fluciclovine-f-18 and Uterine-Cervical-Neoplasms

A 32-year-old woman with a FIGO (International Federation of Gynecology and Obstetrics) stage IIA invasive squamous cell carcinoma of the uterine cervix underwent a clinical FDG PET/CT scan, which revealed intense uptake in the primary. On research F-fluciclovine PET/MRI, the primary showed elevated fluciclovine uptake at 5 and 40 minutes after radiotracer injection, with no evidence of regional or distant metastasis. Fluciclovine PET may have diagnostic value for cervical cancer imaging with a potential advantage over FDG of minimal urinary activity from renal excretion; however, in this patient, the metabolic activity was inferior to that of FDG PET.

Topics: Adult; Carboxylic Acids; Carcinoma, Squamous Cell; Cyclobutanes; Female; Fluorodeoxyglucose F18; Humans; Magnetic Resonance Imaging; Positron Emission Tomography Computed Tomography; Uterine Cervical Neoplasms