| Assay ID | Title | Year | Journal | Article |
|---|
| AID164329 | Inhibition of PKG (protein kinase G) | 2004 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 14, Issue:7
| Meridianins, a new family of protein kinase inhibitors isolated from the ascidian Aplidium meridianum. |
| AID1237082 | Cytotoxicity against human SH-SY5Y cells assessed as cell viability at 30 uM after 24 hrs by MTT assay relative to control | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15
| Meridianin derivatives as potent Dyrk1A inhibitors and neuroprotective agents. |
| AID1478837 | Inhibition of full-length recombinant human His-tagged GSK3B recombinant in baculovirus expression system using Alexa-Fluor tracer-236 incubated for 60 mins by TR-FRET based Lantha-screen Eu kinase assay | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
| Developing DYRK inhibitors derived from the meridianins as a means of increasing levels of NFAT in the nucleus. |
| AID53190 | Inhibition of cyclin-dependent kinase 1-cyclin B | 2004 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 14, Issue:7
| Meridianins, a new family of protein kinase inhibitors isolated from the ascidian Aplidium meridianum. |
| AID1204837 | Antiplasmodial activity against Plasmodium falciparum D6 infected in human RBC assessed as parasite growth inhibition measured as LDH activity after 72 hrs by plate reader analysis | 2015 | European journal of medicinal chemistry, Jun-15, Volume: 98 | Synthesis, antimalarial and antitubercular activities of meridianin derivatives. |
| AID1237096 | Inhibition of Aurora A (unknown origin) at 0.5 uM relative to control | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15
| Meridianin derivatives as potent Dyrk1A inhibitors and neuroprotective agents. |
| AID1204847 | Selectivity index, ratio of IC50 for Plasmodium falciparum W2 to IC50 for African green monkey VERO cells | 2015 | European journal of medicinal chemistry, Jun-15, Volume: 98 | Synthesis, antimalarial and antitubercular activities of meridianin derivatives. |
| AID606452 | Inhibition of pig brain CK1 delta/epsilon using RRKHAAIGpSAYSITA as substrate | 2011 | Journal of medicinal chemistry, Jul-14, Volume: 54, Issue:13
| Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives. |
| AID54168 | Inhibition of human Cyclin-dependent kinase 5-p35nck5a | 2004 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 14, Issue:7
| Meridianins, a new family of protein kinase inhibitors isolated from the ascidian Aplidium meridianum. |
| AID1237080 | Inhibition of Dyrk1A (unknown origin) using Woodtide as substrate at 0.5 uM after 30 mins by P81 membrane assay in presence of [33P]-g-ATP relative to control | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15
| Meridianin derivatives as potent Dyrk1A inhibitors and neuroprotective agents. |
| AID1478836 | Inhibition of full-length recombinant human GST-tagged Dyrk1a expressed in baculovirus expression system using Alexa-Fluor tracer-236 incubated for 60 mins by TR-FRET based Lantha-screen Eu kinase assay | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
| Developing DYRK inhibitors derived from the meridianins as a means of increasing levels of NFAT in the nucleus. |
| AID1204848 | Selectivity index, ratio of IC50 for Plasmodium falciparum W2 to IC50 for pig LLC-PK1 cells | 2015 | European journal of medicinal chemistry, Jun-15, Volume: 98 | Synthesis, antimalarial and antitubercular activities of meridianin derivatives. |
| AID606465 | Antiproliferative activity against human IMR32 cells by MTS reduction assay | 2011 | Journal of medicinal chemistry, Jul-14, Volume: 54, Issue:13
| Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives. |
| AID1204840 | Cytotoxicity against pig LLC-PK1 cells assessed as cell growth inhibition after 48 hrs by neutral red assay | 2015 | European journal of medicinal chemistry, Jun-15, Volume: 98 | Synthesis, antimalarial and antitubercular activities of meridianin derivatives. |
| AID1204839 | Cytotoxicity against African green monkey Vero cells assessed as cell growth inhibition after 48 hrs by neutral red assay | 2015 | European journal of medicinal chemistry, Jun-15, Volume: 98 | Synthesis, antimalarial and antitubercular activities of meridianin derivatives. |
| AID606453 | Inhibition of pig brain GSK-3alpha/beta using YRRAAVPPSPSLSRHSSPHQSpEDEEE as substrate | 2011 | Journal of medicinal chemistry, Jul-14, Volume: 54, Issue:13
| Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives. |
| AID49211 | Inhibition of Casein kinase I (Not tested) | 2004 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 14, Issue:7
| Meridianins, a new family of protein kinase inhibitors isolated from the ascidian Aplidium meridianum. |
| AID1237093 | Inhibition of GSK3beta (unknown origin) at 0.5 uM relative to control | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15
| Meridianin derivatives as potent Dyrk1A inhibitors and neuroprotective agents. |
| AID606467 | Antiproliferative activity against human PA1 cells after 48 hrs by resazurin reduction test | 2011 | Journal of medicinal chemistry, Jul-14, Volume: 54, Issue:13
| Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives. |
| AID1204838 | Antiplasmodial activity against Plasmodium falciparum W2 infected in human RBC assessed as parasite growth inhibition measured as LDH activity after 72 hrs by plate reader analysis | 2015 | European journal of medicinal chemistry, Jun-15, Volume: 98 | Synthesis, antimalarial and antitubercular activities of meridianin derivatives. |
| AID606462 | Antiproliferative activity against human primary fibroblasts after 48 hrs by resazurin reduction test | 2011 | Journal of medicinal chemistry, Jul-14, Volume: 54, Issue:13
| Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives. |
| AID606454 | Inhibition of human recombinant GST-tagged CLK1 using GRSRSRSRSRSR as substrate | 2011 | Journal of medicinal chemistry, Jul-14, Volume: 54, Issue:13
| Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives. |
| AID1237094 | Inhibition of CDK2 (unknown origin) at 0.5 uM relative to control | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15
| Meridianin derivatives as potent Dyrk1A inhibitors and neuroprotective agents. |
| AID1694920 | Antibiofilm activity against Mycobacterium smegmatis mc2 155 ATCC 700084 assessed as inhibition of biofilm formation measured after 24 hrs by crystal violet reporter assay | 2020 | RSC medicinal chemistry, Jan-01, Volume: 11, Issue:1
| Meridianin D analogues possess antibiofilm activity against |
| AID73829 | Inhibition of glycogen synthase kinase-3 beta | 2004 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 14, Issue:7
| Meridianins, a new family of protein kinase inhibitors isolated from the ascidian Aplidium meridianum. |
| AID606464 | Antiproliferative activity against human SH-SY5Y cells by MTS reduction assay | 2011 | Journal of medicinal chemistry, Jul-14, Volume: 54, Issue:13
| Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives. |
| AID1237100 | Inhibition of IKKbeta (unknown origin) at 0.5 uM relative to control | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15
| Meridianin derivatives as potent Dyrk1A inhibitors and neuroprotective agents. |
| AID1237097 | Inhibition of Aurora B (unknown origin) at 0.5 uM relative to control | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15
| Meridianin derivatives as potent Dyrk1A inhibitors and neuroprotective agents. |
| AID1204841 | Cytotoxicity against human SK-MEL cells assessed as cell growth inhibition after 48 hrs by neutral red assay | 2015 | European journal of medicinal chemistry, Jun-15, Volume: 98 | Synthesis, antimalarial and antitubercular activities of meridianin derivatives. |
| AID1237092 | Inhibition of PKCalpha (unknown origin) at 0.5 uM relative to control | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15
| Meridianin derivatives as potent Dyrk1A inhibitors and neuroprotective agents. |
| AID287279 | Effect on viability of Ehrlich ascites carcinoma cells at 100 ug/mL after 2 hrs by trypan blue dye exclusion test | 2007 | Bioorganic & medicinal chemistry, Feb-01, Volume: 15, Issue:3
| Synthesis and antitumor activity of indolylpyrimidines: marine natural product meridianin D analogues. |
| AID1237101 | Inhibition of Abl (unknown origin) at 0.5 uM relative to control | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15
| Meridianin derivatives as potent Dyrk1A inhibitors and neuroprotective agents. |
| AID287277 | Effect on viability of Ehrlich ascites carcinoma cells at 25 ug/mL after 2 hrs by trypan blue dye exclusion test | 2007 | Bioorganic & medicinal chemistry, Feb-01, Volume: 15, Issue:3
| Synthesis and antitumor activity of indolylpyrimidines: marine natural product meridianin D analogues. |
| AID606466 | Antiproliferative activity against human MCF7 cells after 48 hrs by resazurin reduction test | 2011 | Journal of medicinal chemistry, Jul-14, Volume: 54, Issue:13
| Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives. |
| AID419615 | Inhibition of human GSK3-beta | 2009 | European journal of medicinal chemistry, Jun, Volume: 44, Issue:6
| Fragment and knowledge-based design of selective GSK-3beta inhibitors using virtual screening models. |
| AID1204849 | Antitubercular activity against Mycobacterium tuberculosis H37Rv assessed as parasite growth inhibition after 7 days by broth microdilution assay | 2015 | European journal of medicinal chemistry, Jun-15, Volume: 98 | Synthesis, antimalarial and antitubercular activities of meridianin derivatives. |
| AID1204843 | Cytotoxicity against human BT549 cells assessed as cell growth inhibition after 48 hrs by neutral red assay | 2015 | European journal of medicinal chemistry, Jun-15, Volume: 98 | Synthesis, antimalarial and antitubercular activities of meridianin derivatives. |
| AID164458 | Inhibition of PKA (protein kinase A) | 2004 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 14, Issue:7
| Meridianins, a new family of protein kinase inhibitors isolated from the ascidian Aplidium meridianum. |
| AID1237102 | Inhibition of IGF-1R (unknown origin) at 0.5 uM relative to control | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15
| Meridianin derivatives as potent Dyrk1A inhibitors and neuroprotective agents. |
| AID1142242 | Inhibition of CDK2/cyclinA kinase (unknown origin) at 10 uM | 2014 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 24, Issue:11
| Pim kinase inhibitory and antiproliferative activity of a novel series of meridianin C derivatives. |
| AID1694921 | Antibiofilm activity against Mycobacterium smegmatis mc2 155 ATCC 700084 assessed as dispersion of preformed biofilms measured after 24 hrs by crystal violet reporter assay | 2020 | RSC medicinal chemistry, Jan-01, Volume: 11, Issue:1
| Meridianin D analogues possess antibiofilm activity against |
| AID1237091 | Inhibition of PKBbeta (unknown origin) at 0.5 uM relative to control | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15
| Meridianin derivatives as potent Dyrk1A inhibitors and neuroprotective agents. |
| AID1237099 | Inhibition of CK1 (unknown origin) at 0.5 uM relative to control | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15
| Meridianin derivatives as potent Dyrk1A inhibitors and neuroprotective agents. |
| AID1237104 | Inhibition of VEGFR1 (unknown origin) at 0.5 uM relative to control | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15
| Meridianin derivatives as potent Dyrk1A inhibitors and neuroprotective agents. |
| AID287275 | Cytotoxicity against human U251 cells after 48 hrs by SRB assay | 2007 | Bioorganic & medicinal chemistry, Feb-01, Volume: 15, Issue:3
| Synthesis and antitumor activity of indolylpyrimidines: marine natural product meridianin D analogues. |
| AID606455 | Inhibition of rat recombinant GST-tagged DYRK1A using myelin protein as substrate and [gamma32]-ATP after 30 mins by scintillation counting | 2011 | Journal of medicinal chemistry, Jul-14, Volume: 54, Issue:13
| Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives. |
| AID606463 | Antiproliferative activity against mouse HT22 cells by MTS reduction assay | 2011 | Journal of medicinal chemistry, Jul-14, Volume: 54, Issue:13
| Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives. |
| AID1204842 | Cytotoxicity against human KB cells assessed as cell growth inhibition after 48 hrs by neutral red assay | 2015 | European journal of medicinal chemistry, Jun-15, Volume: 98 | Synthesis, antimalarial and antitubercular activities of meridianin derivatives. |
| AID1237103 | Inhibition of IR (unknown origin) at 0.5 uM relative to control | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15
| Meridianin derivatives as potent Dyrk1A inhibitors and neuroprotective agents. |
| AID1237098 | Inhibition of AMPK (unknown origin) at 0.5 uM relative to control | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15
| Meridianin derivatives as potent Dyrk1A inhibitors and neuroprotective agents. |
| AID1237090 | Inhibition of PKBalpha (unknown origin) at 0.5 uM relative to control | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15
| Meridianin derivatives as potent Dyrk1A inhibitors and neuroprotective agents. |
| AID606469 | Antiproliferative activity against human DU145 cells after 48 hrs by resazurin reduction test | 2011 | Journal of medicinal chemistry, Jul-14, Volume: 54, Issue:13
| Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives. |
| AID287276 | Cytotoxicity against human HEPG2 cells after 48 hrs by SRB assay | 2007 | Bioorganic & medicinal chemistry, Feb-01, Volume: 15, Issue:3
| Synthesis and antitumor activity of indolylpyrimidines: marine natural product meridianin D analogues. |
| AID1478838 | Induction of nuclear translocation of human GFP-tagged NFATc1 expressed in virus infected primary human skeletal muscle myoblasts after 3 hrs by DAPI staining based assay | 2017 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 27, Issue:11
| Developing DYRK inhibitors derived from the meridianins as a means of increasing levels of NFAT in the nucleus. |
| AID287278 | Effect on viability of Ehrlich ascites carcinoma cells at 50 ug/mL after 2 hrs by trypan blue dye exclusion test | 2007 | Bioorganic & medicinal chemistry, Feb-01, Volume: 15, Issue:3
| Synthesis and antitumor activity of indolylpyrimidines: marine natural product meridianin D analogues. |
| AID1204846 | Selectivity index, ratio of IC50 for Plasmodium falciparum D6 to IC50 for pig LLC-PK1 cells | 2015 | European journal of medicinal chemistry, Jun-15, Volume: 98 | Synthesis, antimalarial and antitubercular activities of meridianin derivatives. |
| AID606468 | Antiproliferative activity against human PC3 cells after 48 hrs by resazurin reduction test | 2011 | Journal of medicinal chemistry, Jul-14, Volume: 54, Issue:13
| Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives. |
| AID733179 | Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5
| Inhibiting NF-κB-inducing kinase (NIK): discovery, structure-based design, synthesis, structure-activity relationship, and co-crystal structures. |
| AID1237095 | Inhibition of CDK9 (unknown origin) at 0.5 uM relative to control | 2015 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 25, Issue:15
| Meridianin derivatives as potent Dyrk1A inhibitors and neuroprotective agents. |
| AID606451 | Inhibition of human recombinant CDK5/p25 using Histone H1 and [gamma32]-ATP after 30 mins by scintillation counting | 2011 | Journal of medicinal chemistry, Jul-14, Volume: 54, Issue:13
| Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives. |
| AID1204845 | Selectivity index, ratio of IC50 for Plasmodium falciparum D6 to IC50 for African green monkey VERO cells | 2015 | European journal of medicinal chemistry, Jun-15, Volume: 98 | Synthesis, antimalarial and antitubercular activities of meridianin derivatives. |
| AID1204844 | Cytotoxicity against human SKOV3 cells assessed as cell growth inhibition after 48 hrs by neutral red assay | 2015 | European journal of medicinal chemistry, Jun-15, Volume: 98 | Synthesis, antimalarial and antitubercular activities of meridianin derivatives. |
| AID1796542 | Kinase Inhibition Assay from Article 10.1016/j.bmcl.2004.01.050: \\Meridianins, a new family of protein kinase inhibitors isolated from the ascidian Aplidium meridianum.\\ | 2004 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 14, Issue:7
| Meridianins, a new family of protein kinase inhibitors isolated from the ascidian Aplidium meridianum. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |