Compounds > chloride of pseudoisocyanine
Page last updated: 2024-08-01 21:20:41

chloride of pseudoisocyanine

Description

1,1'-diethyl-2,2'-cyanine chloride : no description available [CHeBI]

Cross-References

ID SourceID
PubMed CID5717105
CHEMBL ID576409
CHEBI ID38004
MeSH IDM0327493

Synonyms (31)

Synonym
2,2'-quinocyanine chloride
1,2'-cyanine chloride
n,n'-diethylpseudoisocyanine
nsc97374
diethylcyanine
2,2'-cyanine chloride
pseudoisocyanine chloride
2402-42-8
pseudoisocyanine diethyl chloride
n,n'-diethylpseudoisocyanine chloride
1-ethyl-2-[(1-ethyl-2(1h)-quinolinylidene)methyl]quinolinium chloride
1,1'-diethyl-2,2'-cyanine chloride
CHEBI:38004 ,
1-ethyl-2-{[1-ethylquinolin-2(1h)-ylidene]methyl}quinolinium chloride
CHEMBL576409
AKOS003601262
HMS2172F09
quinolinium, 1-ethyl-2-((1-ethyl-2(1h)-quinolinylidene)methyl)-, chloride
einecs 219-279-7
1-ethyl-2-((1-ethyl-1,2-dihydro-2-quinolylidene)methyl)quinoliniumchloride
unii-vxj7avj43d
nsc 97374
vxj7avj43d ,
quinolinium, 1-ethyl-2-((1-ethyl-2(1h)-quinolinylidene)methyl)-, chloride (1:1)
(2e)-1-ethyl-2-[(1-ethylquinolin-1-ium-2-yl)methylidene]quinoline;chloride
SR-01000391515-1
sr-01000391515
Q27117339
nsc-97374 chloride
1-ethyl-2-((1-ethyl-2(1h)-quinolylidene)methyl)quinolinium chloride
quinolinium,1-ethyl-2-[(1-ethyl-2(1h)-quinolinylidene)methyl]-,chloride

Drug Classes (2)

ClassDescription
1,1'-diethyl-2,2'-cyanine halide
organic chloride salt

Protein Targets (66)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency35.4813AID504339
Chain A, ATP-DEPENDENT DNA HELICASE Q1Homo sapiens (human)Potency44.9647AID2549; AID504841
Chain A, Ferritin light chainEquus caballus (horse)Potency19.9526AID485281
LuciferasePhotinus pyralis (common eastern firefly)Potency21.3313AID588342
glp-1 receptor, partialHomo sapiens (human)Potency5.5756AID624172; AID624417
thioredoxin reductaseRattus norvegicus (Norway rat)Potency56.2341AID588453
BRCA1Homo sapiens (human)Potency3.9811AID624202
WRNHomo sapiens (human)Potency44.6684AID651768
phosphopantetheinyl transferaseBacillus subtilisPotency50.1187AID1490
ATAD5 protein, partialHomo sapiens (human)Potency9.2000AID504467
USP1 protein, partialHomo sapiens (human)Potency28.1838AID743255
TDP1 proteinHomo sapiens (human)Potency1.5470AID686978; AID686979
Microtubule-associated protein tauHomo sapiens (human)Potency3.1623AID1460
thioredoxin glutathione reductaseSchistosoma mansoniPotency7.9433AID485364
Smad3Homo sapiens (human)Potency1.7783AID588855
apical membrane antigen 1, AMA1Plasmodium falciparum 3D7Potency22.3872AID720542
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency28.1838AID1030
PINK1Homo sapiens (human)Potency2.8184AID624263
hypothetical protein, conservedTrypanosoma bruceiPotency18.9895AID624173; AID720569; AID720584
nonstructural protein 1Influenza A virus (A/WSN/1933(H1N1))Potency3.9811AID2326
67.9K proteinVaccinia virusPotency12.5893AID720580
ParkinHomo sapiens (human)Potency2.8184AID624263
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency70.7946AID504333
pyruvate kinaseLeishmania mexicana mexicanaPotency14.1254AID1721; AID1722
IDH1Homo sapiens (human)Potency6.5131AID686970
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency11.2202AID504332
chromobox protein homolog 1Homo sapiens (human)Potency17.7828AID540317
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency2.9093AID504444
transcriptional regulator ERG isoform 3Homo sapiens (human)Potency25.1189AID624246
huntingtin isoform 2Homo sapiens (human)Potency3.1623AID1688
importin subunit beta-1 isoform 1Homo sapiens (human)Potency89.1251AID540263
pyruvate kinase PKM isoform aHomo sapiens (human)Potency14.1254AID1631; AID1634
DNA polymerase betaHomo sapiens (human)Potency15.8489AID485314
flap endonuclease 1Homo sapiens (human)Potency39.8107AID588795
ras-related protein Rab-9AHomo sapiens (human)Potency0.7943AID485297
snurportin-1Homo sapiens (human)Potency89.1251AID540263
histone-lysine N-methyltransferase 2A isoform 2 precursorHomo sapiens (human)Potency89.1251AID2662
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Potency84.9214AID504891
tumor susceptibility gene 101 proteinHomo sapiens (human)Potency56.2341AID493005
DNA polymerase eta isoform 1Homo sapiens (human)Potency12.5893AID588591
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency5.8654AID2546; AID2551
DNA polymerase kappa isoform 1Homo sapiens (human)Potency79.4328AID588579
VprHuman immunodeficiency virus 1Potency22.3872AID651644
survival motor neuron protein isoform dHomo sapiens (human)Potency1.5849AID1458
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency3.9811AID2675
DNA dC->dU-editing enzyme APOBEC-3G isoform 1Homo sapiens (human)Potency16.5044AID602310; AID651812; AID651813
DNA dC->dU-editing enzyme APOBEC-3F isoform aHomo sapiens (human)Potency12.5893AID602313
lamin isoform A-delta10Homo sapiens (human)Potency5.6234AID1487
neuropeptide S receptor isoform AHomo sapiens (human)Potency7.9433AID1461
Rap guanine nucleotide exchange factor 3Homo sapiens (human)Potency56.2341AID720709
Endothelin receptor type BRattus norvegicus (Norway rat)Potency14.1254AID1721
Endothelin-1 receptorRattus norvegicus (Norway rat)Potency14.1254AID1721
Alpha-synucleinHomo sapiens (human)Potency11.2202AID652106
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency10.6101AID1457; AID901
TAR DNA-binding protein 43Homo sapiens (human)Potency10.0000AID652104
phosphoglycerate kinaseTrypanosoma brucei brucei TREU927Potency26.0988AID602233; AID686980

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
nonstructural protein 1Influenza A virus (A/California/07/2009(H1N1))IC5012.8460AID504329
sphingosine 1-phosphate receptor 2Homo sapiens (human)IC502.0925AID851; AID856
eukaryotic translation initiation factor 4 gamma 1 isoform 4Homo sapiens (human)IC5033.7653AID855
eukaryotic translation initiation factor 4E isoform 1Mus musculus (house mouse)IC5033.7653AID855
rac GTPase-activating protein 1 isoform aHomo sapiens (human)IC5046.4600AID624330
alkaline phosphatase, germ cell type preproproteinHomo sapiens (human)IC5010.6000AID690

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
alkaline phosphatase, germ cell type preproproteinHomo sapiens (human)EC50999.0000AID696
streptokinase A precursorStreptococcus pyogenes M1 GASEC5078.0425AID1902; AID1914
Estrogen receptorRattus norvegicus (Norway rat)EC50150.0000AID1914
Estrogen receptor betaRattus norvegicus (Norway rat)EC50150.0000AID1914

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
glycogen synthase kinase-3 alphaHomo sapiens (human)AC5066.1400AID463203

Bioassays (7)

Assay IDTitleYearJournalArticle
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
ISSN: 1552-4922		Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
ISSN: 1557-8127		High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
ISSN: 1552-4922		Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
ISSN: 1557-8127		High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
ISSN: 1945-7170		A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
ISSN: 1552-4922		Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
ISSN: 1557-8127		High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
ISSN: 1945-7170		A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1745845Primary qHTS for Inhibitors of ATXN expression2022The Journal of biological chemistry, 08, Volume: 298, Issue:8
ISSN: 1083-351X
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression2022The Journal of biological chemistry, 08, Volume: 298, Issue:8
ISSN: 1083-351X

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
guanidine hydrochloride
0
one-carbon compound;
organic chloride salt		protein denaturant00low000000
tetraethylammonium chloride
0
organic chloride salt;
quaternary ammonium salt		potassium channel blocker00low000000
thiamine
0
organic chloride salt;
vitamin B1		00low000000
methylene blue
0
organic chloride saltacid-base indicator;
antidepressant;
antimalarial;
antimicrobial agent;
antioxidant;
cardioprotective agent;
EC 1.4.3.4 (monoamine oxidase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 4.6.1.2 (guanylate cyclase) inhibitor;
fluorochrome;
histological dye;
neuroprotective agent;
physical tracer		00low000000
rhodamine b
0
organic chloride salt;
xanthene dye		fluorescent probe;
fluorochrome;
histological dye		00low000000
acriflavine chloride
0
organic chloride saltantibacterial agent;
antiseptic drug;
carcinogenic agent;
histological dye;
intercalator		00low000000
pyronine
0
iminium salt;
organic chloride salt		histological dye00low000000
ambenonium chloride
0
organic chloride salt;
quaternary ammonium salt		EC 3.1.1.8 (cholinesterase) inhibitor;
neurotransmitter agent		00low000000
thiamine pyrophosphate
0
organic chloride salt;
vitamin B1		00low000000
triphenyltetrazolium chloride
0
organic chloride saltdye;
indicator		00low000000
dequalinium chloride
0
organic chloride saltantifungal agent;
antineoplastic agent;
antiseptic drug;
mitochondrial NADH:ubiquinone reductase inhibitor		00low000000
thiamine monophosphate
0
organic chloride salt;
vitamin B1		00low000000
gentian violet
0
organic chloride saltanthelminthic drug;
antibacterial agent;
antifungal agent;
antiseptic drug;
histological dye		00low000000
malachite green
0
organic chloride saltantibacterial agent;
antifungal drug;
carcinogenic agent;
environmental contaminant;
fluorochrome;
histological dye;
teratogenic agent		00low000000
pyronine b
0
iminium salt;
organic chloride salt		histological dye00low000000
basic blue k
0
iminium salt;
organic chloride salt		fluorochrome;
histological dye		00low000000
thioflavin t
0
organic chloride saltfluorochrome;
geroprotector;
histological dye		00low000000
ethyl violet
0
organic chloride saltfluorochrome;
histological dye		00low000000
victoria blue b
0
iminium salt;
organic chloride salt		fluorochrome;
histological dye		00low000000
pathilon
0
organic chloride salt00low000000
cetylpyridinium chloride anhydrous
0
chloride salt;
organic chloride salt		antiseptic drug;
surfactant		00low000000
iodonitrotetrazolium
0
organic chloride salthistological dye00low000000
rhodamine 123
0
organic chloride salt;
xanthene dye		fluorochrome00low000000
phenosafranine
0
organic chloride saltfluorochrome;
histological dye;
photosensitizing agent		00low000000
tetrabutylammonium chloride
0
organic chloride salt;
tetrabutylammonium salt		00low000000
tetrazolium violet
0
organic chloride saltantineoplastic agent;
apoptosis inducer;
dye		00low000000
methylene green
0
organic chloride saltfluorochrome;
histological dye		00low000000
janus green b
0
organic chloride saltdye00low000000
victoria blue 4r
0
iminium salt;
organic chloride salt		fluorochrome;
histological dye		00low000000
calmidazolium
0
organic chloride saltapoptosis inducer;
calmodulin antagonist		00low000000
safranine t
0
organic chloride saltfluorochrome;
histological dye		00low000000
diphenyleneiodium chloride
0
organic chloride saltEC 1.6.3.1. [NAD(P)H oxidase (H2O2-forming)] inhibitor;
G-protein-coupled receptor agonist		00low000000
1-methyl-3-octylimidazolium chloride
0
organic chloride salt00low000000
4-anisyltetrazolium blue
0
organic chloride saltdye00low000000
rhodamine 123
0
organic chloride salt;
xanthene dye		fluorochrome00low000000
alcian yellow
0
iminium salt;
organic chloride salt		fluorochrome;
histological dye		00low000000
mitotracker orange
0
organic chloride saltfluorochrome00low000000
pralidoxime chloride
0
organic chloride salt;
pyridinium salt		cholinergic drug;
cholinesterase reactivator		00low000000
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Inflammation0
1
2010201014.0high000100
Innate Inflammatory Response0
1
2010201014.0high000100