human COLO205 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID329276Cytotoxicity against human A496 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID329234Cytotoxicity against human HOP92 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID332982Growth inhibition of human 786-O cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID332968Growth inhibition of human MALME-3M cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID355115Antineoplastic activity against mouse P388 cells1996Journal of natural products, Aug, Volume: 59, Issue:8
Progress in the discovery of biosynthetic anticancer drugs.
AID332952Growth inhibition of human DLD1 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID8829In vitro cytotoxicity against Renal A-498 human tumors following a 2 day exposure.1999Bioorganic & medicinal chemistry letters, Sep-06, Volume: 9, Issue:17
On topography and functionality in the B-D rings of cephalostatin cytotoxins.
AID329232Cytotoxicity against human HOP18 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID329224Cytotoxicity against human CCRF-CEM cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID156037In vitro cytotoxicity against prostate PC-3 human tumors following a 2 day exposure.1999Bioorganic & medicinal chemistry letters, Sep-06, Volume: 9, Issue:17
On topography and functionality in the B-D rings of cephalostatin cytotoxins.
AID329257Cytotoxicity against human SNB78 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID332962Growth inhibition of human SNB19 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID144796In vitro cytotoxicity against a subset of 60 cell lines (NCI-60) in human tumors following a 2 day exposure. Values in parentheses is the % cell lines affected.1999Bioorganic & medicinal chemistry letters, Sep-06, Volume: 9, Issue:17
On topography and functionality in the B-D rings of cephalostatin cytotoxins.
AID332948Growth inhibition of human LXFL529 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID332979Growth inhibition of human OVCAR5 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID332937Growth inhibition of human SR cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID332934Growth inhibition of human K562 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID329229Cytotoxicity against human SR cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID332958Growth inhibition of human SW620 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID1230351Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay2015Journal of natural products, Jun-26, Volume: 78, Issue:6
The Cephalostatins. 24. Isolation, Structure, and Cancer Cell Growth Inhibition of Cephalostatin 20.
AID332986Growth inhibition of human RXF393 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID329288Cytotoxicity against human MDA-MB-231 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID329245Cytotoxicity against human HCC2996 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID8998Cytotoxicity against A-549 cell line in the purdue cell culture screen was determined1999Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3
On the relationship of OSW-1 to the cephalostatins.
AID329272Cytotoxicity against human OVCAR5 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID332944Growth inhibition of human NCI-H23 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID329251Cytotoxicity against human SW620 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID329235Cytotoxicity against human NCI-H226 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID329227Cytotoxicity against human MOLT4 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID332970Growth inhibition of human M19-MEL cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID332961Growth inhibition of human SF539 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID329289Cytotoxicity against human HS578T cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID329286Cytotoxicity against human MCF7 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID329248Cytotoxicity against human HT29 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID329265Cytotoxicity against human SK-MEL-28 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID332973Growth inhibition of human SK-MEL-5 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID329246Cytotoxicity against human HCT116 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID329255Cytotoxicity against human SNB19 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID156029In vitro cytotoxicity against prostate PC-3 human tumors following a 6 day exposure1999Bioorganic & medicinal chemistry letters, Sep-06, Volume: 9, Issue:17
On topography and functionality in the B-D rings of cephalostatin cytotoxins.
AID332966Growth inhibition of human XF498 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID92293In vitro cytotoxicity against various human tumors (6-8 lines) as determined in the Purdue cell culture laboratory, following a 6 day exposure1999Bioorganic & medicinal chemistry letters, Sep-06, Volume: 9, Issue:17
On topography and functionality in the B-D rings of cephalostatin cytotoxins.
AID332946Growth inhibition of human NCI-H460 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID329249Cytotoxicity against human KM12 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID329233Cytotoxicity against human HOP62 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID329236Cytotoxicity against human NCI-H23 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID332932Growth inhibition of human CCRF-CEM cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID333028Growth inhibition of human KM12 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID332984Growth inhibition of human ACHN cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID332964Growth inhibition of human SNB78 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID144777In vitro cytotoxicity against a subset of 10 cell lines (NCI-10) in human tumors following a 2 day exposure. Values in parentheses is the % cell lines affected.1999Bioorganic & medicinal chemistry letters, Sep-06, Volume: 9, Issue:17
On topography and functionality in the B-D rings of cephalostatin cytotoxins.
AID332935Growth inhibition of human MOLT4 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID329243Cytotoxicity against human COLO205 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID332987Growth inhibition of human SN12C cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID329231Cytotoxicity against human EKVX cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID1230350Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay2015Journal of natural products, Jun-26, Volume: 78, Issue:6
The Cephalostatins. 24. Isolation, Structure, and Cancer Cell Growth Inhibition of Cephalostatin 20.
AID154436In vitro cytotoxicity against Bladder PACA-2 human tumors following a 6 day exposure1999Bioorganic & medicinal chemistry letters, Sep-06, Volume: 9, Issue:17
On topography and functionality in the B-D rings of cephalostatin cytotoxins.
AID332950Growth inhibition of human DMS273 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID332959Growth inhibition of human SF268 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID86094In vitro cytotoxicity against Colon HT-29 human tumors following a 2 day exposure.1999Bioorganic & medicinal chemistry letters, Sep-06, Volume: 9, Issue:17
On topography and functionality in the B-D rings of cephalostatin cytotoxins.
AID82504In vitro cytotoxicity against HL-60 leukemia human tumors following a 2 day exposure.1999Bioorganic & medicinal chemistry letters, Sep-06, Volume: 9, Issue:17
On topography and functionality in the B-D rings of cephalostatin cytotoxins.
AID329269Cytotoxicity against human IGROV1 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID329230Cytotoxicity against human A549 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID329239Cytotoxicity against human NCI-H522 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID332971Growth inhibition of human SK-MEL-2 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID150357In vitro cytotoxicity against P388 leukemic cell line following a 6 day exposure.1999Bioorganic & medicinal chemistry letters, Sep-06, Volume: 9, Issue:17
On topography and functionality in the B-D rings of cephalostatin cytotoxins.
AID332945Growth inhibition of human NCI-H322M cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID8824Cytotoxicity against A-498 cell line in the purdue cell culture screen was determined1999Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3
On the relationship of OSW-1 to the cephalostatins.
AID329285Cytotoxicity against human DU145 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID329258Cytotoxicity against human U251 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID332960Growth inhibition of human SF295 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID329263Cytotoxicity against human M19-MEL cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID329268Cytotoxicity against human UACC62 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID329244Cytotoxicity against human DLD1 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID8827In vitro cytotoxicity against Renal A-498 human tumors following a 6 day exposure.1999Bioorganic & medicinal chemistry letters, Sep-06, Volume: 9, Issue:17
On topography and functionality in the B-D rings of cephalostatin cytotoxins.
AID329277Cytotoxicity against human ACHN cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID329291Cytotoxicity against human MDAN cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID1228614Cytotoxicity against mouse P388 cells assessed as growth inhibition after 48 hrs by coulter particle counter analysis2015Journal of natural products, May-22, Volume: 78, Issue:5
The Cephalostatins. 23. Conversion of Hecogenin to a Steroidal 1,6-Dioxaspiro[5.5]nonane Analogue for Cephalostatin 11.
AID329293Cytotoxicity against human T47D cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID329254Cytotoxicity against human SF539 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID329282Cytotoxicity against human TK20 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID329250Cytotoxicity against human KM20L2 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID329290Cytotoxicity against human MDA-MB-435 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID154432Cytotoxicity against PACA-2 cell line in the purdue cell culture screen was determined1999Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3
On the relationship of OSW-1 to the cephalostatins.
AID401738Growth inhibition of human NCI60 cells1998Journal of natural products, Jul, Volume: 61, Issue:7
Antineoplastic agents. 398. Isolation and structure elucidation of cephalostatins 18 and 19.
AID1230353Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay2015Journal of natural products, Jun-26, Volume: 78, Issue:6
The Cephalostatins. 24. Isolation, Structure, and Cancer Cell Growth Inhibition of Cephalostatin 20.
AID86077In vitro cytotoxicity against Colon HT-29 human tumors following a 6 day exposure.1999Bioorganic & medicinal chemistry letters, Sep-06, Volume: 9, Issue:17
On topography and functionality in the B-D rings of cephalostatin cytotoxins.
AID103257Cytotoxicity against MCF-7R cell line in the purdue cell culture screen was determined; NT= not tested1999Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3
On the relationship of OSW-1 to the cephalostatins.
AID329261Cytotoxicity against human MALME3M cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID329256Cytotoxicity against human SNB75 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID332981Growth inhibition of human SKOV3 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID329278Cytotoxicity against human CAKI1 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID332980Growth inhibition of human OVCAR8 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID332933Growth inhibition of human HL-60(TB) cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID329225Cytotoxicity against human HL60(TB) cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID9210In vitro cytotoxicity against Lung A-549 human tumors following a 6 day exposure.1999Bioorganic & medicinal chemistry letters, Sep-06, Volume: 9, Issue:17
On topography and functionality in the B-D rings of cephalostatin cytotoxins.
AID332972Growth inhibition of human SK-MEL-28 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID1228613Cytotoxicity against human NCI60 cells2015Journal of natural products, May-22, Volume: 78, Issue:5
The Cephalostatins. 23. Conversion of Hecogenin to a Steroidal 1,6-Dioxaspiro[5.5]nonane Analogue for Cephalostatin 11.
AID329270Cytotoxicity against human OVCAR-3 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID329226Cytotoxicity against human K562 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID332955Growth inhibition of human HCT15 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID329283Cytotoxicity against human UO31 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID332963Growth inhibition of human SNB75 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID332983Growth inhibition of human A498 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID332947Growth inhibition of human NCI-H522 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID329284Cytotoxicity against human PC3 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID332969Growth inhibition of human M14 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID332938Growth inhibition of human A549 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID332941Growth inhibition of human HOP62 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID329240Cytotoxicity against human LXFL529 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID9211In vitro cytotoxicity against Lung A-549 human tumors following a 2 day exposure.1999Bioorganic & medicinal chemistry letters, Sep-06, Volume: 9, Issue:17
On topography and functionality in the B-D rings of cephalostatin cytotoxins.
AID332956Growth inhibition of human HT-29 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID332965Growth inhibition of human U251 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID156025Cytotoxicity against PC-3 cell line in the purdue cell culture screen was determined1999Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3
On the relationship of OSW-1 to the cephalostatins.
AID86074Cytotoxicity against HT-29 cell line in the purdue cell culture screen was determined1999Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3
On the relationship of OSW-1 to the cephalostatins.
AID332967Growth inhibition of human LOXIMVI cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID103239Cytotoxicity against MCF-7ADR cell line in the purdue cell culture screen was determined1999Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3
On the relationship of OSW-1 to the cephalostatins.
AID329247Cytotoxicity against human HCT15 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID329267Cytotoxicity against human UACC257 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID332974Growth inhibition of human UACC257 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID329237Cytotoxicity against human NCI-H322M cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID332985Growth inhibition of human Caki1 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID329287Cytotoxicity against human NCI/ADR-RES cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID100690In vitro cytotoxicity against Skin LOX IMVI human tumors following a 2 day exposure.1999Bioorganic & medicinal chemistry letters, Sep-06, Volume: 9, Issue:17
On topography and functionality in the B-D rings of cephalostatin cytotoxins.
AID329264Cytotoxicity against human SK-MEL-2 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID93474In vitro cytotoxicity against Ovary IGROVIg OVI human tumors following a 2 day exposure.1999Bioorganic & medicinal chemistry letters, Sep-06, Volume: 9, Issue:17
On topography and functionality in the B-D rings of cephalostatin cytotoxins.
AID329275Cytotoxicity against human 786-O cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID329228Cytotoxicity against human RPMI8226 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID676129Growth inhibition of mouse P388 cells2012Journal of natural products, Jun-22, Volume: 75, Issue:6
The cephalostatins. 22. synthesis of bis-steroidal pyrazine pyrones (1).
AID329273Cytotoxicity against human OVCAR8 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID332939Growth inhibition of human EKVX cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID329242Cytotoxicity against human DMS273 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID332943Growth inhibition of human NCI-H226 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID329292Cytotoxicity against human BT549 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID329260Cytotoxicity against human LOXIMVI cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID329262Cytotoxicity against human M14 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID332954Growth inhibition of human HCT116 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID329238Cytotoxicity against human NCI-H460 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID332977Growth inhibition of human OVCAR-3 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID91665In vitro cytotoxicity against Breast avg 1-3 types of human tumors following a 6 day exposure.1999Bioorganic & medicinal chemistry letters, Sep-06, Volume: 9, Issue:17
On topography and functionality in the B-D rings of cephalostatin cytotoxins.
AID167415In vitro cytotoxicity against Renal RXF-393 human tumors following a 2 day exposure.1999Bioorganic & medicinal chemistry letters, Sep-06, Volume: 9, Issue:17
On topography and functionality in the B-D rings of cephalostatin cytotoxins.
AID103062In vitro cytotoxicity against Breast MCF-7 human tumors following a 2 day exposure.1999Bioorganic & medicinal chemistry letters, Sep-06, Volume: 9, Issue:17
On topography and functionality in the B-D rings of cephalostatin cytotoxins.
AID1228612Cytotoxicity against mouse P388 cells assessed as growth inhibition2015Journal of natural products, May-22, Volume: 78, Issue:5
The Cephalostatins. 23. Conversion of Hecogenin to a Steroidal 1,6-Dioxaspiro[5.5]nonane Analogue for Cephalostatin 11.
AID332953Growth inhibition of human HCC2998 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID329280Cytotoxicity against human RXF631 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID329241Cytotoxicity against human DMS144 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID332936Growth inhibition of human RPMI8226 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID1230349Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay2015Journal of natural products, Jun-26, Volume: 78, Issue:6
The Cephalostatins. 24. Isolation, Structure, and Cancer Cell Growth Inhibition of Cephalostatin 20.
AID332940Growth inhibition of human HOP18 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID103703Cytotoxicity against MCF-7 cell line in the purdue cell culture screen was determined1999Bioorganic & medicinal chemistry letters, Feb-08, Volume: 9, Issue:3
On the relationship of OSW-1 to the cephalostatins.
AID329259Cytotoxicity against human XF498 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID329274Cytotoxicity against human SK-OV-3 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID329266Cytotoxicity against human SK-MEL-5 cells2008Journal of natural products, Mar, Volume: 71, Issue:3
The cephalostatin way of apoptosis.
AID1230348Cytotoxicity against human BxPC3 cells after 48 hrs by sulforhodamine B assay2015Journal of natural products, Jun-26, Volume: 78, Issue:6
The Cephalostatins. 24. Isolation, Structure, and Cancer Cell Growth Inhibition of Cephalostatin 20.
AID332989Growth inhibition of human UO31 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID332976Growth inhibition of human IGROV1 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID332978Growth inhibition of human OVCAR4 cells1994Journal of natural products, Jan, Volume: 57, Issue:1
Isolation and structure of cephalostatins 10 and 11.
AID1230352Cytotoxicity against human KM20L2 cells after 48 hrs by sulforhodamine B assay2015Journal of natural products, Jun-26, Volume: 78, Issue:6
The Cephalostatins. 24. Isolation, Structure, and Cancer Cell Growth Inhibition of Cephalostatin 20.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (33)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's5 (15.15)18.2507
2000's15 (45.45)29.6817
2010's13 (39.39)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Trials0 (0.00%)5.53%
Reviews3 (30.00%)6.00%
Reviews6 (22.22%)6.00%
Case Studies0 (0.00%)4.05%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Observational0 (0.00%)0.25%
Other7 (70.00%)84.16%
Other21 (77.78%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
taurine
[no description available]		3.0910amino sulfonic acid;
zwitterion		antioxidant;
Escherichia coli metabolite;
glycine receptor agonist;
human metabolite;
mouse metabolite;
nutrient;
radical scavenger;
Saccharomyces cerevisiae metabolite
helenalin
helenalin : A sesquiterpene lactone that is 3,3a,4,4a,7a,8,9,9a-octahydroazuleno[6,5-b]furan-2,5-dione substituted by a hydroxy group at position 4, methyl groups at positions 4a and 8 and a methylidene group at position 3 (the 3aS,4S,4aR,7aR,8R,9aR stereoisomer).. NF-kappaB inhibitor : An inhibitor of NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B cells), a protein complex involved in the transcription of DNA.. helenalin: toxic principle of Helenium microcephalum (smallhead sneezeweed); structure		3.0910cyclic ketone;
gamma-lactone;
organic heterotricyclic compound;
secondary alcohol;
sesquiterpene lactone		anti-inflammatory agent;
antineoplastic agent;
metabolite;
plant metabolite
doxorubicin hydrochloride
[no description available]		210anthracycline
dolastatin 10
dolastatin 10: from mollusk Dolabella auricularia; contains four amino acids, dolavaline, dolaisoleucine, dolaproine, valine and the primary amine dolaphenine; deo-dolastatin 10 is a new dolastatin 10 chiral derivative with MW of 784. dolastatin 10 : A tetrapeptide that is isolated from the sea hare Dolabella auricularia. It is a potent anticancer agent which inhibits tubulin polymerization.		3.09101,3-thiazoles;
tetrapeptide		animal metabolite;
antineoplastic agent;
apoptosis inducer;
marine metabolite;
microtubule-destabilising agent
carbamates
[no description available]		3.1810amino-acid anion
spironolactone
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827). spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.		2.01103-oxo-Delta(4) steroid;
oxaspiro compound;
steroid lactone;
thioester		aldosterone antagonist;
antihypertensive agent;
diuretic;
environmental contaminant;
xenobiotic
boranes
Boranes: The collective name for the boron hydrides, which are analogous to the alkanes and silanes. Numerous boranes are known. Some have high calorific values and are used in high-energy fuels. (From Grant & Hackh's Chemical Dictionary, 5th ed). borane : The simplest borane, consisting of a single boron atom carrying three hydrogens.. boranes : The molecular hydrides of boron.		2.4620boranes;
mononuclear parent hydride
methylene chloride
Methylene Chloride: A chlorinated hydrocarbon that has been used as an inhalation anesthetic and acts as a narcotic in high concentrations. Its primary use is as a solvent in manufacturing and food technology.. dichloromethane : A member of the class of chloromethanes that is methane in which two of the hydrogens have been replaced by chlorine. A dense, non-flammible colourless liquid at room temperature (b.p. 40degreeC, d = 1.33) which is immiscible with water, it is widely used as a solvent, a paint stripper, and for the removal of caffeine from coffee and tea.		2.0710chloromethanes;
volatile organic compound		carcinogenic agent;
polar aprotic solvent;
refrigerant
boron trifluoride etherate
[no description available]		2.0610
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.		3.1810pyrrole;
secondary amine
nonane
nonane : A straight chain alkane composed of 9 carbon atoms.. iotrochotin: toxin from the Caribbean sponge Iotrochota birotulata, which selectively permeabilizes synaptosomes		2.1110alkaneplant metabolite;
volatile oil component
thiazoles
[no description available]		3.18101,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
pyrazines
Pyrazines: A heterocyclic aromatic organic compound with the chemical formula C4H4N2.. pyrazine : A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.		4.4160diazine;
pyrazines		Daphnia magna metabolite
chromium trioxide
chromium trioxide: oxidizing agent. chromium trioxide : A chromium oxide composed of a single chromium bound (oxidation state +6) to three oxygens; the acidic anhydride of chromic acid.		2.0510chromium oxide
rhamnose
[no description available]		2.0610L-rhamnose
25-hydroxycholesterol
[no description available]		2.061025-hydroxy steroid;
oxysterol		human metabolite
1,7-phenanthroline
[no description available]		3.1810phenanthroline
hecogenin
hecogenin: steroidal sapogenin which has been isolated from plants particularly from numerous Agave species; used in prep of steroidal hormones; structure; RN given refers to (3beta,5alpha,25R)-isomer		2.4820triterpenoid
hecogenin acetate
hecogenin acetate: structure in first source		2.7830triterpenoid
ecteinascidin 743
[no description available]		3.1810acetate ester;
azaspiro compound;
bridged compound;
hemiaminal;
isoquinoline alkaloid;
lactone;
organic heteropolycyclic compound;
organic sulfide;
oxaspiro compound;
polyphenol;
tertiary amino compound		alkylating agent;
angiogenesis modulating agent;
anti-inflammatory agent;
antineoplastic agent;
marine metabolite
osw 1
OSW 1: RN given for the (3beta,16beta)-isomer		2.0610
ascididemin
ascididemin: can be viewed as a fused phenanthroline with quinoline; from the Mediterranean ascidian Cystodytes dellechiajei; structure in first source		3.1810
stilbenes
Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.. trans-stilbene : The trans-isomer of stilbene.		2.0610stilbene
schweinfurthin a
schweinfurthin A: a geranyl stilbene from plant Macaranga schweinfurthii; structure in first source		2.0610
beta-escin
[no description available]		2.0610
hippuristanol
hippuristanol: from the gorgonian Isis hippuris		2.0510
marizomib
marizomib: a proteasome inhibitor from a marine bacterium Salinospora; structure in first source		3.1810beta-lactone;
gamma-lactam;
organic heterobicyclic compound;
organochlorine compound;
salinosporamide		antineoplastic agent;
proteasome inhibitor
discodermolide
discodermolide: a lactone-bearing polyhydroxylated alkatetraene from the marine sponge Discodermia dissoluta; microtubule-stabilizing agent like taxol		3.1810
cytochrome c-t
Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.		2.0410
calpain
Calpain: Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 3.4.22.4.		2.0410
sapogenins
Sapogenins: The aglucon moiety of a saponin molecule. It may be triterpenoid or steroid, usually spirostan, in nature.		2.7430
glycolipids
[no description available]		2.0610
bryostatin 1
bryostatin 1: a protein kinase C activator; macrocyclic lactone from marine Bryozoan Bugula neritina; RN given refers to (1S*-(1R*,3R*,5Z,7S*,8E,11R*,12R*(2E,4E),13E,15R*,17S*(S*),21S*,23S*,25R*))-isomer; structure given in first source; activates protein kinase c. bryostatin 1 : A member of the class of bryostatins that is (17E)-2-oxooxacyclohexacos-17-ene which is substituted by hydroxy groups at positions 4, 10, and 20; an acetoxy group at position 8; methyl groups at positions 9, 9, 18, and 19; 2-methoxy-2-oxoethylidene groups at positions 14 and 24; an (E,E)-octa-2,4-dienoyloxy group at position 21; and with oxygen bridges linking positions 6 to 10, 12 to 16, and 20 to 24. It is one of the most abundant member of the class of bryostatins.		3.1810
kahalalide f
kahalalide F: a cyclodepsipeptide toxin; isolated from a mollusk, Elysia rubefescens; exhibits antitumoral activity against cell lines of colon cancer and prostatic cancer; structure given in first source		3.1810
ritterazine b
ritterazine B: ritterazine analog extracted from Ritterella tokioka, has been shown to be chemically similar to cephalostatin 1; structure in first source		4.9240
ConditionIndicatedRelationship StrengthStudiesTrials
Breast Cancer
[description not available]		02.4520
Carcinoma, Anaplastic
[description not available]		02.0510
Cancer of Lung
[description not available]		02.0510
Colorectal Cancer
[description not available]		02.0510
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.4520
Carcinoma
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.		02.0510
Lung Neoplasms
Tumors or cancer of the LUNG.		02.0510
Colorectal Neoplasms
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.		02.0510
Benign Neoplasms
[description not available]		03.3920
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		03.3920
Leukemia, Lymphocytic, T Cell
[description not available]		02.0110
Leukemia, T-Cell
A malignant disease of the T-LYMPHOCYTES in the bone marrow, thymus, and/or blood.		02.0110
Cancer of Liver
[description not available]		02.0410
Cancer of Stomach
[description not available]		02.0410
Liver Neoplasms
Tumors or cancer of the LIVER.		02.0410
Stomach Neoplasms
Tumors or cancer of the STOMACH.		02.0410