1,1,1,2-tetrachloroethane profile

1,1,1,2-Tetrachloroethane (also known as 1,1,1,2-TeCA or TCA) is a colorless, volatile liquid with a sweet, chloroform-like odor.

**Importance in Research:**

1,1,1,2-Tetrachloroethane is **not** a commonly used research chemical and doesn't have widespread importance in scientific fields. It is **not** known for any specific biological or chemical properties that would make it particularly valuable for research.

**Why it might be mentioned in research:**

* **Historical context:** It might be mentioned in older literature due to its past use as a **solvent and industrial chemical**. However, due to its toxicity, it is no longer widely used in these applications.
* **Environmental studies:** Due to its previous industrial use, it might be a **contaminant in environmental samples**. Researchers may analyze it to study environmental pollution and its potential impact on ecosystems.
* **Toxicological studies:** It could be used in **limited toxicological studies** to understand its effects on organisms. However, these studies would be conducted under strict safety protocols and with appropriate ethical considerations.

**Important Note:**

1,1,1,2-Tetrachloroethane is **highly toxic** and should be handled with extreme caution. Exposure to it can cause serious health problems, including liver damage, respiratory issues, and even death. It is crucial to avoid contact with this chemical and to handle it only under strict laboratory conditions and with proper personal protective equipment.

**Alternatives:**

If you are looking for a chemical with similar properties but less toxicity, it is important to consult with experts in your field to find suitable alternatives. Many safe and effective solvents are available for various research applications.

1,1,1,2-tetrachloroethane: see also record for tetrachloroethane [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	12418
CHEMBL ID	155816
CHEBI ID	34024
SCHEMBL ID	2565
MeSH ID	M0098539

Synonym
BIDD:ER0593
1,1,1,2-tetrachlorethane
CHEBI:34024 ,
1,1,1,2-tetrachloraethan
inchi=1/c2h2cl4/c3-1-2(4,5)6/h1h
1,1,1,2-tetrachloroethane
ethane, 1,1,1,2-tetrachloro-
630-20-6
nci-c52459
einecs 211-135-1
rcra waste number u208
brn 1733216
rcra waste no. u208
tetrachloroethane, 1,1,1,2-
ccris 577
hsdb 4148
CHEMBL155816
1,1,1,2-tetrachloro-ethane
S0647
T0695
NCGC00248924-01
alpha,beta,beta,beta-tetrachloroethyl
ethyl, 1,2,2,2-tetrachloro-
23425-39-0
cas-630-20-6
NCGC00258661-01
dtxsid2021317 ,
dtxcid801317
tox21_201109
AKOS006228374
25322-20-7
4-01-00-00143 (beilstein handbook reference)
0s5mke574x ,
unii-0s5mke574x
SCHEMBL2565
1,1,1,2-tetrachloroethane [hsdb]
hcc 130a
1,1,1,2-tetrachloroethane [iarc]
f 130a
(chloromethyl)trichloromethane
ch2clccl3
mfcd00000807
1,1,1,2-tetrachloroethane, analytical standard
1,1,1,2-tetrachloroethane, reagentplus(r), 99%
1,1,1,2-tetrachloroethane 100 microg/ml in methanol
FT-0750803
Q161264
D92380
contest group c full
25 - vocs in soil

Class	Description
chloroethanes	A chloroalkane that is ethane in which one or more of the hydrogens is replaced by chlorine.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
RAR-related orphan receptor gamma	Mus musculus (house mouse)	Potency	28.3646	0.0060	38.0041	19,952.5996	AID1159521
SMAD family member 2	Homo sapiens (human)	Potency	64.0813	0.1737	34.3047	61.8120	AID1346859
SMAD family member 3	Homo sapiens (human)	Potency	64.0813	0.1737	34.3047	61.8120	AID1346859
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	31.8256	0.0003	23.4451	159.6830	AID743065
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Assay ID	Title	Year	Journal	Article
AID433903	Hepatotoxicity in mouse assessed as carcinogenic potency	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Development of QSAR models for predicting hepatocarcinogenic toxicity of chemicals.
AID19825	Partition coefficient (logP)	1995	Journal of medicinal chemistry, Feb-17, Volume: 38, Issue:4	Molecular similarity matrices and quantitative structure-activity relationships: a case study with methodological implications.
AID37562	Induction of aneuploidy in Aspergillus nidulans.	1995	Journal of medicinal chemistry, Feb-17, Volume: 38, Issue:4	Molecular similarity matrices and quantitative structure-activity relationships: a case study with methodological implications.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	4 (26.67)	18.7374
1990's	3 (20.00)	18.2507
2000's	4 (26.67)	29.6817
2010's	4 (26.67)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (13.33%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	13 (86.67%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
ethylene dichloride ethylene dichloride: RN given refers to 1,2-isomer; structure given in first source. 1,2-dichloroethane : A member of the class of chloroethanes substituted by two chloro groups at positions 1 and 2.	3.48	2	chloroethanes	hepatotoxic agent; mutagen; non-polar solvent
chlordecone [no description available]	2.05	1	cyclic ketone; organochlorine compound	insecticide; persistent organic pollutant
dithionite Dithionite: Dithionite. The dithionous acid ion and its salts.	2.05	1	sulfur oxide; sulfur oxoanion
phenytoin [no description available]	2.05	1	imidazolidine-2,4-dione	anticonvulsant; drug allergen; sodium channel blocker; teratogenic agent
chloral hydrate [no description available]	2.1	1	aldehyde hydrate; ethanediol; organochlorine compound	general anaesthetic; mouse metabolite; sedative; xenobiotic
dichlorodiphenyl dichloroethylene Dichlorodiphenyl Dichloroethylene: An organochlorine pesticide, it is the ethylene metabolite of DDT.	2.05	1	chlorophenylethylene; monochlorobenzenes	human xenobiotic metabolite; persistent organic pollutant
4-dichlorobenzene dichlorobenzene : Any member of the class of chlorobenzenes carrying two chloro groups at unspecified positions.. 1,4-dichlorobenzene : A dichlorobenzene carrying chloro groups at positions 1 and 4.	2.05	1	dichlorobenzene	insecticide
phenobarbital Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.. phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.	3.06	1	barbiturates	anticonvulsant; drug allergen; excitatory amino acid antagonist; sedative
sulfasalazine Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907). sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.	2.05	1
sulfisoxazole Sulfisoxazole: A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms.. sulfisoxazole : A sulfonamide antibacterial with an oxazole substituent. It has antibiotic activity against a wide range of gram-negative and gram-positive organisms.	2.05	1	isoxazoles; sulfonamide antibiotic; sulfonamide	antibacterial drug; drug allergen
bromoform bromoform: structure	1.98	1	bromohydrocarbon; bromomethanes
trifluralin Trifluralin: A microtubule-disrupting pre-emergence herbicide.. trifluralin : A substituted aniline that is N,N-dipropylaniline substituted by a nitro groups at positions 2 and 6 and a trifluoromethyl group at position 4. It is an agrochemical used as a pre-emergence herbicide.	2.05	1	(trifluoromethyl)benzenes; C-nitro compound; substituted aniline	agrochemical; environmental contaminant; herbicide; xenobiotic
carbon tetrachloride Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed). tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.	1.98	1	chlorocarbon; chloromethanes	hepatotoxic agent; refrigerant
chloroform Chloroform: A commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its suspected carcinogenicity.. chloroform : A one-carbon compound that is methane in which three of the hydrogens are replaced by chlorines.	2.41	2	chloromethanes; one-carbon compound	carcinogenic agent; central nervous system drug; inhalation anaesthetic; non-polar solvent; refrigerant
hexachloroethane [no description available]	3.78	3	chlorocarbon; chloroethanes	carcinogenic agent; refrigerant
1,1,1-trichloroethane Trichloroethanes: Chlorinated ethanes which are used extensively as industrial solvents. They have been utilized in numerous home-use products including spot remover preparations and inhalant decongestant sprays. These compounds cause central nervous system and cardiovascular depression and are hepatotoxic. Include 1,1,1- and 1,1,2-isomers.. 1,1,1-trichloroethane : A member of the class of chloroethanes carrying three chloro substituents at position 1.	3.98	4	chloroethanes	polar solvent
perthane perthane: structure	2.05	1
ethane Ethane: A two carbon alkane with the formula H3C-CH3.. ethane : An alkane comprising of two carbon atoms.	5.55	13	alkane; gas molecular entity	plant metabolite; refrigerant
bromoethane bromoethane : A bromoalkane that is ethane carrying a bromo substituent. It is an alkylating agent used as a chemical intermediate in various organic syntheses.	1.98	1	bromoalkane; bromohydrocarbon; volatile organic compound	alkylating agent; carcinogenic agent; local anaesthetic; refrigerant; solvent
bromochloromethane bromochloromethane: inhibitor of ruminal methane production. bromochloromethane : A halomethane that is chloromethane in which one of the hydrogens has been replaced by a bromine atom.	1.98	1	halomethane
ethyl chloride Ethyl Chloride: A gas that condenses under slight pressure. Because of its low boiling point ethyl chloride sprayed on skin produces an intense cold by evaporation. Cold blocks nerve conduction. Ethyl chloride has been used in surgery but is primarily used to relieve local pain in sports medicine.. chloroethane : The simplest and least toxic member of the class of chloroethanes, that is ethane in which a single hydrogen is substituted by a chlorine. A colourless gas at room temperature and pressure (boiling point 12degreeC), it is used as a mild topical anaesthetic to numb the skin prior to ear piercing, skin biopsies, etc., and is also used in the treatment of sports injuries. It was formerly used in the production of tetraethyllead.	2.05	1	chloroethanes	antipruritic drug; inhalation anaesthetic; local anaesthetic
methylene chloride Methylene Chloride: A chlorinated hydrocarbon that has been used as an inhalation anesthetic and acts as a narcotic in high concentrations. Its primary use is as a solvent in manufacturing and food technology.. dichloromethane : A member of the class of chloromethanes that is methane in which two of the hydrogens have been replaced by chlorine. A dense, non-flammible colourless liquid at room temperature (b.p. 40degreeC, d = 1.33) which is immiscible with water, it is widely used as a solvent, a paint stripper, and for the removal of caffeine from coffee and tea.	2.41	2	chloromethanes; volatile organic compound	carcinogenic agent; polar aprotic solvent; refrigerant
bromodichloromethane bromodichloromethane: RN given refers to parent cpd. bromodichloromethane : A halomethane that is dichloromethane in which oneof the hydrogens has been replaced by a bromine atom. It occurs as a contaminant in drinking water.	2.41	2	halomethane	environmental contaminant; reagent
1,1-dichloroethane [no description available]	1.98	1	organochlorine compound
vinylidene chloride vinylidene chloride: potent hepatotoxin. 1,1-dichloroethene : A member of the class of chloroethenes that is ethene in which both of the hydrogens attached to one of the carbons are replaced by chlorines.	2.38	2	chloroethenes	carcinogenic agent; mouse metabolite; mutagen
bromotrichloromethane Bromotrichloromethane: A potent liver poison. In rats, bromotrichloromethane produces about three times the degree of liver microsomal lipid peroxidation as does carbon tetrachloride.	1.98	1
trichlorofluoromethane trichlorofluoromethane: refrigerant, aerosol propellant; RN given refers to parent cpd; structure. trichlorofluoromethane : A one-carbon compound that is methane in which the hydrogens have been replaced by three chlorine and one fluorine atom.	1.98	1	chlorofluorocarbon; halomethane	environmental contaminant; NMR chemical shift reference compound; NMR solvent; refrigerant
trichloroacetaldehyde trichloroacetaldehyde : An organochlorine compound that consists of acetaldehyde where all the methyl hydrogens are replaced by chloro groups.	2.1	1	aldehyde; organochlorine compound	mouse metabolite
pentachloroethane [no description available]	2.41	2	chloroethanes	non-polar solvent
trichloroacetic acid Trichloroacetic Acid: A strong acid used as a protein precipitant in clinical chemistry and also as a caustic for removing warts.. trichloroacetic acid : A monocarboxylic acid that is acetic acid in which all three methyl hydrogens are substituted by chlorine.	2.1	1	monocarboxylic acid; organochlorine compound	carcinogenic agent; metabolite; mouse metabolite
propylene dichloride propylene dichloride: Russian drug; structure. 1,2-dichloropropane : A chloroalkane that is propane in which a hydrogen from each of two adjacent carbons has been replaced by chlorines.	1.98	1	chloroalkane; volatile organic compound
2,3-dichloro-1-propene 2,3-dichloro-1-propene: soil fumigant	1.98	1
1,1,2-trichloroethane 1,1,2-trichloroethane: RN given refers to cpd with locants as specified. 1,1,2-trichloroethane : A member of the class of chloroethanes that is ethane substituted by chloro groups at positions 1, 1 and 2.	4	4	chloroethanes
trichloroethylene Trichloroethylene: A highly volatile inhalation anesthetic used mainly in short surgical procedures where light anesthesia with good analgesia is required. It is also used as an industrial solvent. Prolonged exposure to high concentrations of the vapor can lead to cardiotoxicity and neurological impairment.. triol : A chemical compound containing three hydroxy groups.	4.35	6	chloroethenes	inhalation anaesthetic; mouse metabolite
1,1,2,2-tetrachloroethane 1,1,2,2-tetrachloroethane: see also record for tetrachloroethane. 1,1,2,2-tetrachloroethane : A member of the class of chloroethanes that is ethane substituted by chloro groups at positions 1, 1, 2 and 2.	4.01	4	chloroethanes
dichloroacetic acid [no description available]	2.1	1	monocarboxylic acid; organochlorine compound	astringent; marine metabolite
1-amino-2,4-dibromoanthraquinone 1-amino-2,4-dibromoanthraquinone: intermediate in the production of dyes	2.05	1	anthraquinone
1-chloronaphthalene 1-chloronaphthalene: word preservative; in xylamon the active ingredient is 60% 1-chloronaphthalene; structure in Merck Index, 9th ed, #2126	1.96	1
michler's ketone [no description available]	2.05	1	benzophenones
cdec CDEC: structure	2.05	1	thiocarbonyl compound
2,4-diaminotoluene 2,4-diaminotoluene: RN given refers to unlabeled parent cpd; structure. 2,4-diaminotoluene : An aminotoluene that is para-toluidine with an additional amino group at position 2.	2.05	1	aminotoluene	metabolite
4-chloro-1,2-diaminobenzene 4-chloro-1,2-diaminobenzene: RN given refers to parent cpd	2.05	1	monochlorobenzenes
1,2,3-trichloropropane [no description available]	2.41	2	organochlorine compound
nitrobenzene nitrobenzene : A nitroarene consisting of benzene carrying a single nitro substituent. An industrial chemical used widely in the production of aniline.	2.05	1	nitroarene; nitrobenzenes
5-nitro-2-toluidine 5-nitro-2-toluidine: structure given in first source; RN given refers to parent cpd. 5-nitro-o-toluidine : A C-nitro compound in which the nitro compound is meta to the amino group and para to the methyl group of o-toluidine.	2.05	1	C-nitro compound
5-nitro-2-methoxyaniline 5-nitro-2-methoxyaniline: RN given refers to parent cpd	2.05	1	4-nitroanisoles; substituted aniline
styrene Styrene: A colorless, toxic liquid with a strong aromatic odor. It is used to make rubbers, polymers and copolymers, and polystyrene plastics.. styrene : A vinylarene that is benzene carrying a vinyl group. It has been isolated from the benzoin resin produced by Styrax species.	2.05	1	styrenes; vinylarene; volatile organic compound	mouse metabolite; mutagen; plant metabolite
di-(4-aminophenyl)ether di-(4-aminophenyl)ether: structure	2.05	1	aromatic ether
1,3-butadiene buta-1,3-diene : A butadiene with unsaturation at positions 1 and 3.	2.05	1	butadiene	carcinogenic agent; mutagen
1-bromo-2-chloroethane 1-bromo-2-chloroethane : A haloalkane that is bromoethane substituted by chlorine at position 2.	1.98	1	haloalkane; organobromine compound; organochlorine compound	mutagen
butyl bromide [no description available]	1.98	1
butyl chloride butyl chloride: structure	1.98	1
tetrahydrofuran oxolane : A cyclic ether that is butane in which one hydrogen from each methyl group is substituted by an oxygen.	2.05	1	cyclic ether; oxolanes; saturated organic heteromonocyclic parent; volatile organic compound	polar aprotic solvent
tetrafluoroethylene tetrafluoroethylene: RN given refers to parent cpd; structure	2.05	1	fluorocarbon
2-aminoanthraquinone [no description available]	2.05	1	anthraquinone
cresidine cresidine: structure	2.05	1	methoxybenzenes
amiben Amiben: RN given refers to parent cpd	2.05	1	chlorobenzoic acid
2,4,5-trimethylaniline 2,4,5-trimethylaniline: RN given refers to parent cpd	2.05	1	substituted aniline
4,4'-thiodianiline 4,4'-thiodianiline: structure	2.05	1	substituted aniline
1,3-dichloropropane 1,3-dichloropropane : A chloroalkane that is propane in which a hydrogen from each of the terminal methyl groups has been replaced by a chlorine.	1.98	1	chloroalkane; chlorohydrocarbon	environmental contaminant; nematicide
chlorobenzilate chlorobenzilate: structure	2.05	1	diarylmethane
1-chloro-2-methylpropene [no description available]	1.98	1	organochlorine compound
1-chlorohexane [no description available]	1.98	1
3-chloro-2-methylprop-1-ene [no description available]	1.98	1	organochlorine compound
2,2-dichloropropane 2,2-dichloropropane: a water pollutant	1.98	1
5-nitroacenaphthene [no description available]	2.05	1	nitronaphthalene
2,3,7,8-tetrachlorodibenzodioxine Tetrachlorodibenzodioxin: A mixture of isomers.	2.05	1	polychlorinated dibenzodioxine
nitrofen nitrofen: structure	2.05	1	organic molecular entity	EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor; herbicide
1,5-naphthalenediamine 1,5-diaminonaphthalene: structure in first source. naphthalene-1,5-diamine : A naphthalenediamine compound having amino substituents in the 1- and 5-positions.	2.05	1	naphthalenediamine	carcinogenic agent
n-methylamino-2-nitro-4-n',n'-bis(2-hydroxyethyl)aminobenzene N-methylamino-2-nitro-4-N',N'-bis(2-hydroxyethyl)aminobenzene: structure	2.05	1	C-nitro compound
silver Silver: An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.	2.01	1	copper group element atom; elemental silver	Escherichia coli metabolite
chromium Chromium: A trace element that plays a role in glucose metabolism. It has the atomic symbol Cr, atomic number 24, and atomic weight 52. According to the Fourth Annual Report on Carcinogens (NTP85-002,1985), chromium and some of its compounds have been listed as known carcinogens.. chromium ion : An chromium atom having a net electric charge.. chromium atom : A chromium group element atom that has atomic number 24.	2.47	2	chromium group element atom; metal allergen	micronutrient
chromium chromium hexavalent ion: a human respiratory carcinogen	2.05	1	chromium cation; monoatomic hexacation
1,2-diphenylhydrazine [no description available]	2.05	1
1,4-dioxane 1,4-dioxane: dehydrating agent; polar solvent miscible both with water & most organic solvents. dioxane : Any member of the class of dioxanes that is a cyclohexane in which two carbon atoms are replaced by oxygen atoms.. 1,4-dioxane : A dioxane with oxygen atoms at positions 1 and 4.	2.05	1	dioxane; volatile organic compound	carcinogenic agent; metabolite; NMR chemical shift reference compound; non-polar solvent
chlorodibromomethane [no description available]	1.98	1	organochlorine compound
chloroprene Chloroprene: Toxic, possibly carcinogenic, monomer of neoprene, a synthetic rubber; causes damage to skin, lungs, CNS, kidneys, liver, blood cells and fetuses. Synonym: 2-chlorobutadiene.	2.05	1	chloroolefin
tetrachloroethylene Tetrachloroethylene: A chlorinated hydrocarbon used as an industrial solvent and cooling liquid in electrical transformers. It is a potential carcinogen.	4.49	7	chlorocarbon; chloroethenes	nephrotoxic agent
(+)-limonene (4R)-limonene : An optically active form of limonene having (4R)-configuration.	2.05	1	limonene	plant metabolite
ethylenethiourea Ethylenethiourea: A degradation product of ethylenebis(dithiocarbamate) fungicides. It has been found to be carcinogenic and to cause THYROID hyperplasia.	2.05	1	imidazolidines
nadp [no description available]	1.97	1
cinnamyl anthranilate [no description available]	2.05	1	benzoate ester
nad NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.	1.97	1	organophosphate oxoanion	cofactor; human metabolite; hydrogen acceptor; Saccharomyces cerevisiae metabolite

Condition	Relationship Strength	Studies
Aneuploid [description not available]	1.98	1
Benign Neoplasms [description not available]	2.1	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.1	1
Experimental Neoplasms [description not available]	2.91	1

1,1,1,2-tetrachloroethane

Description

Cross-References

Synonyms (50)

Drug Classes (1)

Protein Targets (4)

Potency Measurements

Bioassays (3)

Research

Studies (15)

Market Indicators

Research Demand Index: 47.90

Study Types