fluciclovine-f-18 and beta-Thalassemia

We present a case demonstrating increased diagnostic difficulty in interpretation of F-flucyclovine PET/CT in a patient with beta-thalassemia. F-flucyclovine PET/CT demonstrated diffuse increased marrow activity. Additional findings of extramedullary hematopoiesis including intrasplenic extramedullary hematopoiesis are presented. Despite the background marrow activity, an osseous metastatic lesion representing recurrent metastatic prostate carcinoma was identified. This case demonstrates a spectrum of findings of F-flucyclovine uptake in thalassemia, which increased the difficulty of identifying recurrent disease.

Topics: Aged; beta-Thalassemia; Carboxylic Acids; Cyclobutanes; Hematopoiesis, Extramedullary; Humans; Male; Positron Emission Tomography Computed Tomography; Prostatic Neoplasms; Recurrence