fluciclovine-f-18 and Carcinoma--Squamous-Cell

A 32-year-old woman with a FIGO (International Federation of Gynecology and Obstetrics) stage IIA invasive squamous cell carcinoma of the uterine cervix underwent a clinical FDG PET/CT scan, which revealed intense uptake in the primary. On research F-fluciclovine PET/MRI, the primary showed elevated fluciclovine uptake at 5 and 40 minutes after radiotracer injection, with no evidence of regional or distant metastasis. Fluciclovine PET may have diagnostic value for cervical cancer imaging with a potential advantage over FDG of minimal urinary activity from renal excretion; however, in this patient, the metabolic activity was inferior to that of FDG PET.

Topics: Adult; Carboxylic Acids; Carcinoma, Squamous Cell; Cyclobutanes; Female; Fluorodeoxyglucose F18; Humans; Magnetic Resonance Imaging; Positron Emission Tomography Computed Tomography; Uterine Cervical Neoplasms

Topics: Aged; Carboxylic Acids; Carcinoma, Squamous Cell; Cyclobutanes; Humans; Male; Neoplasm Recurrence, Local; Penile Neoplasms; Positron Emission Tomography Computed Tomography; Prognosis; Prostatic Neoplasms

We present a case of oropharyngeal squamous cell carcinoma (SCC) of the tongue base incidentally detected on F-fluciclovine PET/CT. A 79-year-old man with history of locally advanced prostate cancer (Gleason score 4 + 5 = 9; cT2cN1M0) previously treated with androgen deprivation therapy (luprolide + bicalutamide) presented with a slowly rising serum prostate-specific antigen over 3 years, concerning for recurrent disease. F-fluciclovine PET/CT, obtained to identify potential sites of recurrence, demonstrated prostate bed uptake with possible left seminal vesicle involvement. Additionally, an exophytic, tracer-avid right tongue base mass was incidentally noted and later confirmed to be p16+ SCC on biopsy.

Topics: Aged; Carboxylic Acids; Carcinoma, Squamous Cell; Cyclobutanes; Fluorodeoxyglucose F18; Humans; Incidental Findings; Male; Oropharyngeal Neoplasms; Positron Emission Tomography Computed Tomography; Radiopharmaceuticals

Fluorine-18-labeled 1-amino-3-fluorocyclobutane-1-carboxylic acid (fluciclovine) is a synthetic amino acid radiopharmaceutical initially developed to improve noninvasive diagnosis of gliomas and currently FDA approved for prostate cancer imaging. Although fluciclovine positron emission tomography (PET) has proven to be efficacious in detecting multiple types of cancer, its ability to detect oropharyngeal squamous cell carcinoma (OPSCC) is largely unknown.. We describe a case of incidental OPSCC detection with fluciclovine PET in a 66-year old male patient during workup for recurrent prostate adenocarcinoma.. Fluciclovine PET detected a left base of tongue (BOT) lesion, which was subsequently confirmed as invasive SCC on surgical pathology.. Given these findings, we discuss potential future directions for research with fluciclovine to overcome some of the known limitations of

Topics: Aged; Carboxylic Acids; Carcinoma, Squamous Cell; Cyclobutanes; Humans; Incidental Findings; Male; Oropharyngeal Neoplasms; Positron-Emission Tomography; Radiopharmaceuticals