Page last updated: 2024-12-06

2-chloro-2',3'-dideoxyadenosine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Cross-References

ID SourceID
PubMed CID359064
CHEMBL ID14562
SCHEMBL ID19242566
MeSH IDM0156274

Synonyms (10)

Synonym
mls003373963 ,
nsc-619531
nsc619531
NCI60_005778
2-chloro-2',3'-dideoxyadenosine
CHEMBL14562
smr002048752
SCHEMBL19242566
FT-0774787
PD043020
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
GLS proteinHomo sapiens (human)Potency17.78280.35487.935539.8107AID624170
TDP1 proteinHomo sapiens (human)Potency1.24520.000811.382244.6684AID686978; AID686979
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (26)

Assay IDTitleYearJournalArticle
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID89820Compound was tested for its relative effect on p24 viral core protein production by HIV -infected human T4+ lymphocytes (C8166) at 200 uM1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
Synthesis of the 2-chloro analogues of 3'-deoxyadenosine, 2',3'-dideoxyadenosine, and 2',3'-didehydro-2',3'-dideoxyadenosine as potential antiviral agents.
AID89819Compound was tested for its relative effect on p24 viral core protein production by HIV -infected human T4+ lymphocytes (C8166) at 20 uM1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
Synthesis of the 2-chloro analogues of 3'-deoxyadenosine, 2',3'-dideoxyadenosine, and 2',3'-didehydro-2',3'-dideoxyadenosine as potential antiviral agents.
AID89818Compound was tested for its relative effect on p24 viral core protein production by HIV -infected human T4+ lymphocytes (C8166) at 100 uM1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
Synthesis of the 2-chloro analogues of 3'-deoxyadenosine, 2',3'-dideoxyadenosine, and 2',3'-didehydro-2',3'-dideoxyadenosine as potential antiviral agents.
AID89810Compound was tested for its effect on Reverse Transcriptase (RT) production by HIV-Infected Human T4+ Lymphocytes (C8166) at 20 uM1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
Synthesis of the 2-chloro analogues of 3'-deoxyadenosine, 2',3'-dideoxyadenosine, and 2',3'-didehydro-2',3'-dideoxyadenosine as potential antiviral agents.
AID89815Compound was tested for its effect on the growth of human T4+ lymphocytes (C8166) in culture at 100 uM1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
Synthesis of the 2-chloro analogues of 3'-deoxyadenosine, 2',3'-dideoxyadenosine, and 2',3'-didehydro-2',3'-dideoxyadenosine as potential antiviral agents.
AID89809Compound was tested for its effect on Reverse Transcriptase (RT) production by HIV-Infected Human T4+ Lymphocytes (C8166) at 2 uM1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
Synthesis of the 2-chloro analogues of 3'-deoxyadenosine, 2',3'-dideoxyadenosine, and 2',3'-didehydro-2',3'-dideoxyadenosine as potential antiviral agents.
AID89817Compound was tested for its effect on the growth of human T4+ lymphocytes (C8166) in culture at 500 uM1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
Synthesis of the 2-chloro analogues of 3'-deoxyadenosine, 2',3'-dideoxyadenosine, and 2',3'-didehydro-2',3'-dideoxyadenosine as potential antiviral agents.
AID155643Percentage of apoptotic cells in human peripheral blood mononuclear cells after 72 hour incubation at the concentration 1 uM1998Bioorganic & medicinal chemistry letters, Sep-22, Volume: 8, Issue:18
Modulation of apoptosis in human lymphocytes by adenosine analogues.
AID89814Compound was tested for its effect on the growth of human T4+ lymphocytes (C8166) in culture at 10 uM1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
Synthesis of the 2-chloro analogues of 3'-deoxyadenosine, 2',3'-dideoxyadenosine, and 2',3'-didehydro-2',3'-dideoxyadenosine as potential antiviral agents.
AID155782Percentage of apoptotic cells in human peripheral blood mononuclear cells after 72 hour incubation at the concentration 60 uM1998Bioorganic & medicinal chemistry letters, Sep-22, Volume: 8, Issue:18
Modulation of apoptosis in human lymphocytes by adenosine analogues.
AID155644Percentage of apoptotic cells in human peripheral blood mononuclear cells after 72 hour incubation at the concentration 10 uM1998Bioorganic & medicinal chemistry letters, Sep-22, Volume: 8, Issue:18
Modulation of apoptosis in human lymphocytes by adenosine analogues.
AID89816Compound was tested for its effect on the growth of human T4+ lymphocytes (C8166) in culture at 1000 uM1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
Synthesis of the 2-chloro analogues of 3'-deoxyadenosine, 2',3'-dideoxyadenosine, and 2',3'-didehydro-2',3'-dideoxyadenosine as potential antiviral agents.
AID89808Compound was tested for its effect on Reverse Transcriptase (RT) production by HIV-Infected Human T4+ Lymphocytes (C8166) at 100 uM1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
Synthesis of the 2-chloro analogues of 3'-deoxyadenosine, 2',3'-dideoxyadenosine, and 2',3'-didehydro-2',3'-dideoxyadenosine as potential antiviral agents.
AID155645Percentage of apoptotic cells in human peripheral blood mononuclear cells after 72 hour incubation at the concentration 30 uM1998Bioorganic & medicinal chemistry letters, Sep-22, Volume: 8, Issue:18
Modulation of apoptosis in human lymphocytes by adenosine analogues.
AID89811Compound was tested for its effect on Reverse Transcriptase (RT) production by HIV-Infected Human T4+ Lymphocytes (C8166) at 200 uM1989Journal of medicinal chemistry, May, Volume: 32, Issue:5
Synthesis of the 2-chloro analogues of 3'-deoxyadenosine, 2',3'-dideoxyadenosine, and 2',3'-didehydro-2',3'-dideoxyadenosine as potential antiviral agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (20.00)18.7374
1990's2 (20.00)18.2507
2000's3 (30.00)29.6817
2010's2 (20.00)24.3611
2020's1 (10.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]