helicide and Neuralgia

Natural helicid (4-formylphenyl-O-β-d-allopyranoside), a main active constituent from seeds of the Chinese herb Helicia nilagirica, has been reported to exert a sedative, analgesic and hypnotic effect, and is used clinically to treat neurasthenic syndrome, vascular headaches and trigeminal neuralgia. In the current study, mechanical allodynia tests, electroencephalograms, electromyogram recordings and c-Fos expression in neuropathic pain-like model mice of partial sciatic nerve ligation were used to investigate the effect of helicid on neuropathic pain and co-morbid insomnia. Our results showed that helicid at a dose of 100, 200 or 400 mg kg

Topics: Analgesics; Animals; Benzaldehydes; Disease Models, Animal; Electroencephalography; Electromyography; Genes, fos; Gyrus Cinguli; Hyperalgesia; Hypnotics and Sedatives; Hypothalamic Area, Lateral; Ligation; Male; Mice; Neuralgia; Preoptic Area; Sciatic Nerve; Sleep; Sleep Initiation and Maintenance Disorders