Page last updated: 2024-09-03

osw 1 and beta-escin

osw 1 has been researched along with beta-escin in 56 studies

Compound Research Comparison

Studies (osw 1)	Trials (osw 1)	Recent Studies (post-2010) (osw 1)	Studies (beta-escin)	Trials (beta-escin)	Recent Studies (post-2010) (beta-escin)
57	0	31	14,137	211	6,278

Research

Studies (56)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (5.36)	18.2507
2000's	20 (35.71)	29.6817
2010's	26 (46.43)	24.3611
2020's	7 (12.50)	2.80

Authors

Authors	Studies
Honda, H; Kogo, H; Mimaki, Y; Sashida, Y	1
Honda, H; Kogo, H; Mimaki, Y; Sashida, Y; Tamura, K	1
Fuchs, PL; Guo, C; LaCour, TG	1
Ding, J; Hui, Y; Ma, X; Xiao, D; Yu, B	1
Jin, Z; Yu, W	2
Ding, J; Hui, Y; Ma, X; Miao, Z; Yu, B	2
Morzycki, JW; Wojtkielewicz, A	1
Deng, L; Jiang, M; Wu, H; Wu, J; Yu, B	1
Morzycki, JW; Wojtkielewicz, A; Wołczyński, S	1
Shi, B; Wu, H; Wu, J; Yu, B	1
Wu, J; Xiong, L; Yu, B; Zhu, J	1
Hu, X; Liu, JO; Shi, B; Tang, P; Yu, B	1
Carney, DA; Estrov, Z; Garcia-Prieto, C; Harris, DM; Huang, P; Jin, Z; Kang, Y; Keating, MJ; Kondo, S; Liu, J; Lou, C; Pelicano, H; Xu, RH; Yu, W; Zhou, Y	1
Hu, X; Liu, JO; Mamdani, F; Tang, P; Yu, B	1
Honda, T; Kasai, HF; Matsuo, S; Tsubuki, M	1
Długosz, M; Maj, J; Morzycki, JW; Nowakowski, M; Renkiewicz, J; Strnad, M; Swaczynová, J; Wilczewska, AZ; Wójcik, J; Wojtkielewicz, A	1
Adam, S; Eustache, J; Kamoshita, K; Maruyama, S; Masuda, S; Matsuya, Y; Nemoto, H; Ohsawa, N; Tschamber, T	1
Hu, X; Liu, JO; Peng, W; Tang, P; Yu, B	1
Guo, Z; Liu, P; Pan, Y; Xue, J	1
Ahmed, KB; Huang, P; Jin, Z; Kang, Y; Lou, C	1
Honda, T; Kasai, H; Nambara, T; Shimada, K; Tsubuki, M	1
Morzycki, JW; Pérez-Díaz, JO; Santillan, R; Wojtkielewicz, A	1
Chen, X; Guan, Y; Lei, P; Zheng, D; Zhou, L; Zhou, W	1
Asaka, H; Fukumoto, T; Moriyama, N; Noguchi, K; Sakurai, K; Sato, N; Yohda, M	1
Maj, J; Morzycki, JW; Oklest'ková, J; Rárová, L; Strnad, M; Wojtkielewicz, A	1
Chang, H; Guan, Y; Lei, P; She, P; Wang, H; Wang, N; Yan, Z; Zheng, D; Zhou, L	1
Chen, X; Guan, Y; Lei, P; Xu, Y; Zheng, D	1
Anderson, DR; Burgett, AW; Cornella-Taracido, I; Fortner, KC; Kikuchi, C; Kuroda, M; Mimaki, Y; Murphy, JP; Okubo, S; Petrella, EC; Poulsen, TB; Schirle, M; Schwalb, DJ; Shair, MD; Shimada, K; Tallarico, JA; Wangkanont, K	1
Chen, Z; Garcia-Prieto, C; Hammoudi, N; Huang, P; Jin, Z; Kang, Y; Lou, C; Mei, Y; Riaz Ahmed, KB; Zhou, Y	1
Jiang, H; Jin, J; Jin, X; Qian, C; Ruan, Y	1
Duan, JA; Li, N; Tang, Y; Tao, W	1
Jin, JC; Jin, XL; Liu, SP; Piao, YS; Zhang, X	1
Guan, YY; Lei, PS; Song, C	1
Kong, JQ; Lu, D; Wang, ZB	1
Hiraizumi, M; Ohta, Y; Sakurai, K; Shinohe, D; Takeshita, T; Yamada, R	1
Burgett, AW; Kothapalli, NR; Liu, R; Pan, N; Rao, W; Yang, Z	1
Hiraizumi, M; Sakurai, K; Takeshita, T; Yamada, R	1
Albulescu, L; Neyts, J; Shair, MD; Strating, JR; Thibaut, HJ; van der Linden, L; van Kuppeveld, FJ	1
Hiraizumi, M; Isogai, N; Komatsu, R; Ohta, Y; Sakurai, K; Shibata, T	1
Albulescu, L; Bigay, J; Biswas, B; Delang, L; Dorobantu, CM; Jung, YS; Neyts, J; Olkkonen, VM; Strating, JRPM; van der Schaar, HM; van Kuppeveld, FJM; Weber-Boyvat, M	1
Hiraizumi, M; Komatsu, R; Ohta, Y; Sakurai, K; Shibata, T	1
Fan, K; Fang, F; Guo, H; Ma, J; Yu, P; Zhang, J; Zhang, Y	1
Hanashima, S; Malabed, R; Murata, M; Sakurai, K	2
Antonny, B; Bigay, J; Jamecna, D; Lacas-Gervais, S; Mesmin, B; Polidori, J	1
Iguchi, T; Kuroda, M; Matsuo, Y; Mimaki, Y; Naito, R; Watanabe, T; Yokosuka, A	1
Fukutani, Y; Kimura, M; Ohsawa, I; Sakurai, K; Sasaki, K; Yohda, M; Yoshida, H	1
Komatsu, R; Sakurai, K	1
Fukaya, K; Hiraizumi, M; Matsumoto, T; Noguchi, K; Sakurai, K; Urabe, D	1
Ding, X; Li, J; Li, Y; Yin, Y	1
Adams, DJ; Allimuthu, D; Hubler, Z; Sax, JL	1
Elgehama, A	1
Alessandro, R; Arena, GO; Bella, MAD; Cascioferro, SM; Cirrincione, G; Corbeil, D; Diana, P; Fontana, S; Huang, K; Huynh, T; Karbanová, J; Lorico, A; Moschetti, M; Parrino, B; Pope, MR; Rappa, G; Santos, MF; Vistoli, G; Woo, G	1
Hirata, Y; Nakamura, H; Ogawa, H; Oh-Hashi, K; Sakurai, K	1

Reviews

2 review(s) available for osw 1 and beta-escin

Article	Year
Structure, bioactivity, and chemical synthesis of OSW-1 and other steroidal glycosides in the genus Ornithogalum. Chemical reviews, 2013, Jul-10, Volume: 113, Issue:7 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cholestenones; Drug Screening Assays, Antitumor; Glycosides; Humans; Neoplasms; Ornithogalum; Saponins; Steroids; Structure-Activity Relationship	2013
Development of Chemical Probes for Functional Analysis of Anticancer Saponin OSW-1. Chemical record (New York, N.Y.), 2019, Volume: 19, Issue:12 Topics: Affinity Labels; Antineoplastic Agents; Biotinylation; Cell Line, Tumor; Cell Proliferation; Cholestenones; Fluorescent Dyes; Humans; Proteins; Saponins	2019

Other Studies

54 other study(ies) available for osw 1 and beta-escin

Article	Year
Influence of OSW-1 [3 beta,16 beta,17 alpha-trihydroxycholest-5-en-22-one 16-O-(2-O-4-methoxybenzoyl-beta-D-xylopyranosyl)-(1--> 3)-(2-O-acetyl-alpha-L-arabinopyranoside)], a steroidal saponin, on endothelium dependent relaxation caused by acetylcholine i Biological & pharmaceutical bulletin, 1997, Volume: 20, Issue:4 Topics: Acetylcholine; Animals; Antineoplastic Agents, Phytogenic; Aorta, Thoracic; Cholestenones; Endothelium, Vascular; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Rats; Rats, Wistar; Saponins; Vasoconstrictor Agents	1997
Inhibitory effect of a new steroidal saponin, OSW-1, on ovarian functions in rats. British journal of pharmacology, 1997, Volume: 121, Issue:8 Topics: Animals; Antineoplastic Agents, Phytogenic; Aorta, Thoracic; Cholestenones; Estrus; Female; Follicle Stimulating Hormone; Gonadal Steroid Hormones; Luteinizing Hormone; Ovary; Rats; Rats, Wistar; Saponins; Vasodilation	1997
On the relationship of OSW-1 to the cephalostatins. Bioorganic & medicinal chemistry letters, 1999, Feb-08, Volume: 9, Issue:3 Topics: Antineoplastic Agents, Phytogenic; Cholestenones; Saponins; Structure-Activity Relationship	1999
Synthesis of glycosides bearing the disaccharide of OSW-1 or its 1-->4-linked analogue and their antitumor activities. Carbohydrate research, 2000, Nov-17, Volume: 329, Issue:3 Topics: Animals; Antineoplastic Agents, Phytogenic; Cholestenones; Disaccharides; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Mice; Saponins; Structure-Activity Relationship; Tumor Cells, Cultured	2000
A new strategy for the stereoselective introduction of steroid side chain via alpha-alkoxy vinyl cuprates: total synthesis of a highly potent antitumor natural product OSW-1. Journal of the American Chemical Society, 2001, Apr-11, Volume: 123, Issue:14 Topics: Antineoplastic Agents, Phytogenic; Cholestenones; Copper; Organometallic Compounds; Saponins; Stereoisomerism; Steroids; Vinyl Compounds	2001
Synthesis of steroidal glycosides bearing the disaccharide moiety of OSW-1 and their antitumor activities. Carbohydrate research, 2001, Aug-23, Volume: 334, Issue:2 Topics: Antineoplastic Agents; Cholestenones; Disaccharides; Glucosides; Glycosylation; Saponins; Steroids	2001
Synthesis of OSW-1 analogues and a dimer and their antitumor activities. Bioorganic & medicinal chemistry letters, 2001, Aug-20, Volume: 11, Issue:16 Topics: Animals; Antineoplastic Agents; Cell Division; Cholestenones; Dimerization; Drug Screening Assays, Antitumor; Humans; Leukemia P388; Mice; Saponins; Tumor Cells, Cultured	2001
Total synthesis of the anticancer natural product OSW-1. Journal of the American Chemical Society, 2002, Jun-12, Volume: 124, Issue:23 Topics: Antineoplastic Agents, Phytogenic; Cholestenones; Dehydroepiandrosterone; Liliaceae; Saponins; Stereoisomerism	2002
Synthesis of a cholestane glycoside OSW-1 with potent cytostatic activity. Carbohydrate research, 2002, Aug-16, Volume: 337, Issue:14 Topics: Antineoplastic Agents; Cholestenones; Indicators and Reagents; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Saponins	2002
Synthesis of OSW-1 analogs with modified side chains and their antitumor activities. Bioorganic & medicinal chemistry letters, 2004, Jun-07, Volume: 14, Issue:11 Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cholestenones; Drug Design; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Saponins; Structure-Activity Relationship	2004
Synthesis of analogues of a potent antitumor saponin OSW-1. Bioorganic & medicinal chemistry letters, 2004, Jun-21, Volume: 14, Issue:12 Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cholestenones; Humans; Ornithogalum; Saponins	2004
23-oxa-analogues of OSW-1: efficient synthesis and extremely potent antitumor activity. Angewandte Chemie (International ed. in English), 2004, Aug-20, Volume: 43, Issue:33 Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; Cholestenones; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Ornithogalum; Saponins; Structure-Activity Relationship	2004
Apoptosis induced by a new member of saponin family is mediated through caspase-8-dependent cleavage of Bcl-2. Molecular pharmacology, 2005, Volume: 68, Issue:6 Topics: Animals; Apoptosis; Caspase 8; Caspases; CHO Cells; Cholestenones; Cricetinae; Dose-Response Relationship, Drug; Kinetics; Mitochondrial Proteins; Protein Binding; Proto-Oncogene Proteins c-bcl-2; Saponins; Two-Hybrid System Techniques	2005
OSW saponins: facile synthesis toward a new type of structures with potent antitumor activities. The Journal of organic chemistry, 2005, Dec-09, Volume: 70, Issue:25 Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cholestenones; Dehydroepiandrosterone; Humans; Saponins; Stereoisomerism	2005
OSW-1: a natural compound with potent anticancer activity and a novel mechanism of action. Journal of the National Cancer Institute, 2005, Dec-07, Volume: 97, Issue:23 Topics: Antineoplastic Agents; Apoptosis; Calcium Channels; Cell Line, Tumor; Cholestenones; Drug Resistance, Neoplasm; Humans; Inhibitory Concentration 50; Leukemia, Lymphocytic, Chronic, B-Cell; Microscopy, Electron; Mitochondrial Membranes; Saponins; Vidarabine	2005
Synthesis of OSW saponin analogs with modified sugar residues and their antiproliferative activities. Bioorganic & medicinal chemistry letters, 2007, Feb-15, Volume: 17, Issue:4 Topics: Antineoplastic Agents, Phytogenic; Carbohydrates; Cell Line, Tumor; Cell Proliferation; Cholestenones; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Indicators and Reagents; Jurkat Cells; Ornithogalum; Saponins; Thymidine	2007
Analysis of antitumor active OSW-1 and its analogues by liquid chromatography coupled with electrospray and atmospheric pressure chemical ionization quadrupole mass spectrometry. Rapid communications in mass spectrometry : RCM, 2007, Volume: 21, Issue:7 Topics: Antineoplastic Agents; Atmospheric Pressure; Cholestenones; Chromatography, High Pressure Liquid; Saponins; Spectrometry, Mass, Electrospray Ionization	2007
New analogues of the potent cytotoxic saponin OSW-1. Journal of medicinal chemistry, 2007, Jul-26, Volume: 50, Issue:15 Topics: Antineoplastic Agents; Cell Line, Tumor; Cholestenones; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Saponins; Stereoisomerism; Structure-Activity Relationship	2007
OSW-1 analogues: modification of the carbohydrate moiety. Bioorganic & medicinal chemistry letters, 2007, Sep-15, Volume: 17, Issue:18 Topics: Carbohydrates; Cell Line, Tumor; Cholestenones; Humans; Saponins	2007
Synthesis of the A,B-ring-truncated OSW saponin analogs and their antitumor activities. Bioorganic & medicinal chemistry letters, 2007, Oct-15, Volume: 17, Issue:20 Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cholestenones; Humans; Inhibitory Concentration 50; Molecular Structure; Saponins; Structure-Activity Relationship	2007
A total synthesis of OSW-1. The Journal of organic chemistry, 2008, Jan-04, Volume: 73, Issue:1 Topics: Antineoplastic Agents, Phytogenic; Cholestenones; Molecular Conformation; Ornithogalum; Saponins; Stereoisomerism	2008
Synthesis of biotinylated OSW-1. Bioorganic & medicinal chemistry letters, 2009, Sep-01, Volume: 19, Issue:17 Topics: Antineoplastic Agents, Phytogenic; Biotin; Biotinylation; Cell Line, Tumor; Cholestenones; Humans; Saponins	2009
Analyses of biologically active steroids: antitumor active OSW-1 and cardiotonic marinobufotoxin, by matrix-assisted laser desorption/ionization quadrupole ion trap time-of-flight tandem mass spectrometry. Chemical & pharmaceutical bulletin, 2009, Volume: 57, Issue:9 Topics: Amphibian Venoms; Animals; Antineoplastic Agents; Anura; Cardanolides; Cholestenones; Saponins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization	2009
Unusual oxidative transformations of a steroidal 16alpha,17alpha,22-triol. Steroids, 2010, Volume: 75, Issue:1 Topics: Cholestenones; Circular Dichroism; Crystallography, X-Ray; Models, Chemical; Molecular Structure; Oxidation-Reduction; Saponins; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Steroids	2010
Synthesis of cholestane glycosides bearing OSW-1 disaccharide or its 1-->4-linked analogue and their antitumor activities. Bioorganic & medicinal chemistry letters, 2010, Sep-15, Volume: 20, Issue:18 Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Cholestanes; Cholestenones; Cytotoxins; Drug Screening Assays, Antitumor; Glycosides; Humans; Models, Molecular; Neoplasms; Ornithogalum; Saponins; Structure-Activity Relationship	2010
Three-dimensional structures of OSW-1 and its congener. Organic letters, 2010, Dec-17, Volume: 12, Issue:24 Topics: Cholestenones; Crystallography, X-Ray; Hydrophobic and Hydrophilic Interactions; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Saponins	2010
Synthesis and biological activity of 22-deoxo-23-oxa analogues of saponin OSW-1. Journal of medicinal chemistry, 2011, May-12, Volume: 54, Issue:9 Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 7; Cell Cycle; Cell Line, Tumor; Cholestenones; Drug Screening Assays, Antitumor; Enzyme Activation; Fibroblasts; Humans; Saponins; Stereoisomerism; Structure-Activity Relationship	2011
Synthesis of 5(6)-dihydro-OSW-1 analogs bearing three kinds of disaccharides linking at 15-hydroxy and their antitumor activities. Bioorganic & medicinal chemistry letters, 2011, May-15, Volume: 21, Issue:10 Topics: Antineoplastic Agents; Cell Line, Tumor; Cholestenones; Disaccharides; Humans; Inhibitory Concentration 50; Molecular Structure; Saponins; Structure-Activity Relationship	2011
Synthesis of cholestane saponins as mimics of OSW-1 and their cytotoxic activities. Bioorganic & medicinal chemistry letters, 2011, Jun-01, Volume: 21, Issue:11 Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Cholestanes; Cholestenones; Humans; Inhibitory Concentration 50; Molecular Structure; Saponins; Structure-Activity Relationship	2011
Natural products reveal cancer cell dependence on oxysterol-binding proteins. Nature chemical biology, 2011, Aug-07, Volume: 7, Issue:9 Topics: Biological Products; Carrier Proteins; Cell Line, Tumor; Cell Proliferation; Cholestenones; Humans; Hydroxycholesterols; Lipid Metabolism; Neoplasms; Phenazines; Receptors, Steroid; Saponins; Signal Transduction; Sphingomyelins; Spiro Compounds; Steroids; Stilbenes	2011
Effective killing of leukemia cells by the natural product OSW-1 through disruption of cellular calcium homeostasis. The Journal of biological chemistry, 2013, Feb-01, Volume: 288, Issue:5 Topics: Biological Products; Calcium; Calcium Channels; Calpain; Caspase 3; Cell Death; Cell Line, Tumor; Cholestenones; Cyclosporine; Cytochromes c; Cytosol; Drug Screening Assays, Antitumor; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Enzyme Activation; Extracellular Space; Heat-Shock Proteins; Homeostasis; Humans; Leukemia; Lymphoma; Membrane Potential, Mitochondrial; Mitochondria; Saponins; Sodium-Calcium Exchanger; Thapsigargin; Time Factors	2013
Signaling network of OSW‑1‑induced apoptosis and necroptosis in hepatocellular carcinoma. Molecular medicine reports, 2013, Volume: 7, Issue:5 Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cholestenones; Down-Regulation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Necrosis; Oligonucleotide Array Sequence Analysis; Reproducibility of Results; Saponins; Signal Transduction; Statistics as Topic; Up-Regulation	2013
Effect of OSW-1 on microRNA expression profiles of hepatoma cells and functions of novel microRNAs. Molecular medicine reports, 2013, Volume: 7, Issue:6 Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Cell Line, Tumor; Cholestenones; Down-Regulation; Doxorubicin; Humans; Liver Neoplasms; MicroRNAs; Ornithogalum; Plant Roots; Saponins; Transcriptome; Up-Regulation	2013
Synthesis of three OSW-1 analogs with maltose side chains bearing different protection groups. Journal of Asian natural products research, 2014, Volume: 16, Issue:1 Topics: Cholestenones; Drug Design; Drug Screening Assays, Antitumor; HeLa Cells; Humans; KB Cells; Molecular Structure; Saponins; Structure-Activity Relationship	2014
Molecular cloning and yeast expression of cinnamate 4-hydroxylase from Ornithogalum saundersiae baker. Molecules (Basel, Switzerland), 2014, Jan-28, Volume: 19, Issue:2 Topics: Cholestenones; Cinnamates; Cloning, Molecular; DNA, Complementary; Gene Expression Regulation, Plant; Hydroxylation; Ornithogalum; Plant Roots; Saccharomyces cerevisiae; Saponins; Trans-Cinnamate 4-Monooxygenase	2014
Fluorescent analog of OSW-1 and its cellular localization. Bioorganic & medicinal chemistry letters, 2014, Apr-01, Volume: 24, Issue:7 Topics: Cholestenones; Fluorescence; Fluorescent Dyes; HeLa Cells; Humans; Microscopy, Fluorescence; Molecular Conformation; Saponins; Temperature; Tissue Distribution	2014
The single-probe: a miniaturized multifunctional device for single cell mass spectrometry analysis. Analytical chemistry, 2014, Oct-07, Volume: 86, Issue:19 Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Antineoplastic Agents; Cholestenones; Doxorubicin; HeLa Cells; Humans; Mass Spectrometry; Metabolome; Paclitaxel; Phosphatidylcholines; Saponins; Single-Cell Analysis	2014
Synthesis of OSW-1 derivatives by site-selective acylation and their biological evaluation. Organic letters, 2014, Dec-19, Volume: 16, Issue:24 Topics: Acylation; Biotin; Cell Line, Tumor; Cholestenones; Humans; Molecular Structure; Saponins; Stereoisomerism; Structure-Activity Relationship	2014
Broad-range inhibition of enterovirus replication by OSW-1, a natural compound targeting OSBP. Antiviral research, 2015, Volume: 117 Topics: Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Cholestenones; Enterovirus; Genome, Viral; HeLa Cells; Humans; Ligands; Receptors, Steroid; Saponins; Vero Cells; Viral Load; Virus Replication	2015
Synthesis of a fluorescent photoaffinity probe of OSW-1 by site-selective acylation of an inactive congener and biological evaluation. Chemical communications (Cambridge, England), 2017, 01-03, Volume: 53, Issue:3 Topics: Acylation; Antineoplastic Agents; Cell Proliferation; Cholestenones; Fluorescent Dyes; HeLa Cells; Humans; Neoplasms; Photoaffinity Labels; Saponins	2017
Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307. Antiviral research, 2017, Volume: 140 Topics: Antiviral Agents; Benzamides; Cholestenones; Cytochrome P-450 CYP3A Inhibitors; Enterovirus; Genome, Viral; HeLa Cells; Humans; Imidazoles; Itraconazole; Phosphotransferases (Alcohol Group Acceptor); Poliovirus; Receptors, Steroid; Rhinovirus; Saponins; Virus Replication	2017
Dissecting the structural basis for the intracellular delivery of OSW-1 by fluorescent probes. Organic & biomolecular chemistry, 2017, May-03, Volume: 15, Issue:17 Topics: Biological Transport; Cholestenones; Fluorescent Dyes; HeLa Cells; Humans; Intracellular Space; Saponins	2017
Effective cytotoxic activity of OSW-1 on colon cancer by inducing apoptosis in vitro and in vivo. Oncology reports, 2017, Volume: 37, Issue:6 Topics: Animals; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cholestenones; Colonic Neoplasms; Cytochromes c; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Medicine, Chinese Traditional; Membrane Potential, Mitochondrial; Mice; Saponins; Xenograft Model Antitumor Assays	2017
Sterol-recognition ability and membrane-disrupting activity of Ornithogalum saponin OSW-1 and usual 3-O-glycosyl saponins. Biochimica et biophysica acta. Biomembranes, 2017, Volume: 1859, Issue:12 Topics: Antineoplastic Agents, Phytogenic; beta-Cyclodextrins; Biological Transport; Cholestenones; Cholesterol; Digitonin; Dimyristoylphosphatidylcholine; Erythrocyte Membrane; Fluoresceins; Glycyrrhizic Acid; Hemolysis; Humans; Membrane Lipids; Oleanolic Acid; Ornithogalum; Phosphatidylcholines; Saponins; Unilamellar Liposomes	2017
Sterol transfer, PI4P consumption, and control of membrane lipid order by endogenous OSBP. The EMBO journal, 2017, 11-02, Volume: 36, Issue:21 Topics: Biological Transport; Cholestenones; Cholesterol; Dicarbethoxydihydrocollidine; Endoplasmic Reticulum; Epithelial Cells; Fluorescent Dyes; Gene Expression; HeLa Cells; Humans; Lipid Droplets; Minor Histocompatibility Antigens; Phosphatidylinositol Phosphates; Phosphotransferases (Alcohol Group Acceptor); Receptors, Steroid; Retinal Pigment Epithelium; Saponins; Time-Lapse Imaging; trans-Golgi Network	2017
Cholestane glycosides from Ornithogalum saundersiae bulbs and the induction of apoptosis in HL-60 cells by OSW-1 through a mitochondrial-independent signaling pathway. Journal of natural medicines, 2019, Volume: 73, Issue:1 Topics: Apoptosis; Cholestanes; Cholestenones; Glycosides; HL-60 Cells; Humans; Mitochondria; Ornithogalum; Saponins; Signal Transduction	2019
Anticancer saponin OSW-1 is a novel class of selective Golgi stress inducer. Bioorganic & medicinal chemistry letters, 2019, 07-15, Volume: 29, Issue:14 Topics: Antineoplastic Agents; Cholestenones; Golgi Apparatus; Humans; Saponins	2019
Computational and Experimental Analysis on the Conformational Preferences of Anticancer Saponin OSW-1. The Journal of organic chemistry, 2020, 01-17, Volume: 85, Issue:2 Topics: Antineoplastic Agents, Phytogenic; Carbon-13 Magnetic Resonance Spectroscopy; Cholestenones; Computational Chemistry; Crystallography, X-Ray; Molecular Conformation; Proton Magnetic Resonance Spectroscopy; Saponins	2020
Interactions of OSW-1 with Lipid Bilayers in Comparison with Digitonin and Soyasaponin. Langmuir : the ACS journal of surfaces and colloids, 2020, 04-07, Volume: 36, Issue:13 Topics: Cholestenones; Digitonin; Lipid Bilayers; Saponins	2020
OSW-1 inhibits tumor growth and metastasis by NFATc2 on triple-negative breast cancer. Cancer medicine, 2020, Volume: 9, Issue:15 Topics: Animals; Cell Line, Tumor; Cell Proliferation; Cholestenones; Disease Models, Animal; Female; Humans; Mice; Mice, SCID; Neoplasm Metastasis; NFATC Transcription Factors; Ornithogalum; Saponins; Triple Negative Breast Neoplasms	2020
Screening Reveals Sterol Derivatives with Pro-Differentiation, Pro-Survival, or Potent Cytotoxic Effects on Oligodendrocyte Progenitor Cells. ACS chemical biology, 2021, 07-16, Volume: 16, Issue:7 Topics: Animals; Cell Differentiation; Cell Survival; Cholestenones; Drug Evaluation, Preclinical; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Estrenes; Golgi Apparatus; HeLa Cells; Humans; Mice; Oligodendrocyte Precursor Cells; Oligodendroglia; Pyrrolidinones; Saponins; Small Molecule Libraries; Sterols	2021
Selective obstruction of the mTORC2 complex by a naturally occurring cholestane saponin (OSW-1) for inhibiting prostate cancer cell growth. Journal of Asian natural products research, 2022, Volume: 24, Issue:7 Topics: Cholestanes; Cholestenones; Humans; Male; Mechanistic Target of Rapamycin Complex 2; Molecular Structure; Ornithogalum; Prostatic Neoplasms; Saponins; TOR Serine-Threonine Kinases	2022
Itraconazole inhibits nuclear delivery of extracellular vesicle cargo by disrupting the entry of late endosomes into the nucleoplasmic reticulum. Journal of extracellular vesicles, 2021, Volume: 10, Issue:10 Topics: Active Transport, Cell Nucleus; Antifungal Agents; Cell Line; Cell Movement; Cholestenones; Endocytosis; Endosomes; Extracellular Vesicles; Fatty Acid-Binding Proteins; Humans; Itraconazole; Ketoconazole; Models, Molecular; Nuclear Envelope; rab7 GTP-Binding Proteins; Saponins; Vesicular Transport Proteins	2021
Elucidation of OSW-1-Induced Stress Responses in Neuro2a Cells. International journal of molecular sciences, 2023, Mar-17, Volume: 24, Issue:6 Topics: Animals; Antineoplastic Agents; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Brefeldin A; Cell Line; Cholestenones; Golgi Apparatus; Mice; Saponins	2023