hippuristanol profile

hippuristanol: from the gorgonian Isis hippuris [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Related Flora

Flora	Rank	Flora Definition	Family	Family Definition
Hippuris	genus	[no description available]	Plantaginaceae	A plant family of order Lamiales. The Plantago genus is best known. Lesser known members include Hippuris, Littorella and Callitriche.[MeSH]

ID Source	ID
PubMed CID	9981822
CHEMBL ID	1098427
SCHEMBL ID	1374807
MeSH ID	M0497845

Synonym
desacetoxyhippurin 1
hippuristanol
CHEMBL1098427
80442-78-0
HPHXKNOXVBFETI-SHCCRYCOSA-N
SCHEMBL1374807
DTXSID50433627
AKOS027323973
bdbm50235738
Q10861089
(1s,2s,3's,4s,6r,7r,8r,9s,11s,12s,13s,16r,18s)-2',2',3',7,9,13-hexamethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,5'-oxolane]-7,11,16-triol
furostan-3,11,20-triol, 22,25-epoxy-24-methyl-, (3alpha,5alpha,11beta,22beta,24s)-
45pk2ns4nq ,
(1's,2r,2's,4s,4's,7'r,8'r,9's,11's,12's,13's,16'r,18's)-4,5,5,7',9',13'-hexamethyl-5'-oxaspiro[oxolane-2,6'-pentacyclo[10.8.0.0{2,9}.0{4,8}.0{13,18}]icosane]-7',11',16'-triol
(3.alpha.,5.alpha.,11.beta.,22.beta.,24s)-22,25-epoxy-24-methylfurostan-3,11,20-triol

Excerpt	Reference	Relevance
"Hippuristanol is a natural product that has recently been shown to inhibit eukaryotic translation initiation and tumor cell proliferation. "	( Structural and stereochemical requirements of the spiroketal group of hippuristanol for antiproliferative activity. Dang, Y; Li, W; Liu, JO; Yu, B, 2010)	2.04
"Hippuristanol (Hipp) is a natural product that selectively inhibits protein synthesis by targeting eukaryotic initiation factor (eIF) 4A, a DEAD-box RNA helicase required for ribosome recruitment to mRNA templates. "	( Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5' leader regions. Aboushawareb, SAE; Amiri, M; Baranov, PV; Cencic, R; Chu, J; J Kiniry, S; Maïga, RI; Naineni, SK; Pelletier, J; Robert, F; Shen, L; Sonenberg, N; Steinberger, J; Yachnin, BJ, 2020)	2.27

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Eukaryotic initiation factor 4A-I	Homo sapiens (human)	IC50 (µMol)	0.8618	0.0047	0.4064	3.1000	AID1439856; AID1656113; AID1656114; AID1656115; AID1656116
Eukaryotic initiation factor 4A-I	Mus musculus (house mouse)	IC50 (µMol)	0.4000	0.4000	0.4000	0.4000	AID503175
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
cis assembly of pre-catalytic spliceosome	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
mRNA splicing, via spliceosome	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
osteoblast differentiation	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
mRNA splicing, via spliceosome	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
rRNA processing	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
mRNA export from nucleus	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
associative learning	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
response to organic cyclic compound	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
negative regulation of translation	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
exploration behavior	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
positive regulation of translation	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
embryonic cranial skeleton morphogenesis	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
cellular response to selenite ion	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
negative regulation of excitatory postsynaptic potential	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
regulation of translation at postsynapse, modulating synaptic transmission	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
negative regulation of selenocysteine incorporation	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
cellular response to brain-derived neurotrophic factor stimulus	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
cytoplasmic translational initiation	Eukaryotic initiation factor 4A-I	Homo sapiens (human)
translational initiation	Eukaryotic initiation factor 4A-I	Homo sapiens (human)
translational initiation	Eukaryotic initiation factor 4A-II	Homo sapiens (human)
regulation of translational initiation	Eukaryotic initiation factor 4A-II	Homo sapiens (human)
negative regulation of RNA-dependent RNA polymerase activity	Eukaryotic initiation factor 4A-II	Homo sapiens (human)
cellular response to leukemia inhibitory factor	Eukaryotic initiation factor 4A-II	Homo sapiens (human)
cytoplasmic translational initiation	Eukaryotic initiation factor 4A-II	Homo sapiens (human)
formation of translation preinitiation complex	ATP-dependent RNA helicase DHX29	Homo sapiens (human)
ribosome assembly	ATP-dependent RNA helicase DHX29	Homo sapiens (human)
positive regulation of translational initiation	ATP-dependent RNA helicase DHX29	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
RNA binding	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
RNA helicase activity	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
helicase activity	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
protein binding	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
ATP binding	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
ATP hydrolysis activity	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
identical protein binding	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
RNA binding	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
RNA helicase activity	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
mRNA binding	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
protein binding	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
ATP binding	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
poly(A) binding	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
ATP hydrolysis activity	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
selenocysteine insertion sequence binding	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
RNA stem-loop binding	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
ribonucleoprotein complex binding	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
RNA cap binding	Eukaryotic initiation factor 4A-I	Homo sapiens (human)
RNA binding	Eukaryotic initiation factor 4A-I	Homo sapiens (human)
RNA helicase activity	Eukaryotic initiation factor 4A-I	Homo sapiens (human)
double-stranded RNA binding	Eukaryotic initiation factor 4A-I	Homo sapiens (human)
mRNA binding	Eukaryotic initiation factor 4A-I	Homo sapiens (human)
translation initiation factor activity	Eukaryotic initiation factor 4A-I	Homo sapiens (human)
helicase activity	Eukaryotic initiation factor 4A-I	Homo sapiens (human)
protein binding	Eukaryotic initiation factor 4A-I	Homo sapiens (human)
ATP binding	Eukaryotic initiation factor 4A-I	Homo sapiens (human)
translation factor activity, RNA binding	Eukaryotic initiation factor 4A-I	Homo sapiens (human)
ATP hydrolysis activity	Eukaryotic initiation factor 4A-I	Homo sapiens (human)
RNA binding	Eukaryotic initiation factor 4A-II	Homo sapiens (human)
RNA helicase activity	Eukaryotic initiation factor 4A-II	Homo sapiens (human)
helicase activity	Eukaryotic initiation factor 4A-II	Homo sapiens (human)
protein binding	Eukaryotic initiation factor 4A-II	Homo sapiens (human)
ATP binding	Eukaryotic initiation factor 4A-II	Homo sapiens (human)
ATP hydrolysis activity	Eukaryotic initiation factor 4A-II	Homo sapiens (human)
translation initiation factor activity	Eukaryotic initiation factor 4A-II	Homo sapiens (human)
RNA binding	ATP-dependent RNA helicase DHX29	Homo sapiens (human)
RNA helicase activity	ATP-dependent RNA helicase DHX29	Homo sapiens (human)
translation initiation factor activity	ATP-dependent RNA helicase DHX29	Homo sapiens (human)
ATP binding	ATP-dependent RNA helicase DHX29	Homo sapiens (human)
translation activator activity	ATP-dependent RNA helicase DHX29	Homo sapiens (human)
ATP hydrolysis activity	ATP-dependent RNA helicase DHX29	Homo sapiens (human)
ribonucleoside triphosphate phosphatase activity	ATP-dependent RNA helicase DHX29	Homo sapiens (human)
ribosomal small subunit binding	ATP-dependent RNA helicase DHX29	Homo sapiens (human)
cadherin binding	ATP-dependent RNA helicase DHX29	Homo sapiens (human)
helicase activity	ATP-dependent RNA helicase DHX29	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
nucleus	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
nucleoplasm	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
membrane	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
U4/U6 x U5 tri-snRNP complex	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
spliceosomal complex	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
U5 snRNP	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
U2-type precatalytic spliceosome	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
U2-type catalytic step 1 spliceosome	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
catalytic step 2 spliceosome	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
nucleus	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
nucleoplasm	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
cytoplasm	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
cytosol	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
membrane	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
nuclear speck	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
dendrite	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
exon-exon junction complex	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
neuronal cell body	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
postsynapse	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
glutamatergic synapse	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
U2-type catalytic step 1 spliceosome	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
catalytic step 2 spliceosome	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
nucleolus	Eukaryotic initiation factor 4A-III	Homo sapiens (human)
nucleus	Eukaryotic initiation factor 4A-I	Homo sapiens (human)
cytoplasm	Eukaryotic initiation factor 4A-I	Homo sapiens (human)
cytosol	Eukaryotic initiation factor 4A-I	Homo sapiens (human)
membrane	Eukaryotic initiation factor 4A-I	Homo sapiens (human)
eukaryotic translation initiation factor 4F complex	Eukaryotic initiation factor 4A-I	Homo sapiens (human)
extracellular exosome	Eukaryotic initiation factor 4A-I	Homo sapiens (human)
cytosol	Eukaryotic initiation factor 4A-I	Mus musculus (house mouse)
cytosol	Eukaryotic initiation factor 4A-II	Homo sapiens (human)
eukaryotic translation initiation factor 4F complex	Eukaryotic initiation factor 4A-II	Homo sapiens (human)
perinuclear region of cytoplasm	Eukaryotic initiation factor 4A-II	Homo sapiens (human)
eukaryotic 43S preinitiation complex	ATP-dependent RNA helicase DHX29	Homo sapiens (human)
cytosolic small ribosomal subunit	ATP-dependent RNA helicase DHX29	Homo sapiens (human)
intracellular anatomical structure	ATP-dependent RNA helicase DHX29	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (51)

Assay ID	Title	Year	Journal	Article
AID503193	Inhibition of eIF4A-mediated cap-dependent protein synthesis in Swiss mouse Krebs2 extract transfected with FF-HCV-Ren mRNA in presence of recombinant eIF4AIf by [35S]methionine metabolic labeling study	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID503189	Inhibition of CrPV IRES-mediated translation in Swiss mouse Krebs2 extract transfected with bicistronic mRNA by [35S]methionine metabolic labeling study	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID1656113	Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif repeat AGAGAG in 5'- UTR containing luciferase reporter gene assay	2020	Journal of medicinal chemistry, 06-11, Volume: 63, Issue:11	Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase.
AID503199	Inhibition of eIF4A binding to 32p cap-labeled mRNA at 50 uM	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID503180	Inhibition of eIF4A interaction with mRNA cap structure in presence of 0.6 mM m7 GDP at 50 uM by chemical cross-linking assay	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID1439867	Binding affinity to full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 expressed in Escherichia coli BL21(DE3) assessed as association rate constant administered for 60 to 120 secs by surface plasmon resonance biosensing assay	2017	Bioorganic & medicinal chemistry, 04-01, Volume: 25, Issue:7	Discovery of selective ATP-competitive eIF4A3 inhibitors.
AID1656114	Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif repeat GGCGGC in 5'- UTR containing luciferase reporter gene assay	2020	Journal of medicinal chemistry, 06-11, Volume: 63, Issue:11	Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase.
AID1439859	Inhibition of full length recombinant human N-terminal FLAG-His-tagged DHX29 RNA dependent ATPase activity expressed in baculovirus infected Sf9 insect cells using single stranded poly(U) RNA as substrate after 30 mins by ADP-Glo luminescence assay	2017	Bioorganic & medicinal chemistry, 04-01, Volume: 25, Issue:7	Discovery of selective ATP-competitive eIF4A3 inhibitors.
AID503200	Inhibition of PTV-1 IRES-mediated translation in Swiss mouse Krebs2 extract transfected with bicistronic mRNA by [35S]methionine metabolic labeling study	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID503173	Inhibition of 80S ribosome complex formation in rabbit reticulocyte lysate in presence of 600 uM cyclohexamide assessed as increase in unbound mRNA at 50 uM	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID503171	Inhibition of RNA synthesis in human HeLa cells assessed as [3H] Uridine incorporation at 1 uM by scintillation counting	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID503182	Inhibition of eIF4E interaction with mRNA cap structure in presence of 0.6 mM m7 GDP at 50 uM by chemical cross-linking assay	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID503185	Inhibition of DED1-mediated helicase activity by helicase assay	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID503177	Inhibition of eIF4A-mediated cap-dependent protein synthesis in rabbit reticulocyte lysate transfected with FF-HCV-Ren mRNA by [35S]methionine metabolic labeling study	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID1439856	Inhibition of eIF4G-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A1 RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) using single stranded poly(U) RNA as substrate after 40 mins by ADP-Glo luminescence assay	2017	Bioorganic & medicinal chemistry, 04-01, Volume: 25, Issue:7	Discovery of selective ATP-competitive eIF4A3 inhibitors.
AID503174	Inhibition of 48S ribosome complex formation in wheat germ extract in presence of 1 mM GMP-PNP assessed as increase in unbound mRNA at 50 uM	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID503194	Inhibition of eIF4A activity assessed as processing of adenovirus major late pre-mRNA at 50 uM by in vitro splicing assay	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID503195	Disruption of polyribosmes in human HeLa cells at 1 uM after 20 mins	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID1129018	Inhibition of translation in rabbit reticulocyte lysates using SP6 RNA polymerase at 10 uM by FF/HCV/Ren reporter gene assay	2014	Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6	Synthesis of the antiproliferative agent hippuristanol and its analogues from hydrocortisone via Hg(II)-catalyzed spiroketalization: structure-activity relationship.
AID1656116	Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif repeat CAACAA in 5'- UTR containing luciferase reporter gene assay	2020	Journal of medicinal chemistry, 06-11, Volume: 63, Issue:11	Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase.
AID503201	Induction of eIF4A to [alpha-32P]ATP cross linking relative to control	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID503175	Inhibition of eIF4A-mediated cap-dependent protein synthesis in FF-HCV-Ren mRNA transfected Swiss mouse Krebs2 cell extract by [35S]methionine metabolic labeling study	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID503186	Inhibition of eIF4A-mediated cap-dependent translation in Swiss mouse Krebs2 extract transfected with bicistronic mRNA by [35S]methionine metabolic labeling study	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID503172	Inhibition of protein synthesis in human HeLa cells at 1 uM after 60 mins by [35S]methionine metabolic labeling study	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID1656115	Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif repeat CCGCCG in 5'- UTR containing luciferase reporter gene assay	2020	Journal of medicinal chemistry, 06-11, Volume: 63, Issue:11	Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase.
AID1462005	Inhibition of eIF4A (unknown origin) expressed in Escherichia coli BL21(DE3) at 100 uM preincubated for 10 mins followed by ATP and fluorescently-labeled RNA addition measured after 10 mins by real-time fluorescence assay	2017	Bioorganic & medicinal chemistry letters, 09-01, Volume: 27, Issue:17	ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A.
AID1439857	Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) using 60 ug/ml single stranded poly(U) RNA as substrate after 30 mins by ADP-Glo luminescenc	2017	Bioorganic & medicinal chemistry, 04-01, Volume: 25, Issue:7	Discovery of selective ATP-competitive eIF4A3 inhibitors.
AID503192	Inhibition of viral protein synthesis in poliovirus infected human HeLa cells assessed as eIF4G2 at 80 nM by [35S]methionine metabolic labeling study	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID1439858	Inhibition of eIF4G-induced eIF4A2 (unknown origin) RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) using single stranded poly(U) RNA as substrate after 40 mins by ADP-Glo luminescence assay	2017	Bioorganic & medicinal chemistry, 04-01, Volume: 25, Issue:7	Discovery of selective ATP-competitive eIF4A3 inhibitors.
AID503179	Inhibition of eIF4A-mediated cap-dependent protein synthesis in Escherichia coli S30 extract transfected with FF-HCV-Ren mRNA at 50 uM by [35S]methionine metabolic labeling study	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID503176	Inhibition of HCV IRES-mediated protein synthesis in FF-HCV-Ren mRNA transfected Swiss mouse Krebs2 cell extract at 50 uM by [35S]methionine metabolic labeling study	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID503178	Inhibition of eIF4A-mediated cap-dependent protein synthesis in wheat germ extract transfected with FF-HCV-Ren mRNA by [35S]methionine metabolic labeling study	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID503168	Inhibition of protein synthesis in human HeLa cells after 50 mins by [35S]methionine metabolic labeling study	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID503198	Inhibition of eIF4E RNA binding activity in presence of 0.6 mM m7GDP at 50 uM	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID503191	Growth inhibition of human HeLa cells at 80 nM after 24 hrs	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID503188	Inhibition of EMCV IRES-mediated translation in Swiss mouse Krebs2 extract transfected with bicistronic mRNA by [35S]methionine metabolic labeling study	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID478926	Antiproliferative activity against human HeLa cells by [3H]thymidine incorporation	2010	Bioorganic & medicinal chemistry letters, May-15, Volume: 20, Issue:10	Structural and stereochemical requirements of the spiroketal group of hippuristanol for antiproliferative activity.
AID503184	Inhibition of eIF4A-mediated helicase activity by helicase assay	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID503170	Inhibition of DNA synthesis in human HeLa cells assessed as [3H] thymidine incorporation at 1 uM by scintillation counting	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID503187	Inhibition of polio virus IRES-mediated translation in Swiss mouse Krebs2 extract transfected with bicistronic mRNA by [35S]methionine metabolic labeling study	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID503181	Inhibition of eIF4B interaction with mRNA cap structure in presence of 0.6 mM m7GDP at 50 uM by chemical cross-linking assay	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID1439869	Binding affinity to full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 expressed in Escherichia coli BL21(DE3) assessed as dissociation half-life administered for 60 to 120 secs by surface plasmon resonance biosensing assay	2017	Bioorganic & medicinal chemistry, 04-01, Volume: 25, Issue:7	Discovery of selective ATP-competitive eIF4A3 inhibitors.
AID503196	Inhibition of eIF4A RNA binding activity in presence of 0.6 mM m7GDP at 50 uM	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID1481958	Binding affinity to full-length human recombinant His6-tagged eIF4A3 expressed in Escherichia coli BL21(DE3) by surface plasmon resonance assay	2017	Journal of medicinal chemistry, 04-27, Volume: 60, Issue:8	Discovery of Novel 1,4-Diacylpiperazines as Selective and Cell-Active eIF4A3 Inhibitors.
AID1439860	Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 insect cells using single stranded poly(U) RNA as substrate after 30 mins by ADP-Glo luminescence assay	2017	Bioorganic & medicinal chemistry, 04-01, Volume: 25, Issue:7	Discovery of selective ATP-competitive eIF4A3 inhibitors.
AID503169	Inhibition of protein synthesis in human HeLa cells at 1 uM by [35S]methionine metabolic labeling study	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID503183	Inhibition of eIF4A RNA-dependent ATPase activity assessed as rate of ATP hydrolysis	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID1439865	Binding affinity to full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 expressed in Escherichia coli BL21(DE3) administered for 60 to 120 secs by surface plasmon resonance biosensing assay	2017	Bioorganic & medicinal chemistry, 04-01, Volume: 25, Issue:7	Discovery of selective ATP-competitive eIF4A3 inhibitors.
AID503190	Inhibition of viral protein synthesis in poliovirus infected human HeLa cells at 80 nM after 2 hrs by [35S]methionine metabolic labeling study	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID503197	Inhibition of eIF4B RNA binding activity in presence of 0.6 mM m7GDP at 50 uM	2006	Nature chemical biology, Apr, Volume: 2, Issue:4	Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID1439868	Binding affinity to full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 expressed in Escherichia coli BL21(DE3) assessed as dissociation rate constant administered for 60 to 120 secs by surface plasmon resonance biosensing assay	2017	Bioorganic & medicinal chemistry, 04-01, Volume: 25, Issue:7	Discovery of selective ATP-competitive eIF4A3 inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	9 (21.95)	29.6817
2010's	26 (63.41)	24.3611
2020's	6 (14.63)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	3 (7.32%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	38 (92.68%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
methane Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed). methane : A one-carbon compound in which the carbon is attached by single bonds to four hydrogen atoms. It is a colourless, odourless, non-toxic but flammable gas (b.p. -161degreeC).	2.31	1	alkane; gas molecular entity; mononuclear parent hydride; one-carbon compound	bacterial metabolite; fossil fuel; greenhouse gas
hypericin [no description available]	2.07	1
cycloheximide Cycloheximide: Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.. cycloheximide : A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.	2.63	2	antibiotic fungicide; cyclic ketone; dicarboximide; piperidine antibiotic; piperidones; secondary alcohol	anticoronaviral agent; bacterial metabolite; ferroptosis inhibitor; neuroprotective agent; protein synthesis inhibitor
perylene Perylene: A 20-carbon dibenz(de,kl)anthracene that can be viewed as a naphthalene fused to a phenalene or as dinaphthalene. It is used as fluorescent lipid probe in the cytochemistry of membranes and is a polycyclic hydrocarbon pollutant in soil and water. Derivatives may be carcinogenic.. perylene : An ortho- and peri-fused polycyclic arene comprising of five benzene rings that is anthracene in which the d,e and k,l sides are fused to benzene rings.	2.07	1	ortho- and peri-fused polycyclic arene; perylenes
thiazoles [no description available]	5.45	7	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
mercury Mercury: A silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.. mercury(0) : Elemental mercury of oxidation state zero.	2.76	3	elemental mercury; zinc group element atom	neurotoxin
hecogenin hecogenin: steroidal sapogenin which has been isolated from plants particularly from numerous Agave species; used in prep of steroidal hormones; structure; RN given refers to (3beta,5alpha,25R)-isomer	7.05	1	triterpenoid
carbene carbene: electrically neutral species H2C: and its derivatives, in which the carbon is covalently bonded to two univalent groups of any kind or a divalent group and bears two nonbonding electrons; carbene is the name of the parent hydride :CH2 ; hence, the name dichlorocarbene for :CCl2. However, names for acyclic and cyclic hydrocarbons containing one or more divalent carbon atoms are derived from the name of the corresponding all-4-hydrocarbon using the suffix -ylidene; methylene carbene also available. carbene : The electrically neutral species H2C(2.) and its derivatives, in which the carbon is covalently bonded to two univalent groups of any kind or a divalent group and bears two nonbonding electrons, which may be spin-paired (singlet state) or spin-non-paired (triplet state).	7.31	1	carbene; methanediyl
hippurin hippurin: from gorgonian Isis hippuris; structure given in first source	2.42	2	oxaspiro compound; steroid
anisomycin Anisomycin: An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.. (-)-anisomycin : An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.	2.1	1	monohydroxypyrrolidine; organonitrogen heterocyclic antibiotic	anticoronaviral agent; antimicrobial agent; antineoplastic agent; antiparasitic agent; bacterial metabolite; DNA synthesis inhibitor; protein synthesis inhibitor
benzofurans Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.	2.53	2
22-epi-hippuristanol [no description available]	2.46	2
rocaglamide rocaglamide: RN refers to (1alpha,2alpha,3beta,3abeta,8bbeta)-isomer; isolated from stems of Aglaia elliptifolia; structure given in first source. rocaglamide : An organic heterotricyclic compound that is 2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan substituted by hydroxy groups at positions 1 and 8b, methoxy groups at positions 6 and 8, a 4-methoxyphenyl group at position 3a, a phenyl group at position 3 and a N,N-dimethylcarbamoyl group at position 1. Isolated from Aglaia odorata and Aglaia duperreana, it exhibits antineoplastic activity.	2.53	2	monocarboxylic acid amide; monomethoxybenzene; organic heterotricyclic compound	antileishmanial agent; antineoplastic agent; metabolite
pateamine a pateamine A: a 19-membered macrolide; structure in first source; inhibits eukaryotic translation initiation. pateamine : A marine macrodiolide that is isolated from the sponge Mycale hentscheli and exhibits anticancer and antiviral properties	5.32	6	1,3-thiazoles; macrodiolide; olefinic compound; primary amino compound; tertiary amino compound	antineoplastic agent; antiviral agent; eukaryotic initiation factor 4F inhibitor; marine metabolite
rocagloic acid rocagloic acid: from leaves of Aglaia elliptifolia: structure in first source	2.25	1
silvestrol silvestrol: isolated from the fruit and twig of Aglaia silvestris. silvestrol : An organic heterotricyclic compound that consists of a 2,3,3a,8b-tetrahydro-H-benzo[b]cyclopenta[d]furan framework substituted by hydroxy groups at positions C-1 and C-8b, a methoxycarbonyl group at C-2, a phenyl group at C-3, a 4-methoxyphenyl group at C-3a, a methoxy group at C-8 and a 1,4-dioxan-2-yloxy group at position C-6 which in turn is substituted by a methoxy group at position 3 and a 1,2-dihydroxyethyl group at position 6. Isolated from Aglaia silvestris, it exhibits antineoplastic activity.	4.09	2	dioxanes; ether; methyl ester; organic heterotricyclic compound	antineoplastic agent; metabolite
sapogenins Sapogenins: The aglucon moiety of a saponin molecule. It may be triterpenoid or steroid, usually spirostan, in nature.	2.05	1
guanine [no description available]	2.17	1	2-aminopurines; oxopurine; purine nucleobase	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
2,2'-(hydroxynitrosohydrazono)bis-ethanamine 2,2'-(hydroxynitrosohydrazono)bis-ethanamine: a nitric oxide (NO) generating compound. 1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane : A nitroso compound that is triazane in which the the nitrogen at position 1 is substituted by two 2-aminoethyl groups, that at position 2 is substituted by a hydroxy group, and that at position 3 is substituted by an oxo group.	2.06	1
7-deazaguanine [no description available]	2.17	1	organic molecular entity
pp242 torkinib : A member of the class of pyrazolopyrimidines that is 1H-pyrazolo[3,4-d]pyrimidine substituted by isopropyl, 5-hydroxyindol-2-yl and amino groups at positions 1, 3 and 4 respectively. It is a potent inhibitor of mTOR and exhibits anti-cancer properties.	2.1	1	aromatic amine; biaryl; hydroxyindoles; phenols; primary amino compound; pyrazolopyrimidine	antineoplastic agent; mTOR inhibitor
cephalostatin i cephalostatin I: two steroid units are annulated to a 1,4-pyrazine ring; RN given for (3'R-(3'alpha(R),4'alpha,4'abeta,6'balpha,8'abeta,11'aalpha,11'bbeta,13'alpha,13'aalpha,13'bbeta,14'beta,15'alpha(3R,5''S),16'abeta,17'balpha,19'abeta,22'aalpha,22'bbeta,24'aR'*))-isomer; structure in first source	2.05	1

Condition	Relationship Strength	Studies
Breast Cancer [description not available]	2.52	2
Breast Neoplasms Tumors or cancer of the human BREAST.	2.52	2
Benign Neoplasms [description not available]	4.75	4
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	4.75	4
Granulocytic Leukemia, Chronic [description not available]	2.55	2
Leukemia, Myelogenous, Chronic, BCR-ABL Positive Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.	2.55	2
Cystic Kidney Diseases [description not available]	2.25	1
Kidney, Polycystic [description not available]	2.25	1
Ciliopathies Genetic disorders caused by defects in genes related to the primary CILIUM; BASAL BODY; or CENTROSOME. Primary features may include obesity, SKELETAL DYSPLASIA; POLYDACTYLY and malformations that primarily involve the liver, eye or kidneys.	2.25	1
Polycystic Kidney Diseases Hereditary diseases that are characterized by the progressive expansion of a large number of tightly packed CYSTS within the KIDNEYS. They include diseases with autosomal dominant and autosomal recessive inheritance.	2.25	1
Kidney Diseases, Cystic A heterogeneous group of hereditary and acquired disorders in which the KIDNEY contains one or more CYSTS unilaterally or bilaterally (KIDNEY, CYSTIC).	2.25	1
Atrophy, Muscle [description not available]	2.17	1
Muscular Atrophy Derangement in size and number of muscle fibers occurring with aging, reduction in blood supply, or following immobilization, prolonged weightlessness, malnutrition, and particularly in denervation.	2.17	1
Lymphoma, Primary Effusion A rare neoplasm of large B-cells usually presenting as serious effusions without detectable tumor masses. The most common sites of involvement are the pleural, pericardial, and peritoneal cavities. It is associated with HUMAN HERPESVIRUS 8, most often occurring in the setting of immunodeficiency.	2.08	1
Carcinoma, Anaplastic [description not available]	2.05	1
Cancer of Lung [description not available]	2.05	1
Colorectal Cancer [description not available]	2.05	1
Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.	2.05	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.05	1
Colorectal Neoplasms Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.	2.05	1
ATLL [description not available]	2.06	1
Leukemia-Lymphoma, Adult T-Cell Aggressive T-Cell malignancy with adult onset, caused by HUMAN T-LYMPHOTROPIC VIRUS 1. It is endemic in Japan, the Caribbean basin, Southeastern United States, Hawaii, and parts of Central and South America and sub-Saharan Africa.	2.06	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	2.07	1

hippuristanol

Description

Cross-References

Synonyms (15)

Research Excerpts

Overview

Protein Targets (6)

Inhibition Measurements

Activation Measurements

Biological Processes (27)

Molecular Functions (20)

Ceullar Components (24)

Bioassays (51)

Research

Studies (41)

Market Indicators

Research Demand Index: 28.92

Study Types

hippuristanol

Description

Related Flora

Cross-References

Synonyms (15)

Research Excerpts

Overview

Protein Targets (6)

Inhibition Measurements

Activation Measurements

Biological Processes (27)

Molecular Functions (20)

Ceullar Components (24)

Bioassays (51)

Research

Studies (41)

Market Indicators

Research Demand Index: 28.92

Study Types

Related Drugs (22)

Related Conditions (23)