Anomalous Cervical Rib Syndrome

A condition associated with compression of the BRACHIAL PLEXUS; SUBCLAVIAN ARTERY; and SUBCLAVIAN VEIN at the thoracic outlet and caused by a complete or incomplete anomalous CERVICAL RIB or fascial band connecting the tip of a cervical rib with the first thoracic rib. Clinical manifestations may include pain in the neck and shoulder which radiates into the upper extremity, PARESIS or PARALYSIS of brachial plexus innervated muscles; sensory loss; PARESTHESIAS; ISCHEMIA; and EDEMA. (Adams et al., Principles of Neurology, 6th ed, p214)

Synonym
Naffziger Syndrome
Naffziger's Syndrome
Anomalous Cervical Rib Syndrome
Cervical-Rib-Cervical-Band Syndrome
Cervical Rib Syndrome

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	9 (45.00)	23.3326
1990's	4 (20.00)	12.5806
2000's	5 (25.00)	18.1394
2010's	2 (10.00)	28.8240
2020's	0 (0.00)	9.53

Drug	Relationship Strength	Studies
dalteparin	low	1
aspirin	low	1
chlormezanone	low	1
lidocaine	low	1
orphenadrine	low	1
trolamine salicylate	low	1
nitinol	low	1
salicylates	low	1
phenprocoumon	low	1

Protein Targets (216)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	3	0	0	3
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	1	0	0	1
thioredoxin reductase	3	0	0	3
GLS protein	3	0	0	3
AR protein	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	2	0	0	2
thyroid stimulating hormone receptor	1	0	0	1
hypothetical protein, conserved	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	1	0	0	1
EWS/FLI fusion protein	2	0	0	2
glucocorticoid receptor [Homo sapiens]	1	0	0	1
retinoic acid nuclear receptor alpha variant 1	2	0	0	2
estrogen-related nuclear receptor alpha	1	0	0	1
estrogen nuclear receptor alpha	3	0	0	3
cytochrome P450 2D6	2	0	0	2
glucocerebrosidase	1	0	0	1
peroxisome proliferator-activated receptor delta	2	0	0	2
Rac1 protein	0	0	1	1
IDH1	2	0	0	2
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
euchromatic histone-lysine N-methyltransferase 2	3	0	0	3
Bloom syndrome protein isoform 1	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	2	0	0	2
DNA polymerase kappa isoform 1	1	0	0	1
muscarinic acetylcholine receptor M1	2	0	0	2
lethal factor (plasmid)	1	0	0	1
Prostaglandin-H2 D-isomerase	0	1	0	1
ATP-binding cassette sub-family C member 3	0	2	0	2
Multidrug resistance-associated protein 4	0	2	0	2
Solute carrier family 22 member 6	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Bile salt export pump	0	3	0	3
Epidermal growth factor receptor	0	1	0	1
Carbonic anhydrase 1	0	4	0	4
Carbonic anhydrase 2	0	4	0	4
Fatty acid-binding protein, liver	0	1	0	1
Integrin beta-3	0	1	0	1
Myeloperoxidase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	0	1	0	1
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Adenosine receptor A1	0	2	0	2
Adenosine receptor A2a	0	2	0	2
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	1	0	0	1
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	1	1	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	0	1	1
Sigma non-opioid intracellular receptor 1	0	0	1	1
RAR-related orphan receptor gamma	4	0	0	4
arylsulfatase A	2	0	0	2
peripheral myelin protein 22 isoform 1	1	0	0	1
thyroid hormone receptor beta isoform a	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
lamin isoform A-delta10	2	0	0	2
Cellular tumor antigen p53	1	0	0	1
Chain A, Beta-lactamase	1	0	0	1
TDP1 protein	1	0	0	1
Microtubule-associated protein tau	1	0	0	1
vitamin D (1,25- dihydroxyvitamin D3) receptor	3	0	0	3
chromobox protein homolog 1	1	0	0	1
mitogen-activated protein kinase 1	1	0	0	1
flap endonuclease 1	1	0	0	1
geminin	1	0	0	1
cytochrome P450 3A4 isoform 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	1	0	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit delta	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	1	0	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	1	0	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-2	1	0	0	1
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
GABA theta subunit	1	0	0	1
Multidrug and toxin extrusion protein 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	1	0	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Smad3	1	0	0	1
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Cytochrome P450 2D6	0	2	0	2
Muscarinic acetylcholine receptor M1	0	2	0	2
Alpha-2B adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Sodium-dependent noradrenaline transporter	0	2	0	2
Histamine H2 receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Histamine H1 receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
5-hydroxytryptamine receptor 6	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
retinoid X nuclear receptor alpha	2	0	0	2
peroxisome proliferator activated receptor gamma	1	0	0	1
alpha-galactosidase	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	1	0	0	1
thyroid hormone receptor beta isoform 2	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	1	0	0	1
Polyphenol oxidase 2	0	0	0	1
Carbonic anhydrase 12	0	1	0	1
Endolysin	0	0	1	1
Carbonic anhydrase 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Cannabinoid receptor 1	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Carbonic anhydrase 6	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	0	1	1
Spike glycoprotein	2	0	0	2
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 9	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 3	0	2	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Protease	0	2	0	2
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Luciferase	1	0	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Anomalous Cervical Rib Syndrome

Synonyms(5)

Research

Studies (20)

Protein Targets (216)

Anomalous Cervical Rib Syndrome

Synonyms(5)

Research

Studies (20)

Drugs Studied (11)

Protein Targets (216)