Page last updated: 2024-10-24

spermidine catabolic process

Definition

Target type: biologicalprocess

The chemical reactions and pathways resulting in the breakdown of spermidine, N-(3-aminopropyl)-1,4-diaminobutane. [GOC:ai]

Proteins (2)

ProteinDefinitionTaxonomy
Peroxisomal N(1)-acetyl-spermine/spermidine oxidaseA peroxisomal N(1)-acetyl-spermine/spermidine oxidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6QHF9]Homo sapiens (human)
Deoxyhypusine synthaseA deoxyhypusine synthase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49366]Homo sapiens (human)

Compounds (8)

CompoundDefinitionClassesRoles
n(1)-acetylspermidineN(1)-acetylspermidine : An acetylspermidine having the acetyl group at the N1-position.acetylspermidineEscherichia coli metabolite;
metabolite
bosentan anhydrousBosentan: A sulfonamide and pyrimidine derivative that acts as a dual endothelin receptor antagonist used to manage PULMONARY HYPERTENSION and SYSTEMIC SCLEROSIS.primary alcohol;
pyrimidines;
sulfonamide
antihypertensive agent;
endothelin receptor antagonist
n-acetylputrescineN-acetylputrescine : An N-monoacetylalkane-alpha,omega-diamine that is the N-monoacetyl derivative of putrescine.N-monoacetylalkane-alpha,omega-diamine;
N-substituted putrescine
metabolite;
mouse metabolite
n(8)-acetylspermidineN(8)-acetylspermidine : An acetylspermidine that is 1,8-diamino-4-azaoctane in which one of the hydrogens of the amino group attached to C-8 is replaced by an acetyl group.acetylspermidineEscherichia coli metabolite;
human metabolite
7-(n-(3-aminopropyl)amino)heptan-2-one7-(N-(3-aminopropyl)amino)heptan-2-one: inhibits N(8)-acetylspermidine deacetylation in mice
n-acetyl-1,6-diaminohexane
n(1)-guanyl-1,7-diaminoheptane2-(7-aminoheptyl)guanidine : A member of the class of guanidines in which the imino hydrogen of guanidine itself has been replaced by a 7-aminoheptyl group. It is an inhibitor of deoxyhypusine synthase activity (GO:0034038).

N(1)-guanyl-1,7-diaminoheptane: inhibits deoxyhypusine synthase
guanidines;
primary amino compound
antineoplastic agent;
EC 2.5.1.46 (deoxyhypusine synthase) inhibitor
chlorhexidinechlorhexidine : A bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge.

Chlorhexidine: A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.
biguanides;
monochlorobenzenes
antibacterial agent;
antiinfective agent