Page last updated: 2024-10-24

dynein heavy chain binding

Definition

Target type: molecularfunction

Binding to a heavy chain of the dynein complex. [GOC:bf]

Dynein heavy chain binding is a molecular function that describes the interaction of proteins with the heavy chains of dynein, a motor protein responsible for minus-end directed movement along microtubules. Dynein heavy chains are large multi-domain proteins that contain the ATPase motor domain, responsible for generating movement. The binding of other proteins to dynein heavy chains can regulate its activity, determine its localization, and specify its cargo.

This interaction is crucial for a variety of cellular processes, including:

* **Intracellular transport:** Dynein, with its bound cargo, moves along microtubules to deliver various cellular components, such as organelles, vesicles, and mRNA, to their designated locations within the cell. The binding of specific proteins to dynein heavy chains can direct this transport to particular destinations.
* **Cilia and flagella movement:** Dynein is essential for the motility of cilia and flagella, which are hair-like structures that propel cells or fluids. The precise interaction of dynein with its associated proteins within these structures is critical for their coordinated beating.
* **Nuclear migration:** Dynein plays a role in the positioning of the nucleus within the cell. It can interact with specific proteins associated with the nuclear envelope to regulate nuclear movement during development and cell division.
* **Cell division:** Dynein participates in the separation of chromosomes during cell division. It interacts with proteins that connect chromosomes to microtubules, facilitating their movement to opposite poles of the cell.

The specific mechanism of dynein heavy chain binding varies depending on the interacting protein. Some proteins may bind directly to the heavy chain, while others may require intermediate adapter proteins. This binding can be regulated by various factors, including phosphorylation, ubiquitination, and other post-translational modifications.

The study of dynein heavy chain binding is essential for understanding the complex mechanisms of intracellular transport, cell division, and other vital cellular processes.'
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Proteins (1)

ProteinDefinitionTaxonomy
NischarinA nischarin that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y2I1]Homo sapiens (human)

Compounds (26)

CompoundDefinitionClassesRoles
cirazolinecirazoline: posseses agonist properties at alpha-adrenoreceptor sites; RN given refers to parent cpdaromatic ether
clonidineclonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine;
imidazoline
guanfacineGuanfacine: A centrally acting antihypertensive agent with specificity towards ADRENERGIC ALPHA-2 RECEPTORS.acetamides
naphazolineNaphazoline: An adrenergic vasoconstrictor agent used as a decongestant.naphthalenes
ondansetronOndansetron: A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.carbazoles
oxymetazolineoxymetazoline : A member of the class of phenols that is 2,4-dimethylphenol which is substituted at positions 3 and 6 by 4,5-dihydro-1H-imidazol-2-ylmethyl and tert-butyl groups, respectively. A direct-acting sympathomimetic with marked alpha-adrenergic activity, it is a vasoconstrictor that is used (generally as the hydrochloride salt) to relieve nasal congestion.

Oxymetazoline: A direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1251)
carboxamidine;
imidazolines;
phenols
alpha-adrenergic agonist;
nasal decongestant;
sympathomimetic agent;
vasoconstrictor agent
4-iodoclonidine4-iodoclonidine: structure given in first source
moxonidinemoxonidine: structure given in first sourceorganohalogen compound;
pyrimidines
tizanidinetizanidine : 2,1,3-Benzothiadiazole substituted at C-4 by a Delta(1)-imidazolin-2-ylamino group and at C-4 by a chloro group. It is an agonist at alpha2-adrenergic receptor sites.

tizanidine: RN given refers to parent cpd; structure
benzothiadiazole;
imidazoles
alpha-adrenergic agonist;
muscle relaxant
phentolaminephentolamine : A substituted aniline that is 3-aminophenol in which the hydrogens of the amino group are replaced by 4-methylphenyl and 4,5-dihydro-1H-imidazol-2-ylmethyl groups respectively. An alpha-adrenergic antagonist, it is used for the treatment of hypertension.

Phentolamine: A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
imidazoles;
phenols;
substituted aniline;
tertiary amino compound
alpha-adrenergic antagonist;
vasodilator agent
idazoxanidazoxan : A benzodioxine that is 2,3-dihydro-1,4-benzodioxine in which one of the hydrogens at position 2 has been replaced by a 4,5-dihydro-1H-imidazol-2-yl group.

Idazoxan: A benzodioxane-linked imidazole that has alpha-2 adrenoceptor antagonist activity.
benzodioxine;
imidazolines
alpha-adrenergic antagonist
rilmenidineRilmenidine: Oxazole derivative that acts as an agonist for ALPHA-2 ADRENERGIC RECEPTORS and IMIDAZOLINE RECEPTORS. It is used in the treatment of HYPERTENSION.isourea
efaroxanefaroxan: RN given refers to parent cpd1-benzofurans
tryptolinetryptoline: neurotoxic factor that may be involved in development of Parkinson's disease; enzymatic prep from human brain converts tryptamine to tryptoline; RN given refers to parent cpd; structurebeta-carbolines
293b cpd6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane: RN given for (trans-(+-))-isomer1-benzopyran
4-chloro-2-(2-imidazolin-2-ylamino)isoindoline4-chloro-2-(2-imidazolin-2-ylamino)isoindoline: acts as partial agonist at the postsynaptic alpha-adrenoreceptors of the rat anococcygeus muscle & as antagonist at the presynaptic alpha-adrenoreceptors of the rat vas deferens
harmalanharmalan: structure given in first sourceharmala alkaloid
n(1)-guanyl-1,7-diaminoheptane2-(7-aminoheptyl)guanidine : A member of the class of guanidines in which the imino hydrogen of guanidine itself has been replaced by a 7-aminoheptyl group. It is an inhibitor of deoxyhypusine synthase activity (GO:0034038).

N(1)-guanyl-1,7-diaminoheptane: inhibits deoxyhypusine synthase
guanidines;
primary amino compound
antineoplastic agent;
EC 2.5.1.46 (deoxyhypusine synthase) inhibitor
2-(2-benzofuranyl)-2-imidazoline2-(2-benzofuranyl)-2-imidazoline: structure given in first sourcebenzofurans
harmineharmine : A harmala alkaloid in which the harman skeleton is methoxy-substituted at C-7.

Harmine: Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is one of the active ingredients of hallucinogenic drinks made in the western Amazon region from related plants. It has no therapeutic use, but (as banisterine) was hailed as a cure for postencephalitic PARKINSON DISEASE in the 1920's.
harmala alkaloidanti-HIV agent;
EC 1.4.3.4 (monoamine oxidase) inhibitor;
metabolite
guanabenzGuanabenz: An alpha-2 selective adrenergic agonist used as an antihypertensive agent.dichlorobenzene
tracizolinetracizoline: RN given for (R-(R*,R*))-2,3-dihydroxybutanedionate (1:1); ligand for imidazoline receptor; structure in first source
6-cyano-4-(n-ethylsulfonyl-n-methylamino)-3-hydroxy-2,2-dimethylchromane, (trans-(+))-isomer
cilansetroncilansetron: structure given in first source; binds to 5-HT(3) receptors
4-n-butyl-1-(4-(2-methylphenyl)-4-oxo-1-butyl)-piperidine hydrogen chloride
bix 02565