Compounds > 1,1,1,2-tetrachloroethane
Page last updated: 2024-09-21

1,1,1,2-tetrachloroethane

Description

1,1,1,2-tetrachloroethane: see also record for tetrachloroethane [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID12418
CHEMBL ID155816
CHEBI ID34024
SCHEMBL ID2565
MeSH IDM0098539

Synonyms (50)

Synonym
BIDD:ER0593
1,1,1,2-tetrachlorethane
CHEBI:34024 ,
1,1,1,2-tetrachloraethan
inchi=1/c2h2cl4/c3-1-2(4,5)6/h1h
1,1,1,2-tetrachloroethane
ethane, 1,1,1,2-tetrachloro-
630-20-6
nci-c52459
einecs 211-135-1
rcra waste number u208
brn 1733216
rcra waste no. u208
tetrachloroethane, 1,1,1,2-
ccris 577
hsdb 4148
CHEMBL155816
1,1,1,2-tetrachloro-ethane
S0647
T0695
NCGC00248924-01
alpha,beta,beta,beta-tetrachloroethyl
ethyl, 1,2,2,2-tetrachloro-
23425-39-0
cas-630-20-6
NCGC00258661-01
dtxsid2021317 ,
dtxcid801317
tox21_201109
AKOS006228374
25322-20-7
4-01-00-00143 (beilstein handbook reference)
0s5mke574x ,
unii-0s5mke574x
SCHEMBL2565
1,1,1,2-tetrachloroethane [hsdb]
hcc 130a
1,1,1,2-tetrachloroethane [iarc]
f 130a
(chloromethyl)trichloromethane
ch2clccl3
mfcd00000807
1,1,1,2-tetrachloroethane, analytical standard
1,1,1,2-tetrachloroethane, reagentplus(r), 99%
1,1,1,2-tetrachloroethane 100 microg/ml in methanol
FT-0750803
Q161264
D92380
contest group c full
25 - vocs in soil

Drug Classes (1)

ClassDescription
chloroethanesA chloroalkane that is ethane in which one or more of the hydrogens is replaced by chlorine.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (4)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
RAR-related orphan receptor gammaMus musculus (house mouse)Potency28.36460.006038.004119,952.5996AID1159521
SMAD family member 2Homo sapiens (human)Potency64.08130.173734.304761.8120AID1346859
SMAD family member 3Homo sapiens (human)Potency64.08130.173734.304761.8120AID1346859
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency31.82560.000323.4451159.6830AID743065
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID433903Hepatotoxicity in mouse assessed as carcinogenic potency2009European journal of medicinal chemistry, Sep, Volume: 44, Issue:9
Development of QSAR models for predicting hepatocarcinogenic toxicity of chemicals.
AID19825Partition coefficient (logP)1995Journal of medicinal chemistry, Feb-17, Volume: 38, Issue:4
Molecular similarity matrices and quantitative structure-activity relationships: a case study with methodological implications.
AID37562Induction of aneuploidy in Aspergillus nidulans.1995Journal of medicinal chemistry, Feb-17, Volume: 38, Issue:4
Molecular similarity matrices and quantitative structure-activity relationships: a case study with methodological implications.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (26.67)18.7374
1990's3 (20.00)18.2507
2000's4 (26.67)29.6817
2010's4 (26.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (13.33%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (86.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
ethylene dichloride[no description available]medium20chloroethaneshepatotoxic agent;
mutagen;
non-polar solvent
bromoform[no description available]medium10bromohydrocarbon;
bromomethanes
carbon tetrachloride[no description available]medium10chlorocarbon;
chloromethanes		hepatotoxic agent;
refrigerant
chloroform[no description available]medium20chloromethanes;
one-carbon compound		carcinogenic agent;
central nervous system drug;
inhalation anaesthetic;
non-polar solvent;
refrigerant
hexachloroethane[no description available]medium30chlorocarbon;
chloroethanes		carcinogenic agent;
refrigerant
1,1,1-trichloroethane[no description available]medium40chloroethanespolar solvent
bromoethane[no description available]medium10bromoalkane;
bromohydrocarbon;
volatile organic compound		alkylating agent;
carcinogenic agent;
local anaesthetic;
refrigerant;
solvent
bromochloromethane[no description available]medium10halomethane
methylene chloride[no description available]medium20chloromethanes;
volatile organic compound		carcinogenic agent;
polar aprotic solvent;
refrigerant
bromodichloromethane[no description available]medium20halomethaneenvironmental contaminant;
reagent
1,1-dichloroethane[no description available]medium10organochlorine compound
vinylidene chloride[no description available]medium20chloroethenescarcinogenic agent;
mouse metabolite;
mutagen
bromotrichloromethane[no description available]medium10
trichlorofluoromethane[no description available]medium10chlorofluorocarbon;
halomethane		environmental contaminant;
NMR chemical shift reference compound;
NMR solvent;
refrigerant
pentachloroethane[no description available]medium20chloroethanesnon-polar solvent
propylene dichloride[no description available]medium10chloroalkane;
volatile organic compound
2,3-dichloro-1-propene[no description available]medium10
1,1,2-trichloroethane[no description available]medium40chloroethanes
trichloroethylene[no description available]medium60chloroethenesinhalation anaesthetic;
mouse metabolite
1,1,2,2-tetrachloroethane[no description available]medium40chloroethanes
1,2,3-trichloropropane[no description available]medium20organochlorine compound
1-bromo-2-chloroethane[no description available]medium10haloalkane;
organobromine compound;
organochlorine compound		mutagen
butyl bromide[no description available]medium10
butyl chloride[no description available]medium10
1,3-dichloropropane[no description available]medium10chloroalkane;
chlorohydrocarbon		environmental contaminant;
nematicide
1-chloro-2-methylpropene[no description available]medium10organochlorine compound
1-chlorohexane[no description available]medium10
3-chloro-2-methylprop-1-ene[no description available]medium10organochlorine compound
2,2-dichloropropane[no description available]medium10
chlorodibromomethane[no description available]medium10organochlorine compound
tetrachloroethylene[no description available]medium70chlorocarbon;
chloroethenes		nephrotoxic agent
chlordecone[no description available]medium10cyclic ketone;
organochlorine compound		insecticide;
persistent organic pollutant
phenytoin[no description available]medium10imidazolidine-2,4-dioneanticonvulsant;
drug allergen;
sodium channel blocker;
teratogenic agent
dichlorodiphenyl dichloroethylene[no description available]medium10chlorophenylethylene;
monochlorobenzenes		human xenobiotic metabolite;
persistent organic pollutant
4-dichlorobenzene[no description available]medium10dichlorobenzeneinsecticide
sulfasalazine[no description available]medium10
sulfisoxazole[no description available]medium10isoxazoles;
sulfonamide antibiotic;
sulfonamide		antibacterial drug;
drug allergen
trifluralin[no description available]medium10(trifluoromethyl)benzenes;
C-nitro compound;
substituted aniline		agrochemical;
environmental contaminant;
herbicide;
xenobiotic
perthane[no description available]medium10
ethyl chloride[no description available]medium10chloroethanesantipruritic drug;
inhalation anaesthetic;
local anaesthetic
1-amino-2,4-dibromoanthraquinone[no description available]medium10anthraquinone
michler's ketone[no description available]medium10benzophenones
cdec[no description available]medium10thiocarbonyl compound
2,4-diaminotoluene[no description available]medium10aminotoluenemetabolite
4-chloro-1,2-diaminobenzene[no description available]medium10monochlorobenzenes
5-nitro-2-toluidine[no description available]medium10C-nitro compound
5-nitro-2-methoxyaniline[no description available]medium104-nitroanisoles;
substituted aniline
di-(4-aminophenyl)ether[no description available]medium10aromatic ether
1,3-butadiene[no description available]medium10butadienecarcinogenic agent;
mutagen
tetrahydrofuran[no description available]medium10cyclic ether;
oxolanes;
saturated organic heteromonocyclic parent;
volatile organic compound		polar aprotic solvent
tetrafluoroethylene[no description available]medium10fluorocarbon
2-aminoanthraquinone[no description available]medium10anthraquinone
cresidine[no description available]medium10methoxybenzenes
amiben[no description available]medium10chlorobenzoic acid
2,4,5-trimethylaniline[no description available]medium10substituted aniline
4,4'-thiodianiline[no description available]medium10substituted aniline
chlorobenzilate[no description available]medium10diarylmethane
5-nitroacenaphthene[no description available]medium10nitronaphthalene
2,3,7,8-tetrachlorodibenzodioxine[no description available]medium10polychlorinated dibenzodioxine
nitrofen[no description available]medium10organic molecular entityEC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor;
herbicide
1,5-naphthalenediamine[no description available]medium10naphthalenediaminecarcinogenic agent
n-methylamino-2-nitro-4-n',n'-bis(2-hydroxyethyl)aminobenzene[no description available]medium10C-nitro compound
1,2-diphenylhydrazine[no description available]medium10
1,4-dioxane[no description available]medium10dioxane;
volatile organic compound		carcinogenic agent;
metabolite;
NMR chemical shift reference compound;
non-polar solvent
chloroprene[no description available]medium10chloroolefin
(+)-limonene[no description available]medium10limoneneplant metabolite
ethylenethiourea[no description available]medium10imidazolidines
cinnamyl anthranilate[no description available]medium10benzoate ester
dichloroacetic acid[no description available]medium10monocarboxylic acid;
organochlorine compound		astringent;
marine metabolite
ethane[no description available]medium130alkane;
gas molecular entity		plant metabolite;
refrigerant
trichloroacetaldehyde[no description available]medium10aldehyde;
organochlorine compound		mouse metabolite
trichloroacetic acid[no description available]medium10monocarboxylic acid;
organochlorine compound		carcinogenic agent;
metabolite;
mouse metabolite
chloral hydrate[no description available]medium10aldehyde hydrate;
ethanediol;
organochlorine compound		general anaesthetic;
mouse metabolite;
sedative;
xenobiotic
styrene[no description available]medium10styrenes;
vinylarene;
volatile organic compound		mouse metabolite;
mutagen;
plant metabolite
chromium[no description available]medium10chromium cation;
monoatomic hexacation
dithionite[no description available]medium10sulfur oxide;
sulfur oxoanion
chromium[no description available]medium20chromium group element atom;
metal allergen		micronutrient
nitrobenzene[no description available]medium10nitroarene;
nitrobenzenes
silver[no description available]medium10copper group element atom;
elemental silver		Escherichia coli metabolite
1-chloronaphthalene[no description available]medium10
nad[no description available]medium10organophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite
nadp[no description available]medium10
phenobarbital[no description available]medium10barbituratesanticonvulsant;
drug allergen;
excitatory amino acid antagonist;
sedative
ConditionIndicatedRelationship StrengthStudiesTrials
Aneuploid0low10
Aneuploid Cell0low10
Aneuploidy0low10
Benign Neoplasms0low10
Cancer0low10
Experimental Neoplasms0low10
Malignancy0low10
Malignant Neoplasms0low10
Neoplasia0low10
Neoplasm0low10
Neoplasms0low10
Neoplasms, Benign0low10
Neoplasms, Experimental0low10
Tumors0low10

Research Highlights

Safety/Toxicity (1)

ArticleYear
Development of QSAR models for predicting hepatocarcinogenic toxicity of chemicals.
European journal of medicinal chemistry, Volume: 44, Issue: 9		2009
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]