pateamine-a and zampanolide

pateamine-a has been researched along with zampanolide* in 1 studies

Reviews

1 review(s) available for pateamine-a and zampanolide

ArticleYear
Microtubule-stabilizing drugs from marine sponges: focus on peloruside A and zampanolide.
    Marine drugs, 2010, Mar-31, Volume: 8, Issue:4

    Marine sponges are an excellent source of bioactive secondary metabolites with potential therapeutic value in the treatment of diseases. One group of compounds of particular interest is the microtubule-stabilizing agents, the most well-known compound of this group being paclitaxel (Taxol), an anti-cancer compound isolated from the bark and leaves of the Pacific yew tree. This review focuses on two of the more recent additions to this important class of drugs, peloruside A and zampanolide, both isolated from marine sponges. Peloruside A was isolated from Mycale hentscheli collected in New Zealand coastal waters, and it already shows promising anti-cancer activity. Two other potent bioactive compounds with different modes of action but isolated from the same sponge, mycalamide A and pateamine, will also be discussed. The fourth compound, zampanolide, most recently isolated from the Tongan sponge Cacospongia mycofijiensis, has only recently been added to the microtubule-stabilizing group of compounds, and further work is in progress to determine its activity profile relative to peloruside A and other drugs of this class.

    Topics: Animals; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Epoxy Compounds; Humans; Lactones; Macrolides; Microtubules; Neoplasms; Porifera; Pyrans; Thiazoles

2010