| Assay ID | Title | Year | Journal | Article |
|---|
| AID306697 | Cytostatic activity against human 2209-23 cells | 2007 | Bioorganic & medicinal chemistry letters, May-01, Volume: 17, Issue:9
| Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479. |
| AID1204708 | Inhibition of RSV A2 RNA-dependent RNA polymerase expressed in human Hep2 cells using ATP, GTP, UTP, CTP and 1.5 uCi [alpha-32P] NTP as substrate assessed as reduction of total radiolabled transcript after 90 mins by agarose gel electrophoresis | 2015 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12
| Discovery of β-D-2'-deoxy-2'-α-fluoro-4'-α-cyano-5-aza-7,9-dideaza adenosine as a potent nucleoside inhibitor of respiratory syncytial virus with excellent selectivity over mitochondrial RNA and DNA polymerases. |
| AID1204707 | Antiviral activity against RSV A2 infected in human Hep2 cells assessed as protection against virus-induced cytopathic effect after 4 days by Cell-Titer Glo assay | 2015 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12
| Discovery of β-D-2'-deoxy-2'-α-fluoro-4'-α-cyano-5-aza-7,9-dideaza adenosine as a potent nucleoside inhibitor of respiratory syncytial virus with excellent selectivity over mitochondrial RNA and DNA polymerases. |
| AID493450 | Cytotoxicity against human HuH7 cells by MTS assay | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15
| Synthesis and anti-HCV activity of 3',4'-oxetane nucleosides. |
| AID750143 | Inhibition of HCV 1b NS5b polymerase | 2013 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 23, Issue:11
| Evaluation of 2'-α-fluorine modified nucleoside phosphonates as potential inhibitors of HCV polymerase. |
| AID493448 | Antiviral activity against HCV 1a infected in human HB-1 cells assessed as inhibition of viral RNA replication after 24 hrs | 2010 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 20, Issue:15
| Synthesis and anti-HCV activity of 3',4'-oxetane nucleosides. |
| AID1758995 | Selectivity index, ratio of EC50 for antiviral activity against Measles virus infected in African green monkey Vero cells to CC50 for African green monkey Vero cells | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Enantiomeric 4'-truncated 6'-fluoro-3-deazaneplanocin and its 3-bromo derivative: Synthesis and antiviral properties, including Ebola and Marburg. |
| AID1204711 | Cytotoxicity against human MT4 cells assessed as cell viability after 5 days by Cell-Titer Glo assay | 2015 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12
| Discovery of β-D-2'-deoxy-2'-α-fluoro-4'-α-cyano-5-aza-7,9-dideaza adenosine as a potent nucleoside inhibitor of respiratory syncytial virus with excellent selectivity over mitochondrial RNA and DNA polymerases. |
| AID431226 | Activity of cloned cytidine deaminase in human HuH7 cells by spectrophotometric analysis | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2
| The mechanism of action of beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine involves a second metabolic pathway leading to beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase. |
| AID278932 | Activity of human dCK expressed in HepG2 cells assessed as phosphorylation by coupled enzyme assay | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Mechanism of activation of beta-D-2'-deoxy-2'-fluoro-2'-c-methylcytidine and inhibition of hepatitis C virus NS5B RNA polymerase. |
| AID1758994 | Antiviral activity against Measles virus infected in African green monkey Vero cells by neutral red assay | 2021 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 41 | Enantiomeric 4'-truncated 6'-fluoro-3-deazaneplanocin and its 3-bromo derivative: Synthesis and antiviral properties, including Ebola and Marburg. |
| AID1204709 | Inhibition of human mitochondrial RNA polymerase using 5'-32P-R12/D18 as RNA/DNA template assessed as single nucleotide incorporation rate at 500 uM after 0.17 to 30 mins by PAGE analysis | 2015 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12
| Discovery of β-D-2'-deoxy-2'-α-fluoro-4'-α-cyano-5-aza-7,9-dideaza adenosine as a potent nucleoside inhibitor of respiratory syncytial virus with excellent selectivity over mitochondrial RNA and DNA polymerases. |
| AID431228 | Ratio of Kcat to Km for cloned cytidine deaminase in human HuH7 cells by spectrophotometric analysis | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2
| The mechanism of action of beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine involves a second metabolic pathway leading to beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase. |
| AID278933 | Ratio of Kcat to Km for human dCK expressed in HepG2 cells | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Mechanism of activation of beta-D-2'-deoxy-2'-fluoro-2'-c-methylcytidine and inhibition of hepatitis C virus NS5B RNA polymerase. |
| AID306695 | Antiviral activity against HCV 1b replicon in human 2209-23 cells | 2007 | Bioorganic & medicinal chemistry letters, May-01, Volume: 17, Issue:9
| Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479. |
| AID306696 | Cytotoxicity against human 2209-23 cells | 2007 | Bioorganic & medicinal chemistry letters, May-01, Volume: 17, Issue:9
| Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479. |
| AID1204710 | Inhibition of human mitochondrial DNA polymerase gamma large subunit/DNA polymerase gamma accessory subunit using 32P-D19/D36 as DNA primer/template assessed as single nucleotide incorporation rate at 100 uM after 5 to 90 mins by PAGE analysis relative to | 2015 | Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12
| Discovery of β-D-2'-deoxy-2'-α-fluoro-4'-α-cyano-5-aza-7,9-dideaza adenosine as a potent nucleoside inhibitor of respiratory syncytial virus with excellent selectivity over mitochondrial RNA and DNA polymerases. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |