Compounds > n(1)-guanyl-1-7-diaminoheptane

n(1)-guanyl-1-7-diaminoheptane and Melanoma

n(1)-guanyl-1-7-diaminoheptane has been researched along with Melanoma* in 1 studies

Other Studies

1 other study(ies) available for n(1)-guanyl-1-7-diaminoheptane and Melanoma

Article	Year
Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation. Journal of medicinal chemistry, 2021, 09-23, Volume: 64, Issue:18 Based on the novel allosteric site of deoxyhypusine synthase (DHPS), two series of 30 novel 5-(2-methoxyphenoxy)-2-phenylpyrimidin-4-amine derivatives as DHPS inhibitors were designed and synthesized. Among them, compound Topics: Allosteric Site; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Design; Enzyme Inhibitors; Female; Humans; Male; Melanoma; Mice, Inbred BALB C; Mice, Nude; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Oxidoreductases Acting on CH-NH Group Donors; Protein Binding; Pyrimidines; Rats, Sprague-Dawley; Structure-Activity Relationship; Xenograft Model Antitumor Assays	2021

Article

Year

Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation.

Journal of medicinal chemistry, 2021, 09-23, Volume: 64, Issue:18

Based on the novel allosteric site of deoxyhypusine synthase (DHPS), two series of 30 novel 5-(2-methoxyphenoxy)-2-phenylpyrimidin-4-amine derivatives as DHPS inhibitors were designed and synthesized. Among them, compound

Topics: Allosteric Site; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Design; Enzyme Inhibitors; Female; Humans; Male; Melanoma; Mice, Inbred BALB C; Mice, Nude; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Oxidoreductases Acting on CH-NH Group Donors; Protein Binding; Pyrimidines; Rats, Sprague-Dawley; Structure-Activity Relationship; Xenograft Model Antitumor Assays

2021