andrograpanin: an NSAID isolated from Andrographis paniculata; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Andrographis | genus | A plant genus of the family ACANTHACEAE. Members contain andrographolide and other DITERPENES and androechin, a CHALCONE.[MeSH] | Acanthaceae | A plant family of the order Lamiales. It is characterized by simple leaves in opposite pairs, cystoliths (enlarged cells containing crystals of calcium carbonate), and bilaterally symmetrical and bisexual flowers that are usually crowded together. The common name for Ruellia of wild petunia is easily confused with PETUNIA.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 11666871 |
| CHEMBL ID | 518137 |
| MeSH ID | M0523629 |
| Synonym |
|---|
| andrograpanin |
| CHEMBL518137 |
| 82209-74-3 |
| unii-89m92udm18 |
| 2(5h)-furanone, 3-(2-((1r,4as,5r,8as)-decahydro-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl)ethyl)- |
| 3,14-dideoxyandrographolide |
| 89m92udm18 , |
| andrograpanin (constituent of andrographis) [dsc] |
| andrograpanin, analytical standard |
| 4-[2-[(1r,4as,5r,8as)-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1h-naphthalen-1-yl]ethyl]-2h-furan-5-one |
| Q27270051 |
| MS-24705 |
| AC-34911 |
| 3-[2-[(1r,4as,5r,8as)-decahydro-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-2(5h)-furanone |
| DTXSID901107773 |
| HY-N9388 |
| CS-0159638 |
| AKOS040759736 |
Andrograpanin is a compound of Andrographis paniculata, which has an important role in many inflammatory diseases. The molecular mechanism of andrograpAnin to combat inflammation is unclear.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Andrograpanin is a compound of Andrographis paniculata, which has an important role in many inflammatory diseases, but the molecular mechanism of andrograpanin to combat inflammation is unclear." | ( Andrograpanin mitigates lipopolysaccharides induced endometritis via TLR4/NF-κB pathway. Chen, Y; Deng, G; Ma, X; Umar, T; Umar, Z; Umer, S; Yin, B, 2022) | 2.89 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID383495 | Antiproliferative activity against human HL60 cells by trypan blue assay | 2008 | Journal of natural products, May, Volume: 71, Issue:5 | ent-Labdane diterpenoid lactone stereoisomers from Andrographis paniculata. |
| AID380103 | Antimicrobial activity against Micrococcus luteus at 10 ug/ml by disk diffusion assay | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3 | ent-Labdane diterpenoids from Andrographis paniculata. |
| AID380101 | Antimicrobial activity against Staphylococcus aureus at 10 ug/ml by disk diffusion assay | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3 | ent-Labdane diterpenoids from Andrographis paniculata. |
| AID380102 | Antimicrobial activity against Escherichia coli at 10 ug/ml by disk diffusion assay | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3 | ent-Labdane diterpenoids from Andrographis paniculata. |
| AID380104 | Antimicrobial activity against Candida albicans at 10 ug/ml by disk diffusion assay | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3 | ent-Labdane diterpenoids from Andrographis paniculata. |
| AID645482 | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method | 2012 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4 | Microbial transformation of deoxyandrographolide and their inhibitory activity on LPS-induced NO production in RAW 264.7 macrophages. |
| AID645483 | Cytotoxicity against mouse RAW264.7 cells assessed as cell viability at 100 uM after 24 hrs by MTT assay | 2012 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4 | Microbial transformation of deoxyandrographolide and their inhibitory activity on LPS-induced NO production in RAW 264.7 macrophages. |
| AID380105 | Antimicrobial activity against Candida sake at 10 ug/ml by disk diffusion assay | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3 | ent-Labdane diterpenoids from Andrographis paniculata. |
| AID380106 | Antimicrobial activity against Aspergillus niger at 10 ug/ml by disk diffusion assay | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3 | ent-Labdane diterpenoids from Andrographis paniculata. |
| AID380100 | Antimicrobial activity against Bacillus subtilis at 10 ug/ml by disk diffusion assay | 2006 | Journal of natural products, Mar, Volume: 69, Issue:3 | ent-Labdane diterpenoids from Andrographis paniculata. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 3 (37.50) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (23.10) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 8 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||