Page last updated: 2024-09-04

1-deazaadenosine and adenosine

1-deazaadenosine has been researched along with adenosine in 7 studies

Compound Research Comparison

Studies
(1-deazaadenosine)
Trials
(1-deazaadenosine)
Recent Studies (post-2010)
(1-deazaadenosine)
Studies
(adenosine)
Trials
(adenosine)
Recent Studies (post-2010) (adenosine)
210432,5361,0758,930

Protein Interaction Comparison

ProteinTaxonomy1-deazaadenosine (IC50)adenosine (IC50)
high affinity choline transporter 1 isoform aHomo sapiens (human)0.3851
Sodium/nucleoside cotransporter 1Homo sapiens (human)5.5
Sodium/nucleoside cotransporter 2Homo sapiens (human)5.5
Adenosine receptor A3Homo sapiens (human)0.0011
Adenosine receptor A1Homo sapiens (human)0.0023
Equilibrative nucleoside transporter 1Homo sapiens (human)63
Solute carrier family 28 member 3Homo sapiens (human)3.3

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19903 (42.86)18.7374
1990's3 (42.86)18.2507
2000's1 (14.29)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cristalli, G; Franchetti, P; Grifantini, M; Klotz, KN; Lohse, MJ; Vittori, S1
Bordoni, T; Cristalli, G; Franchetti, P; Geroni, C; Grifantini, M; Vittori, S1
Antonini, I; Cristalli, G; Franchetti, P; Grifantini, M; Lupidi, G; Martelli, S; Riva, F1
Ding, H; Groziak, MP; Huan, ZW; Meng, Z; Robinson, PD; Stevens, WC1
Frieden, C; Kurz, LC; Moix, L; Riley, MC1
Kalinichenko, EN; Mikhailopulo, IA; Player, MR; Podkopaeva, TL; Seela, F; Torrence, PF1
Costanzi, S; Cristalli, G; IJzerman, AP; Kunzel, JK; Lorenzen, A; Stannek, C; Vittori, S; Volpini, R1

Other Studies

7 other study(ies) available for 1-deazaadenosine and adenosine

ArticleYear
Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:6

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclases; Aminoglycosides; Animals; Anti-Bacterial Agents; Cattle; Humans; Rats; Receptors, Purinergic; Structure-Activity Relationship; Tubercidin

1988
Improved synthesis and antitumor activity of 1-deazaadenosine.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:9

    Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line; Female; HeLa Cells; Humans; Leukemia L1210; Leukemia P388; Mice; Ribonucleosides; Tubercidin; Uterine Cervical Neoplasms

1987
Adenosine deaminase inhibitors. Synthesis of deaza analogues of erythro-9-(2-hydroxy-3-nonyl)adenine.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:3

    Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Cattle; Intestines; Nucleoside Deaminases

1984
Effect of a chemical modification on the hydrated adenosine intermediate produced by adenosine deaminase and a model reaction for a potential mechanism of action of 5-aminoimidazole ribonucleotide carboxylase.
    Journal of medicinal chemistry, 1997, Oct-10, Volume: 40, Issue:21

    Topics: Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Carboxy-Lyases; Crystallography, X-Ray; Decarboxylation; Enzyme Inhibitors; Escherichia coli; Imidazoles; Kinetics; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Molecular; Molecular Conformation; Molecular Structure; Ribose

1997
The rate of formation of transition-state analogues in the active site of adenosine deaminase is encounter-controlled: implications for the mechanism.
    Biochemistry, 1992, Jan-14, Volume: 31, Issue:1

    Topics: Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Binding Sites; Catalysis; Cattle; Circular Dichroism; Intestines; Purine Nucleosides; Ribonucleosides; Solvents; Spectrophotometry, Ultraviolet; Tubercidin

1992
Dissection of the roles of adenine ring nitrogen (N-1) and exocyclic amino (N-6) moieties in the interaction of 2-5A with RNase L.
    Biochemical and biophysical research communications, 1998, Apr-17, Volume: 245, Issue:2

    Topics: Adenine Nucleotides; Adenosine; Endoribonucleases; Enzyme Activation; Humans; Molecular Structure; Oligoribonucleotides; Recombinant Proteins; RNA-Binding Proteins; Tubercidin

1998
N-cycloalkyl derivatives of adenosine and 1-deazaadenosine as agonists and partial agonists of the A(1) adenosine receptor.
    Journal of medicinal chemistry, 2000, Jan-27, Volume: 43, Issue:2

    Topics: Adenosine; Animals; Brain; Guanosine 5'-O-(3-Thiotriphosphate); Magnetic Resonance Spectroscopy; Phenethylamines; Purinergic P1 Receptor Agonists; Radioligand Assay; Rats; Tubercidin; Xanthines

2000