1-(3,5-dichlorophenyl)-3-(4-morpholinyl)pyrrolidine-2,5-dione

1-(3,5-dichlorophenyl)-3-(4-morpholinyl)pyrrolidine-2,5-dione is a chemical compound with the molecular formula C₁₄H₁₄Cl₂N₂O₃. It's often referred to by its shorter name, **(3,5-Dichlorophenyl)morpholinopyrrolidinedione** or its trade name **GSK-3787** (developed by GlaxoSmithKline).

Here's why it's important for research:

**Pharmacological Activity:**

* **Potent and selective inhibitor of HDAC6:** This compound is a highly specific inhibitor of Histone Deacetylase 6 (HDAC6), a key enzyme involved in cellular processes like protein degradation and cell survival.
* **Potential therapeutic applications:** Inhibition of HDAC6 has shown promise in treating various diseases, including:
* **Cancer:** It can induce cancer cell death and suppress tumor growth.
* **Neurodegenerative diseases:** It might be helpful in treating Alzheimer's disease, Huntington's disease, and Parkinson's disease by protecting neurons from damage.
* **Inflammatory diseases:** It could potentially reduce inflammation in conditions like arthritis and inflammatory bowel disease.

**Research Significance:**

* **Understanding HDAC6 function:** The development of GSK-3787 has provided a valuable tool for researchers to study the role of HDAC6 in various biological processes.
* **Drug discovery:** It has led to the development of other HDAC6 inhibitors with improved properties, paving the way for new therapeutic strategies for various diseases.
* **Preclinical studies:** Extensive preclinical studies using GSK-3787 have provided insights into its efficacy and potential safety profile, laying the groundwork for clinical trials.

**Ongoing Research:**

* **Clinical trials:** Several clinical trials are ongoing to evaluate the safety and efficacy of GSK-3787 and other HDAC6 inhibitors in treating different diseases.
* **Further optimization:** Researchers continue to explore ways to improve the potency, selectivity, and pharmacokinetic properties of HDAC6 inhibitors, aiming to develop even better therapies.

**Overall, 1-(3,5-dichlorophenyl)-3-(4-morpholinyl)pyrrolidine-2,5-dione (GSK-3787) has been a significant research tool in understanding the role of HDAC6 and its potential therapeutic applications. It has contributed to the development of new drugs for various diseases and continues to be a focus of ongoing research.**