osw 1 and beta-escin
osw 1 has been researched along with beta-escin in 56 studies
Compound Research Comparison
| Studies (osw 1) | Trials (osw 1) | Recent Studies (post-2010) (osw 1) | Studies (beta-escin) | Trials (beta-escin) | Recent Studies (post-2010) (beta-escin) |
|---|---|---|---|---|---|
| 57 | 0 | 31 | 14,137 | 211 | 6,278 |
Research
Studies (56)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (5.36) | 18.2507 |
| 2000's | 20 (35.71) | 29.6817 |
| 2010's | 26 (46.43) | 24.3611 |
| 2020's | 7 (12.50) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Honda, H; Kogo, H; Mimaki, Y; Sashida, Y | 1 |
| Honda, H; Kogo, H; Mimaki, Y; Sashida, Y; Tamura, K | 1 |
| Fuchs, PL; Guo, C; LaCour, TG | 1 |
| Ding, J; Hui, Y; Ma, X; Xiao, D; Yu, B | 1 |
| Jin, Z; Yu, W | 2 |
| Ding, J; Hui, Y; Ma, X; Miao, Z; Yu, B | 2 |
| Morzycki, JW; Wojtkielewicz, A | 1 |
| Deng, L; Jiang, M; Wu, H; Wu, J; Yu, B | 1 |
| Morzycki, JW; Wojtkielewicz, A; Wołczyński, S | 1 |
| Shi, B; Wu, H; Wu, J; Yu, B | 1 |
| Wu, J; Xiong, L; Yu, B; Zhu, J | 1 |
| Hu, X; Liu, JO; Shi, B; Tang, P; Yu, B | 1 |
| Carney, DA; Estrov, Z; Garcia-Prieto, C; Harris, DM; Huang, P; Jin, Z; Kang, Y; Keating, MJ; Kondo, S; Liu, J; Lou, C; Pelicano, H; Xu, RH; Yu, W; Zhou, Y | 1 |
| Hu, X; Liu, JO; Mamdani, F; Tang, P; Yu, B | 1 |
| Honda, T; Kasai, HF; Matsuo, S; Tsubuki, M | 1 |
| Długosz, M; Maj, J; Morzycki, JW; Nowakowski, M; Renkiewicz, J; Strnad, M; Swaczynová, J; Wilczewska, AZ; Wójcik, J; Wojtkielewicz, A | 1 |
| Adam, S; Eustache, J; Kamoshita, K; Maruyama, S; Masuda, S; Matsuya, Y; Nemoto, H; Ohsawa, N; Tschamber, T | 1 |
| Hu, X; Liu, JO; Peng, W; Tang, P; Yu, B | 1 |
| Guo, Z; Liu, P; Pan, Y; Xue, J | 1 |
| Ahmed, KB; Huang, P; Jin, Z; Kang, Y; Lou, C | 1 |
| Honda, T; Kasai, H; Nambara, T; Shimada, K; Tsubuki, M | 1 |
| Morzycki, JW; Pérez-Díaz, JO; Santillan, R; Wojtkielewicz, A | 1 |
| Chen, X; Guan, Y; Lei, P; Zheng, D; Zhou, L; Zhou, W | 1 |
| Asaka, H; Fukumoto, T; Moriyama, N; Noguchi, K; Sakurai, K; Sato, N; Yohda, M | 1 |
| Maj, J; Morzycki, JW; Oklest'ková, J; Rárová, L; Strnad, M; Wojtkielewicz, A | 1 |
| Chang, H; Guan, Y; Lei, P; She, P; Wang, H; Wang, N; Yan, Z; Zheng, D; Zhou, L | 1 |
| Chen, X; Guan, Y; Lei, P; Xu, Y; Zheng, D | 1 |
| Anderson, DR; Burgett, AW; Cornella-Taracido, I; Fortner, KC; Kikuchi, C; Kuroda, M; Mimaki, Y; Murphy, JP; Okubo, S; Petrella, EC; Poulsen, TB; Schirle, M; Schwalb, DJ; Shair, MD; Shimada, K; Tallarico, JA; Wangkanont, K | 1 |
| Chen, Z; Garcia-Prieto, C; Hammoudi, N; Huang, P; Jin, Z; Kang, Y; Lou, C; Mei, Y; Riaz Ahmed, KB; Zhou, Y | 1 |
| Jiang, H; Jin, J; Jin, X; Qian, C; Ruan, Y | 1 |
| Duan, JA; Li, N; Tang, Y; Tao, W | 1 |
| Jin, JC; Jin, XL; Liu, SP; Piao, YS; Zhang, X | 1 |
| Guan, YY; Lei, PS; Song, C | 1 |
| Kong, JQ; Lu, D; Wang, ZB | 1 |
| Hiraizumi, M; Ohta, Y; Sakurai, K; Shinohe, D; Takeshita, T; Yamada, R | 1 |
| Burgett, AW; Kothapalli, NR; Liu, R; Pan, N; Rao, W; Yang, Z | 1 |
| Hiraizumi, M; Sakurai, K; Takeshita, T; Yamada, R | 1 |
| Albulescu, L; Neyts, J; Shair, MD; Strating, JR; Thibaut, HJ; van der Linden, L; van Kuppeveld, FJ | 1 |
| Hiraizumi, M; Isogai, N; Komatsu, R; Ohta, Y; Sakurai, K; Shibata, T | 1 |
| Albulescu, L; Bigay, J; Biswas, B; Delang, L; Dorobantu, CM; Jung, YS; Neyts, J; Olkkonen, VM; Strating, JRPM; van der Schaar, HM; van Kuppeveld, FJM; Weber-Boyvat, M | 1 |
| Hiraizumi, M; Komatsu, R; Ohta, Y; Sakurai, K; Shibata, T | 1 |
| Fan, K; Fang, F; Guo, H; Ma, J; Yu, P; Zhang, J; Zhang, Y | 1 |
| Hanashima, S; Malabed, R; Murata, M; Sakurai, K | 2 |
| Antonny, B; Bigay, J; Jamecna, D; Lacas-Gervais, S; Mesmin, B; Polidori, J | 1 |
| Iguchi, T; Kuroda, M; Matsuo, Y; Mimaki, Y; Naito, R; Watanabe, T; Yokosuka, A | 1 |
| Fukutani, Y; Kimura, M; Ohsawa, I; Sakurai, K; Sasaki, K; Yohda, M; Yoshida, H | 1 |
| Komatsu, R; Sakurai, K | 1 |
| Fukaya, K; Hiraizumi, M; Matsumoto, T; Noguchi, K; Sakurai, K; Urabe, D | 1 |
| Ding, X; Li, J; Li, Y; Yin, Y | 1 |
| Adams, DJ; Allimuthu, D; Hubler, Z; Sax, JL | 1 |
| Elgehama, A | 1 |
| Alessandro, R; Arena, GO; Bella, MAD; Cascioferro, SM; Cirrincione, G; Corbeil, D; Diana, P; Fontana, S; Huang, K; Huynh, T; Karbanová, J; Lorico, A; Moschetti, M; Parrino, B; Pope, MR; Rappa, G; Santos, MF; Vistoli, G; Woo, G | 1 |
| Hirata, Y; Nakamura, H; Ogawa, H; Oh-Hashi, K; Sakurai, K | 1 |
Reviews
2 review(s) available for osw 1 and beta-escin
| Article | Year |
|---|---|
Structure, bioactivity, and chemical synthesis of OSW-1 and other steroidal glycosides in the genus Ornithogalum.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cholestenones; Drug Screening Assays, Antitumor; Glycosides; Humans; Neoplasms; Ornithogalum; Saponins; Steroids; Structure-Activity Relationship | 2013 |
Development of Chemical Probes for Functional Analysis of Anticancer Saponin OSW-1.
Topics: Affinity Labels; Antineoplastic Agents; Biotinylation; Cell Line, Tumor; Cell Proliferation; Cholestenones; Fluorescent Dyes; Humans; Proteins; Saponins | 2019 |
Other Studies
54 other study(ies) available for osw 1 and beta-escin
| Article | Year |
|---|---|
Influence of OSW-1 [3 beta,16 beta,17 alpha-trihydroxycholest-5-en-22-one 16-O-(2-O-4-methoxybenzoyl-beta-D-xylopyranosyl)-(1--> 3)-(2-O-acetyl-alpha-L-arabinopyranoside)], a steroidal saponin, on endothelium dependent relaxation caused by acetylcholine i
Topics: Acetylcholine; Animals; Antineoplastic Agents, Phytogenic; Aorta, Thoracic; Cholestenones; Endothelium, Vascular; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Rats; Rats, Wistar; Saponins; Vasoconstrictor Agents | 1997 |
Inhibitory effect of a new steroidal saponin, OSW-1, on ovarian functions in rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Aorta, Thoracic; Cholestenones; Estrus; Female; Follicle Stimulating Hormone; Gonadal Steroid Hormones; Luteinizing Hormone; Ovary; Rats; Rats, Wistar; Saponins; Vasodilation | 1997 |
On the relationship of OSW-1 to the cephalostatins.
Topics: Antineoplastic Agents, Phytogenic; Cholestenones; Saponins; Structure-Activity Relationship | 1999 |
Synthesis of glycosides bearing the disaccharide of OSW-1 or its 1-->4-linked analogue and their antitumor activities.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cholestenones; Disaccharides; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Mice; Saponins; Structure-Activity Relationship; Tumor Cells, Cultured | 2000 |
A new strategy for the stereoselective introduction of steroid side chain via alpha-alkoxy vinyl cuprates: total synthesis of a highly potent antitumor natural product OSW-1.
Topics: Antineoplastic Agents, Phytogenic; Cholestenones; Copper; Organometallic Compounds; Saponins; Stereoisomerism; Steroids; Vinyl Compounds | 2001 |
Synthesis of steroidal glycosides bearing the disaccharide moiety of OSW-1 and their antitumor activities.
Topics: Antineoplastic Agents; Cholestenones; Disaccharides; Glucosides; Glycosylation; Saponins; Steroids | 2001 |
Synthesis of OSW-1 analogues and a dimer and their antitumor activities.
Topics: Animals; Antineoplastic Agents; Cell Division; Cholestenones; Dimerization; Drug Screening Assays, Antitumor; Humans; Leukemia P388; Mice; Saponins; Tumor Cells, Cultured | 2001 |
Total synthesis of the anticancer natural product OSW-1.
Topics: Antineoplastic Agents, Phytogenic; Cholestenones; Dehydroepiandrosterone; Liliaceae; Saponins; Stereoisomerism | 2002 |
Synthesis of a cholestane glycoside OSW-1 with potent cytostatic activity.
Topics: Antineoplastic Agents; Cholestenones; Indicators and Reagents; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Saponins | 2002 |
Synthesis of OSW-1 analogs with modified side chains and their antitumor activities.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cholestenones; Drug Design; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Saponins; Structure-Activity Relationship | 2004 |
Synthesis of analogues of a potent antitumor saponin OSW-1.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cholestenones; Humans; Ornithogalum; Saponins | 2004 |
23-oxa-analogues of OSW-1: efficient synthesis and extremely potent antitumor activity.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; Cholestenones; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Ornithogalum; Saponins; Structure-Activity Relationship | 2004 |
Apoptosis induced by a new member of saponin family is mediated through caspase-8-dependent cleavage of Bcl-2.
Topics: Animals; Apoptosis; Caspase 8; Caspases; CHO Cells; Cholestenones; Cricetinae; Dose-Response Relationship, Drug; Kinetics; Mitochondrial Proteins; Protein Binding; Proto-Oncogene Proteins c-bcl-2; Saponins; Two-Hybrid System Techniques | 2005 |
OSW saponins: facile synthesis toward a new type of structures with potent antitumor activities.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cholestenones; Dehydroepiandrosterone; Humans; Saponins; Stereoisomerism | 2005 |
OSW-1: a natural compound with potent anticancer activity and a novel mechanism of action.
Topics: Antineoplastic Agents; Apoptosis; Calcium Channels; Cell Line, Tumor; Cholestenones; Drug Resistance, Neoplasm; Humans; Inhibitory Concentration 50; Leukemia, Lymphocytic, Chronic, B-Cell; Microscopy, Electron; Mitochondrial Membranes; Saponins; Vidarabine | 2005 |
Synthesis of OSW saponin analogs with modified sugar residues and their antiproliferative activities.
Topics: Antineoplastic Agents, Phytogenic; Carbohydrates; Cell Line, Tumor; Cell Proliferation; Cholestenones; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Indicators and Reagents; Jurkat Cells; Ornithogalum; Saponins; Thymidine | 2007 |
Analysis of antitumor active OSW-1 and its analogues by liquid chromatography coupled with electrospray and atmospheric pressure chemical ionization quadrupole mass spectrometry.
Topics: Antineoplastic Agents; Atmospheric Pressure; Cholestenones; Chromatography, High Pressure Liquid; Saponins; Spectrometry, Mass, Electrospray Ionization | 2007 |
New analogues of the potent cytotoxic saponin OSW-1.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cholestenones; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Saponins; Stereoisomerism; Structure-Activity Relationship | 2007 |
OSW-1 analogues: modification of the carbohydrate moiety.
Topics: Carbohydrates; Cell Line, Tumor; Cholestenones; Humans; Saponins | 2007 |
Synthesis of the A,B-ring-truncated OSW saponin analogs and their antitumor activities.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cholestenones; Humans; Inhibitory Concentration 50; Molecular Structure; Saponins; Structure-Activity Relationship | 2007 |
A total synthesis of OSW-1.
Topics: Antineoplastic Agents, Phytogenic; Cholestenones; Molecular Conformation; Ornithogalum; Saponins; Stereoisomerism | 2008 |
Synthesis of biotinylated OSW-1.
Topics: Antineoplastic Agents, Phytogenic; Biotin; Biotinylation; Cell Line, Tumor; Cholestenones; Humans; Saponins | 2009 |
Analyses of biologically active steroids: antitumor active OSW-1 and cardiotonic marinobufotoxin, by matrix-assisted laser desorption/ionization quadrupole ion trap time-of-flight tandem mass spectrometry.
Topics: Amphibian Venoms; Animals; Antineoplastic Agents; Anura; Cardanolides; Cholestenones; Saponins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2009 |
Unusual oxidative transformations of a steroidal 16alpha,17alpha,22-triol.
Topics: Cholestenones; Circular Dichroism; Crystallography, X-Ray; Models, Chemical; Molecular Structure; Oxidation-Reduction; Saponins; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Steroids | 2010 |
Synthesis of cholestane glycosides bearing OSW-1 disaccharide or its 1-->4-linked analogue and their antitumor activities.
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Cholestanes; Cholestenones; Cytotoxins; Drug Screening Assays, Antitumor; Glycosides; Humans; Models, Molecular; Neoplasms; Ornithogalum; Saponins; Structure-Activity Relationship | 2010 |
Three-dimensional structures of OSW-1 and its congener.
Topics: Cholestenones; Crystallography, X-Ray; Hydrophobic and Hydrophilic Interactions; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Saponins | 2010 |
Synthesis and biological activity of 22-deoxo-23-oxa analogues of saponin OSW-1.
Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 7; Cell Cycle; Cell Line, Tumor; Cholestenones; Drug Screening Assays, Antitumor; Enzyme Activation; Fibroblasts; Humans; Saponins; Stereoisomerism; Structure-Activity Relationship | 2011 |
Synthesis of 5(6)-dihydro-OSW-1 analogs bearing three kinds of disaccharides linking at 15-hydroxy and their antitumor activities.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cholestenones; Disaccharides; Humans; Inhibitory Concentration 50; Molecular Structure; Saponins; Structure-Activity Relationship | 2011 |
Synthesis of cholestane saponins as mimics of OSW-1 and their cytotoxic activities.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Cholestanes; Cholestenones; Humans; Inhibitory Concentration 50; Molecular Structure; Saponins; Structure-Activity Relationship | 2011 |
Natural products reveal cancer cell dependence on oxysterol-binding proteins.
Topics: Biological Products; Carrier Proteins; Cell Line, Tumor; Cell Proliferation; Cholestenones; Humans; Hydroxycholesterols; Lipid Metabolism; Neoplasms; Phenazines; Receptors, Steroid; Saponins; Signal Transduction; Sphingomyelins; Spiro Compounds; Steroids; Stilbenes | 2011 |
Effective killing of leukemia cells by the natural product OSW-1 through disruption of cellular calcium homeostasis.
Topics: Biological Products; Calcium; Calcium Channels; Calpain; Caspase 3; Cell Death; Cell Line, Tumor; Cholestenones; Cyclosporine; Cytochromes c; Cytosol; Drug Screening Assays, Antitumor; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Enzyme Activation; Extracellular Space; Heat-Shock Proteins; Homeostasis; Humans; Leukemia; Lymphoma; Membrane Potential, Mitochondrial; Mitochondria; Saponins; Sodium-Calcium Exchanger; Thapsigargin; Time Factors | 2013 |
Signaling network of OSW‑1‑induced apoptosis and necroptosis in hepatocellular carcinoma.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cholestenones; Down-Regulation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Necrosis; Oligonucleotide Array Sequence Analysis; Reproducibility of Results; Saponins; Signal Transduction; Statistics as Topic; Up-Regulation | 2013 |
Effect of OSW-1 on microRNA expression profiles of hepatoma cells and functions of novel microRNAs.
Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Cell Line, Tumor; Cholestenones; Down-Regulation; Doxorubicin; Humans; Liver Neoplasms; MicroRNAs; Ornithogalum; Plant Roots; Saponins; Transcriptome; Up-Regulation | 2013 |
Synthesis of three OSW-1 analogs with maltose side chains bearing different protection groups.
Topics: Cholestenones; Drug Design; Drug Screening Assays, Antitumor; HeLa Cells; Humans; KB Cells; Molecular Structure; Saponins; Structure-Activity Relationship | 2014 |
Molecular cloning and yeast expression of cinnamate 4-hydroxylase from Ornithogalum saundersiae baker.
Topics: Cholestenones; Cinnamates; Cloning, Molecular; DNA, Complementary; Gene Expression Regulation, Plant; Hydroxylation; Ornithogalum; Plant Roots; Saccharomyces cerevisiae; Saponins; Trans-Cinnamate 4-Monooxygenase | 2014 |
Fluorescent analog of OSW-1 and its cellular localization.
Topics: Cholestenones; Fluorescence; Fluorescent Dyes; HeLa Cells; Humans; Microscopy, Fluorescence; Molecular Conformation; Saponins; Temperature; Tissue Distribution | 2014 |
The single-probe: a miniaturized multifunctional device for single cell mass spectrometry analysis.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Antineoplastic Agents; Cholestenones; Doxorubicin; HeLa Cells; Humans; Mass Spectrometry; Metabolome; Paclitaxel; Phosphatidylcholines; Saponins; Single-Cell Analysis | 2014 |
Synthesis of OSW-1 derivatives by site-selective acylation and their biological evaluation.
Topics: Acylation; Biotin; Cell Line, Tumor; Cholestenones; Humans; Molecular Structure; Saponins; Stereoisomerism; Structure-Activity Relationship | 2014 |
Broad-range inhibition of enterovirus replication by OSW-1, a natural compound targeting OSBP.
Topics: Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Cholestenones; Enterovirus; Genome, Viral; HeLa Cells; Humans; Ligands; Receptors, Steroid; Saponins; Vero Cells; Viral Load; Virus Replication | 2015 |
Synthesis of a fluorescent photoaffinity probe of OSW-1 by site-selective acylation of an inactive congener and biological evaluation.
Topics: Acylation; Antineoplastic Agents; Cell Proliferation; Cholestenones; Fluorescent Dyes; HeLa Cells; Humans; Neoplasms; Photoaffinity Labels; Saponins | 2017 |
Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307.
Topics: Antiviral Agents; Benzamides; Cholestenones; Cytochrome P-450 CYP3A Inhibitors; Enterovirus; Genome, Viral; HeLa Cells; Humans; Imidazoles; Itraconazole; Phosphotransferases (Alcohol Group Acceptor); Poliovirus; Receptors, Steroid; Rhinovirus; Saponins; Virus Replication | 2017 |
Dissecting the structural basis for the intracellular delivery of OSW-1 by fluorescent probes.
Topics: Biological Transport; Cholestenones; Fluorescent Dyes; HeLa Cells; Humans; Intracellular Space; Saponins | 2017 |
Effective cytotoxic activity of OSW-1 on colon cancer by inducing apoptosis in vitro and in vivo.
Topics: Animals; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cholestenones; Colonic Neoplasms; Cytochromes c; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Medicine, Chinese Traditional; Membrane Potential, Mitochondrial; Mice; Saponins; Xenograft Model Antitumor Assays | 2017 |
Sterol-recognition ability and membrane-disrupting activity of Ornithogalum saponin OSW-1 and usual 3-O-glycosyl saponins.
Topics: Antineoplastic Agents, Phytogenic; beta-Cyclodextrins; Biological Transport; Cholestenones; Cholesterol; Digitonin; Dimyristoylphosphatidylcholine; Erythrocyte Membrane; Fluoresceins; Glycyrrhizic Acid; Hemolysis; Humans; Membrane Lipids; Oleanolic Acid; Ornithogalum; Phosphatidylcholines; Saponins; Unilamellar Liposomes | 2017 |
Sterol transfer, PI4P consumption, and control of membrane lipid order by endogenous OSBP.
Topics: Biological Transport; Cholestenones; Cholesterol; Dicarbethoxydihydrocollidine; Endoplasmic Reticulum; Epithelial Cells; Fluorescent Dyes; Gene Expression; HeLa Cells; Humans; Lipid Droplets; Minor Histocompatibility Antigens; Phosphatidylinositol Phosphates; Phosphotransferases (Alcohol Group Acceptor); Receptors, Steroid; Retinal Pigment Epithelium; Saponins; Time-Lapse Imaging; trans-Golgi Network | 2017 |
Cholestane glycosides from Ornithogalum saundersiae bulbs and the induction of apoptosis in HL-60 cells by OSW-1 through a mitochondrial-independent signaling pathway.
Topics: Apoptosis; Cholestanes; Cholestenones; Glycosides; HL-60 Cells; Humans; Mitochondria; Ornithogalum; Saponins; Signal Transduction | 2019 |
Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer.
Topics: Antineoplastic Agents; Cholestenones; Golgi Apparatus; Humans; Saponins | 2019 |
Computational and Experimental Analysis on the Conformational Preferences of Anticancer Saponin OSW-1.
Topics: Antineoplastic Agents, Phytogenic; Carbon-13 Magnetic Resonance Spectroscopy; Cholestenones; Computational Chemistry; Crystallography, X-Ray; Molecular Conformation; Proton Magnetic Resonance Spectroscopy; Saponins | 2020 |
Interactions of OSW-1 with Lipid Bilayers in Comparison with Digitonin and Soyasaponin.
Topics: Cholestenones; Digitonin; Lipid Bilayers; Saponins | 2020 |
OSW-1 inhibits tumor growth and metastasis by NFATc2 on triple-negative breast cancer.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cholestenones; Disease Models, Animal; Female; Humans; Mice; Mice, SCID; Neoplasm Metastasis; NFATC Transcription Factors; Ornithogalum; Saponins; Triple Negative Breast Neoplasms | 2020 |
Screening Reveals Sterol Derivatives with Pro-Differentiation, Pro-Survival, or Potent Cytotoxic Effects on Oligodendrocyte Progenitor Cells.
Topics: Animals; Cell Differentiation; Cell Survival; Cholestenones; Drug Evaluation, Preclinical; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Estrenes; Golgi Apparatus; HeLa Cells; Humans; Mice; Oligodendrocyte Precursor Cells; Oligodendroglia; Pyrrolidinones; Saponins; Small Molecule Libraries; Sterols | 2021 |
Selective obstruction of the mTORC2 complex by a naturally occurring cholestane saponin (OSW-1) for inhibiting prostate cancer cell growth.
Topics: Cholestanes; Cholestenones; Humans; Male; Mechanistic Target of Rapamycin Complex 2; Molecular Structure; Ornithogalum; Prostatic Neoplasms; Saponins; TOR Serine-Threonine Kinases | 2022 |
Itraconazole inhibits nuclear delivery of extracellular vesicle cargo by disrupting the entry of late endosomes into the nucleoplasmic reticulum.
Topics: Active Transport, Cell Nucleus; Antifungal Agents; Cell Line; Cell Movement; Cholestenones; Endocytosis; Endosomes; Extracellular Vesicles; Fatty Acid-Binding Proteins; Humans; Itraconazole; Ketoconazole; Models, Molecular; Nuclear Envelope; rab7 GTP-Binding Proteins; Saponins; Vesicular Transport Proteins | 2021 |
Elucidation of OSW-1-Induced Stress Responses in Neuro2a Cells.
Topics: Animals; Antineoplastic Agents; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Brefeldin A; Cell Line; Cholestenones; Golgi Apparatus; Mice; Saponins | 2023 |