fluciclovine-f-18 and Neoplasms

fluciclovine-f-18 has been researched along with Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for fluciclovine-f-18 and Neoplasms

Article	Year
Improved synthesis of anti-[18F]FACBC: improved preparation of labeling precursor and automated radiosynthesis. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2003, Volume: 58, Issue:6 The non-natural amino acid anti-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid (FACBC) has shown promise for tumor imaging with positron emission tomography. An improved synthesis of the precursor of anti-[18F]FACBC has been devised which demonstrates high stereoselectivity and suitability for large-scale preparations. An automated radiosynthesis has been developed which provides anti-[18F]FACBC in 24% decay-corrected yield. Additionally, the major non-radioactive species present in doses of anti-[18F]FACBC has been identified as anti-1-amino-3-hydroxycyclobutane-1-carboxylic acid. Together, these results are important steps towards the routine production of anti-[18F]FACBC for human use. Topics: Carboxylic Acids; Cyclobutanes; Humans; Isotope Labeling; Neoplasms; Quality Control; Radiopharmaceuticals; Tomography, Emission-Computed	2003

Article

Year

Improved synthesis of anti-[18F]FACBC: improved preparation of labeling precursor and automated radiosynthesis.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2003, Volume: 58, Issue:6

The non-natural amino acid anti-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid (FACBC) has shown promise for tumor imaging with positron emission tomography. An improved synthesis of the precursor of anti-[18F]FACBC has been devised which demonstrates high stereoselectivity and suitability for large-scale preparations. An automated radiosynthesis has been developed which provides anti-[18F]FACBC in 24% decay-corrected yield. Additionally, the major non-radioactive species present in doses of anti-[18F]FACBC has been identified as anti-1-amino-3-hydroxycyclobutane-1-carboxylic acid. Together, these results are important steps towards the routine production of anti-[18F]FACBC for human use.

Topics: Carboxylic Acids; Cyclobutanes; Humans; Isotope Labeling; Neoplasms; Quality Control; Radiopharmaceuticals; Tomography, Emission-Computed

2003