rosmanol and Neoplasms

rosmanol has been researched along with Neoplasms* in 2 studies

Reviews

2 review(s) available for rosmanol and Neoplasms

ArticleYear
The Mediterranean Diet as source of bioactive compounds with multi-targeting anti-cancer profile.
    European journal of medicinal chemistry, 2019, Nov-01, Volume: 181

    Many bioactive agents have been extracted from plants or belong to functional foods and have been considered in the treatment of serious and multifactorial diseases, such as cancer. In particular, this review is focused on the anti-cancer properties owned by several natural products typically from the Mediterranean area. In some regions of the South of Italy, a lower cancer incidence has been observed. There is increasing evidence that adherence to a Mediterranean dietary pattern correlates with reduced risk of several cancer types. This could be mainly attributed to the typical lifestyle aspects of the Mediterranean diet, such as high consumption of fruit and vegetables. In this review, the main natural products of the Mediterranean area are discussed, with particular attention on their anti-cancer properties endowed with multi-target profiles.

    Topics: Anticarcinogenic Agents; Antioxidants; Diet, Mediterranean; Fruit; Humans; Neoplasms; Olive Oil; Vegetables; Wine

2019
Diterpenes from rosemary (Rosmarinus officinalis): Defining their potential for anti-cancer activity.
    Cancer letters, 2015, Oct-28, Volume: 367, Issue:2

    Recently, rosemary extracts standardized to diterpenes (e.g. carnosic acid and carnosol) have been approved by the European Union (EU) and given a GRAS (Generally Recognized as Safe) status in the United States by the Food and Drug Administration (FDA). Incorporation of rosemary into our food system and through dietary selection (e.g. Mediterranean Diet) has increased the likelihood of exposure to diterpenes in rosemary. In consideration of this, a more thorough understanding of rosemary diterpenes is needed to understand its potential for a positive impact on human health. Three agents in particular have received the most attention that includes carnosic acid, carnosol, and rosmanol with promising results of anti-cancer activity. These studies have provided evidence of diterpenes to modulate deregulated signaling pathways in different solid and blood cancers. Rosemary extracts and the phytochemicals therein appear to be well tolerated in different animal models as evidenced by the extensive studies performed for approval by the EU and the FDA as an antioxidant food preservative. This mini-review reports on the pre-clinical studies performed with carnosic acid, carnosol, and rosmanol describing their mechanism of action in different cancers.

    Topics: Abietanes; Animals; Antineoplastic Agents, Phytogenic; Diterpenes; Humans; Neoplasms; Phytotherapy; Plant Extracts; Plants, Medicinal; Rosmarinus; Signal Transduction

2015