Cubital Tunnel Syndrome

Compression of the ULNAR NERVE in the cubital tunnel, which is formed by the two heads of the flexor carpi ulnaris muscle, humeral-ulnar aponeurosis, and medial ligaments of the elbow. This condition may follow trauma or occur in association with processes which produce nerve enlargement or narrowing of the canal. Manifestations include elbow pain and PARESTHESIA radiating distally, weakness of ulnar innervated intrinsic hand muscles, and loss of sensation over the hypothenar region, fifth finger, and ulnar aspect of the ring finger. (Joynt, Clinical Neurology, 1995, Ch51, p43)

Synonym
Cubital Tunnel Syndrome
Ulnar Nerve Compression, Cubital Tunnel
Ulnar Nerve Entrapment, Elbow

Excerpt	Reference
"Cubital tunnel syndrome is the second most commonly encountered compression neuropathy of the upper limb."	( Ch'ng, S; Griffin, PA; Nikitins, MD; Rice, NJ, 2002)

Excerpt	Reference
"Our management of cubital tunnel syndrome has expanded to involve multiple adjunctive procedures, including supercharged end-to-side anterior interosseous to ulnar nerve transfer, cross-palm nerve grafts from the median to ulnar nerve, and profundus tenodesis."	( Evans, A; Fongsri, W; Kennedy, CR; Mackinnon, SE; Padovano, WM; Patterson, JMM; Wood, MD, 2023)

Excerpt	Reference
"The optimal treatment for cubital tunnel syndrome is widely debated."	( Gu, YD; Jiang, S; Shen, Y; Xu, JG; Xu, W, 2012)
"To review the current progress of treatment of cubital tunnel syndrome (CTS)."	( Fan, C; Liu, S; Yu, S, 2014)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	1 (2.94)	23.3326
1990's	0 (0.00)	12.5806
2000's	6 (17.65)	18.1394
2010's	21 (61.76)	28.8240
2020's	6 (17.65)	9.53

Drug	Relationship Strength	Studies	Trials
uric acid	low	2	0
acetaminophen	low	1	0
lidocaine	medium	1	1
methylprednisolone acetate	medium	1	1
methylprednisolone	medium	4	1
tungsten	low	1	0
trolamine salicylate	low	1	0
hydrocodone	low	1	0
oxycodone	low	1	0

Protein Targets (165)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
RAR-related orphan receptor gamma	3	0	0	3
ATAD5 protein, partial	1	0	0	1
GLS protein	2	0	0	2
Microtubule-associated protein tau	2	0	0	2
Smad3	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	2	0	0	2
thyroid stimulating hormone receptor	1	0	0	1
nuclear receptor subfamily 1, group I, member 3	1	0	0	1
progesterone receptor	2	0	0	2
EWS/FLI fusion protein	1	0	0	1
retinoic acid nuclear receptor alpha variant 1	1	0	0	1
retinoid X nuclear receptor alpha	3	0	0	3
estrogen-related nuclear receptor alpha	2	0	0	2
estrogen nuclear receptor alpha	3	0	0	3
peroxisome proliferator activated receptor gamma	1	0	0	1
aryl hydrocarbon receptor	1	0	0	1
chromobox protein homolog 1	2	0	0	2
thyroid hormone receptor beta isoform 2	1	0	0	1
peripheral myelin protein 22	2	0	0	2
cytochrome P450 3A4 isoform 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	2	0	0	2
ATP-binding cassette sub-family C member 3	0	3	0	3
Multidrug resistance-associated protein 4	0	3	0	3
Solute carrier family 22 member 6	0	1	0	1
Carbonic anhydrase 12	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Bile salt export pump	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	1	0	0	1
Bile salt export pump	0	3	0	3
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Cytochrome P450 3A4	0	1	0	1
Cytochrome P450 2D6	0	1	0	1
Cytochrome P450 2C9	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	2	0	0	2
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	2	0	0	2
UDP-glucuronosyltransferase 1-6	0	0	0	1
Glutamate receptor 2	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	2	0	0	2
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	0	0	1
Carbonic anhydrase 4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	2	0	0	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Prostaglandin G/H synthase 2	0	0	0	1
Carbonic anhydrase 7	0	1	0	1
Nuclear receptor ROR-gamma	1	0	0	1
Cytochrome P450 2J2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-2	2	0	0	2
Carbonic anhydrase 9	0	1	0	1
GABA theta subunit	2	0	0	2
Canalicular multispecific organic anion transporter 1	0	3	0	3
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	2	0	0	2
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
toxin B	0	0	0	1
phosphopantetheinyl transferase	1	0	0	1
lamin isoform A-delta10	2	0	0	2
Solute carrier family 22 member 1	0	2	0	2
Mu-type opioid receptor	0	2	1	3
Kappa-type opioid receptor	0	1	1	2
Mas-related G-protein coupled receptor member X2	0	0	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	2	0	0	2
Chain A, Beta-lactamase	1	0	0	1
thioredoxin reductase	1	0	0	1
TDP1 protein	2	0	0	2
AR protein	3	0	0	3
vitamin D (1,25- dihydroxyvitamin D3) receptor	2	0	0	2
IDH1	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	1	0	0	1
mitogen-activated protein kinase 1	1	0	0	1
flap endonuclease 1	1	0	0	1
geminin	3	0	0	3
muscarinic acetylcholine receptor M1	1	0	0	1
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	3	0	3
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	1	0	0	1
cytochrome P450 2D6	1	0	0	1
acetylcholinesterase	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	1	0	0	1
PPM1D protein	1	0	0	1
GLI family zinc finger 3	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
nonstructural protein 1	1	0	0	1
glucocorticoid receptor [Homo sapiens]	2	0	0	2
pregnane X nuclear receptor	1	0	0	1
G	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	2	0	0	2
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
muscleblind-like protein 1 isoform 1	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Interferon beta	1	0	0	1
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Glucocorticoid receptor	0	2	0	2
Glycine receptor subunit alpha-1	0	2	0	2
Androgen receptor	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Inositol hexakisphosphate kinase 1	1	0	0	1
ATPase family AAA domain-containing protein 5	1	0	0	1
Ataxin-2	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
cytochrome P450 2C9, partial	1	0	0	1
ATP-dependent phosphofructokinase	1	0	0	1
USP1 protein, partial	1	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Delta-type opioid receptor	0	0	1	1
Kappa-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	0	1	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 22 member 6	0	0	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(3)

Research Excerpts

Overview

Context

Treatment

Research

Studies (34)

Protein Targets (165)

Cubital Tunnel Syndrome

Synonyms(3)

Research Excerpts

Overview

Context

Treatment

Research

Studies (34)

Drugs Studied (13)

Protein Targets (165)