Compounds > neoandrographolide
Page last updated: 2024-12-11

neoandrographolide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

neoandrographolide: structure in first source; isolated from Andrographis paniculata [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
AndrographisgenusA plant genus of the family ACANTHACEAE. Members contain andrographolide and other DITERPENES and androechin, a CHALCONE.[MeSH]AcanthaceaeA plant family of the order Lamiales. It is characterized by simple leaves in opposite pairs, cystoliths (enlarged cells containing crystals of calcium carbonate), and bilaterally symmetrical and bisexual flowers that are usually crowded together. The common name for Ruellia of wild petunia is easily confused with PETUNIA.[MeSH]
Andrographis paniculataspeciesA plant species in the genus Andrographis, family Acanthaceae. Its bitter tasting leaves have been used in traditional medicine and contain labdane-type diterpene lactone andrographolide.[MeSH]AcanthaceaeA plant family of the order Lamiales. It is characterized by simple leaves in opposite pairs, cystoliths (enlarged cells containing crystals of calcium carbonate), and bilaterally symmetrical and bisexual flowers that are usually crowded together. The common name for Ruellia of wild petunia is easily confused with PETUNIA.[MeSH]

Cross-References

ID SourceID
PubMed CID9848024
CHEMBL ID480853
SCHEMBL ID2225354
MeSH IDM0219794

Synonyms (31)

Synonym
ACON1_000667
neoandrographolide
MEGXP0_000981
NCGC00169477-01
BRD-K66516195-001-01-4
CHEMBL480853
(-)-neoandrographolide
neoandrographiside
27215-14-1
2(5h)-furanone, 3-(2-(5-((beta-d-glucopyranosyloxy)methyl)decahydro-5,8a-dimethyl-2-methylene-1-naphthalenyl)ethyl)-, (1r-(1alpha,4abeta,5alpha,8aalpha))-
xby0z806j2 ,
unii-xby0z806j2
S9157
2(5h)-furanone, 3-(2-((1r,4as,5r,8as)-5-((.beta.-d-glucopyranosyloxy)methyl)decahydro-5,8a-dimethyl-2-methylene-1-naphthalenyl)ethyl)-
5.beta.,9.beta.h,10.alpha.-labda-8(20),13-dien-16-oic acid, 18-(glucosyloxy)-15-hydroxy-, .gamma.-lactone
neoandrographolide (constituent of andrographis) [dsc]
2(5h)-furanone, 3-(2-(5-((.beta.-d-glucopyranosyloxy)methyl)decahydro-5,8a-dimethyl-2-methylene-1-naphthalenyl)ethyl)-, (1r-(1.alpha.,4a.beta.,5.alpha.,8a.alpha.))-
CS-3656
SCHEMBL2225354
W-202147
HY-N0721
AKOS030526126
neoandrographolide, analytical standard
NCGC00169477-02
3-(2-((1r,4as,5r,8as)-5,8a-dimethyl-2-methylene-5-((((2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yl)oxy)methyl)decahydronaphthalen-1-yl)ethyl)furan-2(5h)-one
mfcd07779130
CCG-269552
Q27293767
DTXSID80904895
AS-56986
3-[2-[(4as,5r,8as)-5,8a-dimethyl-2-methylidene-5-[[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-3,4,4a,6,7,8-hexahydro-1h-naphthalen-1-yl]ethyl]-5h-furan-2-one

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)		0.51

Dosage Studied

ExcerptRelevanceReference
" Compared with the model group, the plasma TC levels of experimental groups with AND and NEO at 100 mg/kg dosage decreased by 23."( Hypolipidemic effects of andrographolide and neoandrographolide in mice and rats.
Shi, HX; Wang, CH; Wang, ZT; Yang, T, 2013)		0.65
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (29)

Assay IDTitleYearJournalArticle
AID1347160Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347159Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347149Furin counterscreen qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID339171Immunostimulant activity in sheep RBC-immunized BALB/c albino mouse assessed as hemagglutininating antibody titer at 1 mg/kg, po administered daily for 7 days by microtiter hemagglutinination technique1993Journal of natural products, Jul, Volume: 56, Issue:7
Immunostimulant agents from Andrographis paniculata.
AID1204903Cytotoxicity against human Jurkat T cells assessed as apoptosis after 24 hrs by annexin V-FLUOS/propidium iodide staining-based flow cytometric analysis2015Journal of natural products, Feb-27, Volume: 78, Issue:2
Specificity and inhibitory mechanism of andrographolide and its analogues as antiasthma agents on NF-κB p50.
AID1204909Inhibition of TNF-alpha-stimulated NF-kappaB p50 (unknown origin) expressed in HEK293 cells preincubated for 4 hrs followed by TNF-alpha challenge measured after 24 hrs by secreted alkaline phosphatase reporter assay2015Journal of natural products, Feb-27, Volume: 78, Issue:2
Specificity and inhibitory mechanism of andrographolide and its analogues as antiasthma agents on NF-κB p50.
AID339164Immunostimulant activity in sheep RBC-immunized BALB/c albino mouse assessed as hemagglutininating antibody titer at 4 mg/kg, ip administered on day 7 and 3 prior to immunization measured after 5 days by microtiter hemagglutinination technique1993Journal of natural products, Jul, Volume: 56, Issue:7
Immunostimulant agents from Andrographis paniculata.
AID380100Antimicrobial activity against Bacillus subtilis at 10 ug/ml by disk diffusion assay2006Journal of natural products, Mar, Volume: 69, Issue:3
ent-Labdane diterpenoids from Andrographis paniculata.
AID1544513Induction of neurite outgrowth in rat PC12 cells assessed as neurite bearing cells in absence of 20 ng/ml NGF incubated for 48 hrs by light microscopy2019Bioorganic & medicinal chemistry, 06-01, Volume: 27, Issue:11
Synthesis of andrographolide analogues and their neuroprotection and neurite outgrowth-promoting activities.
AID380104Antimicrobial activity against Candida albicans at 10 ug/ml by disk diffusion assay2006Journal of natural products, Mar, Volume: 69, Issue:3
ent-Labdane diterpenoids from Andrographis paniculata.
AID1204906Binding affinity to 6His-tagged recombinant human NF-kappaB p50 N-terminal domain expressed in Escherichia coli BL21 (DE3) up to 10:1 compound to protein molar ratio after 2 hrs by mass spectrometric analysis2015Journal of natural products, Feb-27, Volume: 78, Issue:2
Specificity and inhibitory mechanism of andrographolide and its analogues as antiasthma agents on NF-κB p50.
AID1544507Cytotoxicity in mouse BV2 cells assessed as reduction in cell viability2019Bioorganic & medicinal chemistry, 06-01, Volume: 27, Issue:11
Synthesis of andrographolide analogues and their neuroprotection and neurite outgrowth-promoting activities.
AID380106Antimicrobial activity against Aspergillus niger at 10 ug/ml by disk diffusion assay2006Journal of natural products, Mar, Volume: 69, Issue:3
ent-Labdane diterpenoids from Andrographis paniculata.
AID339170Immunostimulant activity in sheep RBC-immunized BALB/c albino mouse assessed as macrophage migration index at 1 mg/kg, po administered daily for 7 days measured after 18 to 24 hrs1993Journal of natural products, Jul, Volume: 56, Issue:7
Immunostimulant agents from Andrographis paniculata.
AID1544501Neuroprotective activity against H2O2-induced toxicity in rat PC12 cells assessed as increase in cell viability at 20 uM pretreated for 24 hrs followed by H2O2 challenge and measured after 24 hrs by MTT assay2019Bioorganic & medicinal chemistry, 06-01, Volume: 27, Issue:11
Synthesis of andrographolide analogues and their neuroprotection and neurite outgrowth-promoting activities.
AID1544506Induction of neurite outgrowth in NGF-induced rat PC12 cells assessed as neurite bearing cells cotreated with 20 ng/ml NGF incubated for 48 hrs by light microscopy2019Bioorganic & medicinal chemistry, 06-01, Volume: 27, Issue:11
Synthesis of andrographolide analogues and their neuroprotection and neurite outgrowth-promoting activities.
AID380101Antimicrobial activity against Staphylococcus aureus at 10 ug/ml by disk diffusion assay2006Journal of natural products, Mar, Volume: 69, Issue:3
ent-Labdane diterpenoids from Andrographis paniculata.
AID1544493Antiinflammatory activity in mouse BV2 cells assessed as reduction in LPS-induced NO production at 20 uM incubated for 24 hrs by Griess method2019Bioorganic & medicinal chemistry, 06-01, Volume: 27, Issue:11
Synthesis of andrographolide analogues and their neuroprotection and neurite outgrowth-promoting activities.
AID380102Antimicrobial activity against Escherichia coli at 10 ug/ml by disk diffusion assay2006Journal of natural products, Mar, Volume: 69, Issue:3
ent-Labdane diterpenoids from Andrographis paniculata.
AID383495Antiproliferative activity against human HL60 cells by trypan blue assay2008Journal of natural products, May, Volume: 71, Issue:5
ent-Labdane diterpenoid lactone stereoisomers from Andrographis paniculata.
AID339167Nonspecific immunostimulant activity in sheep RBC-immunized BALB/c albino mouse assessed as macrophage migration index at 4 mg/kg, ip administered on day 7 and 3 prior to immunization measured after 18 to 24 hrs1993Journal of natural products, Jul, Volume: 56, Issue:7
Immunostimulant agents from Andrographis paniculata.
AID1544494Lipophilicity, log P of the compound2019Bioorganic & medicinal chemistry, 06-01, Volume: 27, Issue:11
Synthesis of andrographolide analogues and their neuroprotection and neurite outgrowth-promoting activities.
AID380105Antimicrobial activity against Candida sake at 10 ug/ml by disk diffusion assay2006Journal of natural products, Mar, Volume: 69, Issue:3
ent-Labdane diterpenoids from Andrographis paniculata.
AID380103Antimicrobial activity against Micrococcus luteus at 10 ug/ml by disk diffusion assay2006Journal of natural products, Mar, Volume: 69, Issue:3
ent-Labdane diterpenoids from Andrographis paniculata.
AID1544514Induction of neurite outgrowth in NGF-induced rat PC12 cells assessed as neurite bearing cells at 20 uM cotreated with 20 ng/ml NGF incubated for 48 hrs by methylene blue staining based light microscopy2019Bioorganic & medicinal chemistry, 06-01, Volume: 27, Issue:11
Synthesis of andrographolide analogues and their neuroprotection and neurite outgrowth-promoting activities.
AID1544503Neuroprotective activity against 6-OHDA -induced toxicity in rat PC12 cells assessed as increase in cell viability at 20 uM pretreated for 24 hrs followed by 6-OHDA challenge and measured after 24 hrs by MTT assay2019Bioorganic & medicinal chemistry, 06-01, Volume: 27, Issue:11
Synthesis of andrographolide analogues and their neuroprotection and neurite outgrowth-promoting activities.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (45)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's3 (6.67)18.2507
2000's12 (26.67)29.6817
2010's24 (53.33)24.3611
2020's6 (13.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 28.31

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index28.31 (24.57)
Research Supply Index3.89 (2.92)
Research Growth Index5.01 (4.65)
Search Engine Demand Index34.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (28.31)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (2.08%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other47 (97.92%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
methanol
Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.		2.110alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound		amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite
carbon tetrachloride
Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed). tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.		1.9810chlorocarbon;
chloromethanes		hepatotoxic agent;
refrigerant
sucrose
Saccharum: A plant genus of the family POACEAE widely cultivated in the tropics for the sweet cane that is processed into sugar.		2.2110glycosyl glycosidealgal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent
tert-butylhydroperoxide
tert-Butylhydroperoxide: A direct-acting oxidative stress-inducing agent used to examine the effects of oxidant stress on Ca(2+)-dependent signal transduction in vascular endothelial cells. It is also used as a catalyst in polymerization reactions and to introduce peroxy groups into organic molecules.. tert-butyl hydroperoxide : An alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes.		1.9810alkyl hydroperoxideantibacterial agent;
oxidising agent
trifluoroacetic acid
Trifluoroacetic Acid: A very strong halogenated derivative of acetic acid. It is used in acid catalyzed reactions, especially those where an ester is cleaved in peptide synthesis.. trifluoroacetic acid : A monocarboxylic acid that is the trifluoro derivative of acetic acid.		2.0710fluoroalkanoic acidhuman xenobiotic metabolite;
NMR chemical shift reference compound;
reagent
succinic anhydride
[no description available]		210cyclic dicarboxylic anhydride;
tetrahydrofurandione
malondialdehyde
Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.		1.9810dialdehydebiomarker
glycyrrhizic acid
glycyrrhizinic acid : A triterpenoid saponin that is the glucosiduronide derivative of 3beta-hydroxy-11-oxoolean-12-en-30-oic acid.		3.1410enone;
glucosiduronic acid;
pentacyclic triterpenoid;
tricarboxylic acid;
triterpenoid saponin		EC 3.4.21.5 (thrombin) inhibitor;
plant metabolite
glucose, (beta-d)-isomer
beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.		6.05350D-glucopyranoseepitope;
mouse metabolite
kutkoside
kutkoside: structure in first source		3.1410
phyllanthin
[no description available]		3.1410lignan
lignans
Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)		3.1410
curcumin
Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.. curcumin : A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.		3.1410aromatic ether;
beta-diketone;
diarylheptanoid;
enone;
polyphenol		anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
biological pigment;
contraceptive drug;
dye;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor;
EC 1.8.1.9 (thioredoxin reductase) inhibitor;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
flavouring agent;
food colouring;
geroprotector;
hepatoprotective agent;
immunomodulator;
iron chelator;
ligand;
lipoxygenase inhibitor;
metabolite;
neuroprotective agent;
nutraceutical;
radical scavenger
dinoprostone
prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.		2.0310prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
andrographolide
[no description available]		6.03340carbobicyclic compound;
gamma-lactone;
labdane diterpenoid;
primary alcohol;
secondary alcohol		anti-HIV agent;
anti-inflammatory drug;
antineoplastic agent;
metabolite
ap 10
[no description available]		2.9940diterpene lactonemetabolite
andrographoside
andrographoside: from Andrographis paniculata Nees; structure given in first source		1.9810
14-deoxyandrographolide
14-deoxyandrographolide: from Andrographis paniculata; structure in first source		3.4870
andrograpanin
andrograpanin: an NSAID isolated from Andrographis paniculata; structure in first source		2.7430
calcimycin
Calcimycin: An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.		2.0510benzoxazole
14-deoxy-11,12-didehydroandrographolide
14-deoxy-11,12-didehydroandrographolide: a diterpenoid from Andrographis paniculata; structure in first source		2.9840
andrographoside
[no description available]		2.4420
hypophyllanthin
hypophyllanthin: Anti-inflammatory from Phyllanthus amarus		3.1410
dehydroandrographolide
[no description available]		8.7190
ConditionIndicatedRelationship StrengthStudiesTrials
Delayed Hypersensitivity
[description not available]		01.9810
Acute Confusional Senile Dementia
[description not available]		02.2110
Alzheimer Disease
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)		02.2110
Congenital Zika Syndrome
[description not available]		02.2510
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.2510
Zika Virus Infection
A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.		02.2510
Biliary Calculi
[description not available]		02.610
Gallstones
Solid crystalline precipitates in the BILIARY TRACT, usually formed in the GALLBLADDER, resulting in the condition of CHOLELITHIASIS. Gallstones, derived from the BILE, consist mainly of calcium, cholesterol, or bilirubin.		02.610
2019 Novel Coronavirus Disease
[description not available]		02.610
Injury, Myocardial Reperfusion
[description not available]		02.3110
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.5120
Hyperlipemia
[description not available]		02.0810
Hyperlipidemias
Conditions with excess LIPIDS in the blood.		02.0810
Ear Diseases
Pathological processes of the ear, the hearing, and the equilibrium system of the body.		02.0310
Anasarca
[description not available]		02.0310
Edema
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.		02.0310
Liver Dysfunction
[description not available]		02.9610
Liver Diseases
Pathological processes of the LIVER.		02.9610
Acute Liver Injury, Drug-Induced
[description not available]		01.9810
Chemical and Drug Induced Liver Injury
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.		01.9810