Aristolactam AIIIa: polo-like kinase 1 (Plk1) inhibitor; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 10356352 |
| CHEMBL ID | 388956 |
| MeSH ID | M0543059 |
| Synonym |
|---|
| aristolactam aiiia |
| bdbm50197834 |
| aristololactam a iiia |
| 2,9-dihydroxy-1-methoxydibenzo[cd,f]indol-4(5h)-one |
| CHEMBL388956 , |
| sch-546909 |
| 97399-91-2 |
| c16h11no4 |
| AKOS032948654 |
| FS-9211 |
| aristolactam a iiia |
| aristololactam a iiia; sch 546909 |
| 4,14-dihydroxy-15-methoxy-10-azatetracyclo[7.6.1.02,7.012,16]hexadeca-1,3,5,7,9(16),12,14-heptaen-11-one |
| HY-N2892 |
| CS-0023477 |
| dibenz[cd,f]indol-4(5h)-one, 2,9-dihydroxy-1-methoxy- |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Aurora kinase A | Homo sapiens (human) | IC50 (µMol) | 5.0000 | 0.0000 | 0.4620 | 8.6000 | AID457607 |
| Cyclin-dependent kinase 1 | Homo sapiens (human) | IC50 (µMol) | 0.2070 | 0.0004 | 1.3452 | 10.0000 | AID457605; AID457945 |
| Cyclin-dependent kinase 4 | Homo sapiens (human) | IC50 (µMol) | 1.7100 | 0.0006 | 0.5706 | 10.0000 | AID457606; AID457946 |
| Cyclin-dependent kinase 2 | Homo sapiens (human) | IC50 (µMol) | 0.1400 | 0.0004 | 1.0444 | 10.0000 | AID457604; AID457944 |
| Aurora kinase B | Homo sapiens (human) | IC50 (µMol) | 2.1400 | 0.0003 | 0.9634 | 9.8000 | AID457947 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID457610 | Antiproliferative activity against human MCF7 cells by soft agar growth assay | 2010 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 20, Issue:4 | Semi-synthetic aristolactams--inhibitors of CDK2 enzyme. |
| AID457606 | Inhibition of CDK4 | 2010 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 20, Issue:4 | Semi-synthetic aristolactams--inhibitors of CDK2 enzyme. |
| AID457607 | Inhibition of AUR2 | 2010 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 20, Issue:4 | Semi-synthetic aristolactams--inhibitors of CDK2 enzyme. |
| AID457946 | Inhibition of CDK4 | 2010 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 20, Issue:4 | New potential antitumor compounds from the plant Aristolochia manshuriensis as inhibitors of the CDK2 enzyme. |
| AID284361 | Cytotoxicity against BALB/c mouse spleen cells | 2007 | Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2 | Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr. |
| AID284365 | Selectivity index, ratio of CC50 for BALB/c mouse T cells to IC50 for BALB/c mouse B cells | 2007 | Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2 | Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr. |
| AID457604 | Inhibition of CDK2 | 2010 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 20, Issue:4 | Semi-synthetic aristolactams--inhibitors of CDK2 enzyme. |
| AID377201 | Inhibition of arachidonic acid-induced rabbit platelet aggregation at 100 ug/ml | 2000 | Journal of natural products, Aug, Volume: 63, Issue:8 | Aristolactams and dioxoaporphines from Fissistigma balansae and Fissistigma oldhamii. |
| AID457947 | Inhibition of Aurora 2 kinase | 2010 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 20, Issue:4 | New potential antitumor compounds from the plant Aristolochia manshuriensis as inhibitors of the CDK2 enzyme. |
| AID457605 | Inhibition of CDC2 | 2010 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 20, Issue:4 | Semi-synthetic aristolactams--inhibitors of CDK2 enzyme. |
| AID457948 | Inhibition of MAPK | 2010 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 20, Issue:4 | New potential antitumor compounds from the plant Aristolochia manshuriensis as inhibitors of the CDK2 enzyme. |
| AID457945 | Inhibition of CDC2 | 2010 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 20, Issue:4 | New potential antitumor compounds from the plant Aristolochia manshuriensis as inhibitors of the CDK2 enzyme. |
| AID284363 | Inhibition of LPS-induced BALB/c mouse B cell proliferation | 2007 | Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2 | Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr. |
| AID457944 | Inhibition of CDK2 | 2010 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 20, Issue:4 | New potential antitumor compounds from the plant Aristolochia manshuriensis as inhibitors of the CDK2 enzyme. |
| AID377200 | Inhibition of thrombin-induced rabbit platelet aggregation at 100 ug/ml | 2000 | Journal of natural products, Aug, Volume: 63, Issue:8 | Aristolactams and dioxoaporphines from Fissistigma balansae and Fissistigma oldhamii. |
| AID457611 | Antiproliferative activity against human MCF7 cells by clonogenicity assay | 2010 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 20, Issue:4 | Semi-synthetic aristolactams--inhibitors of CDK2 enzyme. |
| AID457608 | Inhibition of MAPK | 2010 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 20, Issue:4 | Semi-synthetic aristolactams--inhibitors of CDK2 enzyme. |
| AID284364 | Selectivity index, ratio of CC50 for BALB/c mouse spleen cells to IC50 for BALB/c mouse T cells | 2007 | Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2 | Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr. |
| AID377203 | Inhibition of platelet-activating factor-induced rabbit platelet aggregation at 100 ug/ml | 2000 | Journal of natural products, Aug, Volume: 63, Issue:8 | Aristolactams and dioxoaporphines from Fissistigma balansae and Fissistigma oldhamii. |
| AID377202 | Inhibition of collagen-induced rabbit platelet aggregation at 100 ug/ml | 2000 | Journal of natural products, Aug, Volume: 63, Issue:8 | Aristolactams and dioxoaporphines from Fissistigma balansae and Fissistigma oldhamii. |
| AID284362 | Inhibition of ConA-induced BALB/c mouse T cell proliferation | 2007 | Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2 | Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (14.29%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (85.71%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||