4-aminobutyrate transaminase complex

Definition

Target type: cellularcomponent

A homodimeric protein complex that possesses 4-aminobutyrate transaminase activity. [GOC:mah, PMID:15528998]

The 4-aminobutyrate transaminase (GABA-T) complex is a multi-protein assembly found primarily in the mitochondria of neurons and astrocytes. This complex plays a crucial role in the metabolism of the neurotransmitter GABA. The core of the complex is formed by two copies of the GABA-T enzyme, which catalyzes the reversible transamination of GABA to succinic semialdehyde. The GABA-T complex also includes several other proteins, including:

1. **Mitochondrial import receptor subunits** (TOM20, TOM22, TOM40, TOM70): These proteins are involved in the import of GABA-T and other mitochondrial proteins from the cytosol into the mitochondrial matrix.
2. **Mitochondrial matrix chaperones** (Hsp60, Hsp70): These chaperones help to maintain the proper folding and assembly of GABA-T and other mitochondrial proteins.
3. **Mitochondrial matrix enzymes** (succinic semialdehyde dehydrogenase, glutamate dehydrogenase): These enzymes participate in the downstream metabolic pathways of GABA.

The complex assembly is essential for the efficient and regulated metabolism of GABA. The interaction between GABA-T and other components of the complex facilitates substrate channeling and prevents the accumulation of potentially toxic intermediates. Additionally, the association of GABA-T with the mitochondrial matrix promotes its localization to the appropriate cellular compartment and protects it from proteolytic degradation.'
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Proteins (1)

Compounds (16)