2',6'-dimethyltyrosine has been researched along with tyrosine in 26 studies
| Studies (2',6'-dimethyltyrosine) | Trials (2',6'-dimethyltyrosine) | Recent Studies (post-2010) (2',6'-dimethyltyrosine) | Studies (tyrosine) | Trials (tyrosine) | Recent Studies (post-2010) (tyrosine) |
|---|---|---|---|---|---|
| 27 | 0 | 6 | 44,273 | 846 | 8,225 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (15.38) | 18.2507 |
| 2000's | 16 (61.54) | 29.6817 |
| 2010's | 5 (19.23) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Anthony, E; Beardsley, PM; Chandrakumar, NS; Drury, B; Lopez, OT; Reichman, M; Savage, MA; Stapelfeld, A; Williamson, LN | 1 |
| Amodeo, P; Balboni, G; Crescenzi, O; Guerrini, R; Picone, D; Salvadori, S; Tancredi, T; Temussi, PA | 1 |
| Csösz, M; Manninger, K; Tyihák, E | 1 |
| Ambo, A; Ouchi, H; Sasaki, Y; Suto, T; Yamamoto, Y | 1 |
| Brown, W; Butterworth, J; Labarre, M; McClory, A; Mischki, T; Pagé, D; Payza, K; Schmidt, R; St-Onge, S | 1 |
| Balboni, G; Bianchi, C; Bryant, SD; Calliendo, G; Guerrini, R; Lazarus, LH; Salvadori, S; Santagada, V | 1 |
| Balboni, G; Bianchi, C; Bryant, SD; Caliendo, G; Guerrini, R; Lazarus, LH; Salvadori, S; Santagada, V | 1 |
| Bellemare, D; Brown, W; Coupal, M; Gosselin, M; Labarre, M; Naismith, A; Pagé, D; Payza, K; Schmidt, R | 1 |
| Caliendo, G; Ceccarelli, F; Giusti, L; Mazzoni, MR; Perissutti, E; Salvadori, S; Santagada, V; Severino, B; Temussi, PA | 1 |
| Harrison, BA; Pasternak, GW; Verdine, GL | 1 |
| Bryant, SD; Jinsmaa, Y; Lazarus, LH; Okada, Y; Salvadori, S | 1 |
| Berezowska, I; Chung, NN; Lemieux, C; Schiller, PW; Szeto, HH; Zelent, B | 1 |
| Birk, AV; Schiller, PW; Soong, Y; Szeto, HH; Wu, D; Zhao, GM; Zhao, K | 1 |
| Ben, Y; Lee, NM; Schiller, PW; Smith, AP | 1 |
| Ambo, A; Bryant, SD; Fujita, Y; Jinsmaa, Y; Lazarus, LH; Li, T; Miyazaki, A; Motoyama, T; Niizuma, H; Okada, Y; Sasaki, Y; Tsuda, Y; Yokoi, T | 1 |
| Berezowska, I; Chen, H; Chung, NN; Lemieux, C; Schiller, PW; Weltrowska, G | 1 |
| Chung, NN; Lemieux, C; Leow Augustine, YW; Lu, Y; Lum, TK; Nguyen, TM; Schiller, PW; Weltrowska, G | 1 |
| Blanchfield, JT; Koda, Y; Okada, Y; Shiotani, K; Toth, I; Tsuda, Y | 1 |
| Bryant, SD; Jinsmaa, Y; Lazarus, LH; Li, T; Marczak, ED; Okada, Y; Tsuda, Y | 1 |
| Ambo, A; Bryant, SD; Lazarus, LH; Li, T; Miyazaki, A; Okada, Y; Sasaki, Y; Shiotani, K; Tsuda, Y; Yokoi, T | 1 |
| Ambo, A; Balboni, G; Lazarus, LH; Marczak, ED; Marzola, E; Salvadori, S; Sasaki, Y | 1 |
| Davis, P; Hruby, VJ; Jacobsen, NE; Lai, J; Largent-Milnes, TM; Ma, SW; Nair, P; Porreca, F; Vanderah, TW; Yamamoto, T; Yamamura, HI | 1 |
| do-Rego, JC; Fichna, J; Gach, K; Janecka, A; Janecki, T; Kluczyk, A; Perlikowska, R; Piekielna, J; Toth, G; Wyrębska, A | 1 |
| Benedek, G; Horváth, G; Kovács, G; Mallareddy, JR; Petrovszki, Z; Tóth, G | 1 |
| Balboni, G; Calò, G; Costa, T; Guerrini, R; Molinari, P; Onaran, HO; Vezzi, V | 1 |
| Albanese, V; Cristofori, V; De Ventura, T; Fantinati, A; Illuminati, D; Marzola, E; Oble, J; Perrone, D; Poli, G; Sturaro, C; Trapella, C | 1 |
1 review(s) available for 2',6'-dimethyltyrosine and tyrosine
| Article | Year |
|---|---|
Dmt and opioid peptides: a potent alliance.
Topics: Animals; Opioid Peptides; Receptors, Opioid; Structure-Activity Relationship; Tyrosine | 2003 |
25 other study(ies) available for 2',6'-dimethyltyrosine and tyrosine
| Article | Year |
|---|---|
Analogs of the delta opioid receptor selective cyclic peptide [2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions.
Topics: Amides; Amino Acid Sequence; Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glycine; Male; Mice; Molecular Sequence Data; Muscle Contraction; Neuroblastoma; Peptides, Cyclic; Phenylalanine; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship; Substrate Specificity; Tumor Cells, Cultured; Tyrosine; Vas Deferens | 1992 |
Conformational analysis of potent and very selective delta opioid dipeptide antagonists.
Topics: Dipeptides; Drug Design; Isomerism; Isoquinolines; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Receptors, Opioid, delta; Tetrahydroisoquinolines; Tyrosine | 1995 |
Induction of resistance of wheat plants to pathogens by pretreatment with N-methylated substances.
Topics: Betaine; Fungi; Methylation; Triticum; Tyrosine | 1998 |
Biological properties of opioid peptides replacing Tyr at position 1 by 2,6-dimethyl-Tyr.
Topics: Animals; Enkephalin, Leucine; Guinea Pigs; Isomerism; Mice; Opioid Peptides; Rats; Receptors, Opioid; Structure-Activity Relationship; Tyrosine | 1999 |
Novel Dmt-Tic dipeptide analogues as selective delta-opioid receptor antagonists.
Topics: Benzamides; Binding, Competitive; Dipeptides; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Isoquinolines; Piperazines; Receptors, Opioid, delta; Tetrahydroisoquinolines; Tyrosine | 2000 |
Opioid pseudopeptides containing heteroaromatic or heteroaliphatic nuclei.
Topics: Alanine; Benzimidazoles; Binding Sites; Carbolines; Carboxylic Acids; Dipeptides; Isoquinolines; Kinetics; Ligands; Peptides; Proline; Propionates; Protein Conformation; Receptors, Opioid, delta; Receptors, Opioid, mu; Serine; Tetrahydroisoquinolines; Tyrosine | 2000 |
Assessment of substitution in the second pharmacophore of Dmt-Tic analogues.
Topics: Analgesics; Animals; Binding, Competitive; Dipeptides; Guinea Pigs; Inhibitory Concentration 50; Isoquinolines; Mice; Receptors, Opioid, mu; Structure-Activity Relationship; Tetrahydroisoquinolines; Tyrosine | 2000 |
Novel C-terminus modifications of the Dmt-Tic motif: a new class of dipeptide analogues showing altered pharmacological profiles toward the opioid receptors.
Topics: Dipeptides; Humans; Isoquinolines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetrahydroisoquinolines; Tyrosine | 2001 |
Probing the shape of a hydrophobic pocket in the active site of delta-opioid antagonists.
Topics: Amino Acid Substitution; Animals; Binding Sites; Binding, Competitive; Brain; Dipeptides; Isoquinolines; Molecular Conformation; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Tetrahydroisoquinolines; Thermodynamics; Tyrosine | 2001 |
2,6-Dimethyltyrosine analogues of a stereodiversified ligand library: highly potent, selective, non-peptidic mu opioid receptor agonists.
Topics: Animals; Binding, Competitive; Cell Line; Cerebellum; Cricetinae; Guinea Pigs; Humans; In Vitro Techniques; Ligands; Radioligand Assay; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship; Tyrosine | 2003 |
Highly potent fluorescent analogues of the opioid peptide [Dmt1] DALDA.
Topics: Animals; Cricetinae; Fluorescence; Guinea Pigs; Oligopeptides; Propionates; Receptors, Opioid, mu; Spectrometry, Fluorescence; Tyrosine | 2003 |
Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury.
Topics: Amino Acid Motifs; Animals; Antioxidants; Caco-2 Cells; Calcium; Cardiolipins; Cell Death; Cell Survival; Cytochromes c; Humans; Hydrogen Peroxide; Intracellular Membranes; Liver; Male; Mice; Mitochondria; Mitochondria, Liver; Nitro Compounds; Oxidative Stress; Oxygen; Oxygen Consumption; Peptides; Propionates; Reactive Oxygen Species; Reperfusion; Reperfusion Injury; tert-Butylhydroperoxide; Time Factors; Tyrosine | 2004 |
Tolerance develops in spinal cord, but not in brain with chronic [Dmt1]DALDA treatment.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Mice; Mice, Inbred ICR; Oligopeptides; Pain Measurement; Spinal Cord; Tyrosine | 2004 |
Studies on the structure-activity relationship of 2',6'-dimethyl-l-tyrosine (Dmt) derivatives: bioactivity profile of H-Dmt-NH-CH(3).
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Guinea Pigs; Ilium; Ligands; Male; Mice; Pain; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship; Tyrosine; Vas Deferens | 2005 |
Type and location of fluorescent probes incorporated into the potent mu-opioid peptide [Dmt]DALDA affect potency, receptor selectivity and intrinsic efficacy.
Topics: 2-Naphthylamine; Alanine; Animals; Dansyl Compounds; Fluoresceins; Fluorescent Dyes; Mice; Oligopeptides; ortho-Aminobenzoates; Receptors, Opioid, mu; Tyrosine | 2005 |
Replacement of the N-terminal tyrosine residue in opioid peptides with 3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid (Dcp) results in novel opioid antagonists.
Topics: Benzamides; Molecular Structure; Narcotic Antagonists; Opioid Peptides; Phenylpropionates; Stereoisomerism; Structure-Activity Relationship; Tyrosine | 2006 |
Comparison of the in vitro apparent permeability and stability of opioid mimetic compounds with that of the native peptide.
Topics: Analgesics, Opioid; Blood-Brain Barrier; Caco-2 Cells; Chemistry, Pharmaceutical; Drug Design; Humans; Inhibitory Concentration 50; Injections, Intraventricular; Kinetics; Molecular Conformation; Oligopeptides; Peptides; Permeability; Receptors, Opioid; Tyrosine | 2007 |
[N-allyl-Dmt1]-endomorphins are micro-opioid receptor antagonists lacking inverse agonist properties.
Topics: Analgesics, Opioid; Animals; Brain; Cell Line; Cell Membrane; Cyclic AMP; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Oligopeptides; Protein Binding; Radioligand Assay; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Tyrosine | 2007 |
Design and synthesis of opioidmimetics containing 2',6'-dimethyl-L-tyrosine and a pyrazinone-ring platform.
Topics: Analgesics, Opioid; Drug Design; Molecular Mimicry; Pyrazines; Tyrosine | 2007 |
Role of 2',6'-dimethyl-l-tyrosine (Dmt) in some opioid lead compounds.
Topics: Analgesics, Opioid; Animals; Guinea Pigs; Male; Narcotic Antagonists; Opioid Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Tyrosine | 2010 |
Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies.
Topics: Amino Acid Sequence; Analgesics; Animals; Drug Discovery; Drug Stability; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Humans; Ileum; Magnetic Resonance Spectroscopy; Male; Mice; Micelles; Molecular Conformation; Neurokinin-1 Receptor Antagonists; Peptides; Rats; Receptors, Neurokinin-1; Receptors, Opioid, mu; Receptors, sigma; Structure-Activity Relationship; Tyrosine; Vas Deferens | 2011 |
Effect of 2',6'-dimethyl-L-tyrosine (Dmt) on pharmacological activity of cyclic endomorphin-2 and morphiceptin analogs.
Topics: Amino Acid Sequence; Animals; Drug Interactions; Endorphins; Male; Mice; Oligopeptides; Opioid Peptides; Peptides, Cyclic; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship; Tyrosine | 2011 |
Characterization of antinociceptive potency of endomorphin-2 derivatives with unnatural amino acids in rats.
Topics: Aminobutyrates; Analgesics, Opioid; Animals; Arthralgia; Carboxylic Acids; Chronic Pain; Cyclobutanes; Disease Models, Animal; Drug Design; Edema; Hyperalgesia; Injections, Spinal; Male; Nociceptors; Oligopeptides; p-Fluorophenylalanine; Rats; Rats, Wistar; Tyrosine | 2012 |
Ligands raise the constraint that limits constitutive activation in G protein-coupled opioid receptors.
Topics: Arrestins; beta-Arrestins; Cell Line, Tumor; Computer Simulation; Drug Inverse Agonism; GTP-Binding Proteins; Guanosine Diphosphate; Humans; Ligands; Models, Biological; Quinuclidines; Receptors, Opioid, delta; Receptors, Opioid, mu; Tyrosine | 2013 |
Synthesis of 2,6-Dimethyltyrosine-Like Amino Acids through Pinacolinamide-Enabled C-H Dimethylation of 4-Dibenzylamino Phenylalanine.
Topics: Amino Acids; Phenylalanine; Tyrosine | 2022 |