Compounds > n(1)-guanyl-1-7-diaminoheptane

n(1)-guanyl-1-7-diaminoheptane and Ovarian-Neoplasms

n(1)-guanyl-1-7-diaminoheptane has been researched along with Ovarian-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for n(1)-guanyl-1-7-diaminoheptane and Ovarian-Neoplasms

ArticleYear
EIF5A1 promotes epithelial ovarian cancer proliferation and progression.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 100

    Epithelial ovarian cancer (EOC) is one of the most common gynecological cancers and has the highest mortality rate thereof. We found abundant eukaryotic translation initiation factor 5A1 (EIF5A1) in 54 EOC tissues, and high EIF5A1 levels predicted poor survival. EIF5A1 ectopic expression enhanced EOC cell proliferative, migration, and invasive capabilities, while EIF5A1 knockdown suppressed them. Most importantly, GC7 (N1-guanyl-1,7-diaminoheptane, an EIF5A1 hypusination inhibitor) could reverse the effect of EIF5A1 upregulation on EOC cell proliferation, migration, and invasion and mutant type EIF5A1

    Topics: Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Movement; Cell Proliferation; Epithelial Cells; Eukaryotic Translation Initiation Factor 5A; Female; Guanine; Humans; Neoplasm Invasiveness; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Ovary; Peptide Initiation Factors; RNA-Binding Proteins; Up-Regulation

2018