Page last updated: 2024-10-24

4-aminobutyrate:2-oxoglutarate transaminase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate. [EC:2.6.1.19, GOC:mah]

4-Aminobutyrate:2-oxoglutarate transaminase activity, also known as GABA transaminase, is an enzymatic reaction that catalyzes the transfer of an amino group from gamma-aminobutyric acid (GABA) to alpha-ketoglutarate. This reaction results in the formation of succinic semialdehyde and glutamate. GABA transaminase plays a crucial role in the metabolism of the neurotransmitter GABA by converting it into an inactive form. This enzyme is involved in the regulation of neuronal excitability and is a target for various medications used in the treatment of neurological disorders, including epilepsy and anxiety. The molecular function of GABA transaminase can be summarized as the transfer of an amino group from GABA to alpha-ketoglutarate, ultimately leading to the inactivation of GABA and regulation of neuronal activity.'
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Proteins (1)

ProteinDefinitionTaxonomy
4-aminobutyrate aminotransferase, mitochondrialA 4-aminobutyrate aminotransferase, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:P80404]Homo sapiens (human)

Compounds (16)

CompoundDefinitionClassesRoles
gamma-aminobutyric acidgamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.

gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid
human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule
4-hydroxybenzyl alcohol4-hydroxybenzyl alcohol: the aglycone of gastrodin

p-hydroxybenzyl alcohol : A member of the class of benzyl alcohols that is benzyl alcohol substituted by a hydroxy group at position 4. It has been isolated from Arcangelisia gusanlung.
benzyl alcohols;
phenols
plant metabolite
4-hydroxybenzaldehydehydroxybenzaldehydeEC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor;
mouse metabolite;
plant metabolite
4-hydroxybenzoic acid4-hydroxybenzoic acid : A monohydroxybenzoic acid that is benzoic acid carrying a hydroxy substituent at C-4 of the benzene ring.monohydroxybenzoic acidalgal metabolite;
plant metabolite
anthranilic acidanthranilic acid : An aminobenzoic acid that is benzoic acid having a single amino substituent located at position 2. It is a metabolite produced in L-tryptophan-kynurenine pathway in the central nervous system.

anthranilic acid: RN given refers to parent cpd; structure in Negwer, 5th ed, #565
aminobenzoic acidhuman metabolite;
mouse metabolite
4-aminobenzoic acid4-aminobenzoic acid : An aminobenzoic acid in which the amino group is para to the carboxy group.

4-Aminobenzoic Acid: An aminobenzoic acid isomer that combines with pteridine and GLUTAMIC ACID to form FOLIC ACID. The fact that 4-aminobenzoic acid absorbs light throughout the UVB range has also resulted in its use as an ingredient in SUNSCREENS.

4-ammoniobenzoate : A zwitterion obtained by transfer of a proton from the carboxy to the amino group of 4-aminobenzoic acid.
aminobenzoic acid;
aromatic amino-acid zwitterion
allergen;
Escherichia coli metabolite;
plant metabolite
vanillinVanilla: A plant genus of the family ORCHIDACEAE that is the source of the familiar flavoring used in foods and medicines (FLAVORING AGENTS).benzaldehydes;
monomethoxybenzene;
phenols
anti-inflammatory agent;
anticonvulsant;
antioxidant;
flavouring agent;
plant metabolite
vigabatringamma-amino acidanticonvulsant;
EC 2.6.1.19 (4-aminobutyrate--2-oxoglutarate transaminase) inhibitor
4-hydroxypropiophenoneacetophenones
3-aminobenzoic acid3-aminobenzoic acid : An aminobenzoic acid carrying an amino group at position 3.

3-aminobenzoic acid: RN given refers to parent cpd
aminobenzoic acid
4-hydroxyacetophenone4-hydroxyacetophenone: promotes secretion of bile & bile salts, which promotes griseofulvin absorption in the duodenum

4'-hydroxyacetophenone : A monohydroxyacetophenone carrying a hydroxy substituent at position 4'.
monohydroxyacetophenonefungal metabolite;
mouse metabolite;
plant metabolite
4-anisaldehyde4-anisaldehyde: RN given refers to cpd with specified locants for methoxy moieties; structure in Merck, 9th ed, #696

p-methoxybenzaldehyde : A member of the class of benzaldehydes consisting of benzaldehyde itself carrying a methoxy substituent at position 4.
benzaldehydesbacterial metabolite;
human urinary metabolite;
insect repellent;
plant metabolite
4-hydroxybenzylamine4-hydroxybenzylamine: RN given refers to parent cpdaromatic amine
gastrodingastrodin: the glucoside of 4-hydroxybenzyl alcohol (gastrodigenin); isolated from Gastrodia elata Blume;glycoside
baicaleintrihydroxyflavoneangiogenesis inhibitor;
anti-inflammatory agent;
antibacterial agent;
anticoronaviral agent;
antifungal agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
EC 4.1.1.17 (ornithine decarboxylase) inhibitor;
ferroptosis inhibitor;
geroprotector;
hormone antagonist;
plant metabolite;
prostaglandin antagonist;
radical scavenger
helicidehelicide: structure given in first sourceglycoside