Compounds > aristololactam a ii
Page last updated: 2024-12-08

aristololactam a ii

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

aristololactam A II: from the stems of Uvaria kweichowensis; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
UvariagenusA plant genus of the family ANNONACEAE. Members contain uvarigrin, uvarigrandin, chamuvaritin and other acetogenins and benzylisoquinoline alkaloids.[MeSH]AnnonaceaeThe custard-apple plant family of the order Magnoliales, subclass Magnoliidae, class Magnoliopsida. Some members provide large pulpy fruits and commercial timber. Leaves and wood are often fragrant. Leaves are simple, with smooth margins, and alternately arranged in two rows along the stems.[MeSH]

Cross-References

ID SourceID
PubMed CID148657
CHEMBL ID390368
MeSH IDM0536880

Synonyms (22)

Synonym
aristolactam aii
nsc615450
nsc-615450
aristololactam a ii
aristolactam-aii
CHEMBL390368
dibenz(cd,f)indol-4(5h)-one, 2-hydroxy-1-methoxy-
ccris 2996
53948-07-5
dibenz[cd,f]indol-4(5h)-one, 2-hydroxy-1-methoxy-
DTXSID50202234
AKOS028108588
14-hydroxy-15-methoxy-10-azatetracyclo[7.6.1.0^{2,7.0^{12,16]hexadeca-1(16),2,4,6,8,12,14-heptaen-11-one
FS-8607
aristolactam a ii
aristololactam a ii; nsc 615450
14-hydroxy-15-methoxy-10-azatetracyclo[7.6.1.02,7.012,16]hexadeca-1(16),2,4,6,8,12,14-heptaen-11-one
14-hydroxy-15-methoxy-10-azatetracyclo[7.6.1.0?,?.0??,??]hexadeca-1(16),2(7),3,5,8,12,14-heptaen-11-one
CS-0023475
HY-N2891
aristolactamaii
B0005-476528
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (17)

Assay IDTitleYearJournalArticle
AID377202Inhibition of collagen-induced rabbit platelet aggregation at 100 ug/ml2000Journal of natural products, Aug, Volume: 63, Issue:8
Aristolactams and dioxoaporphines from Fissistigma balansae and Fissistigma oldhamii.
AID338068Cytotoxicity against mouse P388 cells
AID379919Cytotoxicity against mouse P388 cells by SRB assay2006Journal of natural products, Dec, Volume: 69, Issue:12
Cytotoxic styryl-lactones from the leaves and twigs of Polyalthia crassa.
AID379923Cytotoxicity against human Lu1 cells by SRB assay2006Journal of natural products, Dec, Volume: 69, Issue:12
Cytotoxic styryl-lactones from the leaves and twigs of Polyalthia crassa.
AID390347Cytotoxicity against human KB cells after 72 hrs by neutral red staining2008Journal of natural products, Dec, Volume: 71, Issue:12
Antiplasmodial alkaloids from Desmos rostrata.
AID338069Cytotoxicity against human KB cells
AID284362Inhibition of ConA-induced BALB/c mouse T cell proliferation2007Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2
Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr.
AID284363Inhibition of LPS-induced BALB/c mouse B cell proliferation2007Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2
Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr.
AID377200Inhibition of thrombin-induced rabbit platelet aggregation at 100 ug/ml2000Journal of natural products, Aug, Volume: 63, Issue:8
Aristolactams and dioxoaporphines from Fissistigma balansae and Fissistigma oldhamii.
AID284361Cytotoxicity against BALB/c mouse spleen cells2007Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2
Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr.
AID379920Cytotoxicity against human KB cells by SRB assay2006Journal of natural products, Dec, Volume: 69, Issue:12
Cytotoxic styryl-lactones from the leaves and twigs of Polyalthia crassa.
AID377203Inhibition of platelet-activating factor-induced rabbit platelet aggregation at 100 ug/ml2000Journal of natural products, Aug, Volume: 63, Issue:8
Aristolactams and dioxoaporphines from Fissistigma balansae and Fissistigma oldhamii.
AID379921Cytotoxicity against human Col2 cells by SRB assay2006Journal of natural products, Dec, Volume: 69, Issue:12
Cytotoxic styryl-lactones from the leaves and twigs of Polyalthia crassa.
AID379922Cytotoxicity against human BCA1 cells by SRB assay2006Journal of natural products, Dec, Volume: 69, Issue:12
Cytotoxic styryl-lactones from the leaves and twigs of Polyalthia crassa.
AID377201Inhibition of arachidonic acid-induced rabbit platelet aggregation at 100 ug/ml2000Journal of natural products, Aug, Volume: 63, Issue:8
Aristolactams and dioxoaporphines from Fissistigma balansae and Fissistigma oldhamii.
AID390346Antiplasmodial activity against Plasmodium falciparum FcB1 as [3H]hypoxanthine uptake after 24 hrs2008Journal of natural products, Dec, Volume: 71, Issue:12
Antiplasmodial alkaloids from Desmos rostrata.
AID379924Cytotoxicity against mouse ASK cells by SRB assay2006Journal of natural products, Dec, Volume: 69, Issue:12
Cytotoxic styryl-lactones from the leaves and twigs of Polyalthia crassa.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.87

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.87 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.82 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.87)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
aspirin
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5). acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.. acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.		210benzoic acids;
phenyl acetates;
salicylates		anticoagulant;
antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
EC 1.1.1.188 (prostaglandin-F synthase) inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
plant activator;
platelet aggregation inhibitor;
prostaglandin antagonist;
teratogenic agent
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		2.0410aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
ellipticine
ellipticine : A organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11.		2.0310indole alkaloid;
organic heterotetracyclic compound;
organonitrogen heterocyclic compound;
polycyclic heteroarene		antineoplastic agent;
plant metabolite
glaucine
glaucine: RN given refers to (+-)-isomer		2.0310aporphine alkaloid;
organic heterotetracyclic compound;
polyether;
tertiary amino compound		antibacterial agent;
antineoplastic agent;
antitussive;
muscle relaxant;
NF-kappaB inhibitor;
plant metabolite;
platelet aggregation inhibitor;
rat metabolite
isoteolin
isoteolin: mixture of isomers isoboldine (RN 3019-51-0) & bracteoline (RN 25651-04-1)		2.0310aporphine alkaloid
liridine
liridine: Antibacterial from Artabotrys crassifolius; structure in first source		2.0310
docetaxel
[no description available]		2.0410hydrate;
secondary alpha-hydroxy ketone		antineoplastic agent
corytuberine
corytuberine: structure. (S)-corytuberine : An aporphine alkaloid that is aporphine which is substituted by hydroxy groups at positions 1 and 11, and by methoxy groups at positions 2 and 10 (the S enantiomer).		2.0310aporphine alkaloid;
aromatic ether;
organic heterotetracyclic compound;
polyphenol;
tertiary amino compound		plant metabolite
aristololactam bii
aristololactam BII: isolated from Saururus cernuus; structure given in first source		2.0310
norcepharadione b
norcepharadione B: isolated from Houttynia cordata; structure in first source		2.0310
piperolactam a
piperolactam A: isolated from Houttynia cordata; structure in first source		2.4220alkaloid
cyclosporine
ramihyphin A: one of the metabolites produced by Fusarium sp. S-435; RN given refers to cpd with unknown MF		2.0310homodetic cyclic peptideanti-asthmatic drug;
anticoronaviral agent;
antifungal agent;
antirheumatic drug;
carcinogenic agent;
dermatologic drug;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
geroprotector;
immunosuppressive agent;
metabolite
aristolactam aiiia
Aristolactam AIIIa: polo-like kinase 1 (Plk1) inhibitor; structure in first source		2.4220
ConditionIndicatedRelationship StrengthStudiesTrials