fluciclovine-f-18 and Atherosclerosis

fluciclovine-f-18 has been researched along with Atherosclerosis* in 1 studies

Other Studies

1 other study(ies) available for fluciclovine-f-18 and Atherosclerosis

Article	Year
In vivo alpha-V beta-3 integrin expression in human aortic atherosclerosis. Heart (British Cardiac Society), 2019, Volume: 105, Issue:24 Intraplaque angiogenesis and inflammation are key promoters of atherosclerosis and are mediated by the alpha-V beta-3 (α. Vascular 18F-fluciclatide binding was evaluated using ex vivo analysis of carotid endarterectomy samples with autoradiography and immunohistochemistry, and in vivo kinetic modelling following radiotracer administration. Forty-six subjects with a spectrum of atherosclerotic disease categorised as stable (n=27) or unstable (n=19; recent myocardial infarction) underwent PET and CT imaging of the thorax after administration of 229 (IQR 217-237) MBq 18F-fluciclatide. Thoracic aortic 18F-fluciclatide uptake was quantified on fused PET-CT images and corrected for blood-pool activity using the maximum tissue-to-background ratio (TBR. In vivo expression of α Topics: Aged; Aorta, Thoracic; Aortic Diseases; Atherosclerosis; Carboxylic Acids; Carotid Stenosis; Cyclobutanes; Female; Humans; Image Interpretation, Computer-Assisted; Integrin alphaVbeta3; Male; Middle Aged; Myocardial Infarction; Positron Emission Tomography Computed Tomography; Radiopharmaceuticals; Vascular Calcification	2019

Article

Year

In vivo alpha-V beta-3 integrin expression in human aortic atherosclerosis.

Heart (British Cardiac Society), 2019, Volume: 105, Issue:24

Intraplaque angiogenesis and inflammation are key promoters of atherosclerosis and are mediated by the alpha-V beta-3 (α. Vascular 18F-fluciclatide binding was evaluated using ex vivo analysis of carotid endarterectomy samples with autoradiography and immunohistochemistry, and in vivo kinetic modelling following radiotracer administration. Forty-six subjects with a spectrum of atherosclerotic disease categorised as stable (n=27) or unstable (n=19; recent myocardial infarction) underwent PET and CT imaging of the thorax after administration of 229 (IQR 217-237) MBq 18F-fluciclatide. Thoracic aortic 18F-fluciclatide uptake was quantified on fused PET-CT images and corrected for blood-pool activity using the maximum tissue-to-background ratio (TBR. In vivo expression of α

Topics: Aged; Aorta, Thoracic; Aortic Diseases; Atherosclerosis; Carboxylic Acids; Carotid Stenosis; Cyclobutanes; Female; Humans; Image Interpretation, Computer-Assisted; Integrin alphaVbeta3; Male; Middle Aged; Myocardial Infarction; Positron Emission Tomography Computed Tomography; Radiopharmaceuticals; Vascular Calcification

2019