nucleoside binding

Definition

Target type: molecularfunction

Binding to a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose. [GOC:hjd]

Nucleoside binding is a molecular function that describes the interaction of a protein or other molecule with a nucleoside. Nucleosides are composed of a nitrogenous base (adenine, guanine, cytosine, thymine, or uracil) linked to a pentose sugar (ribose or deoxyribose). This interaction is essential for a wide variety of biological processes, including DNA replication and repair, RNA transcription and translation, and signal transduction. The binding of nucleosides to proteins can be highly specific, with individual proteins recognizing and binding only certain nucleosides or nucleoside analogs. The binding interaction is typically mediated by non-covalent forces, such as hydrogen bonding, van der Waals interactions, and hydrophobic interactions. The specific amino acids involved in nucleoside binding can vary depending on the protein and the nucleoside. However, common binding motifs include the purine-binding motif (PBM), the ribose-binding motif (RBM), and the deoxyribose-binding motif (DBM). These motifs often contain conserved amino acid residues that form hydrogen bonds with the sugar and base moieties of the nucleoside. The binding of nucleosides to proteins can have a number of biological effects. For example, the binding of ATP to enzymes can activate or inhibit their catalytic activity. The binding of nucleotides to DNA polymerase can promote DNA replication. And the binding of guanine nucleotides to G-protein coupled receptors can trigger signal transduction pathways. In summary, nucleoside binding is a fundamental molecular function that is essential for a wide range of biological processes. The interaction of proteins with nucleosides is highly specific and is mediated by non-covalent forces. The binding of nucleosides to proteins can have a variety of biological effects, including activation or inhibition of enzyme activity, promotion of DNA replication, and triggering of signal transduction pathways.'
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Proteins (2)

Compounds (33)