Acquired Adult Flatfoot Deformity

Progressive acquired flatfoot in which the arch of the foot is flat only when standing. It is often caused by POSTERIOR TIBIAL TENDON DYSFUNCTION.

Synonym
Talipes Calcaneovalgus
Vertical Talus
Talipes Valgus
Splayfoot
Rigid Flatfoot
Vertical Talus, Congenital
Convex Foot
Acquired Adult Flatfoot Deformity
Flexible Flatfoot
Flatfoot
Flat Feet
Pes Valgus, Congenital Convex
Convex Pes Valgus
Flat Foot
Rocker-Bottom Foot
Pes Planus
Flatfeet

Excerpt	Reference
"Pes planus, or flat foot, is one of the earliest and most common concerns."	( Killam, PE, 1989)
"Adult flatfoot is a common pathology characterized by multiplanar deformity involving hindfoot, midfoot, and forefoot."	( Bianchi, A; Cerbone, V; Malerba, F; Martinelli, N; Parrini, MM; Romeo, G, 2019)
"Flatfoot is a very common static deformity."	( Hacke, C; Hamm, A; Liebau, KH; Mittelmeier, W; Schmitt, AP; Schulze, C, 2022)
"Idiopathic flexible flatfoot is a common condition in children which typically improves with age and remains asymptomatic."	( Małecki, K; Niedzielski, KR; Sibiński, M; Szesz, A, 2023)

Excerpt	Reference
"For treatment of a symptomatic flat foot in a child or an acquired flatfoot from posterior tibial dysfunction in the adult, an understanding of the biomechanics and function of the foot and leg is essential to achieve an excellent outcome."	( Borrelli, AH, 1999)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	89 (58.55)	23.3326
1990's	13 (8.55)	12.5806
2000's	11 (7.24)	18.1394
2010's	20 (13.16)	28.8240
2020's	19 (12.50)	9.53

Drug	Relationship Strength	Studies	Trials
lactic acid	low	1	0
hydrogen carbonate	low	1	0
antipyrine	low	1	0
carisoprodol	low	1	0
glyphosate	low	1	0
apnea	low	1	0
phenylbutazone	low	1	0
pridinol	low	1	0
procaine	low	2	0
thyroxine	low	1	0
penicillamine	low	1	0
methionine	low	1	0
methanesulfonic acid	low	1	0
isoprene	low	1	0
acrylic acid	low	1	0
cyclamic acid	low	1	0
thiazoles	low	1	0
homocystine	low	1	0
technetium	low	2	0
titanium	low	6	0
gold	low	1	0
calcium sulfate	low	3	0
trolamine salicylate	low	34	0
technetium 99m	low	1	0
denotivir	low	1	0
fomesafen	low	1	0
homocysteine	low	1	0
n-formyl-13-dihydrocarminomycin	low	1	0
deamino arginine vasopressin	low	1	0
vendex	medium	3	1
piperidines	low	1	0
hyaluronoglucosaminidase	low	2	0
technetium tc 99m medronate	low	1	0
folic acid	low	1	0
leptin	low	1	0

Protein Targets (197)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
glucocorticoid receptor [Homo sapiens]	7	0	0	7
euchromatic histone-lysine N-methyltransferase 2	7	0	0	7
peripheral myelin protein 22	2	0	0	2
lamin isoform A-delta10	6	0	0	6
Choline O-acetyltransferase	0	1	0	1
ATAD5 protein, partial	2	0	0	2
USP1 protein, partial	5	0	0	5
GLI family zinc finger 3	4	0	0	4
nuclear receptor subfamily 1, group I, member 3	4	0	0	4
retinoic acid nuclear receptor alpha variant 1	4	0	0	4
retinoid X nuclear receptor alpha	4	0	0	4
estrogen nuclear receptor alpha	10	0	0	10
67.9K protein	1	0	0	1
peroxisome proliferator-activated receptor delta	2	0	0	2
chromobox protein homolog 1	3	0	0	3
thyroid hormone receptor beta isoform a	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	4	0	0	4
geminin	3	0	0	3
ATP-binding cassette sub-family C member 3	0	1	0	1
Multidrug resistance-associated protein 4	0	1	0	2
Bile salt export pump	0	4	0	4
Cytochrome P450 2C9	0	2	0	2
Cytochrome P450 2J2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Canalicular multispecific organic anion transporter 1	0	1	0	1
thioredoxin reductase	4	0	0	4
TDP1 protein	3	0	0	3
Microtubule-associated protein tau	3	0	0	3
estrogen-related nuclear receptor alpha	6	0	0	6
arylsulfatase A	1	0	0	1
Bloom syndrome protein isoform 1	2	0	0	2
D(1A) dopamine receptor	2	0	0	2
neuropeptide S receptor isoform A	2	0	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
RAR-related orphan receptor gamma	5	0	0	5
NFKB1 protein, partial	1	0	0	1
thyroid stimulating hormone receptor	4	0	0	4
EWS/FLI fusion protein	2	0	0	2
pregnane X nuclear receptor	5	0	0	5
flap endonuclease 1	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
DNA polymerase iota isoform a (long)	2	0	0	2
DNA polymerase kappa isoform 1	3	0	0	3
cytochrome P450 3A4 isoform 1	2	0	0	2
muscarinic acetylcholine receptor M1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	2	0	0	2
Rap guanine nucleotide exchange factor 3	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit delta	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-2	2	0	0	2
GABA theta subunit	2	0	0	2
Gamma-aminobutyric acid receptor subunit epsilon	2	0	0	2
ATP-dependent phosphofructokinase	2	0	0	2
Cellular tumor antigen p53	4	0	0	4
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	0	1	1
Vasopressin V1a receptor	0	1	1	2
Vasopressin V1b receptor	0	1	1	2
Translocator protein	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	2	0	0	2
Chain A, Dihydrofolate reductase	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
Chain A, Ferritin light chain	1	0	0	1
acid sphingomyelinase	1	0	0	1
glp-1 receptor, partial	1	0	0	1
AR protein	5	0	0	5
aldehyde dehydrogenase 1 family, member A1	4	0	0	4
glucocerebrosidase	1	0	0	1
vitamin D (1,25- dihydroxyvitamin D3) receptor	4	0	0	4
alpha-galactosidase	1	0	0	1
activating transcription factor 6	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
DNA polymerase beta	1	0	0	1
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Alpha-synuclein	1	0	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
Luciferase	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	1	0	0	1
progesterone receptor	2	0	0	2
peroxisome proliferator activated receptor gamma	3	0	0	3
Histone H2A.x	1	0	0	1
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase	0	1	0	1
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase	0	1	0	1
Glutamine synthetase	0	1	0	1
Cytochrome P450 71B1	0	1	0	2
Glutamine synthetase	0	1	0	1
2-dehydro-3-deoxyphosphooctonate aldolase	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
interleukin 8	1	0	0	1
aryl hydrocarbon receptor	3	0	0	3
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	2	0	0	2
cellular tumor antigen p53 isoform a	2	0	0	2
Integrin beta-3	2	0	0	2
Integrin alpha-IIb	2	0	0	2
acetylcholinesterase	1	0	0	1
estrogen receptor 2 (ER beta)	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	4	0	0	4
cytochrome P450 2D6	2	0	0	2
thyroid stimulating hormone receptor	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	2	0	0	2
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
phosphopantetheinyl transferase	4	0	0	4
vitamin D3 receptor isoform VDRA	3	0	0	3
Bile salt export pump	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	1	0	1
pregnane X receptor	1	0	0	1
GLS protein	1	0	0	1
Estrogen receptor 1	0	1	0	1
regulator of G-protein signaling 4	1	0	0	1
nonstructural protein 1	1	0	0	1
G	2	0	0	2
Parkin	1	0	0	1
cytochrome P450 2C9 precursor	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
fMet-Leu-Phe receptor	0	1	0	1
mitogen-activated protein kinase 1	1	0	0	1
survival motor neuron protein isoform d	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
Interferon beta	2	0	0	2
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Histamine H2 receptor	1	0	0	1
TAR DNA-binding protein 43	1	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Cyclooxygenase-2	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Inositol hexakisphosphate kinase 1	2	0	0	2
cytochrome P450 2C9, partial	2	0	0	2
cytochrome P450 2D6 isoform 1	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
thyroid hormone receptor beta isoform 2	2	0	0	2
Spike glycoprotein	1	0	0	1
Inositol monophosphatase 1	1	0	0	1
histone acetyltransferase KAT2A isoform 1	1	0	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
apical membrane antigen 1, AMA1	1	0	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	2	2
UDP-glucuronosyltransferase 1A1	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Solute carrier organic anion transporter family member 1B1	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Acquired Adult Flatfoot Deformity

Synonyms(17)

Research Excerpts

Overview

Treatment

Research

Studies (152)

Protein Targets (197)

Acquired Adult Flatfoot Deformity

Synonyms(17)

Research Excerpts

Overview

Treatment

Research

Studies (152)

Drugs Studied (42)

Protein Targets (197)