yh 439 has been researched along with thiazoles in 20 studies
| Studies (yh 439) | Trials (yh 439) | Recent Studies (post-2010) (yh 439) | Studies (thiazoles) | Trials (thiazoles) | Recent Studies (post-2010) (thiazoles) |
|---|---|---|---|---|---|
| 21 | 0 | 2 | 33,179 | 2,100 | 12,330 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (70.00) | 18.2507 |
| 2000's | 4 (20.00) | 29.6817 |
| 2010's | 2 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jeong, KS; Lee, IJ; Lee, JW; Roberts, BJ; Soh, Y; Song, BJ; Yoo, JK | 1 |
| Lee, JW; Lee, MG; Lee, WI; Park, JH; Shim, CK; Yoon, WH | 1 |
| Lee, JW; Shlyankevich, M; Surh, YJ; Yoo, JK | 1 |
| Fernandez-Salguero, P; Gonzalez, FJ; Jeong, KS; Kallarakal, AT; Lee, IJ; Roberts, BJ; Song, BJ | 1 |
| Cho, E; Jang, SH; Kim, ND; Lee, JW; Lee, MG | 1 |
| Kim, ND; Kim, SH; Lee, JW; Lee, MG; Park, KJ; Yoon, WH | 1 |
| Choi, EY; Kim, ND; Kim, SG; Lee, JW; Shin, JK; Yoo, JK | 1 |
| Chae, JS; Huh, S; Kim, M; Lee, JW; Myung, SW; Park, J; Yoo, JK | 1 |
| Lee, JW; Lee, MG; Shim, CK; Yoo, JK; Yoon, WH | 2 |
| Kim, SG; Lee, JW; Liem, A; Miller, JA; Sohn, Y; Surh, YJ; Yoo, JK | 1 |
| Carrasquillo, JA; Green, MV; Jeong, KS; Kim, IS; Kim, MK; Kobayashi, H; Paik, CH; Seidel, J; Soh, Y; Song, BJ | 1 |
| Kim, SG; Lee, JW; Liem, A; Miller, JA; Surh, YJ | 1 |
| Han, KS; Kim, J; Lee, JW; Lee, MG | 1 |
| Felder, MR; Hardwick, JP; Jeng, J; Jeong, KS; Soh, Y; Song, BJ | 1 |
| Bae, MA; Pie, JE; Song, BJ | 1 |
| Chung, SJ; Kuh, HJ; Lee, MG; Park, HW; Shim, CK | 1 |
| Choi, MK; Chung, SJ; Hong, SS; Li, H; Shim, CK | 1 |
| Gao, ZG; Han, DH; Jin, YZ; Jin, ZH; Shen, YY; Yin, XZ | 1 |
| DeGroot, DE; Denison, MS | 1 |
20 other study(ies) available for yh 439 and thiazoles
| Article | Year |
|---|---|
Transcriptional inhibition of cytochrome P4502E1 by a synthetic compound, YH439.
Topics: Animals; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Liver; Male; Oxidoreductases, N-Demethylating; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiazoles; Transcription, Genetic | 1996 |
Factors influencing the protein binding of YH-439 using an equilibrium dialysis technique. A new hepatoprotective agent.
Topics: Animals; Anticoagulants; Azides; Buffers; Chromatography, High Pressure Liquid; Dialysis; Dogs; Edetic Acid; Heparin; Humans; Hydrogen-Ion Concentration; Indicators and Reagents; Membranes, Artificial; Molecular Weight; Orosomucoid; Protein Binding; Rabbits; Rats; Serum Albumin; Sodium Azide; Species Specificity; Thiazoles | 1995 |
Inhibition of covalent DNA binding and mutagenicity of benzo[a]pyrene by isopropyl-2-(1,3-dithietane-2-ylidene)-2-[N-(4-methylthiazol-2-yl) carbamoyl]acetate (YH439), a novel hepatoprotective agent.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Anticarcinogenic Agents; Antimutagenic Agents; Benzo(a)pyrene; Biotransformation; DNA; DNA Adducts; Liver; Microsomes, Liver; Molecular Structure; Mutagenicity Tests; Mutagens; Rats; Rats, Sprague-Dawley; Salmonella typhimurium; Thiazoles | 1996 |
Transcriptional induction of the cytochrome P4501A1 gene by a thiazolium compound, YH439.
Topics: Animals; Base Sequence; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Electrophoresis; Enzyme Induction; Humans; Male; Malonates; Mice; Molecular Sequence Data; Oxidoreductases; Rats; Rats, Sprague-Dawley; Receptors, Aryl Hydrocarbon; RNA, Messenger; Thiazoles; Transcription, Genetic; Tumor Cells, Cultured | 1996 |
Metabolic changes of acetaminophen after intravenous administration to rats pretreated with a hepatoprotective agent, YH-439.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Bile; Half-Life; Injections, Intravenous; Liver; Metabolic Clearance Rate; Rats; Rats, Sprague-Dawley; Thiazoles | 1996 |
Effect of a hepatoprotective agent, YH-439, on the pharmacokinetics of furosemide and azosemide in rats.
Topics: Animals; Area Under Curve; Chemical and Drug Induced Liver Injury; Diuretics; Drug Interactions; Furosemide; Half-Life; Injections, Intravenous; Male; Rats; Rats, Sprague-Dawley; Sulfanilamides; Thiazoles | 1996 |
Suppression of rat hepatic cytochrome P450 2E1 expression by isopropyl 2-(1,3-dithioetane-2-ylidene)-2-[N-(4-methyl-thiazol-2-yl)carbamoyl] acetate (YH439), an experimental hepatoprotectant: protective role against hepatic injury.
Topics: Animals; Base Sequence; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1; Gene Expression; In Vitro Techniques; Liver; Male; Malonates; Microsomes, Liver; Oligonucleotide Probes; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiazoles | 1996 |
Identification of YH439 and its metabolites in rat urine by gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Male; Mass Spectrometry; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet; Thiazoles | 1997 |
Species differences in pharmacokinetics of a hepatoprotective agent, YH439, and its metabolites, M4, M5, and M7, after intravenous and oral administration to rats, rabbits, and dogs.
Topics: Animals; Dogs; Inactivation, Metabolic; Molecular Structure; Rabbits; Rats; Thiazoles | 1998 |
Simultaneous determination of a new hepatoprotective agent, YH439, and its metabolites, M4, M5, and M7 in plasma and urine by high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Humans; Rats; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Thiazoles | 1998 |
Inhibition of vinyl carbamate-induced hepatotoxicity, mutagenicity, and tumorigenicity by isopropyl-2-(1,3-dithietane-2-ylidene)-2-[N-(4-methylthiazol-2- yl)carbamoyl]acetate (YH439).
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cytochrome P-450 CYP2E1; Down-Regulation; Female; Liver; Liver Neoplasms, Experimental; Male; Mice; Rats; Rats, Sprague-Dawley; Thiazoles; Urethane | 1998 |
Use of 99mTc-mercaptoacetyltriglycine (MAG3)-biocytin hepatobiliary scintigraphy to study the protective effect of a synthetic enzyme inhibitor on acute hepatotoxicity in mice.
Topics: Animals; Biliary Tract; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Drug Interactions; Enzyme Inhibitors; Female; Liver; Liver Diseases; Lysine; Mice; Mice, Inbred BALB C; Necrosis; Organotechnetium Compounds; Radionuclide Imaging; Radiopharmaceuticals; Thiazoles | 1998 |
Inhibitory effects of isopropyl-2-(1,3-dithietane-2-ylidene)-2- [N-(4-methylthiazol-2-yl)carbamoyl]acetate (YH439) on benzo[a]pyrene-induced skin carcinogenesis and micronucleated reticulocyte formation in mice.
Topics: Animals; Anticarcinogenic Agents; Antimutagenic Agents; Antineoplastic Agents; Benzo(a)pyrene; Crosses, Genetic; Female; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Micronuclei, Chromosome-Defective; Micronucleus Tests; Papilloma; Reticulocytes; Skin Neoplasms; Thiazoles | 1999 |
Hepatic and intestinal first-pass effects of a new hepatoprotective agent, YH439, in rats.
Topics: Animals; Drug Administration Routes; Intestinal Absorption; Intestinal Mucosa; Liver; Male; Rats; Rats, Sprague-Dawley; Thiazoles | 1998 |
Cytochrome P450 2E1 (CYP2E1)-dependent production of a 37-kDa acetaldehyde-protein adduct in the rat liver.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Aldehyde Dehydrogenase; Animals; Anticarcinogenic Agents; Body Weight; Cytochrome P-450 CYP2E1; Ethanol; Immunoblotting; Immunohistochemistry; Liver; Male; Molecular Weight; Rats; Rats, Wistar; Thiazoles | 2000 |
Acetaminophen induces apoptosis of C6 glioma cells by activating the c-Jun NH(2)-terminal protein kinase-related cell death pathway.
Topics: Acetaminophen; Acetanilides; Analgesics; Analgesics, Non-Narcotic; Androstadienes; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspases; Cytochrome c Group; Cytochrome P-450 CYP2E1; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Glioma; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyridines; Rats; Thiazoles; Time Factors; Tumor Cells, Cultured; Wortmannin | 2001 |
The transport of a hepatoprotective agent, isopropryl 2-(1-3-dithiethane-2-ylidene)-2[N-(4-methyl-thiazole-2-yl) carbamoyl] acetate (YH439), across Caco-2 cell monolayers.
Topics: Biological Availability; Biological Transport; Caco-2 Cells; Humans; Liver; Solubility; Thiazoles | 2001 |
Effect of a new hepatoprotective agent, YH-439, on the hepatobiliary transport of organic cations (OCs): selective inhibition of sinusoidal OCs uptake without influencing glucose uptake and canalicular OCs excretion.
Topics: Animals; Bile Canaliculi; Biological Transport; Cations; Glucose; Hepatocytes; In Vitro Techniques; Male; Protective Agents; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Thiazoles | 2005 |
Thermal reversible microemulsion system for poorly water-soluble YH439 for oral delivery.
Topics: Administration, Oral; Animals; Biological Availability; Caco-2 Cells; Decanoic Acids; Emulsions; Humans; Male; Palmitic Acid; Permeability; Polyethylene Glycols; Protective Agents; Rats; Rats, Sprague-Dawley; Solubility; Surface-Active Agents; Thiazoles | 2010 |
Nucleotide specificity of DNA binding of the aryl hydrocarbon receptor:ARNT complex is unaffected by ligand structure.
Topics: Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; beta-Naphthoflavone; Binding Sites; Cell Line, Tumor; DNA; Genes, Reporter; Guinea Pigs; Immunoprecipitation; Indoles; Kynurenine; Ligands; Methylcholanthrene; Mice; Molecular Structure; Polychlorinated Dibenzodioxins; Polymerase Chain Reaction; Receptors, Aryl Hydrocarbon; Response Elements; Structure-Activity Relationship; Thiazoles; Transfection | 2014 |