Page last updated: 2024-12-07

beta-casomorphin 7

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Beta-casomorphin 7 (BCM-7) is a seven-amino acid opioid peptide derived from the breakdown of the protein casein, found in milk. BCM-7 is produced in the gastrointestinal tract when casein is digested by enzymes. BCM-7 has been shown to have opioid-like effects, including analgesia and sedation, in animal studies. Its effects are mediated by the mu-opioid receptor. BCM-7 has been implicated in the development of autism and other neurological disorders, as well as digestive issues. Research on BCM-7 focuses on understanding its role in these conditions and its potential as a therapeutic agent.'

beta-casomorphin 7: opioid peptide isolated from casein peptone; corresponds to sequence 60-66 of beta-casein; from a variety of organisms; see also record for general term beta-casomorphin [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID121946
CHEMBL ID2370605
SCHEMBL ID22413056
MeSH IDM0122112

Synonyms (23)

Synonym
tyr-pro-phe-pro-gly-pro-ile
l-isoleucine, n-(1-(n-(1-(n-(1-l-tyrosyl-l-prolyl)-l-phenylalanyl)-l-prolyl)glycyl)-l-prolyl)-
tyrosyl-prolyl-phenylalanyl-prolylglycyl-prolyl-isoleucine
beta-casomorphin 7
bdbm50089072
2-({1-[2-({1-[2-({1-[2-amino-3-(4-hydroxy-phenyl)-propionyl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionyl]-pyrrolidine-2-carbonyl}-amino)-acetyl]-pyrrolidine-2-carbonyl}-amino)-3-methyl-pentanoic acid
chembl2370605 ,
72122-62-4
l-tyrosyl-l-prolyl-l-phenylalanyl-l-prolylglycyl-l-prolyl-l-isoleucine
(2s,3s)-2-[[(2s)-1-[2-[[(2s)-1-[(2s)-2-[[(2s)-1-[(2s)-2-amino-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoic acid
beta casomorphin
beta-casomorphine-7
beta-casomorphin (bovine)
(2s,3s)-2-((s)-1-(2-((s)-1-((s)-2-((s)-1-((s)-2-amino-3-(4-hydroxyphenyl)propanoyl)pyrrolidine-2-carboxamido)-3-phenylpropanoyl)pyrrolidine-2-carboxamido)acetyl)pyrrolidine-2-carboxamido)-3-methylpentanoic acid
DTXSID10992846
n-[hydroxy(1-{n-[hydroxy(1-{n-[hydroxy(1-tyrosylpyrrolidin-2-yl)methylidene]phenylalanyl}pyrrolidin-2-yl)methylidene]glycyl}pyrrolidin-2-yl)methylidene]isoleucine
CS-0021096
HY-P0179
SCHEMBL22413056
-casomorphin, bovine
-casomorphin-7 (bovine);bovine -casomorphin-7
beta-casomorphin bovine
beta-casomorphin-7 (bovine)

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" The findings point to a need for further studies on the possible function of peptides derived from milk proteins as orally bioavailable immunopotentiatory compounds."( Stimulation of human peripheral blood lymphocytes by bioactive peptides derived from bovine milk proteins.
Kayser, H; Meisel, H, 1996
)
0.29

Dosage Studied

ExcerptRelevanceReference
" Only beta-CM5 was effective, and the dose-response relationship was graded."( beta-Casomorphin causes hypoalgesia in 10-day-old rats: evidence for central mediation.
Blass, EM; Blom, J, 1996
)
0.29
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID151450Inhibitory concentration against [3H]DAMGO binding to Opioid receptor mu 1 in rat brain membrane2000Bioorganic & medicinal chemistry letters, Jun-05, Volume: 10, Issue:11
Beta-casomorphins: substitution of phenylalanine with beta-homo phenylalanine increases the mu-type opioid receptor affinity.
AID151757Compound was evaluated for the binding affinity of Opioid receptor mu 1 by displacing the radioligand [3H]DAMGO from rat brain membrane2000Bioorganic & medicinal chemistry letters, Jun-05, Volume: 10, Issue:11
Beta-casomorphins: substitution of phenylalanine with beta-homo phenylalanine increases the mu-type opioid receptor affinity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (79)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (2.53)18.7374
1990's14 (17.72)18.2507
2000's25 (31.65)29.6817
2010's33 (41.77)24.3611
2020's5 (6.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 36.08

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index36.08 (24.57)
Research Supply Index4.54 (2.92)
Research Growth Index5.41 (4.65)
Search Engine Demand Index46.75 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (36.08)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials3 (3.33%)5.53%
Reviews6 (6.67%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other81 (90.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]