Placenta Increta

Invasion of CHORIONIC VILLI occurs through the MYOMETRIUM penetrating the uterine SEROSA.

Synonym
Placenta Increta
Placenta Percreta

Excerpt	Reference
"Placenta percreta is a severe condition associated with maternal morbidity and mortality even when surgery is performed electively."	( DuBeshter, B; Jaffe, R; Sherer, DM; Thompson, EA; Woods, JR, 1994)
"Although placenta percreta is rare, its sequelae include potentially lethal hemorrhage and loss of reproductive function."	( Caritis, SN; Hill, LM; Legro, RS; Price, FV, 1994)
"Placenta percreta is a rare but potentially lethal condition."	( Butt, K; Delisle, MF; Gagnon, A, 2002)
"Placenta percreta is a rare obstetric condition associated with potentially life-threatening hemorrhage."	( Dudenhausen, JW; Ehrenstein, T; Fuchs, I; Henrich, W; Kjos, S; Schmider, A, 2002)
"Placenta percreta is a severe condition associated with maternal morbidity and mortality even when surgery is performed electively."	( Antonetti-N'Diaye, E; Benoit, G; Bruyère, M; Chauveaud-Lambling, A; de Rudnicki, S; Frydman, R, 2005)
"Placenta percreta is a rare obstetric condition associated with life-threatening hemorrhage."	( Armstrong, M; El-Bialy, G; Kassab, A, 2007)
"Although placenta percreta is rare, its sequelae include potentially lethal hemorrhage and loss of reproduction function."	( Heinonen, S; Heiskanen, N; Kainulainen, S; Kröger, J, 2008)
"Placenta percreta is associated with significant morbidity and mortality."	( Alvarez Secord, A; Bakelaar, R; Ellestad, SC; Fitpatrick, CB; Havrilesky, LJ; Lee, PS, 2008)
"Placenta increta is a potentially life-threatening condition that may complicate a first trimester abortion in rare occasion."	( Imoto, S; Koyama, K; Mori, M; Nakamura, H; Nakano, T; Takeda, A, 2010)
"Placenta percreta is a complication of pregnancy with significant morbidity and mortality rates."	( Barber, JT; Goodman, JD; Martinez, FJ; Peisner, DB; Taboada, CD; Tressler, TB; Willis, GS, 2011)
"Placenta percreta is associated with maternal morbidity and mortality."	( Akashi, Y; Endo, T; Habata, S; Ishioka, S; Matsuura, M; Saito, T; Tamate, M; Tanaka, R, 2015)
"Placenta percreta is a rare condition that presents a risk of massive intraoperative hemorrhage."	( Endo, M; Kimura, T; Kumasawa, K; Matsuzaki, S; Mimura, K; Sawada, M, 2016)
"Placenta percreta is increasing in incidence and is associated with the risk of life-threatening haemorrhage."	( Huang, M; Schlumbrecht, M; Wong, AJ, 2018)
"Second trimester placenta percreta is a rare entity, with very few case reports in the literature."	( Allen, L; Chan, WV; Hobson, S; Kingdom, J; Mathur, S; McGrattan, M; Murji, A; Shirreff, L; Solnik, MJ, 2022)

Excerpt	Reference
"A woman with placenta percreta, suspected clinically and documented radiographically, was treated nonsurgically."	( Caritis, SN; Hill, LM; Legro, RS; Price, FV, 1994)
"The hCG elimination in retained placenta percreta is predictable in a log-linear manner that is similar to other reports of retained abnormally adherent placentae treated with or without methotrexate."	( Gerard Jackson, M; Holls, WH; Stitely, ML, 2014)
"In cases of placenta percreta with bladder involvement, conservative treatment may be the optimal management."	( Goffinet, F; Kayem, G; Sentilhes, L, 2013)
"We encountered a case of placenta percreta that was successfully treated by conservative management without complications or other clinical interventions."	( Endo, M; Kimura, T; Kumasawa, K; Matsuzaki, S; Mimura, K; Sawada, M, 2016)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	29 (14.22)	23.3326
1990's	23 (11.27)	12.5806
2000's	38 (18.63)	18.1394
2010's	87 (42.65)	28.8240
2020's	27 (13.24)	9.53

Drug	Relationship Strength	Studies	Trials
dalteparin	low	1	0
iodine	low	1	0
selenious acid	low	1	0
urea	low	2	0
caffeine	low	1	0
cefuroxime	low	1	0
chlorambucil	low	1	0
ciprofloxacin	low	1	0
diphenhydramine	low	1	0
furosemide	low	1	0
hydroxychloroquine	low	1	0
mechlorethamine	low	2	0
nitroglycerin	low	2	0
aminosalicylic acid	low	1	0
potassium chloride	low	3	0
tranexamic acid	low	6	0
prednisolone	low	1	0
hydroxyproline	low	1	0
medroxyprogesterone acetate	low	1	0
tromethamine	low	1	0
methylergonovine	low	2	0
meglumine	low	1	0
ephedrine	low	1	0
betamethasone	low	1	0
hematoxylin	low	1	0
eosine yellowish-(ys)	low	1	0
octamethylcyclotetrasiloxane	low	2	0
bucrylate	low	1	0
d-alpha tocopherol	low	1	0
tocopherols	low	1	0
streptomycin	low	1	0
enbucrilate	low	1	0
technetium	low	2	0
argon	low	2	0
gadolinium	low	4	0
magnesium sulfate	low	1	0
phosphotyrosine	low	1	0
cetylpyridinium chloride anhydrous	low	1	0
pregnanolone	low	1	0
4-methoxyamphetamine	low	1	0
etoposide	low	2	0
mifepristone	low	5	0
remifentanil	low	1	0
fibrinogen	low	7	0
methotrexate	low	75	0
borneo	low	1	0
fibrin	low	1	0
oxytocin	medium	21	1
ergonovine	low	2	0
retinol	low	1	0
diethylstilbestrol	low	1	0
dactinomycin	low	2	0
bromochloroacetic acid	low	1	0
lypressin	low	1	0
polidocanol	low	1	0
indigo carmine	low	1	0
dimemorfan	low	1	0
dinoprostone	low	4	0
dinoprost	low	2	0
alprostadil	low	2	0
hemabate	low	1	0
carboprost	low	1	0
gemeprost	low	1	0
misoprostol	low	7	0
goserelin	low	1	0
sulprostone	low	2	0
indium	low	1	0
selenium	low	2	0
gadolinium dtpa	low	2	0
morphinans	low	1	0
losartan potassium	low	3	0
pituitrin	low	5	0
endothelin-1	low	1	0
piperidines	low	1	0
interleukin-8	low	3	0
natriuretic peptide, brain	low	2	0
transforming growth factor beta	low	4	0
hyaluronoglucosaminidase	low	2	0
exudates	low	1	0
levoleucovorin	low	4	0

Protein Targets (641)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
5-hydroxytryptamine receptor 2C	0	2	1	4
5-hydroxytryptamine receptor 2A	0	2	1	3
5-hydroxytryptamine receptor 1A	0	6	1	7
5-hydroxytryptamine receptor 1B	0	6	1	7
5-hydroxytryptamine receptor 1D	0	1	1	2
5-hydroxytryptamine receptor 1F	0	1	1	2
5-hydroxytryptamine receptor 2B	0	1	1	2
5-hydroxytryptamine receptor 6	0	0	1	1
Sodium-dependent serotonin transporter	0	2	1	3
Sodium-dependent serotonin transporter	0	1	0	1
5-hydroxytryptamine receptor 7	0	0	1	1
5-hydroxytryptamine receptor 5A	0	0	1	1
5-hydroxytryptamine receptor 5B	0	0	1	1
5-hydroxytryptamine receptor 3A	0	0	1	1
5-hydroxytryptamine receptor 4	0	0	1	1
5-hydroxytryptamine receptor 3B	0	0	1	1
TDP1 protein	20	0	0	20
AR protein	27	0	0	27
glucocorticoid receptor [Homo sapiens]	20	0	0	20
estrogen nuclear receptor alpha	31	0	0	31
peroxisome proliferator activated receptor gamma	13	0	0	13
ATP-binding cassette sub-family C member 3	0	12	0	12
Multidrug resistance-associated protein 4	0	12	0	15
Bile salt export pump	0	15	0	15
Cellular tumor antigen p53	23	0	0	23
Thromboxane-A synthase	0	2	0	2
Prostaglandin E2 receptor EP3 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	2	0	2
Prostacyclin receptor	0	4	2	6
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Solute carrier organic anion transporter family member 2A1	0	2	0	5
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Canalicular multispecific organic anion transporter 1	0	12	0	13
Solute carrier organic anion transporter family member 2A1	0	1	0	4
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Solute carrier organic anion transporter family member 3A1	0	0	0	1
Chain A, 2-oxoglutarate Oxygenase	5	0	0	5
Microtubule-associated protein tau	12	0	0	12
thioredoxin glutathione reductase	4	0	0	4
Smad3	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	13	0	0	13
microphthalmia-associated transcription factor isoform 9	0	1	0	1
Carbonic anhydrase 1	0	7	0	8
Carbonic anhydrase 2	0	7	1	9
Tyrosine-protein phosphatase non-receptor type 1	0	0	1	1
pregnane X receptor	5	0	0	5
GLI family zinc finger 3	17	0	0	17
progesterone receptor	12	0	0	12
cytochrome P450 family 3 subfamily A polypeptide 4	13	0	0	13
estrogen-related nuclear receptor alpha	21	0	0	21
farnesoid X nuclear receptor	13	0	0	13
pregnane X nuclear receptor	15	0	0	15
vitamin D (1,25- dihydroxyvitamin D3) receptor	12	0	0	12
IDH1	4	0	0	4
aryl hydrocarbon receptor	8	0	0	8
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	12	0	0	12
nuclear receptor subfamily 1, group I, member 2	5	0	0	5
thyroid hormone receptor beta isoform a	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 2	7	0	0	7
galanin receptor type 3	0	1	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	20	0	0	20
Voltage-dependent calcium channel gamma-2 subunit	14	0	0	14
Glucocorticoid receptor	1	10	4	22
Glycine receptor subunit alpha-1	0	10	0	10
Glutamate receptor 2	14	0	0	14
Glycine receptor subunit beta	0	10	0	10
Glycine receptor subunit alpha-2	0	10	0	10
Glycine receptor subunit alpha-3	0	10	0	10
ORF73	0	0	1	1
RAR-related orphan receptor gamma	18	0	0	18
estrogen receptor 2 (ER beta)	10	0	0	10
nuclear receptor subfamily 1, group I, member 3	16	0	0	16
retinoic acid nuclear receptor alpha variant 1	20	0	0	20
retinoid X nuclear receptor alpha	15	0	0	15
peroxisome proliferator-activated receptor delta	13	0	0	13
thyroid stimulating hormone receptor	10	0	0	10
activating transcription factor 6	11	0	0	11
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	6	0	0	6
v-jun sarcoma virus 17 oncogene homolog (avian)	13	0	0	13
thyroid hormone receptor beta isoform 2	19	0	0	19
heat shock protein beta-1	8	0	0	8
aldehyde dehydrogenase 1 family, member A1	14	0	0	14
Nuclear receptor ROR-gamma	6	0	0	6
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
phosphopantetheinyl transferase	7	0	0	7
GLS protein	6	0	0	6
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
chromobox protein homolog 1	9	0	0	9
DNA polymerase beta	4	0	0	4
nuclear receptor ROR-gamma isoform 1	11	0	0	11
geminin	15	0	0	15
DNA polymerase kappa isoform 1	4	0	0	4
muscarinic acetylcholine receptor M1	3	0	0	3
lethal factor (plasmid)	3	0	0	3
Potassium channel subfamily K member 2	0	0	1	1
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	1	0	1
Cholinesterase	0	1	0	1
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	2	1	3
Adenosine receptor A3	0	3	0	3
Replicase polyprotein 1ab	0	2	1	3
Amine oxidase [flavin-containing] A	0	1	0	1
Acetylcholinesterase	0	2	0	2
Adenosine receptor A1	0	2	1	4
Amine oxidase [flavin-containing] B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	4	1	6
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	2	0	3
Adenosine receptor A1	0	3	1	6
Adenosine receptor A2a	0	2	1	5
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	2	0	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	2	3
Endochitinase B1	0	1	0	1
Muscarinic acetylcholine receptor	0	0	0	1
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	4
Guanine deaminase	0	1	0	1
ATP-dependent phosphofructokinase	7	0	0	7
Chain A, Ferritin light chain	5	0	0	5
acetylcholinesterase	5	0	0	5
hypoxia-inducible factor 1 alpha subunit	7	0	0	7
SMAD family member 2	8	0	0	8
USP1 protein, partial	12	0	0	12
SMAD family member 3	8	0	0	8
caspase 7, apoptosis-related cysteine protease	7	0	0	7
67.9K protein	6	0	0	6
caspase-3	7	0	0	7
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
thyrotropin-releasing hormone receptor	2	0	0	2
vitamin D3 receptor isoform VDRA	13	0	0	13
mitogen-activated protein kinase 1	5	0	0	5
survival motor neuron protein isoform d	8	0	0	8
Caspase-2	0	0	1	1
Inositol monophosphatase 1	3	0	0	3
ATPase family AAA domain-containing protein 5	12	0	0	12
Ataxin-2	13	0	0	13
Luciferase	7	0	0	7
interleukin 8	5	0	0	5
thioredoxin reductase	6	0	0	6
NFKB1 protein, partial	1	0	0	1
GALC protein	2	0	0	2
Thrombopoietin	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
thyroid stimulating hormone receptor	6	0	0	6
EWS/FLI fusion protein	9	0	0	9
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
Histone H2A.x	8	0	0	8
Bloom syndrome protein isoform 1	4	0	0	4
peripheral myelin protein 22 isoform 1	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	7	0	0	7
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
peripheral myelin protein 22	11	0	0	11
muscleblind-like protein 1 isoform 1	2	0	0	2
lamin isoform A-delta10	16	0	0	16
Carbonic anhydrase 12	0	2	0	3
Cytochrome P450 2D6	0	3	0	3
Spike glycoprotein	9	0	1	10
Carbonic anhydrase 9	0	3	0	4
Solute carrier organic anion transporter family member 1B3	0	4	0	5
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	9	0	0	9
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
Chain A, Cruzipain	7	0	0	7
cytochrome P450 2C9 precursor	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	5	2	0	7
Cytochrome P450 1A2	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Cytochrome P450 3A4	0	4	1	5
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	1	0	3
DNA gyrase subunit B	0	1	0	3
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
DNA topoisomerase 2-alpha	0	2	1	11
Cytochrome P450 2C9	0	6	0	6
Gamma-aminobutyric acid receptor subunit beta-1	5	2	0	7
Gamma-aminobutyric acid receptor subunit delta	5	2	0	7
Gamma-aminobutyric acid receptor subunit gamma-2	5	2	0	7
Gamma-aminobutyric acid receptor subunit alpha-5	5	2	0	7
Gamma-aminobutyric acid receptor subunit alpha-3	5	2	0	7
DNA gyrase subunit A	0	1	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	5	2	0	7
Gamma-aminobutyric acid receptor subunit alpha-2	5	2	0	7
Gamma-aminobutyric acid receptor subunit alpha-4	5	2	0	7
Gamma-aminobutyric acid receptor subunit gamma-3	5	2	0	7
Gamma-aminobutyric acid receptor subunit alpha-6	5	2	0	7
Cytochrome P450 2C19	0	1	0	1
Multidrug resistance protein MdtK	0	0	1	1
Histamine H2 receptor	4	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	5	2	0	7
Gamma-aminobutyric acid receptor subunit beta-3	5	2	0	7
Gamma-aminobutyric acid receptor subunit beta-2	5	2	0	7
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	2
Potassium voltage-gated channel subfamily H member 2	0	6	0	7
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	2	0	2
GABA theta subunit	5	2	0	7
Gamma-aminobutyric acid receptor subunit epsilon	5	2	0	7
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Rap guanine nucleotide exchange factor 3	3	0	0	3
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
15-lipoxygenase, partial	6	0	0	6
RAD51	0	1	0	1
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
huntingtin isoform 2	4	0	0	4
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
cytochrome P450 3A4 isoform 1	5	0	0	5
caspase-1 isoform alpha precursor	2	0	0	2
Interferon beta	9	0	0	9
ATP-dependent translocase ABCB1	0	3	0	5
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	0	1	0	1
Caspase-7	2	0	0	2
Growth factor receptor-bound protein 2	0	1	0	2
Pantothenate synthetase	0	1	0	1
Discoidin domain-containing receptor 2	0	1	0	1
Growth factor receptor-bound protein 2	0	1	0	1
Reverse transcriptase/RNaseH	0	1	0	1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
glp-1 receptor, partial	3	0	0	3
ATAD5 protein, partial	5	0	0	5
regulator of G-protein signaling 4	6	0	0	6
G	6	0	0	6
cytochrome P450 2D6	6	0	0	6
cellular tumor antigen p53 isoform a	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
serine/threonine-protein kinase PLK1	2	0	0	2
high affinity choline transporter 1 isoform a	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	1	0	2
neuropeptide S receptor isoform A	4	0	0	4
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
5-hydroxytryptamine receptor 4	0	8	0	8
Nuclear receptor subfamily 1 group I member 2	0	1	0	1
HLA class I histocompatibility antigen, B alpha chain	6	0	0	6
Estrogen receptor	1	7	3	11
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Integrin beta-3	3	0	0	3
Tyrosine-protein kinase Fyn	0	2	0	2
Aldo-keto reductase family 1 member B1	0	4	0	4
Integrin alpha-IIb	3	0	0	3
Beta-1 adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	7	0	7
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Muscarinic acetylcholine receptor M1	0	5	0	5
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
D(2) dopamine receptor	0	6	0	6
Androgen receptor	0	6	0	6
Alpha-1B adrenergic receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	9	0	9
Alpha-2C adrenergic receptor	0	3	0	3
Muscarinic acetylcholine receptor M3	0	5	0	5
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	6	0	6
Prostaglandin G/H synthase 1	0	3	0	3
Sodium-dependent noradrenaline transporter	0	4	0	4
Alpha-1D adrenergic receptor	0	4	0	4
5-hydroxytryptamine receptor 2A	0	8	0	8
5-hydroxytryptamine receptor 2C	0	8	0	8
Mu-type opioid receptor	0	4	0	4
D(3) dopamine receptor	0	6	0	6
Vasopressin V1a receptor	0	4	1	5
Alpha-synuclein	2	1	0	3
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	4	0	4
5-hydroxytryptamine receptor 2B	0	8	1	9
Alpha-1A adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 6	0	6	0	6
Estrogen-related receptor gamma	0	0	1	1
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Sodium-dependent dopamine transporter	0	2	0	2
Aldehyde oxidase	0	1	0	1
TAR DNA-binding protein 43	2	0	0	2
UDP-glucose 4-epimerase	0	1	0	1
Mitogen-activated protein kinase 14	0	2	0	2
Inositol hexakisphosphate kinase 1	6	0	0	6
Estrogen receptor beta	1	7	3	11
Cysteinyl leukotriene receptor 1	0	2	0	2
cytochrome P450 2C9, partial	6	0	0	6
Solute carrier family 22 member 2	0	0	0	2
Solute carrier family 22 member 1	0	0	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Thromboxane A2 receptor	0	1	1	2
Prostaglandin E2 receptor EP1 subtype	0	3	2	5
Prostaglandin G/H synthase 2	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	3	1	4
Prostaglandin F2-alpha receptor	0	2	0	2
Prostaglandin F2-alpha receptor	0	2	2	4
Prostaglandin E2 receptor EP3 subtype	0	3	2	5
Prostaglandin E2 receptor EP2 subtype	0	3	1	4
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin D2 receptor	0	1	0	1
Solute carrier family 22 member 6	0	0	0	3
Solute carrier family 22 member 7	0	0	0	2
Solute carrier family 22 member 8	0	0	0	3
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Solute carrier family 22 member 11	0	0	0	3
Solute carrier family 22 member 7	0	0	0	2
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
Muscarinic acetylcholine receptor M2	0	4	0	4
Muscarinic acetylcholine receptor M4	0	3	0	3
Muscarinic acetylcholine receptor M5	0	3	0	3
Angiotensin-converting enzyme	0	2	0	2
Histamine H1 receptor	0	0	1	2
Histamine H1 receptor	0	2	0	2
Histamine N-methyltransferase	0	0	0	1
Cytochrome P450 2J2	0	3	0	3
Sodium channel protein type 5 subunit alpha	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Calcium release-activated calcium channel protein 1	0	1	0	1
Protein orai-2	0	1	0	1
Protein orai-3	0	1	0	1
Histamine H4 receptor	0	1	0	1
Histamine H3 receptor	0	0	0	1
Solute carrier family 22 member 2	0	1	0	1
Endothelin-1 receptor	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
ATP-dependent translocase ABCB1	0	2	1	3
LMP1 [Human herpesvirus 4]	0	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	2	0	2
DNA polymerase iota isoform a (long)	7	0	0	7
transactivating tegument protein VP16 [Human herpesvirus 1]	0	2	0	2
nuclear receptor coactivator 3 isoform a	0	2	0	2
Prothrombin	0	0	0	1
Regulatory protein E2	0	0	1	1
DNA topoisomerase 1	0	1	0	2
DNA topoisomerase 2	0	0	0	1
UDP-glucuronosyltransferase 1A1	0	0	0	1
Serum paraoxonase/arylesterase 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	0	0	1
Caspase-3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2B	0	0	0	1
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	1	8
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
Tubulin beta-2B chain	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Bile salt export pump	0	3	0	3
Albumin	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Carbonic anhydrase 4	0	2	0	3
Carbonic anhydrase 6	0	1	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	2	0	3
Carbonic anhydrase 7	0	1	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Multidrug and toxin extrusion protein 1	0	2	0	2
Carbonic anhydrase 13	0	1	0	2
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Carbonic anhydrase 14	0	1	0	2
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	5	0	0	5
Chain E, Fibrin beta chain	0	1	0	1
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
WRN	1	0	0	1
Mcl-1	0	1	0	1
MPI protein	0	1	0	1
Cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0	0	0	1
PPM1D protein	2	0	0	2
alkaline phosphatase, intestinal	0	0	1	1
apical membrane antigen 1, AMA1	2	0	0	2
hypothetical protein, conserved	2	0	0	2
glucocerebrosidase	1	0	0	1
luciferase	1	0	0	1
pyruvate kinase	1	0	0	1
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
CDK5	0	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
major prion protein preproprotein Prp precursor	0	1	0	1
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	0	1	1
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
intestinal alkaline phosphatase precursor	0	0	1	1
flap endonuclease 1	4	0	0	4
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
DNA polymerase eta isoform 1	2	0	0	2
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Vif	0	1	0	1
Tat	0	1	0	1
histone acetyltransferase KAT2A isoform 1	3	0	0	3
alkaline phosphatase, germ cell type preproprotein	0	0	1	1
endoribonuclease toxin MazF	0	0	1	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Pyruvate kinase PKM	0	1	0	1
Endothelin receptor type B	1	0	0	1
Endothelin-1 receptor	1	0	0	1
phosphoglycerate kinase	1	0	0	1
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
large T antigen	0	1	0	1
Genome polyprotein	0	1	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Procathepsin L	0	0	1	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Sigma intracellular receptor 2	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	3	0	3
Angiotensin-converting enzyme 2	0	0	1	1
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Proton-coupled amino acid transporter 1	0	1	0	1
Amino acid transporter	0	1	0	1
histone deacetylase 9 isoform 3	2	0	0	2
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Fumarate hydratase	2	0	0	2
polyprotein	2	0	0	2
Chain A, Beta-lactamase	2	0	0	2
PINK1	1	0	0	1
nonstructural protein 1	3	0	0	3
Parkin	1	0	0	1
transcriptional regulator ERG isoform 3	2	0	0	2
Sex hormone-binding globulin	0	0	1	1
Progesterone receptor	0	6	2	11
Mineralocorticoid receptor	1	5	2	9
Androgen receptor	1	6	3	10
Androgen receptor	0	0	1	1
Histamine H2 receptor	0	2	0	2
Aldo-keto reductase family 1 member C3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Aldo-keto reductase family 1 member C1	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
acid sphingomyelinase	1	0	0	1
dopamine D1 receptor	3	0	0	3
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
alpha-galactosidase	1	0	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
M-phase phosphoprotein 8	4	0	0	4
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Protein-arginine deiminase type-4	0	3	0	3
DNA polymerase III, partial	1	0	0	1
arylsulfatase A	2	0	0	2
D(1A) dopamine receptor	2	0	0	2
tumor susceptibility gene 101 protein	1	0	0	1
Chain A, PROGESTERONE RECEPTOR	0	1	0	1
Glucocorticoid receptor	0	1	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Tegument protein VP16	0	0	1	1
Glucocorticoid receptor	0	2	2	5
Glucocorticoid receptor	0	1	1	2
Coagulation factor VII	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Thyroid hormone receptor alpha	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Tissue factor	0	1	0	1
Substance-P receptor	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
Progesterone receptor	0	0	1	1
Glucocorticoid receptor	0	1	0	1
Atrial natriuretic peptide receptor 1	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	2	2	4
Vasopressin V1a receptor	0	1	0	1
Vasopressin V1b receptor	0	1	1	2
Vasopressin V1b receptor	0	1	0	1
Oxytocin receptor	0	1	0	1
Oxytocin receptor	0	0	1	1
Vasopressin V2 receptor	0	1	0	1
endonuclease IV	1	0	0	1
cytochrome P450 2C19 precursor	1	0	0	1
Tyrosine-protein kinase Lck	0	0	0	1
Proto-oncogene tyrosine-protein kinase Src	0	0	0	1
Tyrosine-protein phosphatase non-receptor type 11	0	0	0	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Sodium/potassium/calcium exchanger 4	0	1	1	2
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Sodium/potassium/calcium exchanger 2	0	1	1	2
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Corticosteroid-binding globulin	0	1	0	1
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Gamma-aminobutyric acid	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	0	1	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Amyloid-beta precursor protein	0	1	0	1
Chain A, PLASMINOGEN	0	0	1	1
Chain A, PLASMINOGEN	0	0	1	1
Plasminogen	0	2	1	3
Urokinase-type plasminogen activator	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	1	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (204)

Protein Targets (641)

Placenta Increta

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (204)

Drugs Studied (92)

Protein Targets (641)