Page last updated: 2024-12-08
columbin
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Description
columbin: from Tinospora Cordifolia Miers & Calumbae Radix (the root of Jateorhiza columba MIERS, Menispermacea) ; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Related Flora
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Jateorhiza | genus | [no description available] | Menispermaceae | A plant family of the order Ranunculales, subclass Magnoliidae, class Magnoliopsida. Members are mostly vines and shrubs and they contain isoquinoline alkaloids, some of which have been used as arrow poisons.[MeSH] |
| Tinospora | genus | A plant genus of the family MENISPERMACEAE. Members have been used in AYURVEDIC MEDICINE. Hypoglycemic effect has been reported.[MeSH] | Menispermaceae | A plant family of the order Ranunculales, subclass Magnoliidae, class Magnoliopsida. Members are mostly vines and shrubs and they contain isoquinoline alkaloids, some of which have been used as arrow poisons.[MeSH] |
| Jateorhiza columba | species | [no description available] | Menispermaceae | A plant family of the order Ranunculales, subclass Magnoliidae, class Magnoliopsida. Members are mostly vines and shrubs and they contain isoquinoline alkaloids, some of which have been used as arrow poisons.[MeSH] |
| Tinospora cordifolia | species | [no description available] | Menispermaceae | A plant family of the order Ranunculales, subclass Magnoliidae, class Magnoliopsida. Members are mostly vines and shrubs and they contain isoquinoline alkaloids, some of which have been used as arrow poisons.[MeSH] |
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 442015 |
| CHEBI ID | 3829 |
| SCHEMBL ID | 2153783 |
| MeSH ID | M0172985 |
Synonyms (16)
| Synonym |
|---|
| C09077 , |
| 546-97-4 |
| columbin |
| SCHEMBL2153783 |
| CHEBI:3829 |
| AC-34240 |
| columbin, >=95% (lc/ms-elsd) |
| AKOS030573585 |
| CS-6235 |
| HY-N0389 |
| Q27106207 |
| 2-(furan-3-yl)-7-hydroxy-6a,10b-dimethyl-1,2,4a,5,6,6a,7,10,10a,10b-decahydro-4h-10,7-(epoxymethano)naphtho[2,1-c]pyran-4,12-dione |
| DTXSID70969857 |
| (1r,2s,3s,5s,8r,11r,12r)-5-(furan-3-yl)-12-hydroxy-3,11-dimethyl-6,14-dioxatetracyclo[10.2.2.02,11.03,8]hexadec-15-ene-7,13-dione |
| (2s,4ar,6ar,7r,10r,10as,10bs)-2-(furan-3-yl)-7-hydroxy-6a,10b-dimethyl-4a,5,6,6a,7,10,10a,10b-octahydro-1h-10,7-(epoxymethano)benzo[f]isochromene-4,12(2h)-dione |
| AS-82882 |
Research Excerpts
Pharmacokinetics
| Excerpt | Reference | Relevance |
|---|---|---|
| " The validated method was used to determine the pharmacokinetic profile of columbin in Wistar rats, and its transport characteristics in the Caco-2 cell culture model." | ( Development and validation of an UPLC-MS/MS method for the quantification of columbin in biological matrices: Applications to absorption, metabolism, and pharmacokinetic studies. Gao, S; Hu, M; Sun, R; Yang, G; Yin, T, 2015) | 0.42 |
Bioavailability
The results showed that columbin was poorly bioavailable (2)
| Excerpt | Reference | Relevance |
|---|---|---|
| " The purpose of the present study was to examine in vivo pharmacokinetics and bioavailability of columbin in rats using a high-performance liquid chromatography coupled with tandem mass spectrometry quantitative detection method." | ( Quantitative LC/MS/MS method and pharmacokinetic studies of columbin, an anti-inflammation furanoditerpen isolated from Radix Tinosporae. Chen, C; Li, H; Liang, M; Liu, R; Pan, Q; Shen, Y; Shi, Q; Wang, X; Zhang, C; Zhang, W, 2007) | 0.34 |
| " The results showed that columbin was poorly bioavailable (2." | ( Development and validation of an UPLC-MS/MS method for the quantification of columbin in biological matrices: Applications to absorption, metabolism, and pharmacokinetic studies. Gao, S; Hu, M; Sun, R; Yang, G; Yin, T, 2015) | 0.42 |
Dosage Studied
| Excerpt | Relevance | Reference |
|---|---|---|
| " They were fed the experimental diets mixed with columbin (4, 20, and 100 ppm) for 4 weeks, starting 1 week before the first dosing of AOM and thereafter maintained on the basal diet without columbin." | ( A bitter diterpenoid furanolactone columbin from Calumbae Radix inhibits azoxymethane-induced rat colon carcinogenesis. Kohno, H; Maeda, M; Mori, H; Sugie, S; Tanaka, T; Tanino, M; Tsukio, Y; Ueda, N; Wada, K, 2002) | 0.31 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Drug Classes (2)
| Class | Description |
|---|---|
| organic heterotricyclic compound | An organic tricyclic compound in which at least one of the rings of the tricyclic skeleton contains one or more heteroatoms. |
| organooxygen compound | An organochalcogen compound containing at least one carbon-oxygen bond. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
Research
Studies (14)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 5 (35.71) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 14 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||