An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of deoxyhypusine synthase (EC 2.5.1.46).
ChEBI ID: 133895
| Member | Definition | Class |
|---|---|---|
| n(1)-guanyl-1,7-diaminoheptane | A member of the class of guanidines in which the imino hydrogen of guanidine itself has been replaced by a 7-aminoheptyl group. It is an inhibitor of deoxyhypusine synthase activity (GO:0034038). | 2-(7-aminoheptyl)guanidine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (10.81) | 18.2507 |
| 2000's | 10 (27.03) | 29.6817 |
| 2010's | 20 (54.05) | 24.3611 |
| 2020's | 3 (8.11) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (2.63%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 37 (97.37%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Deoxyhypusine synthase | Homo sapiens (human) | IC50 | 0.7867 | 3 | 3 |
| Deoxyhypusine synthase | Rattus norvegicus (Norway rat) | IC50 | 0.0300 | 1 | 1 |
| Deoxyhypusine synthase | Plasmodium falciparum (malaria parasite P. falciparum) | Ki | 0.1000 | 1 | 1 |
| Nischarin | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |