dc 107 profile

leinamycin: a thiazole containing macrolide characterized by an unusual 1,3-dioxo-1,2-dithiolane moiety that is spiro fused to an 18 member macrolactam ring; isolated from Streptomyces; MF C22-H26-N2-O6-S3; possible DNA alkylator; the leinamycin biosynthetic gene cluster from Streptomyces atroolivaceus S-140 consists of two polyketide synthases genes [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	9849230
CHEMBL ID	360089
CHEBI ID	80015
MeSH ID	M0164297

Synonym
NSC645777 ,
streptomyces antibiotic dc-107
nsc-645777
leinamycin
120500-15-4
CHEMBL360089
chebi:80015 ,
dc-107
Q25323729
dc107
(2r,4'r,6r,9e,11r,13e,15z)-4',11-dihydroxy-2,4',9-trimethyl-1'-oxospiro[19-thia-3,20-diazabicyclo[15.2.1]icosa-1(20),9,13,15,17-pentaene-6,5'-dithiolane]-3',4,12-trione
gtpl11041

Class	Description
dithiolanes
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (31)

Assay ID	Title	Year	Journal	Article
AID331133	Cytotoxicity against human HeLa S3 cells	2008	Bioorganic & medicinal chemistry letters, May-15, Volume: 18, Issue:10	Possible chemical mechanisms underlying the antitumor activity of S-deoxyleinamycin.
AID716724	Cytotoxicity against chinese hamster kU86-mutant Xrs-5 cells assessed as cell survival by clonogenic survival assay	2012	Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14	DNA cleavage induced by antitumor antibiotic leinamycin and its biological consequences.
AID716720	Ratio for chinese hamster AA8 cells to chinese hamster BER-mutant EM9 cells	2012	Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14	DNA cleavage induced by antitumor antibiotic leinamycin and its biological consequences.
AID1249584	Cytotoxicity against human A375 cells after 4 days by MTT assay	2015	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 25, Issue:21	Synthesis and evaluation of 8,4'-dideshydroxy-leinamycin revealing new insights into the structure-activity relationship of the anticancer natural product leinamycin.
AID712885	Induction of DNA cleavage in 32P-labeled oligomer duplex Sp25 DNA at 2 ug/ml to 100 ug/ml after 24 hrs by PAGE analysis without hot piperidine treatment	2012	Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14	DNA cleavage induced by antitumor antibiotic leinamycin and its biological consequences.
AID121812	In vivo antitumor activity against sarcoma 180 infected mice was determined as treated versus control of tumor volume	1999	Journal of medicinal chemistry, Apr-22, Volume: 42, Issue:8	Synthesis and antitumor activity of novel thioester derivatives of leinamycin.
AID1249587	Cytotoxicity against human T47D cells after 4 days by MTT assay	2015	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 25, Issue:21	Synthesis and evaluation of 8,4'-dideshydroxy-leinamycin revealing new insights into the structure-activity relationship of the anticancer natural product leinamycin.
AID99264	In vivo antitumor activity of compound was tested as maximal increase in life span (ILSmax) against lymphocytic leukemia P388 in mice	1998	Bioorganic & medicinal chemistry letters, Apr-21, Volume: 8, Issue:8	Synthesis and antitumor activity of leinamycin derivatives: modifications of C-8 hydroxy and C-9 keto groups.
AID1249589	Cytotoxicity against human MDA-MB-231 cells after 4 days by MTT assay	2015	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 25, Issue:21	Synthesis and evaluation of 8,4'-dideshydroxy-leinamycin revealing new insights into the structure-activity relationship of the anticancer natural product leinamycin.
AID671221	Half life of the compound at 100 uM in HEPES buffer (250 mM, pH 7.0) at 24 degC containing no organic solvent	2012	Bioorganic & medicinal chemistry letters, Jun-01, Volume: 22, Issue:11	The macrocycle of leinamycin imparts hydrolytic stability to the thiol-sensing 1,2-dithiolan-3-one 1-oxide unit of the natural product.
AID712889	Cytotoxicity against chinese hamster NER-mutant UV5 cells assessed as cell survival by clonogenic survival assay	2012	Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14	DNA cleavage induced by antitumor antibiotic leinamycin and its biological consequences.
AID1249588	Cytotoxicity against human SKBR cells after 4 days by MTT assay	2015	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 25, Issue:21	Synthesis and evaluation of 8,4'-dideshydroxy-leinamycin revealing new insights into the structure-activity relationship of the anticancer natural product leinamycin.
AID26136	Half-life determined by HPLC (330 nM)	1999	Journal of medicinal chemistry, Apr-22, Volume: 42, Issue:8	Synthesis and antitumor activity of novel thioester derivatives of leinamycin.
AID712888	Induction of DNA cleavage in 32P-labeled oligomer duplex Sp25 DNA after 8 hrs by PAGE analysis with hot piperidine treatment	2012	Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14	DNA cleavage induced by antitumor antibiotic leinamycin and its biological consequences.
AID716726	Cytotoxicity against chinese hamster NER-mutant UV41 cells assessed as cell survival by clonogenic survival assay	2012	Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14	DNA cleavage induced by antitumor antibiotic leinamycin and its biological consequences.
AID87749	In vitro antiproliferative activity against human uterine carcinoma HeLa S3 cells.	1998	Bioorganic & medicinal chemistry letters, Apr-21, Volume: 8, Issue:8	Synthesis and antitumor activity of leinamycin derivatives: modifications of C-8 hydroxy and C-9 keto groups.
AID712886	Induction of DNA cleavage in 32P-labeled oligomer duplex Sp25 DNA at 2 ug/ml to 100 ug/ml after 24 hrs by PAGE analysis followed by hot piperidine treatment	2012	Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14	DNA cleavage induced by antitumor antibiotic leinamycin and its biological consequences.
AID716730	Cytotoxicity against human MiaPaCa cells by MTT assay	2012	Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14	DNA cleavage induced by antitumor antibiotic leinamycin and its biological consequences.
AID669388	Half life of the compound at 70 uM in MOPS aqueous buffer (250 mM, pH 7.0) containing MeCN (25% v/v) at 24 degC by HPLC analysis	2012	Bioorganic & medicinal chemistry letters, Jun-01, Volume: 22, Issue:11	The macrocycle of leinamycin imparts hydrolytic stability to the thiol-sensing 1,2-dithiolan-3-one 1-oxide unit of the natural product.
AID716727	Cytotoxicity against chinese hamster AA8 cells assessed as cell survival by clonogenic survival assay	2012	Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14	DNA cleavage induced by antitumor antibiotic leinamycin and its biological consequences.
AID716723	Cytotoxicity against chinese hamster BER-mutant EM9 cells assessed as cell survival by clonogenic survival assay	2012	Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14	DNA cleavage induced by antitumor antibiotic leinamycin and its biological consequences.
AID716728	Cytotoxicity against human MiaPaCa cells assessed as potentiation of methoxyamine-mediated cytotoxicity by MTT assay	2012	Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14	DNA cleavage induced by antitumor antibiotic leinamycin and its biological consequences.
AID716725	Cytotoxicity against chinese hamster NER-mutant UV135 cells assessed as cell survival by clonogenic survival assay	2012	Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14	DNA cleavage induced by antitumor antibiotic leinamycin and its biological consequences.
AID669389	Half life of the compound at 70 uM in MOPS aqueous buffer (300 mM, pH 7.0) containing MeCN (25% v/v) at 24 degC in presence of 700 uM GSH by HPLC analysis	2012	Bioorganic & medicinal chemistry letters, Jun-01, Volume: 22, Issue:11	The macrocycle of leinamycin imparts hydrolytic stability to the thiol-sensing 1,2-dithiolan-3-one 1-oxide unit of the natural product.
AID671222	Half life of the compound in sodium phosphate buffer (10 mM, pH 7.0) at 37 degC containing methanol (10% v/v)	2012	Bioorganic & medicinal chemistry letters, Jun-01, Volume: 22, Issue:11	The macrocycle of leinamycin imparts hydrolytic stability to the thiol-sensing 1,2-dithiolan-3-one 1-oxide unit of the natural product.
AID1249586	Cytotoxicity against human MCF7 cells after 4 days by MTT assay	2015	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 25, Issue:21	Synthesis and evaluation of 8,4'-dideshydroxy-leinamycin revealing new insights into the structure-activity relationship of the anticancer natural product leinamycin.
AID99266	Compound was tested in vivo for antitumor activity against lymphocytic leukemia P388 in mice	1998	Bioorganic & medicinal chemistry letters, Apr-21, Volume: 8, Issue:8	Synthesis and antitumor activity of leinamycin derivatives: modifications of C-8 hydroxy and C-9 keto groups.
AID87753	In vitro antiproliferative activity against HeLa S3 cells	1999	Journal of medicinal chemistry, Apr-22, Volume: 42, Issue:8	Synthesis and antitumor activity of novel thioester derivatives of leinamycin.
AID712887	Induction of DNA cleavage in 32P-labeled oligomer duplex Sp25 DNA up to 24 hrs by PAGE analysis without hot piperidine treatment	2012	Bioorganic & medicinal chemistry, Jul-15, Volume: 20, Issue:14	DNA cleavage induced by antitumor antibiotic leinamycin and its biological consequences.
AID119956	Optimal dose for in vivo antitumor activity against sarcoma 180 infected mice	1999	Journal of medicinal chemistry, Apr-22, Volume: 42, Issue:8	Synthesis and antitumor activity of novel thioester derivatives of leinamycin.
AID1249585	Cytotoxicity against human Raji cells after 4 days by MTT assay	2015	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 25, Issue:21	Synthesis and evaluation of 8,4'-dideshydroxy-leinamycin revealing new insights into the structure-activity relationship of the anticancer natural product leinamycin.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (3.77)	18.7374
1990's	5 (9.43)	18.2507
2000's	25 (47.17)	29.6817
2010's	17 (32.08)	24.3611
2020's	4 (7.55)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	5 (9.43%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	48 (90.57%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
benzoic acid Benzoic Acid: A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid.. benzoic acid : A compound comprising a benzene ring core carrying a carboxylic acid substituent.. aromatic carboxylic acid : Any carboxylic acid in which the carboxy group is directly bonded to an aromatic ring.	3.59	2	benzoic acids	algal metabolite; antimicrobial food preservative; drug allergen; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; EC 3.1.1.3 (triacylglycerol lipase) inhibitor; human xenobiotic metabolite; plant metabolite
pyridoxal phosphate Pyridoxal Phosphate: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).. pyridoxal 5'-phosphate : The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.	3.31	1	methylpyridines; monohydroxypyridine; pyridinecarbaldehyde; vitamin B6 phosphate	coenzyme; cofactor; EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
guanidine Guanidine: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.. guanidine : An aminocarboxamidine, the parent compound of the guanidines.	2.02	1	carboxamidine; guanidines; one-carbon compound
methoxyamine methoxyamine: analytical reagent for aldehydes and ketones; strong irritant, can probably produce methemoglobinemia; RN given refers to parent cpd; structure	2.07	1	organooxygen compound
netropsin Netropsin: A basic polypeptide isolated from Streptomyces netropsis. It is cytotoxic and its strong, specific binding to A-T areas of DNA is useful to genetics research.	3.35	1
alanine Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.. alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.	2.03	1	alanine zwitterion; alanine; L-alpha-amino acid; proteinogenic amino acid; pyruvate family amino acid	EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor; fundamental metabolite
cyanides Cyanides: Inorganic salts of HYDROGEN CYANIDE containing the -CN radical. The concept also includes isocyanides. It is distinguished from NITRILES, which denotes organic compounds containing the -CN radical.. cyanides : Salts and C-organyl derivatives of hydrogen cyanide, HC#N.. isocyanide : The isomer HN(+)#C(-) of hydrocyanic acid, HC#N, and its hydrocarbyl derivatives RNC (RN(+)#C(-)).. cyanide : A pseudohalide anion that is the conjugate base of hydrogen cyanide.	2	1	pseudohalide anion	EC 1.9.3.1 (cytochrome c oxidase) inhibitor
dimethyl sulfate dimethyl sulfate: RN given refers to unlabeled cpd; structure. dimethyl sulfate : The dimethyl ester of sulfuric acid.	2.01	1	alkyl sulfate	alkylating agent; immunosuppressive agent
pyrroles 1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.	3.35	1	pyrrole; secondary amine
thiophenes Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.	1.99	1	mancude organic heteromonocyclic parent; monocyclic heteroarene; thiophenes; volatile organic compound	non-polar solvent
adamantane Adamantane: A tricyclo bridged hydrocarbon.	3.31	1	adamantanes; polycyclic alkane
thiazoles [no description available]	7.71	52	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
mustard gas Mustard Gas: Severe irritant and vesicant of skin, eyes, and lungs. It may cause blindness and lethal lung edema and was formerly used as a war gas. The substance has been proposed as a cytostatic and for treatment of psoriasis. It has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP-85-002, 1985) (Merck, 11th ed).. bis(2-chloroethyl) sulfide : An ethyl sulfide that is diethyl sulfide in which a hydrogen from each of the terminal methyl groups is replaced by a chlorine. It is a powerful vesicant regulated under the Chemical Weapons Convention.	2.01	1	ethyl sulfide; organochlorine compound	alkylating agent; carcinogenic agent; vesicant
2-piperidone 2-piperidone: structure given in first source. piperidin-2-one : A delta-lactam that is piperidine which is substituted by an oxo group at position 2.	3.31	1	delta-lactam; piperidones	EC 1.2.1.88 (L-glutamate gamma-semialdehyde dehydrogenase) inhibitor
2-chloroethyl ethyl sulfide [no description available]	2.01	1
dithiothreitol 1,4-dimercaptobutane-2,3-diol : A glycol that is butane-2,3-diol in which a hydrogen from each of the methyl groups is replaced by a thiol group.. 1,4-dithiothreitol : The threo-diastereomer of 1,4-dimercaptobutane-2,3-diol.	1.97	1	1,4-dimercaptobutane-2,3-diol; butanediols; dithiol; glycol; thiol	chelator; human metabolite; reducing agent
fluorides [no description available]	2.03	1	halide anion; monoatomic fluorine
daunorubicin Daunorubicin: A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.. anthracycline : Anthracyclines are polyketides that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine.. daunorubicin : A natural product found in Actinomadura roseola.	2.06	1	aminoglycoside antibiotic; anthracycline; p-quinones; tetracenequinones	antineoplastic agent; bacterial metabolite
alkenes [no description available]	2.01	1
allicin [no description available]	2.03	1	botanical anti-fungal agent; sulfoxide	antibacterial agent
saframycin a saframycin A: structure given in first source	3.16	1
proline Proline: A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.. proline : An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2.	3.35	1	amino acid zwitterion; glutamine family amino acid; L-alpha-amino acid; proline; proteinogenic amino acid	algal metabolite; compatible osmolytes; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
thiocysteine cysteine persulfide: structure in first source. 3-disulfanyl-L-alanine : An S-substituted L-cysteine where the S-substituent is specified as sulfanyl.	2.31	1	amino acid zwitterion; S-substituted L-cysteine	human metabolite; mouse metabolite
melphalan Melphalan: An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.. melphalan : A phenylalanine derivative comprising L-phenylalanine having [bis(2-chloroethyl)amino group at the 4-position on the phenyl ring.	2.04	1	L-phenylalanine derivative; nitrogen mustard; non-proteinogenic L-alpha-amino acid; organochlorine compound	alkylating agent; antineoplastic agent; carcinogenic agent; drug allergen; immunosuppressive agent
sodium perchlorate sodium perchlorate : An inorganic sodium salt comprising equal numbers of sodium and perchlorate ions.	2.01	1	inorganic sodium salt
malonyl coenzyme a Malonyl Coenzyme A: A coenzyme A derivative which plays a key role in the fatty acid synthesis in the cytoplasmic and microsomal systems.. omega-carboxyacyl-CoA : An acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with one of the carboxy groups of any alpha,omega-dicarboxylic acid.	2.42	2	malonyl-CoAs	EC 2.3.1.21 (carnitine O-palmitoyltransferase) inhibitor; Escherichia coli metabolite; metabolite; mouse metabolite
cystine [no description available]	2.31	1
mycosubtiline mycosubtiline: antifungal agent isolated from Bacillus subtilis which is a mixture of homologous lipopeptides	3.31	1
pactamycin Pactamycin: Antibiotic produced by Streptomyces pactum used as an antineoplastic agent. It is also used as a tool in biochemistry because it inhibits certain steps in protein synthesis.	3.31	1
sulfur Sulfur: An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.	2.42	2	chalcogen; nonmetal atom	macronutrient
bleomycin [no description available]	2.04	1	bleomycin	antineoplastic agent; metabolite
cysteine Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.	2.98	4	cysteinium	fundamental metabolite
platensimycin platensimycin: has antidiabetic and antisteatotic activities; a pentacyclic ketolide (structurally similar to adamantane) connected by an amide bond to 3-amino-2,4-dihydroxybenzoic acid; inhibits cellular lipid biosynthesis; discovered while screening compounds from Streptomyces platensis bacteria in a South African soil sample with S. aureus bacteria deficient in FabF protein; structure in first source. platensimycin : A monocarboxylic acid amide obtained by the formal condensation of the amino group of 3-amino-2,4-dihydroxybenzoic acid with the carboxy group of the oxatetracyclic cage component. It is an antibiotic isolated from Streptomyces platensis and exhibits inhibitory activity against fatty acid synthase.	3.31	1	aromatic amide; cyclic ether; cyclic ketone; dihydroxybenzoic acid; monocarboxylic acid amide; polycyclic cage	antibacterial agent; antimicrobial agent; bacterial metabolite; EC 2.3.1.85 (fatty acid synthase) inhibitor
isomigrastatin isomigrastatin: isolated from Streptomyces platensis; structure in first source	3.31	1	macrolide
oligonucleotides [no description available]	2.41	2
platencin platencin: inhibits both FabF and FabH; structure in first source. platencin : A monocarboxylic acid amide obtained by the formal condensation of the amino group of 3-amino-2,4-dihydroxybenzoic acid with the carboxy group of the polycyclic cage component. It is an antibiotic isolated from Streptomyces platensis and exhibits inhibitory activity against fatty acid synthase.	3.31	1	aromatic amide; cyclic ketone; dihydroxybenzoic acid; monocarboxylic acid amide; polycyclic cage	antibacterial agent; antimicrobial agent; bacterial metabolite; EC 2.3.1.85 (fatty acid synthase) inhibitor
saxitoxin Saxitoxin: A compound that contains a reduced purine ring system but is not biosynthetically related to the purine alkaloids. It is a poison found in certain edible mollusks at certain times; elaborated by GONYAULAX and consumed by mollusks, fishes, etc. without ill effects. It is neurotoxic and causes RESPIRATORY PARALYSIS and other effects in MAMMALS, known as paralytic SHELLFISH poisoning.. saxitoxin : An alkaloid isolated from the marine dinoflagellates and cyanobacteria that causes paralytic shellfish poisoning.	3.31	1	alkaloid; carbamate ester; guanidines; ketone hydrate; paralytic shellfish toxin; pyrrolopurine	cyanotoxin; marine metabolite; neurotoxin; sodium channel blocker; toxin
guanine [no description available]	2.7	3	2-aminopurines; oxopurine; purine nucleobase	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite

Condition	Relationship Strength	Studies
Sarcoma 180 An experimental sarcoma of mice.	2.41	2
Cancer of Prostate [description not available]	2.11	1
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	2.11	1
Benign Neoplasms [description not available]	2.08	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.08	1
Leukemia P388 An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.	2.01	1
Cancer of Pancreas [description not available]	2.02	1
Pancreatic Neoplasms Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).	2.02	1

dc 107

Description

Cross-References

Synonyms (12)

Drug Classes (1)

Bioassays (31)

Research

Studies (53)

Study Types

dc 107

Description

Cross-References

Synonyms (12)

Drug Classes (1)

Bioassays (31)

Research

Studies (53)

Study Types

Related Drugs (38)

Related Conditions (8)