isoliensinine has been researched along with Malaria* in 1 studies
1 other study(ies) available for isoliensinine and Malaria
| Article | Year |
|---|---|
Isoliensinine from Cissampelos pariera rhizomes exhibits potential gametocytocidal and anti-malarial activities against Plasmodium falciparum clinical isolates.
The unmet demand for effective malaria transmission-blocking agents targeting the transmissible stages of Plasmodium necessitates intensive discovery efforts. In this study, a bioactive bisbenzylisoquinoline (BBIQ), isoliensinine, from Cissampelos pariera (Menispermaceae) rhizomes was identified and characterized for its anti-malarial activity.. Malaria SYBR Green I fluorescence assay was performed to evaluate the in vitro antimalarial activity against D6, Dd2, and F32-ART5 clones, and immediate ex vivo (IEV) susceptibility for 10 freshly collected P. falciparum isolates. To determine the speed- and stage-of-action of isoliensinine, an IC. Isoliensinine displayed a potent in vitro gametocytocidal activity at mean IC. These findings highlight considerable grounds for further exploration of isoliensinine as an amenable scaffold for malaria transmission-blocking chemistry and target validation. Topics: Antimalarials; Cissampelos; Humans; Malaria; Malaria, Falciparum; Plasmodium falciparum; Rhizome | 2023 |