Compounds > andrographoside

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andrographoside

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

andrographoside: from Andrographis paniculata Nees; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Andrographis	genus	A plant genus of the family ACANTHACEAE. Members contain andrographolide and other DITERPENES and androechin, a CHALCONE.[MeSH]	Acanthaceae	A plant family of the order Lamiales. It is characterized by simple leaves in opposite pairs, cystoliths (enlarged cells containing crystals of calcium carbonate), and bilaterally symmetrical and bisexual flowers that are usually crowded together. The common name for Ruellia of wild petunia is easily confused with PETUNIA.[MeSH]
Andrographis paniculata	species	A plant species in the genus Andrographis, family Acanthaceae. Its bitter tasting leaves have been used in traditional medicine and contain labdane-type diterpene lactone andrographolide.[MeSH]	Acanthaceae	A plant family of the order Lamiales. It is characterized by simple leaves in opposite pairs, cystoliths (enlarged cells containing crystals of calcium carbonate), and bilaterally symmetrical and bisexual flowers that are usually crowded together. The common name for Ruellia of wild petunia is easily confused with PETUNIA.[MeSH]
Andrographis	genus	A plant genus of the family ACANTHACEAE. Members contain andrographolide and other DITERPENES and androechin, a CHALCONE.[MeSH]	Acanthaceae	A plant family of the order Lamiales. It is characterized by simple leaves in opposite pairs, cystoliths (enlarged cells containing crystals of calcium carbonate), and bilaterally symmetrical and bisexual flowers that are usually crowded together. The common name for Ruellia of wild petunia is easily confused with PETUNIA.[MeSH]
Andrographis paniculata	species	A plant species in the genus Andrographis, family Acanthaceae. Its bitter tasting leaves have been used in traditional medicine and contain labdane-type diterpene lactone andrographolide.[MeSH]	Acanthaceae	A plant family of the order Lamiales. It is characterized by simple leaves in opposite pairs, cystoliths (enlarged cells containing crystals of calcium carbonate), and bilaterally symmetrical and bisexual flowers that are usually crowded together. The common name for Ruellia of wild petunia is easily confused with PETUNIA.[MeSH]

Cross-References

ID Source	ID
PubMed CID	6439612
MeSH ID	M0111045
PubMed CID	44593583
CHEMBL ID	519275
MeSH ID	M0111045

Synonyms (11)

Synonym
2(3h)-furanone, 3-(2-(5-((beta-d-glucopyranosyloxy)methyl)decahydro-6-hydroxy-5,8a-dimethyl-2-methylene-1-naphthalenyl)ethylidene)dihydro-4-hydroxy-
andrographoside
(3e,4s)-3-[2-[(4as,5r,6r,8as)-6-hydroxy-5,8a-dimethyl-2-methylidene-5-[[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-3,4,4a,6,7,8-hexahydro-1h-naphthalen-1-yl]ethylidene]-4-hydroxyoxolan-2-one
AKOS032948431
andrographiside
CHEMBL519275
NCGC00385287-01
FS-9247
CS-0023446
HY-N2867
AKOS040761352

Research Excerpts

Bioavailability

Excerpt	Reference	Relevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."	( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)	0.51

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (13)

Assay ID	Title	Year	Journal	Article
AID1296008	Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening	2020	SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1	Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347159	Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346986	P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346987	P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347160	Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID380105	Antimicrobial activity against Candida sake at 10 ug/ml by disk diffusion assay	2006	Journal of natural products, Mar, Volume: 69, Issue:3	ent-Labdane diterpenoids from Andrographis paniculata.
AID380100	Antimicrobial activity against Bacillus subtilis at 10 ug/ml by disk diffusion assay	2006	Journal of natural products, Mar, Volume: 69, Issue:3	ent-Labdane diterpenoids from Andrographis paniculata.
AID380106	Antimicrobial activity against Aspergillus niger at 10 ug/ml by disk diffusion assay	2006	Journal of natural products, Mar, Volume: 69, Issue:3	ent-Labdane diterpenoids from Andrographis paniculata.
AID380103	Antimicrobial activity against Micrococcus luteus at 10 ug/ml by disk diffusion assay	2006	Journal of natural products, Mar, Volume: 69, Issue:3	ent-Labdane diterpenoids from Andrographis paniculata.
AID380101	Antimicrobial activity against Staphylococcus aureus at 10 ug/ml by disk diffusion assay	2006	Journal of natural products, Mar, Volume: 69, Issue:3	ent-Labdane diterpenoids from Andrographis paniculata.
AID380104	Antimicrobial activity against Candida albicans at 10 ug/ml by disk diffusion assay	2006	Journal of natural products, Mar, Volume: 69, Issue:3	ent-Labdane diterpenoids from Andrographis paniculata.
AID383495	Antiproliferative activity against human HL60 cells by trypan blue assay	2008	Journal of natural products, May, Volume: 71, Issue:5	ent-Labdane diterpenoid lactone stereoisomers from Andrographis paniculata.
AID380102	Antimicrobial activity against Escherichia coli at 10 ug/ml by disk diffusion assay	2006	Journal of natural products, Mar, Volume: 69, Issue:3	ent-Labdane diterpenoids from Andrographis paniculata.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (15.38)	18.7374
1990's	1 (7.69)	18.2507
2000's	5 (38.46)	29.6817
2010's	1 (7.69)	24.3611
2020's	4 (30.77)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (12.50%)	5.53%
Trials	0 (0.00%)	5.53%
Reviews	1 (12.50%)	6.00%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Observational	0 (0.00%)	0.25%
Other	6 (75.00%)	84.16%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
succinic acid Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851). succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.	3.1	1	0	alpha,omega-dicarboxylic acid; C4-dicarboxylic acid	anti-ulcer drug; fundamental metabolite; micronutrient; nutraceutical; radiation protective agent
carbon tetrachloride Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed). tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.	1.98	1	0	chlorocarbon; chloromethanes	hepatotoxic agent; refrigerant
tert-butylhydroperoxide tert-Butylhydroperoxide: A direct-acting oxidative stress-inducing agent used to examine the effects of oxidant stress on Ca(2+)-dependent signal transduction in vascular endothelial cells. It is also used as a catalyst in polymerization reactions and to introduce peroxy groups into organic molecules.. tert-butyl hydroperoxide : An alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes.	1.98	1	0	alkyl hydroperoxide	antibacterial agent; oxidising agent
malondialdehyde Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.	1.98	1	0	dialdehyde	biomarker
glucose, (beta-d)-isomer beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.	1.98	1	0	D-glucopyranose	epitope; mouse metabolite
ovalbumin Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.	2.05	1	0
andrographolide [no description available]	1.98	1	0	carbobicyclic compound; gamma-lactone; labdane diterpenoid; primary alcohol; secondary alcohol	anti-HIV agent; anti-inflammatory drug; antineoplastic agent; metabolite
neoandrographolide neoandrographolide: structure in first source; isolated from Andrographis paniculata	1.98	1	0
andrographolide [no description available]	2.44	2	0	carbobicyclic compound; gamma-lactone; labdane diterpenoid; primary alcohol; secondary alcohol	anti-HIV agent; anti-inflammatory drug; antineoplastic agent; metabolite
ap 10 [no description available]	2.44	2	0	diterpene lactone	metabolite
neoandrographolide neoandrographolide: structure in first source; isolated from Andrographis paniculata	2.44	2	0
14-deoxyandrographolide 14-deoxyandrographolide: from Andrographis paniculata; structure in first source	2.44	2	0
andrograpanin andrograpanin: an NSAID isolated from Andrographis paniculata; structure in first source	2.44	2	0

Condition	Indicated	Relationship Strength	Studies	Trials
Innate Inflammatory Response [description not available]	0	2.41	1	0
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	0	2.41	1	0
Corynebacterium diphtheriae Infection [description not available]	0	2.6	1	0
Diphtheria A localized infection of mucous membranes or skin caused by toxigenic strains of CORYNEBACTERIUM DIPHTHERIAE. It is characterized by the presence of a pseudomembrane at the site of infection. DIPHTHERIA TOXIN, produced by C. diphtheriae, can cause myocarditis, polyneuritis, and other systemic toxic effects.	0	2.6	1	0
Asthma, Bronchial [description not available]	0	2.05	1	0
Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).	0	2.05	1	0
Bronchial Hyperreactivity Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.	0	2.05	1	0
Encephalitis, Japanese B [description not available]	0	2.92	1	0
Pyrexia [description not available]	0	2.92	1	0
Grippe [description not available]	0	2.92	1	0
Encephalitis, Japanese A mosquito-borne encephalitis caused by the Japanese B encephalitis virus (ENCEPHALITIS VIRUS, JAPANESE) occurring throughout Eastern Asia and Australia. The majority of infections occur in children and are subclinical or have features limited to transient fever and gastrointestinal symptoms. Inflammation of the brain, spinal cord, and meninges may occur and lead to transient or permanent neurologic deficits (including a POLIOMYELITIS-like presentation); SEIZURES; COMA; and death. (From Adams et al., Principles of Neurology, 6th ed, p751; Lancet 1998 Apr 11;351(9109):1094-7)	0	2.92	1	0
Fever An abnormal elevation of body temperature, usually as a result of a pathologic process.	0	2.92	1	0
Influenza, Human An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia.	0	2.92	1	0
Acute Liver Injury, Drug-Induced [description not available]	0	1.98	1	0
Chemical and Drug Induced Liver Injury A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.	0	1.98	1	0
Respiratory Tract Diseases Diseases involving the RESPIRATORY SYSTEM.	0	3.39	1	1
Congenital Zika Syndrome [description not available]	0	2.25	1	0
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	0	2.25	1	0
Zika Virus Infection A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.	0	2.25	1	0